Yu Yi M. Wong
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View article: Gut microbiota analysis in pediatric‐onset multiple sclerosis compared to pediatric monophasic demyelinating syndromes and pediatric controls
Gut microbiota analysis in pediatric‐onset multiple sclerosis compared to pediatric monophasic demyelinating syndromes and pediatric controls Open
Background and purpose Gut microbiota dysbiosis may lead to proinflammatory conditions contributing to multiple sclerosis (MS) etiology. Pediatric‐onset MS patients are close to biological disease onset and less exposed to confounders. The…
View article: Neurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis and not monophasic demyelinating syndromes in childhood
Neurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis and not monophasic demyelinating syndromes in childhood Open
Background: Pediatric-onset multiple sclerosis (POMS) represents the earliest stage of disease pathogenesis. Investigating the cerebrospinal fluid (CSF) proteome in POMS may provide novel insights into early MS processes. Objective: To ana…
View article: Prognostic factors for relapse and outcome in pediatric acute transverse myelitis
Prognostic factors for relapse and outcome in pediatric acute transverse myelitis Open
View article: HLA association in MOG-IgG– and AQP4-IgG–related disorders of the CNS in the Dutch population
HLA association in MOG-IgG– and AQP4-IgG–related disorders of the CNS in the Dutch population Open
The present study demonstrates differences in the immunogenetic background of MOGAD and AQP4-IgG-positive NMOSD. The strong positive association with HLA-A*01, -B*08, and -DRB1*03 is suggestive of a role of this haplotype in the etiology o…
View article: Moving Forward on Acquired Demyelinating Syndromes : Diagnosis, Disease Course and Outcome
Moving Forward on Acquired Demyelinating Syndromes : Diagnosis, Disease Course and Outcome Open
markdownabstractAcquired demyelinating syndromes (ADS) encompass a broad spectrum of inflammatory demyelinating disorders of the central nervous
\nsystem. This thesis focuses on two rare groups of patients in the ADS spectrum: neuromyeliti…
View article: Real-world validation of the 2017 McDonald criteria for pediatric MS
Real-world validation of the 2017 McDonald criteria for pediatric MS Open
This study provides Class II evidence that in children with ADS, the 2017 McDonald criteria are more sensitive but less specific than the 2010 McDonald criteria for predicting CDMS.
View article: Application of the 2017 Revised McDonald Criteria for Multiple Sclerosis to Patients With a Typical Clinically Isolated Syndrome
Application of the 2017 Revised McDonald Criteria for Multiple Sclerosis to Patients With a Typical Clinically Isolated Syndrome Open
The 2017 revised McDonald criteria are associated with greater sensitivity but less specificity for a second attack than the previous 2010 criteria. The tradeoff is that it leads to a higher number of MS diagnoses in patients with a less a…
View article: T-cell activation marker sCD27 is associated with clinically definite multiple sclerosis in childhood-acquired demyelinating syndromes
T-cell activation marker sCD27 is associated with clinically definite multiple sclerosis in childhood-acquired demyelinating syndromes Open
Background: Cerebrospinal fluid (CSF) levels of T-cell activation marker soluble CD27 (sCD27) are associated with subsequent disease activity after a first attack of suspected MS in adults. The predictive value for disease course in childr…
View article: High neurofilament levels are associated with clinically definite multiple sclerosis in children and adults with clinically isolated syndrome
High neurofilament levels are associated with clinically definite multiple sclerosis in children and adults with clinically isolated syndrome Open
Background: A promising biomarker for axonal damage early in the disease course of multiple sclerosis (MS) is neurofilament light chain (NfL). It is unknown whether NfL has the same predictive value for MS diagnosis in children as in adult…
View article: Incidence and outcome of acquired demyelinating syndromes in Dutch children: update of a nationwide and prospective study
Incidence and outcome of acquired demyelinating syndromes in Dutch children: update of a nationwide and prospective study Open
View article: Paediatric acute disseminated encephalomyelitis followed by optic neuritis: disease course, treatment response and outcome
Paediatric acute disseminated encephalomyelitis followed by optic neuritis: disease course, treatment response and outcome Open
Background and purpose Acute disseminated encephalomyelitis followed by optic neuritis ( ADEM ‐ ON ) is a rare demyelinating syndrome that is different from multiple sclerosis and neuromyelitis optica spectrum disorder. The aim of this stu…
View article: Disease Course and Treatment Responses in Children With Relapsing Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease
Disease Course and Treatment Responses in Children With Relapsing Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease Open
Although commonly used to treat patients with multiple sclerosis, DMDs were not associated with clinical improvement in children with MOG-Ab-associated disease, whereas azathioprine, mycophenolate mofetil, rituximab, and particularly intra…
View article: Fatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis
Fatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis Open
Background and Objective: Fatigue and physical impairments are a major concern in children with multiple sclerosis (MS) and after acute disseminated encephalomyelitis (post-ADEM). We here aimed to evaluate the interaction between fatigue, …
View article: Incidence of AQP4-IgG seropositive neuromyelitis optica spectrum disorders in the Netherlands: About one in a million
Incidence of AQP4-IgG seropositive neuromyelitis optica spectrum disorders in the Netherlands: About one in a million Open
Neuromyelitis optica (NMO) is a rare autoimmune disease affecting the optic nerves and spinal cord. In the majority of NMO patients anti-aquaporin-4 antibodies (AQP4-IgG) are detected. Here we assessed a nationwide incidence of AQP4-IgG-se…