Shi‐Yuan Cheng
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View article: STEM-16. COMBINATION THERAPIES WITH CDK9 INHIBITORS AS A PROMISING STRATEGY TO OVERCOME THERAPY RESISTANCE IN GLIOBLASTOMAS
STEM-16. COMBINATION THERAPIES WITH CDK9 INHIBITORS AS A PROMISING STRATEGY TO OVERCOME THERAPY RESISTANCE IN GLIOBLASTOMAS Open
Glioblastomas (GBMs) are highly invasive and contain self-renewing glioma stem cells (GSCs), which contribute to the growth, heterogeneity, and therapeutic resistance of the tumors. Effective GBM therapies should ideally target both GSCs a…
View article: Retraction of Activation of Rac1 by Src-dependent phosphorylation of Dock180Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans
Retraction of Activation of Rac1 by Src-dependent phosphorylation of Dock180Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans Open
View article: Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target
Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target Open
View article: Correction: Giant diatom blooms driven by deep water upwelling since late MIS3? Evidence from the rim of the Mariana Trench
Correction: Giant diatom blooms driven by deep water upwelling since late MIS3? Evidence from the rim of the Mariana Trench Open
View article: Adjusting key performance indicators in ART laboratories according to controlled ovarian stimulation protocol
Adjusting key performance indicators in ART laboratories according to controlled ovarian stimulation protocol Open
Background Reliable key performance indicators (KPIs) have been proposed to facilitate the quality management of embryo laboratories. However, the effects of controlled ovarian stimulation (COS) protocols on KPIs have not been adequately e…
View article: In Vitro Polyploidy Induction of Longshan Lilium lancifolium from Regenerated Shoots and Morphological and Molecular Characterization
In Vitro Polyploidy Induction of Longshan Lilium lancifolium from Regenerated Shoots and Morphological and Molecular Characterization Open
Longshan Lilium lancifolium is a well-known medicinal and edible lily and has been registered as a geographical indicator in China. Polyploidization confers many advantages in lily production; however, characteristics of Longshan L. lancif…
View article: An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs
An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs Open
View article: Managerial myopia and urban carbon emissions: The mediating role of corporate green innovation and the moderating role of environmental multifaceted governance
Managerial myopia and urban carbon emissions: The mediating role of corporate green innovation and the moderating role of environmental multifaceted governance Open
This study explores the externalities caused by managerial myopia from the perspective of carbon emissions in urban areas. Using panel data from 194 Chinese cities and 1 286 listed companies from 2012 to 2021, this study empirically examin…
View article: Giant diatom blooms driven by deep water upwelling since late MIS3? Evidence from the rim of the Mariana Trench
Giant diatom blooms driven by deep water upwelling since late MIS3? Evidence from the rim of the Mariana Trench Open
Laminated Diatom Mats (LDMs) in the low-latitude Western Pacific provide key insights into global climate and carbon cycling. While Ethmodiscus rex ( E. rex ) LDMs research has advanced, two critical aspects remain to be elucidated: (1) th…
View article: A Single-Cell Atlas of RNA Alternative Splicing in the Glioma-Immune Ecosystem
A Single-Cell Atlas of RNA Alternative Splicing in the Glioma-Immune Ecosystem Open
Summary Single-cell analysis has refined our understanding of cellular heterogeneity in glioma, yet RNA alternative splicing (AS)—a critical layer of transcriptome regulation—remains underexplored at single-cell resolution. Here, we presen…
View article: Regulation of Dendritic Cell Function by Ermiaosan via the EP4-cAMP-CREB Signaling Pathway
Regulation of Dendritic Cell Function by Ermiaosan via the EP4-cAMP-CREB Signaling Pathway Open
Ermiao San (EMS), a traditional Chinese medicine composed of Atractylodes macrocephala and Cortex Phellodendron, has demonstrated therapeutic efficacy in rheumatoid arthritis (RA). Studies suggest that EMS modulates dendritic cell (DC) mat…
View article: USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5
USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5 Open
Rationale: Glioblastoma (GBM) is the most aggressive type of primary brain cancer and contains self-renewing GBM stem cells (GSCs) that contribute to tumor growth and therapeutic resistance. However, molecular determinants governing…
View article: High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancy
High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancy Open
View article: Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma
Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma Open
Drug resistance is a major barrier to cancer therapies and remains poorly understood. Recently, non-mutational mechanisms of drug resistance have been proposed where a more plastic metabolic response can play a major role. Here, we show th…
View article: Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway
Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway Open
