Yuanjing Li
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View article: Trigonelline Improves Metabolism and Cardiac Function of HFpEF Mice Via Gut Microbiome Alterations‐Mediated AMPK Activation
Trigonelline Improves Metabolism and Cardiac Function of HFpEF Mice Via Gut Microbiome Alterations‐Mediated AMPK Activation Open
Heart failure with preserved ejection fraction (HFpEF) is a prevalent end‐manifestation of cardiovascular diseases currently lacking effective treatment. Using a high‐fat diet and L‐NAME‐induced mouse model, untargeted metabolomic profilin…
View article: Molecular Dynamics Simulation of Methane Adsorption and Diffusion in Limestone Pores in the Taiyuan Formation of the Ordos Basin, China: Effects of Pore Shapes, Apertures, and Formation Water
Molecular Dynamics Simulation of Methane Adsorption and Diffusion in Limestone Pores in the Taiyuan Formation of the Ordos Basin, China: Effects of Pore Shapes, Apertures, and Formation Water Open
The Taiyuan Formation limestone in the Ordos Basin of China holds significant gas-bearing potential, making it a key target for unconventional natural gas exploration. Clarifying the microscopic occurrence mechanism of gas in limestone is …
View article: Ambient Particulate Matter Exposure Impairs Gut Barrier Integrity and Disrupts Goblet Cell Function
Ambient Particulate Matter Exposure Impairs Gut Barrier Integrity and Disrupts Goblet Cell Function Open
Background: As a well-known environmental hazard, ambient fine particulate matter (PM2.5, aerodynamic diameter ≤ 2.5 µm) has been positively correlated with an increased risk of digestive system diseases, including appendicitis, inflammato…
View article: Corrigendum: Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults
Corrigendum: Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults Open
[This corrects the article DOI: 10.3389/fnagi.2025.1539508.].
View article: Macrophage KDM2A promotes atherosclerosis via regulating FYN and inducing inflammatory response
Macrophage KDM2A promotes atherosclerosis via regulating FYN and inducing inflammatory response Open
Macrophage inflammatory response is the key driver in atherosclerosis development. However, transcriptional remodeling of macrophage inflammatory response remains largely unknown. In this study, transcriptional regulatory networks were con…
View article: Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults
Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults Open
Background The mechanisms underlying olfactory decline in aging need further investigation. Noticeably, the longitudinal relationship of biological markers with olfaction remains underexplored. We investigated whether baseline levels and p…
View article: Emo@KP MBs Modulates the TGF-β1/Smad Signaling Pathway by in situ Micro-Nano Conversion to Reduce Renal Inflammation and Fibrosis Caused by Unilateral Ureteral Obstruction
Emo@KP MBs Modulates the TGF-β1/Smad Signaling Pathway by in situ Micro-Nano Conversion to Reduce Renal Inflammation and Fibrosis Caused by Unilateral Ureteral Obstruction Open
Emo@KP MBs enhanced drug delivery efficiency and therapeutic efficacy through αKIM-1 targeting and UTMD, while providing real-time imaging capabilities, suggesting good potential as a therapeutic approach to reduce renal inflammation and f…
View article: Research on trigger technology of MRPC TOF-PET system and imaging results of $^{22}$Na radioactive source
Research on trigger technology of MRPC TOF-PET system and imaging results of $^{22}$Na radioactive source Open
This study focuses on developing a self-triggered data acquisition system and a noise reduction algorithm for the Multi-gap Resistive Plate Chamber (MRPC) Time-of-Flight Positron Emission Tomography (TOF-PET) system. The system integrates …
View article: Comparative Efficacy of Particulate Embolic Agents Versus Alcohol in Percutaneous Transluminal Septal Myocardial Ablation
Comparative Efficacy of Particulate Embolic Agents Versus Alcohol in Percutaneous Transluminal Septal Myocardial Ablation Open
View article: Characterizing brain structures associated with plasma neurofilament light chain among older adults: variations by sex and APOE gene
Characterizing brain structures associated with plasma neurofilament light chain among older adults: variations by sex and APOE gene Open
Background Plasma neurofilament light (NfL) has emerged as a promising biomarker to track neurodegeneration in Alzheimer’s disease (AD) and other brain degenerative disorders. We sought to characterize brain structures and white matter les…
View article: Constraining Dark Matter Models with a Light Mediator from CDEX-10 Experiment at China Jinping Underground Laboratory
Constraining Dark Matter Models with a Light Mediator from CDEX-10 Experiment at China Jinping Underground Laboratory Open
