Bing Huang
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View article: Neuroform Atlas single-stent coiling for wide-neck MCA bifurcation aneurysms: a retrospective single-centre case series
Neuroform Atlas single-stent coiling for wide-neck MCA bifurcation aneurysms: a retrospective single-centre case series Open
View article: Efficacy of Eszopiclone Plus Acupuncture Therapy by Dispersing the Stagnated Liver-Qi and Regulating the Spirit for Treating Chronic Fatigue Syndrome–Related Sleep Disorders
Efficacy of Eszopiclone Plus Acupuncture Therapy by Dispersing the Stagnated Liver-Qi and Regulating the Spirit for Treating Chronic Fatigue Syndrome–Related Sleep Disorders Open
Eszopiclone plus the acupuncture therapy enhances the efficacy of treating CFS-induced sleep disorders, effectively improves serum 5-HT and BDNF levels in patients, and reduces adverse reactions.
View article: Investigation of the global translational response to oxidative stress in the model archaeon <i>Haloferax volcanii</i> reveals untranslated small RNAs with ribosome occupancy
Investigation of the global translational response to oxidative stress in the model archaeon <i>Haloferax volcanii</i> reveals untranslated small RNAs with ribosome occupancy Open
Oxidative stress induces a wide range of cellular damage, often causing disease and cell death. While many organisms are susceptible to the effects of oxidative stress, haloarchaea have adapted to be highly resistant. Several aspects of th…
View article: 3,3′-Diindolylmethane Ameliorates Metabolism Dysfunction-Associated Fatty Liver Disease via AhR/p38 MAPK Signaling
3,3′-Diindolylmethane Ameliorates Metabolism Dysfunction-Associated Fatty Liver Disease via AhR/p38 MAPK Signaling Open
Background/Objectives: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic hepatic condition marked by lipid buildup, lipotoxicity, and inflammation. Prior research indicates that 3,3′-Diindolemethane (DIM), a natural…
View article: Investigation of the Effects of Bisphenol A and High-Fat Diet Co-Exposure on the Suppression of Insulin Signaling Molecule Expression and GLUT4 Translocation Leading to Insulin Resistance
Investigation of the Effects of Bisphenol A and High-Fat Diet Co-Exposure on the Suppression of Insulin Signaling Molecule Expression and GLUT4 Translocation Leading to Insulin Resistance Open
Background/Objectives: Bisphenol A (BPA) is a pervasive environmental endocrine disruptor, and the lifestyle associated with a high-fat diet is becoming increasingly common. The precise relationship between these factors and the high incid…
View article: Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy
Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy Open
Alzheimer’s disease (AD) and epilepsy (EP) share a complex bidirectional relationship, yet the molecular mechanisms underlying their comorbidity remain insufficiently explored. To identify potential transcriptional programs across animal m…
View article: Neuronal cathepsin S increases neuroinflammation and causes cognitive decline via CX3CL1‐CX3CR1 axis and JAK2‐STAT3 pathway in aging and Alzheimer's disease
Neuronal cathepsin S increases neuroinflammation and causes cognitive decline via CX3CL1‐CX3CR1 axis and JAK2‐STAT3 pathway in aging and Alzheimer's disease Open
Aging is an intricate process involving interactions among multiple factors, which is one of the main risks for chronic diseases, including Alzheimer's disease (AD). As a member of cysteine protease, cathepsin S (CTSS) has been implicated …
View article: Pathoimmunological analyses of fatal E11 infection in premature infants
Pathoimmunological analyses of fatal E11 infection in premature infants Open
E11 causes acute fulminant hepatitis in newborns. We investigated the pathological changes of different tissues from premature male twins who died due to E11 infection. The E11 expression level was higher in the liver than in other tissues…
View article: Expression and Activity of the Transcription Factor CCAAT/Enhancer-Binding Protein β (C/EBPβ) Is Regulated by Specific Pulse-Modulated Radio Frequencies in Oligodendroglial Cells
Expression and Activity of the Transcription Factor CCAAT/Enhancer-Binding Protein β (C/EBPβ) Is Regulated by Specific Pulse-Modulated Radio Frequencies in Oligodendroglial Cells Open
