Yuankun Chen
YOU?
Author Swipe
View article: IL4I1 overexpression protects against nonalcoholic fatty liver disease in part by inhibiting the AKT/FOXO1 pathway-mediated Th17 cell differentiation
IL4I1 overexpression protects against nonalcoholic fatty liver disease in part by inhibiting the AKT/FOXO1 pathway-mediated Th17 cell differentiation Open
Nonalcoholic fatty liver disease (NAFLD) has posed a huge threat to public health globally, but there are currently no approved drugs available. Growing evidence has proved the close association between increased Th17 cells and NAFLD progr…
View article: Tumor exosomal <scp>RNPEP</scp> promotes lung metastasis of liver cancer via inducing cancer‐associated fibroblast activation
Tumor exosomal <span>RNPEP</span> promotes lung metastasis of liver cancer via inducing cancer‐associated fibroblast activation Open
Cancer‐associated fibroblasts (CAFs) are essential players in the tumor microenvironment (TME) due to their roles in facilitating tumor progression and metastasis. It is worth noting that the high‐metastatic hepatocellular carcinoma (HCC) …
View article: CRISPR/Cas13a-based rapid detection method for porcine deltacoronavirus
CRISPR/Cas13a-based rapid detection method for porcine deltacoronavirus Open
Background Porcine deltacoronavirus (PDCoV) is a newly discovered porcine intestinal pathogenic coronavirus with a single-stranded positive-sense RNA genome and an envelope. PDCoV infects pigs of different ages and causes acute diarrhea an…
View article: RPA-CRISPR-Cas13a-assisted detection method of transmissible gastroenteritis virus
RPA-CRISPR-Cas13a-assisted detection method of transmissible gastroenteritis virus Open
Background and aim Transmissible gastroenteritis virus (TGEV) is a highly contagious gastrointestinal virus that causes diarrhea, vomiting, anorexia, dehydration, and weight loss in piglets. In clinical practice, it often occurs in mixed i…
View article: β‐Sitosterol suppresses hepatocellular carcinoma growth and metastasis via FOXM1‐regulated Wnt/β‐catenin pathway
β‐Sitosterol suppresses hepatocellular carcinoma growth and metastasis via FOXM1‐regulated Wnt/β‐catenin pathway Open
β‐Sitosterol is a natural compound with demonstrated anti‐cancer properties against various cancers. However, its effects on hepatocellular carcinoma (HCC) and the underlying mechanisms are not well understood. This study aims to investiga…
View article: Humanized single-domain antibody targeting HER2 enhances function of chimeric antigen receptor T cells
Humanized single-domain antibody targeting HER2 enhances function of chimeric antigen receptor T cells Open
Introduction Chimeric antigen receptors (CARs) can redirect T cells against antigen-expressing tumors, and each component plays an important role in the function and anti-tumor efficacy. It has been reported that using human sequences or a…
View article: β-Sitosterol Suppresses Hepatocellular Carcinoma Growth and Metastasis via FOXM1-Regulated Wnt/β-Catenin Pathway
β-Sitosterol Suppresses Hepatocellular Carcinoma Growth and Metastasis via FOXM1-Regulated Wnt/β-Catenin Pathway Open
INTRODUCTIONHepatocellular carcinoma (HCC), the primary form of hepatic carcinoma and a prevalent malignant tumor, is associated with a poor prognosis (Gentile et al., 2020). Various risk factors, such as cirrhosis, autoimmune hepatitis, H…
View article: β-Sitosterol activates autophagy to inhibit the development of hepatocellular carcinoma by regulating the complement C5a receptor 1/alpha fetoprotein axis
β-Sitosterol activates autophagy to inhibit the development of hepatocellular carcinoma by regulating the complement C5a receptor 1/alpha fetoprotein axis Open
Hepatocellular carcinoma (HCC) is highly refractory. β-Sitosterol has been reported to suppress proliferation and migration as well as interfere with cell metabolism in tumors. However, there is limited information on the effects of β-sito…
View article: β-Sitosterol Suppresses Hepatocellular Carcinoma Growth and Metastasis via FOXM1-Regulated Wnt/β-Catenin Pathway
β-Sitosterol Suppresses Hepatocellular Carcinoma Growth and Metastasis via FOXM1-Regulated Wnt/β-Catenin Pathway Open
Background and Purpose: β-Sitosterol is a natural compound with demonstrated anti-cancer properties against various cancers. However, its effects on hepatocellular carcinoma (HCC) and the underlying mechanisms are not well understood. This…
View article: Inhibition of <scp>PRMT1</scp> alleviates sepsis‐induced acute kidney injury in mice by blocking the <scp>TGF</scp>‐β1 and <scp>IL</scp>‐6 trans‐signaling pathways
