Yunxuan Jiang
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View article: Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health
Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health Open
Delay discounting (DD), a person’s preference for smaller immediate rewards over larger delayed rewards, is a heritable trait that is associated with psychiatric and physical outcomes, yet the biological mechanisms underlying these links a…
View article: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies Open
Major Depression (MD) is a prevalent, disabling and life-limiting condition. The neurobiological associations of genetic risk for MD remain under-explored in large samples, with no comprehensive mega-analysis conducted to date. Our study a…
View article: Identification of Risk Loci for Radiotherapy-Induced Tinnitus and Hearing Loss Through Integrated Genomic Analysis
Identification of Risk Loci for Radiotherapy-Induced Tinnitus and Hearing Loss Through Integrated Genomic Analysis Open
Radiotherapy-induced hearing impairment significantly affects patients’ quality of life, yet its genetic basis remains poorly understood. This study seeks to identify genetic variants associated with radiotherapy-induced tinnitus and heari…
View article: Molecular genetic influences on attentional control and other executive processes and their links with psychopathology in the AFFECT study
Molecular genetic influences on attentional control and other executive processes and their links with psychopathology in the AFFECT study Open
Background Attentional control is a critical component of executive functioning involved in numerous psychiatric and neurological disorders, yet its etiological relationships with many cognitive and behavioral phenotypes remain underexplor…
View article: Ellagic Acid Protects Against Acute Stress‐Induced Kidney Damage in Rats by Regulating the SIRT1/Nrf2 Signaling Pathway
Ellagic Acid Protects Against Acute Stress‐Induced Kidney Damage in Rats by Regulating the SIRT1/Nrf2 Signaling Pathway Open
Ellagic acid displays multiple biological and pharmacological effects. Here, we explore its protective role against acute stress (AS)–induced kidney damage. We established the AS model through excessive swimming (15 min) and restraint stre…
View article: Large-scale analysis demonstrates the influence of CYP2C19 genotype on specific SSRI side effects
Large-scale analysis demonstrates the influence of CYP2C19 genotype on specific SSRI side effects Open
The majority of individuals receiving treatment for major depressive disorder (MDD) do not achieve remission from the first medication they try, and over 80% subsequently discontinue pharmacotherapy or switch to a different medication. SSR…
View article: The shared genetic architecture and evolution of human language and musical rhythm
The shared genetic architecture and evolution of human language and musical rhythm Open
This study aimed to test theoretical predictions over biological underpinnings of previously documented phenotypic correlations between human language-related and musical rhythm traits. Here, after identifying significant genetic correlati…
View article: Genetic neurodevelopmental clustering and dyslexia
Genetic neurodevelopmental clustering and dyslexia Open
Dyslexia is a learning difficulty with neurodevelopmental origins, manifesting as reduced accuracy and speed in reading and spelling. It is substantially heritable and frequently co-occurs with other neurodevelopmental conditions, particul…
View article: The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals
The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals Open
Dog ownership has been associated with several complex traits, and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through a meta-analysis of 31,566 Swedish twins in 5 discovery cohorts…
View article: Genetic analysis and natural history of Parkinson’s disease due to the <i>LRRK2</i> G2019S variant
Genetic analysis and natural history of Parkinson’s disease due to the <i>LRRK2</i> G2019S variant Open
The LRRK2 G2019S variant is the most common cause of monogenic Parkinson’s disease (PD); however, questions remain regarding the penetrance, clinical phenotype and natural history of carriers. We performed a 3.5-year prospective longitudin…
View article: An ensemble penalized regression method for multi-ancestry polygenic risk prediction
An ensemble penalized regression method for multi-ancestry polygenic risk prediction Open
Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve the prediction of complex traits and diseases. However, most existing PRS are primarily trained on European ancestry populations, limiting their transf…
View article: A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals
A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals Open
MVJ, NCK, SBB, SSR and AAP were supported by T32IR5226 and 28IR-0070. SSR was also supported by NIDA DP1DA054394. NCK and RBC were also supported by R25MH081482. ASH was supported by funds from NIAAA K01AA030083. JLMO was supported by VA 1…
View article: MUSSEL: Enhanced Bayesian polygenic risk prediction leveraging information across multiple ancestry groups
MUSSEL: Enhanced Bayesian polygenic risk prediction leveraging information across multiple ancestry groups Open
Polygenic risk scores (PRSs) are now showing promising predictive performance on a wide variety of complex traits and diseases, but there exists a substantial performance gap across populations. We propose MUSSEL, a method for ancestry-spe…
View article: Analysis of rare Parkinson’s disease variants in millions of people
Analysis of rare Parkinson’s disease variants in millions of people Open
Although many rare variants have been reportedly associated with Parkinson’s disease (PD), many have not been replicated or have failed to replicate. Here, we conduct a large-scale replication of rare PD variants. We assessed a total of 27…
View article: Multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma
Multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma Open
Basal cell carcinoma (BCC) is one of the most common malignancies worldwide, yet its genetic determinants are incompletely defined. We perform a European ancestry genome-wide association (GWA) meta-analysis and a Hispanic/Latino ancestry G…
View article: Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference Open
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to …
View article: Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants
Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants Open
Introduction Genome-Wide Association Studies (GWAS) over-represent European ancestries compared to the global population, neglecting all other ancestry groups and low-income nations. Consequently, polygenic risk scores (PRS) more accuratel…
View article: Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen
Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen Open
Total polysaccharides of Pinus massoniana Lamb. pollen (PPPSt) is a natural carbohydrate with known anti-inflammatory effects. Inflammation was the main cause of death due to myocardial damage caused by sepsis. The aim of this study was to…