We search for nuclear recoil signals of dark matter models with a light mediator using data taken from a p-type point-contact germanium detector of the CDEX-10 experiment at the China Jinping Underground Laboratory. The 90% confidence leve…
View article: Dual Transcriptome Analysis Reveals the Changes in Gene Expression in Both Cotton and Verticillium dahliae During the Infection Process
Dual Transcriptome Analysis Reveals the Changes in Gene Expression in Both Cotton and Verticillium dahliae During the Infection Process Open
Cotton is often threatened by Verticillium wilt caused by V. dahliae. Understanding the molecular mechanism of V. dahlia–cotton interaction is important for the prevention of this disease. To analyze the transcriptome profiles in V. dahlia…
View article: Cardioneuroablation eliminating cardiac asystole associated with area postrema syndrome: a case report and literature review
Cardioneuroablation eliminating cardiac asystole associated with area postrema syndrome: a case report and literature review Open
Background There have been few instances of symptomatic bradycardia-arrhythmia in the context of area postrema syndrome (APS), and some of them have been implanted permanent pacemakers. Cardioneuroablation (CNA) has emerged as a viable the…
View article: Causal association of obesity-related anthropometric traits with myopia and the mediating role of educational attainment: a Mendelian randomization study
Causal association of obesity-related anthropometric traits with myopia and the mediating role of educational attainment: a Mendelian randomization study Open
AIM: To study the causal relationship between obesity-related anthropometric traits and myopia and the mediating role of educational attainment (EA). METHODS: Univariable Mendelian randomization (UVMR) was performed to evaluate the causal …
View article: Choroid Plexus Volume in Rural Chinese Older Adults: Distribution and Association With Cardiovascular Risk Factors and Cerebral Small Vessel Disease
Choroid Plexus Volume in Rural Chinese Older Adults: Distribution and Association With Cardiovascular Risk Factors and Cerebral Small Vessel Disease Open
Background The choroid plexus (CP) is involved in neurodegenerative diseases. However, the association of CP with cardiovascular risk factors and cerebral small vessel disease in older adults remains unclear. Methods and Results This popul…
View article: Lung function in relation to brain aging and cognitive transitions in older adults: A population‐based cohort study
Lung function in relation to brain aging and cognitive transitions in older adults: A population‐based cohort study Open
BACKGROUND We investigated the association of peak expiratory flow (PEF) with dementia; cognitive impairment, no dementia (CIND); and transition from CIND to dementia, and possible underlying neuropathological mechanisms. METHODS A populat…
View article: Development and validation of a diagnostic model for cerebral small vessel disease among rural older adults in China
Development and validation of a diagnostic model for cerebral small vessel disease among rural older adults in China Open
Objectives Cerebral small vessel disease (CSVD) visible on MRI can be asymptomatic. We sought to develop and validate a model for detecting CSVD in rural older adults. Methods This study included 1,192 participants in the MRI sub-study wit…
View article: Association of enlarged perivascular spaces with cognitive function in dementia‐free older adults: A population‐based study
Association of enlarged perivascular spaces with cognitive function in dementia‐free older adults: A population‐based study Open
Introduction We sought to characterize cognitive profiles associated with enlarged perivascular spaces (EPVS) among Chinese older adults. Methods This population‐based study included 1191 dementia‐free participants (age ≥60 years) in the M…
View article: Association of cognitive reserve with transitions across cognitive states and death in older adults: A 15‐year follow‐up study
Association of cognitive reserve with transitions across cognitive states and death in older adults: A 15‐year follow‐up study Open
INTRODUCTION We investigated the association of cognitive reserve (CR) with transitions across cognitive states and death. METHODS This population‐based cohort study included 2631 participants (age ≥60 years) who were dementia‐free at base…
View article: 3D-printed passive bellow actuator for portable soft wearable robots
3D-printed passive bellow actuator for portable soft wearable robots Open
The compliance of soft wearable robots driven by fluids is high, but their portability and controllability are limited due to complex fluidic systems. On the other hand, tendon-driven soft wearable robots are compact and easy to control, b…
View article: Comparing glycemic traits in defining diabetes among rural Chinese older adults
