Yanyun Jiang
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View article: The association of physician-clinical pharmacist collaboration frequency and experience on physician burnout: are there gender differences
The association of physician-clinical pharmacist collaboration frequency and experience on physician burnout: are there gender differences Open
Introduction Burnout is a widespread issue among physicians globally, with pronounced gender disparities observed in China. This paper aims to analyze the collaboration characteristics between clinical pharmacists and physicians in China, …
View article: Endogenous Bacterial Endophthalmitis Complicating Hemodialysis Catheter‐Related Sepsis: A Case Report and Review of the Literature
Endogenous Bacterial Endophthalmitis Complicating Hemodialysis Catheter‐Related Sepsis: A Case Report and Review of the Literature Open
Background Endogenous endophthalmitis is an infrequent yet severe complication of hemodialysis catheter‐related sepsis. In this report, we present a case of endogenous bacterial endophthalmitis in a patient with hemodialysis catheter‐relat…
View article: CCN2 functions as a modulator of cell cycle regulation in human dermal fibroblasts
CCN2 functions as a modulator of cell cycle regulation in human dermal fibroblasts Open
CCN2 is widely regarded as a profibrotic factor involved in fibrotic disorders by regulating extracellular matrix (ECM). We report here that CCN2 functions as a critical cell cycle regulator in primary human dermal fibroblasts (HDFs). siRN…
View article: Artifact Correction in Magnetic Resonance Temperature Imaging for Laser Interstitial Thermotherapy with Multi-echo Acquisitions
Artifact Correction in Magnetic Resonance Temperature Imaging for Laser Interstitial Thermotherapy with Multi-echo Acquisitions Open
In MRI-guided laser interstitial thermotherapy (MRgLITT), a signal void sometimes appears at the heating center of the measured temperature map. In neurosurgical MRgLITT treatments, cerebrospinal fluid pulsation (CSF), which may lead to te…
View article: Topical treatment of tyrosine kinase 2 inhibitor through borneol-embedded hydrogel: Evaluation for preventive, therapeutic, and Recurrent management of psoriasis
Topical treatment of tyrosine kinase 2 inhibitor through borneol-embedded hydrogel: Evaluation for preventive, therapeutic, and Recurrent management of psoriasis Open
Psoriasis, an immune-mediated inflammatory skin disorder characterized by a chronically relapsing-remitting course, continues to be primarily managed through topical therapy. While oral administration of tyrosine kinase 2 inhibitors (TYK2i…
View article: Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling
Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling Open
IL-17C is an epithelial cell-derived proinflammatory cytokine whose transcriptional regulation remains unclear. Analysis of the IL17C promoter region identified TCF4 as putative regulator, and siRNA knockdown of TCF4 in human keratinocytes…
View article: Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis
Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis Open
Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to fibrosis of skin and other internal organs. However, the main cellular participants in …
View article: Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-κ activation and APOBEC3G induction
Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-κ activation and APOBEC3G induction Open
CRISPR/Cas9 has been proposed as a treatment for genetically inherited skin disorders. Here we report that CRISPR transfection activates STING-dependent antiviral responses in keratinocytes, resulting in heightened endogenous interferon (I…
View article: Profiling Serum Cytokines and Anticytokine Antibodies in Psoriasis Patients
Profiling Serum Cytokines and Anticytokine Antibodies in Psoriasis Patients Open
Cytokines like IL-17A have been consistently found to be elevated in psoriatic lesional skin, and therapeutic antibodies to IL-17 have demonstrated efficacy in treating psoriatic skin and joint disease. However, results about the circulati…
View article: Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin
Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin Open
The skin serves as the primary interface between our body and the external environment and acts as a barrier against entry of physical agents, chemicals, and microbes. Keratinocytes make up the main cellular constitute of the outermost lay…
View article: Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis
Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis Open
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcr…
View article: Recurrent generalized pustular psoriasis possibly triggered by apremilast
Recurrent generalized pustular psoriasis possibly triggered by apremilast Open
To the Editor: Generalized pustular psoriasis (GPP) is a rare, life-threatening skin disease characterized by recurrent episodes of pustulation. Apremilast, a phosphodiesterase 4 (PDE4) inhibitor, is a relatively new drug for the treatment…
View article: Immune Regulation of TNFAIP3 in Psoriasis through Its Association with Th1 and Th17 Cell Differentiation and p38 Activation
Immune Regulation of TNFAIP3 in Psoriasis through Its Association with Th1 and Th17 Cell Differentiation and p38 Activation Open
Background . Psoriasis is an immune‐mediated chronic inflammatory skin disorder in which the dysregulation of immune cells plays an important role in its development. Tumor necrosis factor‐ (TNF‐) α antagonists affect the immune repertoire…
View article: A novel mutation in MBTPS2 causes ichthyosis follicularis, alopecia, and photophobia syndrome
A novel mutation in MBTPS2 causes ichthyosis follicularis, alopecia, and photophobia syndrome Open
Background The ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome is a rare X‐linked genodermatosis characterized by noninflammatory spiny follicular hyperkeratosis, severe photophobia, and non‐scarring alopecia with variab…
View article: Eosinophilic Pustular Folliculitis Associated with Cutaneous Angiosarcoma
Eosinophilic Pustular Folliculitis Associated with Cutaneous Angiosarcoma Open
To the Editor: A 64-year-old Chinese man had a 12-month history of nonmetastatic primary scalp angiosarcoma [Figure 1a] that had been confirmed by skin biopsy [Figure 1e]. Immunohistochemical examination showed CD31-, CD34-, and D2-40-posi…
View article: Comparison of Clinical Features between Pyoderma Gangrenosum Concomitant by Inflammatory Bowel Disease and Idiopathic Pyoderma Gangrenosum
Comparison of Clinical Features between Pyoderma Gangrenosum Concomitant by Inflammatory Bowel Disease and Idiopathic Pyoderma Gangrenosum Open
PG patients with IBD had increased occurrence rates of arthralgia or arthritis, anemia, and ANCA-positive status compared to idiopathic PG patients.
View article: Characterization of Spodoptera litura (Lepidoptera: Noctuidae) Takeout Genes and Their Differential Responses to Insecticides and Sex Pheromone
Characterization of Spodoptera litura (Lepidoptera: Noctuidae) Takeout Genes and Their Differential Responses to Insecticides and Sex Pheromone Open
Spodoptera litura (S. litura) is one of the most serious agricultural insect pests worldwide. Takeout (TO) is involved in a variety of physiological and biochemical pathways and performs various biological functions. We characterized 18 S.…
View article: microRNA-383 mediates high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells by repressing peroxiredoxin 3.
microRNA-383 mediates high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells by repressing peroxiredoxin 3. Open
Hyperglycemia-mediated damage to retinal pigment epithelial (RPE) cells plays a central role in the pathogenesis of diabetic retinopathy. Dysregulation of microRNA (miR)-383 modulates pancreatic beta cell survival in diabetes; however, its…