Zhuoyuan Zhang
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View article: Comparison of Polygonatum sibiricum Polysaccharides from Different Extraction Methods
Comparison of Polygonatum sibiricum Polysaccharides from Different Extraction Methods Open
Although our previous research has indicated that the ultrasound-assisted extraction–deep eutectic solvent method possessed the highest extraction yield for Polygonatum sibiricum Polysaccharide, it is uncertain whether the Polygonatum sibi…
View article: Comparative study of effectiveness and safety between non-Descemet stripping endothelial keratoplasty and Descemet stripping endothelial keratoplasty for endothelial decompensation
Comparative study of effectiveness and safety between non-Descemet stripping endothelial keratoplasty and Descemet stripping endothelial keratoplasty for endothelial decompensation Open
Purpose To compare the potential effectiveness and safety of non-Descemet stripping endothelial keratoplasty (nDSEK) and Descemet stripping endothelial keratoplasty (DSEK) in treating endothelial decompensation. Methods A retrospective com…
View article: Efficacy, safety and single-cell analysis of neoadjuvant immunochemotherapy in locally advanced oral squamous cell carcinoma: a phase II trial
Efficacy, safety and single-cell analysis of neoadjuvant immunochemotherapy in locally advanced oral squamous cell carcinoma: a phase II trial Open
View article: CD44 on cancer stem cell is a potential immunological and prognostic pan-cancer biomarker
CD44 on cancer stem cell is a potential immunological and prognostic pan-cancer biomarker Open
CD44 is both a cancer stem cell marker and a potential prognostic and immunological biomarker in various malignant tumors. Moreover, CD44 could be a novel target for immune-based therapy.
View article: Accelerated Aging Method of Performance Attenuation of Crystalline Silicon Photovoltaic Modules Under Full-Spectrum Conditions
Accelerated Aging Method of Performance Attenuation of Crystalline Silicon Photovoltaic Modules Under Full-Spectrum Conditions Open
Crystalline silicon photovoltaic modules, when subjected to diverse environmental conditions, undergo progressive performance degradation due to factors such as temperature, humidity, light irradiation, and operational duration. Understand…
View article: Regulation of the Endocytosis System Using Ultrathin g‐C<sub>3</sub>N<sub>4</sub> Nanosheets for Enhanced Photodynamic Therapy of Glioma
Regulation of the Endocytosis System Using Ultrathin g‐C<sub>3</sub>N<sub>4</sub> Nanosheets for Enhanced Photodynamic Therapy of Glioma Open
Glioma is the most aggressive form of brain cancer. Photodynamic therapy (PDT) has emerged as a promising treatment method for glioma; however, its efficacy is often hindered by the blood–brain barrier (BBB) and the need for precise tumor …
View article: Somatic repetitive element insertions Define New Biomarkers in Pan-cancer genome
Somatic repetitive element insertions Define New Biomarkers in Pan-cancer genome Open
Repetitive elements insertions (REIs), including tandem repeat insertions (TRIs) and transposable element insertions (TEIs), constitute >90% of large-scale (>50bp) somatic insertions and are linked to diseases and cancer biomarkers. Howeve…
View article: High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis
High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis Open
Traumatic brain injury (TBI) is one of the leading causes of disability and mortality, which was classified as low-altitude TBI and high-altitude TBI. A large amount of literature shows that high-altitude TBI is associated with more severe…
View article: Comparison and Correlation of the Donor–Recipient Interface Changes and Visual Outcomes Between nDSEK and DSEK
Comparison and Correlation of the Donor–Recipient Interface Changes and Visual Outcomes Between nDSEK and DSEK Open
Purpose: This study aimed to compare the donor–recipient interface changes between non‐Descemet stripping endothelial keratoplasty (nDSEK) and Descemet stripping endothelial keratoplasty (DSEK) and assess their correlation with the postope…
View article: CD44 on cancer stem cell is a potential immunological and prognostic pan-cancer biomarker
CD44 on cancer stem cell is a potential immunological and prognostic pan-cancer biomarker Open
