Yuanjun Lu
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View article: Epigenetic orchestration of cancer-immune dynamics: mechanisms, technologies, and clinical advancements
Epigenetic orchestration of cancer-immune dynamics: mechanisms, technologies, and clinical advancements Open
This review systematically dissects how epigenetic alterations impair anti-tumour immunity at each stage of the CI cycle. It not only integrates fragmented mechanistic evidence but also emphasizes underexplored crosstalk between specific e…
View article: Siwu decoction suppress myeloid-derived suppressor cells through tumour cells necroptosis to inhibit hepatocellular carcinoma
Siwu decoction suppress myeloid-derived suppressor cells through tumour cells necroptosis to inhibit hepatocellular carcinoma Open
Our study observed for the first time that SWD can suppress HCC by regulating MDSCs through necroptosis of tumour cells in the TME. The main effective compound of SWD, albiflorin can be a potential adjuvant therapy in the clinical manageme…
View article: Osteoprotegerin mediates adipogenesis in obesity
Osteoprotegerin mediates adipogenesis in obesity Open
View article: Single‐cell profiling reveals the metastasis‐associated immune signature of hepatocellular carcinoma
Single‐cell profiling reveals the metastasis‐associated immune signature of hepatocellular carcinoma Open
Aim Metastasis is the leading cause of mortality in hepatocellular carcinoma (HCC). The metastasis‐associated immune signature in HCC is worth exploring. Methods Bioinformatic analysis was conducted based on the single‐cell transcriptome d…
View article: Loss of lncRNA LINC01056 leads to sorafenib resistance in HCC
Loss of lncRNA LINC01056 leads to sorafenib resistance in HCC Open
Background and aims Sorafenib is a major nonsurgical option for patients with advanced hepatocellular carcinoma (HCC); however, its clinical efficacy is largely undermined by the acquisition of resistance. The aim of this study was to iden…
View article: PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer
PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer Open
View article: CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress
CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress Open
Our findings provide comprehensive evidence for miR-3689a-3p as a positive regulator and potential druggable target for improving sorafenib treatment in HCC.
View article: Characterization of cuproptosis in gastric cancer and relationship with clinical and drug reactions
Characterization of cuproptosis in gastric cancer and relationship with clinical and drug reactions Open
Gastric cancer (GC) is the fifth most common cancer worldwide. Cuproptosis is associated with cell growth and death as well as tumorigenesis. Aiming to lucubrate the potential influence of CRGs in gastric cancer, we acquired datasets of ga…
View article: The tumor microenvironment in the postsurgical liver: Mechanisms and potential targets of postoperative recurrence in human hepatocellular carcinoma
The tumor microenvironment in the postsurgical liver: Mechanisms and potential targets of postoperative recurrence in human hepatocellular carcinoma Open
Surgery remains to be the mainstay of treatment for hepatocellular carcinoma (HCC). Nonetheless, its therapeutic efficacy is significantly impaired by postoperative recurrence, which occurs in more than half of cases as a result of intrahe…
View article: Multiple Components in Chinese Medicine formula for Drug Discovery: State-of-art and future perspective
Multiple Components in Chinese Medicine formula for Drug Discovery: State-of-art and future perspective Open
It has been the golden criterion in the drug discovery and development industry for hundreds of years that a single and identical component with a clear mechanism of action is a desirable candidate for potential drugs. However, this conven…
View article: Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis
Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis Open
Tumor microenvironment contributes to poor prognosis of pancreatic adenocarcinoma (PAAD) patients. Proper regulation could improve survival. Melatonin is an endogenous hormone that delivers multiple bioactivities. Here we showed that pancr…
View article: Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives
Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives Open
For hundreds of years, the drug discovery and development industry has aimed at identifying single components with a clear mechanism of action as desirable candidates for potential drugs. However, this conventional strategy of drug discove…
View article: Genipin-activating PPARγ impedes CCR2-mediated macrophage infiltration into postoperative liver to suppress recurrence of hepatocellular carcinoma
Genipin-activating PPARγ impedes CCR2-mediated macrophage infiltration into postoperative liver to suppress recurrence of hepatocellular carcinoma Open
A high postoperative tumour recurrence rate has significantly rendered a poorer prognosis in hepatocellular carcinoma (HCC) patients. The aim of this study is to identify a natural compound genipin as a potential and effective candidate to…
View article: Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma
Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma Open
View article: Potential Focal Adhesion Kinase Inhibitors in Management of Cancer: Therapeutic Opportunities from Herbal Medicine
Potential Focal Adhesion Kinase Inhibitors in Management of Cancer: Therapeutic Opportunities from Herbal Medicine Open
Focal adhesion kinase (FAK) is a multifunctional protein involved in cellular communication, integrating and transducing extracellular signals from cell-surface membrane receptors. It plays a central role intracellularly and extracellularl…
