Yuan Seng Wu
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View article: Association of intercellular adhesion molecule 1 (ICAM-1) (rs5498) genetic polymorphism and dengue in Sabah East Malaysia population
Association of intercellular adhesion molecule 1 (ICAM-1) (rs5498) genetic polymorphism and dengue in Sabah East Malaysia population Open
View article: Inverse designed Hamiltonians for perfect state transfer and remote entanglement generation, and applications in superconducting qubits
Inverse designed Hamiltonians for perfect state transfer and remote entanglement generation, and applications in superconducting qubits Open
Hamiltonian inverse engineering enables the design of protocols for specific quantum evolutions or target state preparation. Perfect state transfer (PST) and remote entanglement generation are notable examples, as they serve as key primiti…
View article: Unravelling Alpha-Mangostin as a Promising Anticancer Agent: An Overview of Therapeutic Effects, Molecular Mechanisms, and Strategies to Improve Treatment Outcomes
Unravelling Alpha-Mangostin as a Promising Anticancer Agent: An Overview of Therapeutic Effects, Molecular Mechanisms, and Strategies to Improve Treatment Outcomes Open
Cancer represents a significant global health concern, contributing to a high number of fatalities in the 21st century, with projections indicating a continuous spike in cancer cases. Although chemotherapy is an established cancer treatmen…
View article: Network Pharmacology of Natural Polyphenols for Stroke: A Bioinformatic Approach to Drug Design
Network Pharmacology of Natural Polyphenols for Stroke: A Bioinformatic Approach to Drug Design Open
This study highlights the neuroprotective role of selected polyphenols through the PI3K/Akt pathway. Further studies are required to investigate additional molecular mechanisms between the polyphenols and their derivatives against patholog…
View article: Green synthesis of zinc oxide nanoparticles using Catharanthus pusillus: Characterization, antibacterial, cytotoxicity of A549 cells, and photocatalytic degradation of Eosin (E) dye
Green synthesis of zinc oxide nanoparticles using Catharanthus pusillus: Characterization, antibacterial, cytotoxicity of A549 cells, and photocatalytic degradation of Eosin (E) dye Open
View article: Research article Evaluation of Cytotoxicity Induced by Kalanchoe pinnata Leaf Extraction Solvents: Exploring the Impact of Incubation Period on In vitro Survival of Mice Spermatozoa
Research article Evaluation of Cytotoxicity Induced by Kalanchoe pinnata Leaf Extraction Solvents: Exploring the Impact of Incubation Period on In vitro Survival of Mice Spermatozoa Open
View article: Deciphering the molecular clock: exploring molecular mechanisms and genetic influences on skin ageing
Deciphering the molecular clock: exploring molecular mechanisms and genetic influences on skin ageing Open
Skin ageing is a multifaceted process influenced by both intrinsic genetic factors and extrinsic environmental exposures. This review explores the genetic variants and molecular mechanisms underlying skin ageing phenotypes, while identifyi…
View article: Association of Intercellular Adhesion Molecule 1 (ICAM-1) (rs5498) genetic polymorphism and dengue In Sabah East Malaysia population
Association of Intercellular Adhesion Molecule 1 (ICAM-1) (rs5498) genetic polymorphism and dengue In Sabah East Malaysia population Open
Background Dengue remains a significant public health challenge in Malaysia, particularly in Sabah where indigenous populations such as the Kadazan-Dusun and Bajau are highly affected. Host genetic factors, including polymorphisms in immun…
View article: Anti-Dengue Activity of Revaprazan Hydrochloride: A Repurposed Drug Candidate
Anti-Dengue Activity of Revaprazan Hydrochloride: A Repurposed Drug Candidate Open
Dengue fever is a major health problem, and there are no vaccines or effective antiviral treatments. Drug repurposing is a quick and appealing innovative therapeutic strategy. This study aims to develop a potent anti-dengue drug for the tr…
View article: Exploring varicella zoster virus proteome for construction and validation of a multi-epitope based subunit vaccine using multifaceted immunoinformatics approaches