Background CD44, a widespread cancer stem cell marker, displayed a vital participation in the cancer immune invasion and may related with the response to the immunotherapy. However, the role of CD44 in cancer immunology is not well defined…
View article: FBL Promotes LPS-Induced Neuroinflammation by Activating the NF-κB Signaling Pathway
FBL Promotes LPS-Induced Neuroinflammation by Activating the NF-κB Signaling Pathway Open
LPS induced the expression of FBL in HT22 cells through the RAS/MAPK signaling pathway, and FBL further activated the NF-kB signaling pathway, which promoted the expression of relevant inflammatory genes and the release of cytokines. The p…
View article: Preso enhances mGluR1-mediated excitotoxicity by modulating the phosphorylation of mGluR1-Homer1 complex and facilitating an ER stress after traumatic brain injury
Preso enhances mGluR1-mediated excitotoxicity by modulating the phosphorylation of mGluR1-Homer1 complex and facilitating an ER stress after traumatic brain injury Open
View article: Revolutionizing Ischemic Stroke Diagnosis and Treatment: The Promising Role of Neurovascular Unit-Derived Extracellular Vesicles
Revolutionizing Ischemic Stroke Diagnosis and Treatment: The Promising Role of Neurovascular Unit-Derived Extracellular Vesicles Open
Ischemic stroke is a fatal and disabling disease worldwide and imposes a significant burden on society. At present, biological markers that can be conveniently measured in body fluids are lacking for the diagnosis of ischemic stroke, and t…
View article: Structural and functional basis of bacteriophage K64-ORF41 depolymerase for capsular polysaccharide degradation of Klebsiella pneumoniae K64
Structural and functional basis of bacteriophage K64-ORF41 depolymerase for capsular polysaccharide degradation of Klebsiella pneumoniae K64 Open
Capsule polysaccharide is an important virulence factor of Klebsiella pneumoniae (K. pneumoniae), which protects bacteria against the host immune response. A promising therapeutic approach is using phage-derived depolymerases to degrade th…
View article: Identification of hypoxia- and immune-related biomarkers in patients with ischemic stroke
Identification of hypoxia- and immune-related biomarkers in patients with ischemic stroke Open
In brief, we identified and validated four hub genes-FOS, DDIT3, DUSP1, and NFIL3-which might be involved in the pathological development of IS, potentially providing novel perspectives for the diagnosis and treatment of IS.
View article: Comparative study of efficacy and safety between nDSEK and DSEK for bullous keratopathy
Comparative study of efficacy and safety between nDSEK and DSEK for bullous keratopathy Open
Background Endothelial keratoplasty has evolved significantly through the utilization of different techniques. However, few studies have compared the clinical outcome between nDSEK (a modified version of the DSEK procedure known as non-Des…
View article: Addressing Recycling Inefficiencies in Shanghai Using Circular Economy
Addressing Recycling Inefficiencies in Shanghai Using Circular Economy Open
The recycling rate in Shanghai, despite being a role model among Chinas cities, still has significant room for improvement. If the recycling rate in Shanghai is improved, peoples lives will be better. Being aware of it, and since the lack …
View article: The NAD <sup>+</sup> Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease
The NAD <sup>+</sup> Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease Open
Alpers' syndrome is an early-onset neurodegenerative disorder usually caused by biallelic pathogenic variants in the gene encoding the catalytic subunit of polymerase-gamma (POLG), which is essential for mitochondrial DNA (mtDNA) replicati…
View article: The Spread and Future of Critical Pedagogy in China
The Spread and Future of Critical Pedagogy in China Open
Critical Pedagogy is a political, multi-cultural and class-based theory that criticizes the realistic problems of Education under the capitalist social ideology. The spread of Critical Pedagogy in China is influenced by China's educational…
View article: Medication-related osteonecrosis of the jaw (MRONJ): a review of pathogenesis hypothesis and therapy strategies
Medication-related osteonecrosis of the jaw (MRONJ): a review of pathogenesis hypothesis and therapy strategies Open
