Yu. V. Ostapiuk
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2-(Methoxycarbonyl)thiophen-3-yl-diazonium Salts: Efficient Precursors for the Formation of C–C Bonds in Thiophene-Containing Heterocyclic Systems Open
A first application of 2-(methoxycarbonyl)thiophen-3-diazonium salts in the halothienylation of α,β-unsaturated functionalized compounds under Meerwein reaction conditions is presented. This process provides thiophene-containing building b…
Effect of a thiazole derivative on the activity of antioxidant enzymes in murine lymphoma cells Open
Previous in vitro studies have demonstrated a pronounced cytotoxic effect of the thiazole derivative N-(5-Benzyl-13-thiazole-2-yl)-35-dimethyl-1-benzofuran-2-carboxamide (BF1) on tumor cells. Additionally, it has been determined that scav…
View article: Changes in bioenergetic characteristics of the murine lymphoma cells under the action of a thiazole derivative in complex with polymeric nanoparticles
Changes in bioenergetic characteristics of the murine lymphoma cells under the action of a thiazole derivative in complex with polymeric nanoparticles Open
Background. Mitochondria can influence cancer cells both indirectly via reactive oxygen species mediation and directly through mitochondrial biogenesis. Energy production in mitochondria is crucial as it facilitates the synthesis of essent…
Structural Characterization and Electrochemical Studies of Selected Alkaloid N-Oxides Open
In this work, we synthesized and confirmed the structure of several alkaloid N-oxides using mass spectrometry and Fourier-transform infrared spectroscopy. We also investigated their reduction mechanisms using voltammetry. For the first tim…
Pyrazolyldiazonium Salts in the Synthesis of 4‐Amino‐1,3’‐bipyrazoles Open
An efficient protocol for the synthesis of fluorescent 4‐amino‐1,3′‐bipyrazoles, which are substituted at the positions N‐1′, C‐4′, C‐3 and C‐5, is described. By a two‐step synthetic strategy, an initial azo coupling of ethyl cyanoacetate …
View article: Activity of antioxidant enzymes in hepatocytes of mice with lymphoma under the action of thiazole derivative in complex with polymeric nanocarrier
Activity of antioxidant enzymes in hepatocytes of mice with lymphoma under the action of thiazole derivative in complex with polymeric nanocarrier Open
Many chemotherapeutics drugs have low water solubility, which potentially can decrease their anticancer potential. The use of drug delivery systems has proven to be highly effective in addressing the challenges associated with delivering h…
View article: Genotoxicity and acute toxicity of 2-amino-5-benzylthiazole in complex with polymeric nanocarrier in Allium bioassay
Genotoxicity and acute toxicity of 2-amino-5-benzylthiazole in complex with polymeric nanocarrier in Allium bioassay Open
Background. The search for optimal methods of selective and integral determination of various cytotoxic compounds in biological fluids and tissues, which would have high sensitivity and allow for quick and reliable assessment and detection…
View article: Bioenergetic characteristics of the murine Nemeth-Kellner lymphoma cells exposed to thiazole derivative in complex with polymeric nanoparticles
Bioenergetic characteristics of the murine Nemeth-Kellner lymphoma cells exposed to thiazole derivative in complex with polymeric nanoparticles Open
The development of a new anticancer drugs targeted at energy metabolism of tumor cells is a promising approach for cancer treatment. The aim of our study was to investigate the action of thiazole derivative N-(5-benzyl-1,3-thiazol-2-yl)-3…
View article: Generation of ROS under the influence of thiazole derivative and its complexes with PEG-based polymeric nanoparticles
Generation of ROS under the influence of thiazole derivative and its complexes with PEG-based polymeric nanoparticles Open
Aim.To determine the in vitro effect of thiazole derivative and its complex with polyethylene glycol (PEG)-based nanoscale particles on ROS generation in the NK/Ly lymphoma cells and hepatocytes of mice.Methods.The effects of BF-1 (N-(5-be…
View article: Linked PDF of Table of Contents
Linked PDF of Table of Contents Open
NCu(OAc
CCDC 1584237: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2164635: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2164634: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Synthesis of substituted 5-(thiophen-2-yl)-1H-tetrazoles Open
Novel N-(5-aryl-2-( 1H -tetrazol-5-yl)thiophen-3-yl)acetamides were obtained by the acylation of 2-( 1H -tetrazol-5-yl)-5-aryl-3-aminothiophenes, synthesized by the reaction of 5-aryl-3-aminothiophenes with ammonium azide in the inert atmo…