Exploring varicella zoster virus proteome for construction and validation of a multi-epitope based subunit vaccine using multifaceted immunoinformatics approaches Open
Varicella zoster (VZ) is a viral disease caused by varicella zoster virus (VZV) that is related to alphaherpesvirus subfamily. VZV causes a neurotropic disease in humans. The aim of this work was to stimulate the human immune system by dev…
View article: Recent Advances in Natural and Nanoparticle-Based Therapies for Naegleria fowleri Infections
Recent Advances in Natural and Nanoparticle-Based Therapies for Naegleria fowleri Infections Open
Primary amoebic meningoencephalitis (PAM), caused by Naegleria fowleri, remains an aggressively fatal infection with often ineffectual treatment avenues. This study reviews the antiamoebic efficacy of natural-derived compounds, including p…
View article: The role and mechanism of mesenchymal stem cells in immunomodulation of type 1 diabetes mellitus and its complications: recent research progress and challenges: a review
The role and mechanism of mesenchymal stem cells in immunomodulation of type 1 diabetes mellitus and its complications: recent research progress and challenges: a review Open
View article: Unveiling Postbiotics: Advancing Definitions, Mechanisms and Their Impact on Health and Other Functional Applications
Unveiling Postbiotics: Advancing Definitions, Mechanisms and Their Impact on Health and Other Functional Applications Open
The field of microbiome science has seen rapid advancements, with probiotics, prebiotics, and postbiotics emerging as critical means for modulating gut health and systemic well-being. Among these, postbiotics represent a novel paradigm, de…
View article: Pangu Ultra MoE: How to Train Your Big MoE on Ascend NPUs
Pangu Ultra MoE: How to Train Your Big MoE on Ascend NPUs Open
Sparse large language models (LLMs) with Mixture of Experts (MoE) and close to a trillion parameters are dominating the realm of most capable language models. However, the massive model scale poses significant challenges for the underlying…
View article: Signaling Pathways and Promising Small‐Molecule Therapeutic Agents for Ischemic Stroke
Signaling Pathways and Promising Small‐Molecule Therapeutic Agents for Ischemic Stroke Open
Stroke is the second highest cause of death and leading cause of disability with high economic burden worldwide. The incidence of stroke is increasing faster and more prevalent for the global population over age 65. Ischemic stroke (IS) ha…
View article: Endothelial Dysfunction in Huntington’s Disease: Pathophysiology and Therapeutic Implications
Endothelial Dysfunction in Huntington’s Disease: Pathophysiology and Therapeutic Implications Open
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. While traditionally viewed through the lens of neuronal dysfunction, emerging evidence highlights the critic…
View article: Assessing Renewable Energy Development and Temporal-Spatial Disparities in China: A Sustainability Perspective
Assessing Renewable Energy Development and Temporal-Spatial Disparities in China: A Sustainability Perspective Open
View article: High-Throughput Screening of Wide-Bandgap Perovskites for Efficient Perovskite/Silicon Tandem Solar Cells
High-Throughput Screening of Wide-Bandgap Perovskites for Efficient Perovskite/Silicon Tandem Solar Cells Open
View article: Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches
Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches Open
Angiotensin-converting enzyme 2 receptors (ACE2R) are requisite to enter the host cells for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). ACE2R is constitutive and functions as a type I transmembrane metallo-carboxypeptidas…
View article: In vitro antimicrobial and cytotoxic potential against colorectal cancer cell lines using ethanolic leaf extract of Sansevieria trifasciata (Agavaceae)
In vitro antimicrobial and cytotoxic potential against colorectal cancer cell lines using ethanolic leaf extract of Sansevieria trifasciata (Agavaceae) Open
BACKGROUND: Sansevieria trifasciata , common name, mother-in-law’s tongue, is a member of the Agavaceae family. We undertook this study to evaluate the cytotoxicity of S. trifasciata leaf extract against two cancer cell lines as well as it…