View article: The Role and Mechanisms of Selenium Supplementation on Fatty Liver-Associated Disorder
The Role and Mechanisms of Selenium Supplementation on Fatty Liver-Associated Disorder Open
Non-alcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease without effective therapy. Selenium, as an essential trace element for humans, is notable for its antioxidant properties. The previous study shows that se…
View article: GPC2 Is a Potential Diagnostic, Immunological, and Prognostic Biomarker in Pan-Cancer
GPC2 Is a Potential Diagnostic, Immunological, and Prognostic Biomarker in Pan-Cancer Open
Background Glypican 2 (GPC2), a member of glypican (GPC) family genes, produces proteoglycan with a glycosylphosphatidylinositol anchor. It has shown its ascending significance in multiple cancers such as neuroblastoma, malignant brain tum…
View article: Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma
Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma Open
View article: Preoperative Immune Cells Infiltration in the Tumor Microenvironment as a Prediction and Prognostic Factor for Postoperative Recurrence in Hepatocellular Carcinoma
Preoperative Immune Cells Infiltration in the Tumor Microenvironment as a Prediction and Prognostic Factor for Postoperative Recurrence in Hepatocellular Carcinoma Open
View article: Circulating tumor cells in the early detection of human cancers
Circulating tumor cells in the early detection of human cancers Open
Cancer is a severe disease with high morbidity and mortality globally. Thus, early detection is emerging as an important topic in modern oncology. Although the strategies for early detection have developed rapidly in recent decades, they r…
View article: CRISPR-Cas9 library screening approach for anti-cancer drug discovery: overview and perspectives
CRISPR-Cas9 library screening approach for anti-cancer drug discovery: overview and perspectives Open
CRISPR-Cas9 is a Nobel Prize-winning robust gene-editing tool developed in the last decade. This technique enables a stable genetic engineering method with high precision on the genomes of all organisms. The latest advances in the technolo…
View article: The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development
The Role of Protein SUMOylation in Human Hepatocellular Carcinoma: A Potential Target of New Drug Discovery and Development Open
Small ubiquitin-like modifier (SUMO) is a highly conserved post-translational modification protein, mainly found in eukaryotes. They are widely expressed in different tissues, including the liver. As an essential post-translational modific…
View article: Systematic Review with Meta-Analysis: Effectiveness and Safety of Acupuncture as Adjuvant Therapy for Side Effects Management in Drug Therapy-Receiving Breast Cancer Patients
Systematic Review with Meta-Analysis: Effectiveness and Safety of Acupuncture as Adjuvant Therapy for Side Effects Management in Drug Therapy-Receiving Breast Cancer Patients Open
Objective. To investigate the potential benefits and safety of acupuncture on managing side effects induced by drug therapies in patients with breast cancer using a PRISMA standard systematic review and meta-analysis. Methods. Published ra…
View article: Role of Autophagy in the Maintenance of Stemness in Adult Stem Cells: A Disease-Relevant Mechanism of Action
Role of Autophagy in the Maintenance of Stemness in Adult Stem Cells: A Disease-Relevant Mechanism of Action Open
Autophagy is an intracellular scavenging mechanism induced to eliminate damaged, denatured, or senescent macromolecular substances and organelles in the body. The regulation of autophagy plays essential roles in the processes of cellular h…
View article: PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma
PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma Open
View article: Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy Open
Epigenetics is dynamic and heritable modifications to the genome that occur independently of DNA sequence. It requires interactions cohesively with various enzymes and other molecular components. Aberrant epigenetic alterations can lead to…
View article: Polarization of Tumor-Associated Macrophages by Chinese Medicine Intervention: Mechanisms and Applications
Polarization of Tumor-Associated Macrophages by Chinese Medicine Intervention: Mechanisms and Applications Open
Macrophage polarization is a spectrum of phenotypes and generally can be classified into two states: (1) classically activated or M1 macrophages, which can be driven by lipopolysaccharide (LPS) alone or in association with Th1 cytokines an…
View article: Epstein–Barr virus miR-BART3-3p promotes tumorigenesis by regulating the senescence pathway in gastric cancer
Epstein–Barr virus miR-BART3-3p promotes tumorigenesis by regulating the senescence pathway in gastric cancer Open
Epstein-Barr virus-associated gastric cancer (EBVaGC) accounts for about 10% of all gastric cancer cases and has unique pathological and molecular characteristics. EBV encodes a large number of microRNAs, which actively participate in the …
View article: Epstein-Barr Virus MicroRNA miR-BART5-3p Inhibits p53 Expression
Epstein-Barr Virus MicroRNA miR-BART5-3p Inhibits p53 Expression Open
EBV encodes 44 mature microRNAs, which have been proven to promote EBV-associated diseases by targeting host genes and self-viral genes. In EBV-associated carcinomas, the expression of viral protein is limited but the expression of BART mi…
View article: Suppression Colitis and Colitis-Associated Colon Cancer by Anti-S100a9 Antibody in Mice
Suppression Colitis and Colitis-Associated Colon Cancer by Anti-S100a9 Antibody in Mice Open
The association between chronic inflammation and cancer has long been recognized. The inflammatory bowel disease ulcerative colitis frequently progresses to colon cancer; however, the underlying mechanism is still unclear. S100a9 has been …