Yuanbin Cui
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View article: Bispecific CAR-T cells targeting FAP and GPC3 have the potential to treat hepatocellular carcinoma
Bispecific CAR-T cells targeting FAP and GPC3 have the potential to treat hepatocellular carcinoma Open
Chimeric antigen receptor (CAR) T cell therapy has demonstrated robust efficacy against hematological malignancies, but there are still some challenges regarding treating solid tumors, including tumor heterogeneity, antigen escape, and an …
View article: T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity
T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity Open
Chimeric antigen receptor (CAR) T cell therapy lacks persistent efficacy with "on-target, off-tumor" toxicities for treating solid tumors. Thus, an antibody-guided switchable CAR vector, the chimeric Fc receptor CD64 (CFR64), composed of a…
View article: CAR designs for solid tumors: overcoming hurdles and paving the way for effective immunotherapy
CAR designs for solid tumors: overcoming hurdles and paving the way for effective immunotherapy Open
Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized immunotherapy by modifying patients' immune cells genetically. By expressing CARs, these modified cells can specifically identify and eliminate tumor cells. The success of…
View article: A novel non-viral PDCD1 site-integrated CAR design: killing 2 birds with 1 stone
A novel non-viral PDCD1 site-integrated CAR design: killing 2 birds with 1 stone Open
Although chimeric antigen receptor T-cell (CAR-T-cell) therapy has shown excellent efficacy against refractory/relapsed B-cell lymphoma, B-cell acute lymphoblastic leukemia and multiple myeloma,1,2 the complete response rate of patients wi…
View article: Additional file 3 of Human induced-T-to-natural killer cells have potent anti-tumour activities
Additional file 3 of Human induced-T-to-natural killer cells have potent anti-tumour activities Open
Additional file 3: Table S3. Upregulated differential expression genes (DEGs) in ITNKs compared to NK cells, |Log2FC| > 1, pval< 0.05.
View article: Additional file 9 of Human induced-T-to-natural killer cells have potent anti-tumour activities
Additional file 9 of Human induced-T-to-natural killer cells have potent anti-tumour activities Open
Additional file 9: Table S9. Longitudinal measurement of relative levels for circulating cytokines/chemokines/growth factors in serum of patient GD001 before and after infusion.
View article: Additional file 2 of Human induced-T-to-natural killer cells have potent anti-tumour activities
Additional file 2 of Human induced-T-to-natural killer cells have potent anti-tumour activities Open
Additional file 2: Table S2. KEGG analysis of differential expression genes (DEGs) in CD8 ITNKs compared to CD8 T cells.
View article: Additional file 1 of Human induced-T-to-natural killer cells have potent anti-tumour activities
Additional file 1 of Human induced-T-to-natural killer cells have potent anti-tumour activities Open
Additional file 1: Table S1. Downregulated differential expression genes (DEGs) in CD4 ITNKs compared to CD4 T cells, |Log2FC| > 1, padj< 0.05.
View article: Additional file 8 of Human induced-T-to-natural killer cells have potent anti-tumour activities
Additional file 8 of Human induced-T-to-natural killer cells have potent anti-tumour activities Open
Additional file 8: Table S8. Characteristics of the infused ITNKs in the clinical trial.
View article: Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer
Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer Open
T cell infiltration into tumors is essential for successful immunotherapy against solid tumors. Herein, we found that the expression of hyaluronic acid synthases (HAS) was negatively correlated with patient survival in multiple types of so…
View article: Current status and hurdles for CAR-T cell immune therapy
Current status and hurdles for CAR-T cell immune therapy Open
Chimeric antigen receptor T (CAR-T) cells have emerged as novel and promising immune therapies for the treatment of multiple types of cancer in patients with hematological malignancies. There are several key components critical for develop…
View article: Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function
Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function Open
Polycomb repressive complex 1 (PRC1) plays essential roles in cell-fate determination. Recent studies have found that the composition of mammalian PRC1 is particularly varied and complex; however, little is known about the functional conse…