View article: Chemistry, Pharmacology and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development
Chemistry, Pharmacology and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development Open
Decursin is a pyranocoumarin compounds which are rare secondary metabolic plant products, isolated from the roots of Angelica gigas (A. gigas). The native Korean species Angelica gigas Nakai (AGN) is widely used as a remedy f…
View article: Lawsone Unleashed: A Comprehensive Review on Chemistry, Biosynthesis, and Therapeutic Potentials
Lawsone Unleashed: A Comprehensive Review on Chemistry, Biosynthesis, and Therapeutic Potentials Open
Lawsone, a naturally occurring organic compound also called hennotannic acid, obtained mainly from Lawsonia inermis (Henna). It is a potential drug-like molecule with unique chemical and biological characteristics. Traditionally, he…
View article: Different types of algae beneficial for bone health in animals and in humans – A review
Different types of algae beneficial for bone health in animals and in humans – A review Open
Algae have long been recognized as a valuable source of nutrients and minerals. Recent studies suggest that diverse types of algae may provide benefits for bone health in animals and humans. This review article provides an overview of the …
View article: Bioconversion of organic waste by insects – A comprehensive review
Bioconversion of organic waste by insects – A comprehensive review Open
The ever-growing human population has forced people to intensify agriculture to meet the demand for food and feed. However, the increase in global agricultural production also means an increase in waste generation, which is mostly improper…
View article: Preclinical Therapeutic Effects of Quercetin on Gastrointestinal Cancers
Preclinical Therapeutic Effects of Quercetin on Gastrointestinal Cancers Open
Gastrointestinal (GI) cancers were included in the top 10 most common cancers in 2020. Future incidences are expected to rise due to the varying risk factors and aetiologies. With high incidences and mortality rates, current cancer treatme…
View article: <i>In vitro</i> cytotoxic activity of <i>Sansevieria trifasciata</i> against various cancer cell lines
<i>In vitro</i> cytotoxic activity of <i>Sansevieria trifasciata</i> against various cancer cell lines Open
Purpose: To determine the in vitro anticancer properties of Sansevieria trifasciata extracts. Methods: The cytotoxic activity of n-hexane, ethyl acetate and methanol leaf extracts at different concentrations was assessed against Vero, panc…
View article: A comprehensive review of phytochemicals of Withania somnifera (L.) Dunal (Solanaceae) as antiviral therapeutics
A comprehensive review of phytochemicals of Withania somnifera (L.) Dunal (Solanaceae) as antiviral therapeutics Open
View article: Synthesis, Characterization and Response of Newer Benzamidine Analogues against Porphyromonas gingivalis mediated Peri-Implantitis
Synthesis, Characterization and Response of Newer Benzamidine Analogues against Porphyromonas gingivalis mediated Peri-Implantitis Open
Evidence suggests development of various therapeutic strategies against peri-implantitis ranging from plant extracts to synthetic molecules, but the development of resistance and associated side effects motivates the investigators to explo…
View article: Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity
Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity Open
In this study, zinc oxide nanoparticles (ZnO‐NPs) are synthesized and combined with chitosan (Cs) to create Cs/ZnO‐NPs nanomicelles, aiming to investigate their potential as a novel cancer treatment. The ZnO‐NPs are produced through a sint…
View article: Thymoquinone Reverses Homocysteine-Induced Endothelial Dysfunction Via Inhibition of Endoplasmic Reticulum-Stress Induced Oxidative Stress Pathway
Thymoquinone Reverses Homocysteine-Induced Endothelial Dysfunction Via Inhibition of Endoplasmic Reticulum-Stress Induced Oxidative Stress Pathway Open
Hyperhomocysteinemia causes endoplasmic reticulum (ER) stress, which elevates reactive oxygen species (ROS) and induces endothelial dysfunction, the hallmark of cardiovascular diseases. Nigella sativa seeds contain thymoquinone (TQ), a car…