Yun Yen
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View article: Correction: Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients
Correction: Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients Open
View article: FGFR inhibitors promote the autophagic degradation of IFN-γ-induced PD-L1 and alleviate the PD-L1-mediated transcriptional suppression of FGFR3-TACC3 in non-muscle-invasive bladder cancer
FGFR inhibitors promote the autophagic degradation of IFN-γ-induced PD-L1 and alleviate the PD-L1-mediated transcriptional suppression of FGFR3-TACC3 in non-muscle-invasive bladder cancer Open
View article: Exosomal long noncoding RNAs and microRNAs in colorectal cancer
Exosomal long noncoding RNAs and microRNAs in colorectal cancer Open
A BSTRACT This review focuses on the multifaceted roles of exosomal noncoding RNAs (ncRNAs) in colorectal cancer (CRC), utilizing the provided document as the primary source of information. Exosomes, nanoscale vesicles ranging from 30 to 1…
View article: Exploring the Influence of Ecotourism Attitudes and Involvement on Behavioral Intentions
Exploring the Influence of Ecotourism Attitudes and Involvement on Behavioral Intentions Open
This study explores the relationships among eco-tourists’ attitudes, involvement, and behavioral intentions. Based on a review of relevant literature, two conceptual models were developed to examine the role of involvement: Model A investi…
View article: A method to validate viral copy-number assay involving a hybrid amplicon and duplex droplet digital PCR
A method to validate viral copy-number assay involving a hybrid amplicon and duplex droplet digital PCR Open
View article: Analysis of Personality Traits of Ecotourism Opinion Leaders
Analysis of Personality Traits of Ecotourism Opinion Leaders Open
As ecotourism increasingly emphasizes environmental protection, opinion leaders play a critical role in promoting sustainable travel practices. These leaders, leveraging social media and other platforms, significantly influence consumer tr…
View article: Mechanisms of reduced efficacy of HER2-targeted therapy in HER2-low breast cancer by long-term nicotine exposure in patient-derived xenograft mouse tumor models
Mechanisms of reduced efficacy of HER2-targeted therapy in HER2-low breast cancer by long-term nicotine exposure in patient-derived xenograft mouse tumor models Open
The effects of long-term nicotine exposure on the treatment of HER2-positive breast cancer have only been studied epidemiologically, leaving the molecular mechanisms unclear. Therefore, it's challenging for clinicians to devise effective t…
View article: HERV Modulation in Colorectal Carcinoma Patients: A Snapshot of Endogenous Retroviral Transcriptome
HERV Modulation in Colorectal Carcinoma Patients: A Snapshot of Endogenous Retroviral Transcriptome Open
Human endogenous retroviruses (HERVs) are proviral relics of infections that affected primates' germ line. Many HERV elements retain a residual capacity to encode transcripts and proteins that have been occasionally domesticated for the ho…
View article: The Impact of Environmental Conservation Courses on University Students’ Pro-Environmental Behaviors
The Impact of Environmental Conservation Courses on University Students’ Pro-Environmental Behaviors Open
This study examines the impact of university environmental conservation courses on students’ pro-environmental behavioral intentions using the Theory of Planned Behavior (TPB). Structural equation modeling (SEM) was employed to analyze dat…
View article: Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients
Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients Open
View article: RRM2 inhibition alters cell cycle through ATM/Rb/E2F1 pathway in atypical teratoid rhabdoid tumor
RRM2 inhibition alters cell cycle through ATM/Rb/E2F1 pathway in atypical teratoid rhabdoid tumor Open
Our study highlights the role of ATM/Rb/E2F1 pathway in controlling cell cycle arrest and apoptosis in response to RRM2 inhibition-induced DNA damage. This provides insight into the therapeutic benefits of COH29 and suggests targeting this…
View article: Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer
Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer Open
The incidence of colorectal cancer (CRC) among individuals under age 50, or early-onset CRC (EOCRC), has been rising over the past few decades for unclear reasons, and the etiology of the disease remains largely unknown. Known genetic risk…
View article: Prevalence and Correlates of Depressive Symptoms among Patients with Cancer: A Cross-Sectional Study
Prevalence and Correlates of Depressive Symptoms among Patients with Cancer: A Cross-Sectional Study Open
The purpose of this study was to identify the correlates of depressive symptoms and the prevalence of depression, distress, and demoralization among patients with cancer in Taiwan in relation to their sociodemographics. A cross-sectional s…
View article: The Effect of Oncology Nurse Navigation on Mental Health in Patients with Cancer in Taiwan: A Randomized Controlled Clinical Trial
The Effect of Oncology Nurse Navigation on Mental Health in Patients with Cancer in Taiwan: A Randomized Controlled Clinical Trial Open
In this study, we investigated the prevalence of mental health problems among patients with cancer and whether oncology nurse navigation improved their mental health outcomes and medical experience. In this randomized controlled clinical t…
View article: Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials
Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials Open
Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of rec…
View article: Receptor Ligand-Free Mesoporous Silica Nanoparticles: A Streamlined Strategy for Targeted Drug Delivery across the Blood–Brain Barrier
Receptor Ligand-Free Mesoporous Silica Nanoparticles: A Streamlined Strategy for Targeted Drug Delivery across the Blood–Brain Barrier Open
Mesoporous silica nanoparticles (MSNs) represent a promising avenue for targeted brain tumor therapy. However, the blood-brain barrier (BBB) often presents a formidable obstacle to efficient drug delivery. This study introduces a ligand-fr…
View article: Effect of oncology nurse navigation on mental health in patients with cancer in Taiwan: a randomized controlled clinical trial
Effect of oncology nurse navigation on mental health in patients with cancer in Taiwan: a randomized controlled clinical trial Open
Background Evidence shows that nurse navigation is effective for patients diagnosed with cancer. Research on the effects of oncology nurse navigation on mental health is ongoing, but few studies have investigated the impact of such interve…
View article: A new potential therapeutic approach for ALS: A case report with NGS analysis
A new potential therapeutic approach for ALS: A case report with NGS analysis Open
Rationale: Amyotrophic lateral sclerosis (ALS) poses a significant clinical challenge due to its rapid progression and limited treatment options, often leading to deadly outcomes. Looking for effective therapeutic interventions is critical…
View article: Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor
Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor Open
Background Atypical teratoid rhabdoid tumors (ATRT) is a rare but aggressive malignancy in the central nervous system, predominantly occurring in early childhood. Despite aggressive treatment, the prognosis of ATRT patients remains poor. R…
View article: Protective effects of compound M01 on retinal ganglion cells in experimental anterior ischemic optic neuropathy by inhibiting TXNIP/NLRP3 inflammasome pathway
Protective effects of compound M01 on retinal ganglion cells in experimental anterior ischemic optic neuropathy by inhibiting TXNIP/NLRP3 inflammasome pathway Open
Apoptotic death of retinal ganglion cells (RGCs) is a common pathologic feature in different types of optic neuropathy, including ischemic optic neuropathy and glaucoma, ultimately leading to irreversible visual function loss. Potent and e…
View article: Impact of N221S missense mutation in human ribonucleotide reductase small subunit b on mitochondrial DNA depletion syndrome
Impact of N221S missense mutation in human ribonucleotide reductase small subunit b on mitochondrial DNA depletion syndrome Open
View article: Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies Open
Chimeric antigen receptor (CAR)-T cell therapies have been approved by FDA to treat relapsed or refractory hematological malignancies. However, the adverse effects of CAR-T cell therapies are complex and can be challenging to diagnose and …
View article: Adobe PDF - 0728_sup_tables_1-3,_sup_figs_1-3.pdf from p53R2 Inhibits the Proliferation of Human Cancer Cells in Association with Cell-Cycle Arrest
Adobe PDF - 0728_sup_tables_1-3,_sup_figs_1-3.pdf from p53R2 Inhibits the Proliferation of Human Cancer Cells in Association with Cell-Cycle Arrest Open
Adobe PDF - 0728_sup_tables_1-3,_sup_figs_1-3.pdf from p53R2 Inhibits the Proliferation of Human Cancer Cells in Association with Cell-Cycle Arrest
View article: Supplementary Table 1 from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II
Supplementary Table 1 from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II Open
XLSX file, 9K, IC50s of berbamine on liver cancer cells.
View article: Supplementary Table 2 from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II
Supplementary Table 2 from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II Open
XLSX file, 11K, Sphere formation (2 independent trials).
View article: Data from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II
Data from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II Open
Liver cancer is the third leading cause of cancer deaths worldwide but no effective treatment toward liver cancer is available so far. Therefore, there is an unmet medical need to identify novel therapies to efficiently treat liver cancer …
View article: Data from p53R2 Inhibits the Proliferation of Human Cancer Cells in Association with Cell-Cycle Arrest
Data from p53R2 Inhibits the Proliferation of Human Cancer Cells in Association with Cell-Cycle Arrest Open
Deregulation of the expression of p53R2, a p53-inducible homologue of the R2 subunit of ribonucleotide reductase, has been found in various human cancer tissues; however, the roles p53R2 plays in cancer progression and malignancy remain co…
View article: Supplementary Figure Legends from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II
Supplementary Figure Legends from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II Open
PDF file, 51K.
View article: Data from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II
Data from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II Open
Liver cancer is the third leading cause of cancer deaths worldwide but no effective treatment toward liver cancer is available so far. Therefore, there is an unmet medical need to identify novel therapies to efficiently treat liver cancer …
View article: Supplementary Table 1 from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II
Supplementary Table 1 from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II Open
XLSX file, 9K, IC50s of berbamine on liver cancer cells.