The rapid growth of wireless electronic devices has raised concerns about the harmful effects of leaked electromagnetic radiation (EMR) on human health. Even though numerous studies have been carried out to explore the biological effects o…
View article: Endogenous Amyloid-formed Ca2+-permeable Channels in Aged 3xTg AD Mice
Endogenous Amyloid-formed Ca2+-permeable Channels in Aged 3xTg AD Mice Open
Alzheimer’s disease (AD), the leading cause of dementia, is characterized by the accumulation of beta-amyloid peptides (Aβ). However, whether Aβ itself is a key toxic agent in AD pathogenesis and the precise mechanism of Aβ-elicited neurot…
View article: Persistent increase of accumbens cocaine ensemble excitability induced by IRK downregulation after withdrawal mediates the incubation of cocaine craving
Persistent increase of accumbens cocaine ensemble excitability induced by IRK downregulation after withdrawal mediates the incubation of cocaine craving Open
View article: Long Non-coding RNA TMEM220-AS1 Suppressed Hepatocellular Carcinoma by Regulating the miR-484/MAGI1 Axis as a Competing Endogenous RNA
Long Non-coding RNA TMEM220-AS1 Suppressed Hepatocellular Carcinoma by Regulating the miR-484/MAGI1 Axis as a Competing Endogenous RNA Open
Long non-coding RNAs (lncRNAs) have a considerable regulatory influence on multiple biological processes. Nevertheless, the role of TMEM220-AS1 in hepatocellular carcinoma (HCC) remains unclear. We used The Cancer Genome Atlas (TCGA) datab…
View article: Specific electromagnetic radiation in the wireless signal range increases wakefulness in mice
Specific electromagnetic radiation in the wireless signal range increases wakefulness in mice Open
Significance The steady increase of electromagnetic radiation (EMR) in the environment, particularly the wireless signal, causes serious public concern over its potential negative impact on health. However, it is challenging to examine suc…
View article: Bladder malignant granular cell tumor with EP300 gene mutation: a case report and literature review
Bladder malignant granular cell tumor with EP300 gene mutation: a case report and literature review Open
Background Malignant granular cell tumor (GCT) is extremely rare. Malignant GCT with EP300 gene mutation in the bladder has not been reported in the literature. Case presentation We report a special case of 45 years old female with maligna…
View article: An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma
An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma Open
Active IFNγ signaling is a common feature of tumors responding to PD-1 checkpoint blockade. IFNγ exhibits both anti- and protumor activities. Here, we show that the treatment of lung adenocarcinoma cells with IFNγ led to a rapid increase o…
View article: IFN-γ-induced ER stress impairs autophagy and triggers apoptosis in lung cancer cells
IFN-γ-induced ER stress impairs autophagy and triggers apoptosis in lung cancer cells Open
Interferon-gamma (IFN-γ) is a major effector molecule of immunity and a common feature of tumors responding to immunotherapy. Active IFN-γ signaling can directly trigger apoptosis and cell cycle arrest in human cancer cells. However, the m…
View article: In the Basis of Hashimoto’s Thyroiditis, to Form Papillary Thyroid Carcinoma, Metastasized and Then to De-Differentiate into Poorly Differentiated Squamous Cell Carcinoma
In the Basis of Hashimoto’s Thyroiditis, to Form Papillary Thyroid Carcinoma, Metastasized and Then to De-Differentiate into Poorly Differentiated Squamous Cell Carcinoma Open
Thyroid squamous cell carcinoma is very rare. At present, it is limited to case reports. Since the thyroid follicular epithelium is the non-squamous epithelium, how primary squamous cell carcinoma (SCC) of the thyroid occurs is still a con…
View article: Long Non-Coding RNA TMEM220-AS1 Suppressed Hepatocellular Carcinoma by Regulating the miR-484/MAGI1 Axis as a Competing Endogenous RNA
Long Non-Coding RNA TMEM220-AS1 Suppressed Hepatocellular Carcinoma by Regulating the miR-484/MAGI1 Axis as a Competing Endogenous RNA Open
BackgroundLong non-coding RNA has a considerable regulative influence in multiple biological processes. Nevertheless, the role of TMEM220-AS1 in hepatocellular carcinoma (HCC) remains unclear.MethodsWe used the TCGA database to analyze dif…
View article: IFN-g-induced Jmjd3-Zeb1 axis contributes to an aggressive phenotype in lung adenocarcinoma