Comparing glycemic traits in defining diabetes among rural Chinese older adults Open
Background We sought to identify the optimal cut-off of glycated hemoglobin (HbA1c) for defining diabetes and to assess the agreements of fasting plasma glucose (FPG), fasting serum glucose (FSG), and HbA1c in defining diabetes among rural…
View article: Cognitive Reserve Relationship with Physical Performance in Dementia-Free Older Adults: The MIND-China Study
Cognitive Reserve Relationship with Physical Performance in Dementia-Free Older Adults: The MIND-China Study Open
Background: Cognitive reserve (CR) may be beneficial to the physical function of the elderly. Objective: We aimed to examine the association of CR proxies and composite CR capacity with physical function in older adults while considering a…
View article: Hyperlipidemia Is Not Related to Semen Quality, but to Serum Testosterone Levels
Hyperlipidemia Is Not Related to Semen Quality, but to Serum Testosterone Levels Open
Background . Currently, there are few studies on the effects of hyperlipidemia on semen parameters and serum hormones in men. In this study, we divided the study subjects into two groups of normal and hyperlipidemia according to the criter…
View article: Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population‐based study
Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population‐based study Open
INTRODUCTION To examine the burden and clusters of multimorbidity in association with mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)‐related plasma biomarkers among older adults. METHODS This population‐based study…
View article: Transition in the cognitive continuum from normal cognition to dementia: the interplay of lifelong cognitive reserve with brain aging and genetic predisposition
Transition in the cognitive continuum from normal cognition to dementia: the interplay of lifelong cognitive reserve with brain aging and genetic predisposition Open
Background Higher cognitive reserve (CR) has been associated with lower risks of cognitive decline and dementia. In this study, we sought to investigate associations of lifelong CR capacity with transitions of cognitive phenotypes in older…
View article: Choroid plexus volume, cognitive spectrum, and biomarkers of brain aging in older adults: The MIND‐China MRI Study
Choroid plexus volume, cognitive spectrum, and biomarkers of brain aging in older adults: The MIND‐China MRI Study Open
Background The choroid plexus (CP) is a major source of cerebrospinal fluid (CSF) production that has been involved in clearance of CSF proteins and regulation of brain function, and possibly, in the pathogenesis of Alzheimer’s dementia. H…
View article: Plasma amyloid‐β, total tau, and neurofilament light chain across the Alzheimer clinical spectrum: a population‐based study
Plasma amyloid‐β, total tau, and neurofilament light chain across the Alzheimer clinical spectrum: a population‐based study Open
Background Plasma biomarkers have emerged as a promising approach for defining mild cognitive impairment (MCI) and Alzheimer’s disease (AD). We aimed to characterize Alzheimer’s plasma biomarkers across the clinical continuum of AD, and to…
View article: Lifelong cognitive reserve mitigates the genetic risk of APOE and TOMM40 variants for dementia in Chinese older adults: a cohort study
Lifelong cognitive reserve mitigates the genetic risk of APOE and TOMM40 variants for dementia in Chinese older adults: a cohort study Open
Background Evidence has emerged that cognitive reserve (CR) could mitigate the genetic risk of APOE ε4 allele for dementia and Alzheimer’s disease (AD) in Caucasian and Black populations. Whether CR counteracts dementia risk attributable t…
View article: Associations of anemia and cardiovascular disease with longitudinal changes in brain MRI markers and cognitive decline in older adults: A cohort study
Associations of anemia and cardiovascular disease with longitudinal changes in brain MRI markers and cognitive decline in older adults: A cohort study Open
Background Anemia and cardiovascular disease (CVD) are two prevalent chronic conditions causing cerebral hypoxia in older adults. Although anemia and CVD often coexist in older people and potentially share underlying mechanisms, the indepe…
View article: Exploring key regulators involved in cardiac ischemic preconditioning through proteomic analysis in ischemia reperfusion mice models
Exploring key regulators involved in cardiac ischemic preconditioning through proteomic analysis in ischemia reperfusion mice models Open
Background Reperfusion therapy improved acute coronary syndrome (ACS) patients’ prognosis. However, the ischemia-reperfusion (IR) injury remains unsolved. During clinical practice, patients with recurrent angina manifested better outcomes …