Tumor-associated macrophages (TAMs), which differentiate from tissue-resident macrophages, are recognized for their ability to influence cancer progression and metastasis. However, the specific role of Kupffer cells (KCs), the intrinsic ma…
View article: TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA‐PKcs
TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA‐PKcs Open
The factors driving glioma progression remain poorly understood. Here, the epigenetic regulator TRIM24 is identified as a driver of glioma progression, where TRIM24 overexpression promotes HRas V12 anaplastic astrocytoma (AA) progression i…
View article: RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma
RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma Open
Widespread alterations in RNA alternative splicing (AS) have been identified in adult gliomas. However, their regulatory mechanism, biological significance, and therapeutic potential remain largely elusive. Here, using a computational appr…
View article: Epigenetic Reprogramming of Autophagy Leads to Uncovering a Novel Therapeutic Target for Mutant IDH1 Astrocytomas
Epigenetic Reprogramming of Autophagy Leads to Uncovering a Novel Therapeutic Target for Mutant IDH1 Astrocytomas Open
Mutant isocitrate dehydrogenase 1 (mIDH1) exhibits a gain of function mutation enabling 2-hydroxyglutarate (2HG) production and epigenetic reprogramming. This leads to enhanced DNA-damage response and radioresistance in mIDH1 gliomas. RNA-…
View article: Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Autophagy in Glioblastoma
Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Autophagy in Glioblastoma Open
Glioblastoma, a prevalent malignant CNS tumor, presents a therapeutic challenge because of resistance to standard treatments, including radiation therapy and temozolomide. Both modalities induce autophagy, thereby paradoxically promoting t…
View article: Oxidative Stress Induced Protein Aggregation via GGCT Produced Pyroglutamic Acid in Drug Resistant Glioblastoma
Oxidative Stress Induced Protein Aggregation via GGCT Produced Pyroglutamic Acid in Drug Resistant Glioblastoma Open
View article: Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Treatment-Induced Autophagy in Glioblastoma
Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Treatment-Induced Autophagy in Glioblastoma Open
Glioblastoma, a prevalent malignant CNS tumor, presents a therapeutic challenge because of resistance to standard treatments including radiation therapy and temozolomide. Both modalities induce autophagy, paradoxically promoting tumor surv…
View article: Repurposing Clemastine to Target Glioblastoma Cell Stemness
Repurposing Clemastine to Target Glioblastoma Cell Stemness Open
Brain tumor-initiating cells (BTICs) and tumor cell plasticity promote glioblastoma (GBM) progression. Here, we demonstrate that clemastine, an over-the-counter drug for treating hay fever and allergy symptoms, effectively attenuated the s…
View article: Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis Open
View article: CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity
CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity Open
Background Glioblastoma (GBM) is refractory to current treatment modalities while side effects of treatments result in neurotoxicity and cognitive impairment. Here we test the hypothesis that inhibiting CDK7 or CDK9 would effectively comba…
View article: The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor progression: Implications for therapy
The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor progression: Implications for therapy Open
Cancer is a leading cause of death in humans, with a complex and dynamic nature that makes it challenging to fully comprehend and treat. The Mammalian Sterile 20-Like Kinase 4 (MST4 or STK26) is a serine/threonine-protein kinase that plays…
View article: Supplementary Data from SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes
Supplementary Data from SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes Open
This files contains supplemental figures related to Figures 1-3, 4, and 6, and four supplemental tables, and supplemental materials and methods.
View article: Supplementary Data from SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes
Supplementary Data from SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes Open
This files contains supplemental figures related to Figures 1-3, 4, and 6, and four supplemental tables, and supplemental materials and methods.
View article: Supplementary Table S3 from SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes
Supplementary Table S3 from SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes Open
List of differentially expressed genes after SRSF3-KO in GSCs
View article: Supplementary Table S1 from SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes
Supplementary Table S1 from SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes Open
Primers and gRNA sequences
View article: Data from Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding
Data from Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding Open
Lysine acetyltransferase KAT6A is a chromatin regulator that contributes to histone modification and cancer, but the basis of its actions are not well understood. Here, we identify a KAT6A signaling pathway that facilitates glioblastoma (G…