View article: Observing Extracellular Vesicles Originating from Endothelial Cells <i>in Vivo</i> Demonstrates Improved Astrocyte Function Following Ischemic Stroke via Aggregation-Induced Emission Luminogens
Observing Extracellular Vesicles Originating from Endothelial Cells <i>in Vivo</i> Demonstrates Improved Astrocyte Function Following Ischemic Stroke via Aggregation-Induced Emission Luminogens Open
Extracellular vesicles (EVs) obtained from endothelial cells (ECs) have significant therapeutic potential in the clinical management of individuals with ischemic stroke (IS) because they effectively treat ischemic stroke in animal models. …
View article: The NAD<sup>+</sup>Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers’ Disease
The NAD<sup>+</sup>Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers’ Disease Open
Alpers’ syndrome is an early-onset neurodegenerative disorder usually caused by biallelic pathogenic variants in the gene encoding the catalytic subunit of polymerase-gamma (POLG), which is essential for mitochondrial DNA (mtDNA) replicati…
View article: Quantitative proteomic and phosphoproteomic analyses of the hippocampus reveal the involvement of NMDAR1 signaling in repetitive mild traumatic brain injury
Quantitative proteomic and phosphoproteomic analyses of the hippocampus reveal the involvement of NMDAR1 signaling in repetitive mild traumatic brain injury Open
The cumulative damage caused by repetitive mild traumatic brain injury can cause long-term neurodegeneration leading to cognitive impairment. This cognitive impairment is thought to result specifically from damage to the hippocampus. In th…
View article: Identification of a Fibroblast-Related Prognostic Model in Glioma Based on Bioinformatics Methods
Identification of a Fibroblast-Related Prognostic Model in Glioma Based on Bioinformatics Methods Open
Background: Glioma is the most common primary tumor of the central nervous system with a high lethality rate. This study aims to mine fibroblast-related genes with prognostic value and construct a corresponding prognostic model. Methods: A…
View article: Analysis of the Characteristics of Real-World Emission Factors and VSP Distributions—A Case Study in Beijing
Analysis of the Characteristics of Real-World Emission Factors and VSP Distributions—A Case Study in Beijing Open
Vehicle emissions intensity at a given travel speed is well known among the public since travel speed is the key parameter in both the traffic model and the emission model. Yet, several problems still remain in traditional approaches of me…
View article: Pulsed Electromagnetic Fields Protect Against Brain Ischemia by Modulating the Astrocytic Cholinergic Anti-inflammatory Pathway
Pulsed Electromagnetic Fields Protect Against Brain Ischemia by Modulating the Astrocytic Cholinergic Anti-inflammatory Pathway Open
View article: Fibroblasts rescue oral squamous cancer cell from metformin-induced apoptosis via alleviating metabolic disbalance and inhibiting AMPK pathway
Fibroblasts rescue oral squamous cancer cell from metformin-induced apoptosis via alleviating metabolic disbalance and inhibiting AMPK pathway Open
Metformin is an antidiabetic drug widely used for the treatment of type 2 diabetes. Growing evidence suggests that it may exert antitumor effects in vivo and in vitro. However, even with the promising potency on defeating can…
View article: Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress
Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress Open
C18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma. However, the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear.…
View article: The Review and Prospect of Marx and Engels' Educational Thought Research in China
The Review and Prospect of Marx and Engels' Educational Thought Research in China Open
The study of Marx and Engels' educational thought has experienced different stages in China, different stages show different characteristics, and has made some progress in the aspects of “human nature”, “all-round development of human bein…
View article: Design Requirement and DC Bias Analysis on HVDC Converter Transformer
Design Requirement and DC Bias Analysis on HVDC Converter Transformer Open
The converter transformer plays a critical role in the high-voltage direct current (HVDC) transmission system, which connects but separates the AC grids and the converter. This paper briefly introduced the essential design requirement of t…