IFN-g-induced Jmjd3-Zeb1 axis contributes to an aggressive phenotype in lung adenocarcinoma Open
Background Active IFN-γ signaling is a common feature of tumors responding to PD-1 checkpoint blockade. IFN-γ exhibits both anti- and pro-tumor activities. Therefore, identifying the pro-tumor effects of IFN-γ and their underlying molecula…
View article: <p>Inhibition of PI3K-AKT Signaling Blocks PGE<sub>2</sub>-Induced COX-2 Expression in Lung Adenocarcinoma</p>
Inhibition of PI3K-AKT Signaling Blocks PGE<sub>2</sub>-Induced COX-2 Expression in Lung Adenocarcinoma Open
Simultaneous targeting of COX-2 and PI3K-AKT effectively suppressed PGE2-induced cell proliferation and migration and both acted in a synergistic manner. Targeting the COX-2-PGE2 positive feedback loop may be therapeu…
View article: CD8<sup>+</sup>CD57<sup>+</sup> T cells exhibit distinct features in human non-small cell lung cancer
CD8<sup>+</sup>CD57<sup>+</sup> T cells exhibit distinct features in human non-small cell lung cancer Open
Background The repetitive antigen stimulation during chronic infection often leads to the accumulation of CD8 + CD57 + T cells. These cells express high levels of interferon-γ, granzyme B and perforin with elevated cytolytic effect, and ar…
View article: Correction: 41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo
Correction: 41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo Open
View article: Metastatic low-grade endometrial stromal sarcoma with sex cord and smooth muscle differentiation: A case report
Metastatic low-grade endometrial stromal sarcoma with sex cord and smooth muscle differentiation: A case report Open
LG-ESS is a low-grade malignant tumor with a high recurrence rate and metastasis probability. It is easily misdiagnosed initially. It is essential to distinguish LG-ESS with sex cord-like differentiation from uterine tumour resembling ovar…
View article: β-Arrestin–biased β-adrenergic signaling promotes extinction learning of cocaine reward memory
β-Arrestin–biased β-adrenergic signaling promotes extinction learning of cocaine reward memory Open
Enhancing the activity of the β-arrestin arm of β-adrenergic signaling may help to prevent relapse in cocaine addicts.
View article: Peptide modified mesenchymal stem cells as targeting delivery system transfected with miR-133b for the treatment of cerebral ischemia
Peptide modified mesenchymal stem cells as targeting delivery system transfected with miR-133b for the treatment of cerebral ischemia Open
View article: Unconditioned- and Conditioned- Stimuli Induce Differential Memory Reconsolidation and β-AR-Dependent CREB Activation
Unconditioned- and Conditioned- Stimuli Induce Differential Memory Reconsolidation and β-AR-Dependent CREB Activation Open
Consolidated long-term fear memories become labile and reconsolidated upon retrieval by the presentation of conditioned stimulus (CS) or unconditioned stimulus (US). Whether CS-retrieval or US-retrieval will trigger different memory recons…
View article: Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression
Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression Open
View article: Sequence alignment and predicted secondary structure of VP1 protein of DHAV-1 and DHVA-3 viruses.
Sequence alignment and predicted secondary structure of VP1 protein of DHAV-1 and DHVA-3 viruses. Open
Orange arrows are β strands while green rectangles are α helices. DHAV-1 strain 1-CL/03 is used here as a reference strain for development of a secondary structure model of VP1.
View article: β-Arrestin–biased signaling mediates memory reconsolidation
β-Arrestin–biased signaling mediates memory reconsolidation Open
Significance β-Adrenergic receptors (β-ARs) are hormone and neurotransmitter receptors. The data we present in this paper challenge the assumption that memory reconsolidation is governed by the traditional β-AR/G protein signaling pathway.…
View article: Correction: Synthesis and properties of clickable A(B-b-C)<sub>20</sub> miktoarm star-shaped block copolymers with a terminal alkyne group
Correction: Synthesis and properties of clickable A(B-b-C)<sub>20</sub> miktoarm star-shaped block copolymers with a terminal alkyne group Open
Correction for ‘Synthesis and properties of clickable A(B-b-C)20 miktoarm star-shaped block copolymers with a terminal alkyne group’ by Bing Huang et al., Polym. Chem., 2015, DOI: 10.1039/c5py00338e.