Inhibition of <span>PRMT1</span> alleviates sepsis‐induced acute kidney injury in mice by blocking the <span>TGF</span>‐β1 and <span>IL</span>‐6 trans‐signaling pathways Open
Sepsis‐induced acute kidney injury (SI‐AKI) causes renal dysfunction and has a high mortality rate. Protein arginine methyltransferase‐1 (PRMT1) is a key regulator of renal insufficiency. In the present study, we explored the potential inv…
View article: Inhibitory Effect of <i>β</i>‐Sitosterol on the Ang II‐Induced Proliferation of A7r5 Aortic Smooth Muscle Cells
Inhibitory Effect of <i>β</i>‐Sitosterol on the Ang II‐Induced Proliferation of A7r5 Aortic Smooth Muscle Cells Open
Context . Excessive proliferation of vascular smooth muscle cells (VSMCs) plays a critical role in the development of cardiovascular diseases. β ‐Sitosterol exerts protective effects against the cardiovascular disease. However, whether β ‐…
View article: Prevalence and distribution of subtypes of <i>Blastocystis</i> in Asiatic brush-tailed porcupines (<i>Atherurus macrourus</i>), bamboo rats (<i>Rhizomys pruinosus</i>), and masked palm civets (<i>Paguma larvata</i>) farmed in Hainan, China
Prevalence and distribution of subtypes of <i>Blastocystis</i> in Asiatic brush-tailed porcupines (<i>Atherurus macrourus</i>), bamboo rats (<i>Rhizomys pruinosus</i>), and masked palm civets (<i>Paguma larvata</i>) farmed in Hainan, China Open
Blastocystis sp. is an important gastrointestinal parasite with global distribution, prevalent in humans, farmed animals, and wildlife. Therefore, this study aimed to investigate the prevalence and genetic diversity of Blastocystis sp. in …
View article: Wind load characteristics of photovoltaic panel arrays mounted on flat roof
Wind load characteristics of photovoltaic panel arrays mounted on flat roof Open
To quantify design wind load of photovoltaic panel array mounted on flat roof, wind tunnel tests were conducted in this study. Results show that the first and the last two rows on the roof are the most unfavorable ones regarding to the win…
View article: Probability Characteristics, Area Reduction, and Wind Directionality Effects of Extreme Pressure Coefficients of High-Rise Buildings
Probability Characteristics, Area Reduction, and Wind Directionality Effects of Extreme Pressure Coefficients of High-Rise Buildings Open
Wind tunnel tests are carried out for the Commonwealth Advisory Aeronautical Research Council (CAARC) high-rise building with a scale of 1:400 in exposure categories D. The distribution law of extreme pressure coefficients under different …
View article: Autophagy-Related Genes in Atherosclerosis
Autophagy-Related Genes in Atherosclerosis Open
Background. Atherosclerosis (AS) is a common chronic vascular inflammatory disease and one of the main causes of cardiovascular/cerebrovascular diseases (CVDs). Autophagy-related genes (ARGs) play a crucial part in pathophysiological proce…
View article: Preparation of UV-Resistant TPU Nanofiber and Its Application in Anti-Haze Window Screening
Preparation of UV-Resistant TPU Nanofiber and Its Application in Anti-Haze Window Screening Open
With the rapid development of industrialization, the problem of air pollution is becoming more and more serious. The haze with PM 2.5 as the main component is the most harmful one, which is very harmful to the human respiratory system. Peo…
View article: Preparation of Polystyrene Nanofiber-Supported Metal-Organic Framework with Formaldehyde Adsorption Properties
Preparation of Polystyrene Nanofiber-Supported Metal-Organic Framework with Formaldehyde Adsorption Properties Open
Air quality is particularly important to public health. Therefore, effective purification and filtration of indoor and outdoor air has become an urgent need. Metal-organic frameworks (MOFs) have been used in the field of gas adsorption bec…
View article: Analysis and Prediction of Opioid Crisis Based on Data Mining
Analysis and Prediction of Opioid Crisis Based on Data Mining Open
The final report released by the White House Commission on combating drug addiction and the opioid crisis (2017), noted that opioid prescriptions have quadrupled since 1999 with more than 27 million people using them in non-prescription wa…
View article: Design of Campus Bicycle Rental Management System Based on SSM Framework
Design of Campus Bicycle Rental Management System Based on SSM Framework Open
In view of the chaotic management of bicycle rental in colleges and the high waste rate of resources, the purpose of this paper is designing a bicycle rental management system to make it easier and more efficient for students and leasing b…