View article: Safety profile of thiazole derivative and its complex with PEG-based polymeric nanoparticles on liver and blood cells in tumor-bearing mice
Safety profile of thiazole derivative and its complex with PEG-based polymeric nanoparticles on liver and blood cells in tumor-bearing mice Open
Background. Drug delivery systems (DDS) have demonstrated a significant ability to overcome many of the challenges associated with the delivery of hydrophobic chemotherapeutic compounds to tumor tissues. However, hepatotoxicity and suppres…
View article: Effect of a novel thiazole derivative and its complex with a polymeric carrier on stability of DNA in human breast cancer cells
Effect of a novel thiazole derivative and its complex with a polymeric carrier on stability of DNA in human breast cancer cells Open
Thiazole derivatives are perspective antitumor compounds characterized by a broad range of bioactivity, while polymeric carriers are widely used to enhance the efficiency of biological action of drugs, improve their biocompatibility and wa…
Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides Open
New N-(5-R-benzyl-1,3-thiazol-2-yl)-2-morpholin-4-yl-2-oxoacetamides have been prepared in good yields via the reaction of N-(5-R-benzyl-1,3-thiazol-2-yl)-2-chloroacetamides with sulfur and morfoline. These compounds react with ethendiamin…
Synthesis and Anticancer Activity of Novel Benzofurancarboxamides Open
In our present work, we presented an efficient synthesis and anticancer activity evaluation of some novel benzofurancarboxamides. Our proposed approaches provide the possibility to design benzofurans diversity with a considerable chemical …
Synthesis, anti-inflammatory activityand molecular docking of 2-methyl-3-furamides Open
In an effort to develop novel anti-inflammatory agents, a series of novel 2-methyl-3-furamides were synthesized and modified.The structures of the obtained compounds were confirmed by 1H NMR spectroscopy and elemental analysis.The synthesi…
Synthesis and anticancer properties of N-(5-R-benzyl-1,3-thiazol-2-yl)-2,5-dimethyl-3-furamides Open
Aim. Study of the synthesis and anticancer activity of a series of N-(5-R-benzyl-1,3-thiazol-2-yl)-2,5-dimethyl-3-furamides.Methods.Organic synthesis, analytical and spectral methods, pharmacological screening.Results.N-(5-R-benzyl-1,3-thi…
Spectrophotometry of 1-(1-methyl-1Н-pyrazol-3-il-azo)-naphtalen-2-ol Open
Pyrazolyl azo dyes, due to the intense colouring of the reagents themselves and their complexes with certain metal ions, are widely used in the textile industry, especially for polyamide fibre products dyeing. Another advantage of pyrazoly…
Syntheses of methyl 3-aminothiophene-2-carboxylate amide Open
Methods of the syntheses of 3-aminothiophene amides have not been developed enough yet. Nevertheless, they constitute partial structures of numerous bioactive molecules such as the herbicide and fungicide dimethenamid or the local anesthet…
Synthesis of azo-dyes based on thiophendiazonium salts and their spectrophotometric properties Open
New thienylazo reagents the methyl 3-[(2-hydroxynaphthalen-1-yl)diazenyl]-4-R 1 -5-R 2 -thiophene-2-carboxylates and methyl 2-[(2-hydroxynaphthalen-1-yl)diazenyl]-4-R 1 -5-R 2 -thiophene-3-carboxylates have been synthesized for the first t…
2‐Bromo‐2‐chloro‐3‐arylpropanenitriles as C‐3 Synthons for the Synthesis of Functionalized 3‐Aminothiophenes Open
2‐Bromo‐2‐chloro‐3‐arylpropanenitriles can be prepared by Meerwein reaction from 2‐chloroacrylonitrile and various aryldiazonium salts under copper(II) bromide catalysis. They proved to be stable compounds which form 2‐chlorocinnnamonitril…
Apoptosis induction in human leukemia cells by novel 2-amino-5-benzylthiazole derivatives Open
Derivatives of 2-amino-5-benzylthiazole are heterocyclic pharmacophores that exhibit different pharmacological activities including anticancer action. The mechanisms of such action of these compounds are not clear. The aim of the present s…
A new azo dye of thiazole series: some properties, application in deviceless detection of toxic metal ions and in acid-base titrations Open
A new reagent from the thiazolylazonaphthol series 1-(5-benzylthiazol-2-yl)azonaphthalen-2-ol (BnTAN) was characterized and applied in analytical purposes. The compound was synthesized, purified and studied using spectral methods before th…
Evaluation of antiproliferative activity of pyrazolothiazolopyrimidine derivatives Open
The research aim was to test cytotoxic effects in vitro of seven novel pyrazolothiazolopyrimidine derivatives in targeting several lines of tumor and pseudo-normal mammalian cells. We demonstrated that cytotoxic effects of these derivative…