Yuanlin Qi
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View article: Intracellullar cholesterol accumulation caused by HBV induces ATF6-mediated endoplasmic reticulum stress to trigger endoplasmic reticulophagy
Intracellullar cholesterol accumulation caused by HBV induces ATF6-mediated endoplasmic reticulum stress to trigger endoplasmic reticulophagy Open
Analysis of Gene Expression Omnibus (GEO) database demonstrated that the transcription levels of LDLR, SREBF2/SREBP2, ATF6, MAP1LC3B/LC3B and SQSTM1/P62 in CHB tissues were higher than those in normal liver tissues. The IHC results showed …
View article: Hepatitis B Virus X Protein Upregulates <scp>SREBP2</scp> to Modulate Autophagy in Hepatocellular Carcinoma
Hepatitis B Virus X Protein Upregulates <span>SREBP2</span> to Modulate Autophagy in Hepatocellular Carcinoma Open
Background The interaction between Hepatitis B virus X protein (HBx) and sterol regulatory element binding protein 2 (SREBP2) in modulating autophagy to influence inflammation and tumorigenesis is not fully understood. This research seeks …
View article: The Neuroprotective and Anxiolytic Effects of Magnesium Sulfate on Retinal Dopaminergic Neurons in 6-OHDA-Induced Parkinsonian Rats: A Pilot Study
The Neuroprotective and Anxiolytic Effects of Magnesium Sulfate on Retinal Dopaminergic Neurons in 6-OHDA-Induced Parkinsonian Rats: A Pilot Study Open
This study investigates the protective effects of magnesium sulfate on dopamine neurons in the retinas of rats with 6-hydroxydopamine (6-OHDA)-induced Parkinson’s disease (PD). Rapidly progressing cognitive decline often precedes or coinci…
View article: Combination of Sintilimab and Anlotinib for Metastatic Osteosarcoma: A Case Report
Combination of Sintilimab and Anlotinib for Metastatic Osteosarcoma: A Case Report Open
This case demonstrates that sintilimab plus anlotinib may be a feasible treatment regimen for osteosarcoma patients.
View article: Magnesium Ion: A New Switch in Tumor Treatment
Magnesium Ion: A New Switch in Tumor Treatment Open
The magnesium ion is an essential cation in the human body and participates in numerous physiological activities. A deficiency in magnesium ions is closely associated with tumor development, and supplementation with magnesium ions has been…
View article: Deciphering the Effects of the PYCR Family on Cell Function, Prognostic Value, Immune Infiltration in ccRCC and Pan-Cancer
Deciphering the Effects of the PYCR Family on Cell Function, Prognostic Value, Immune Infiltration in ccRCC and Pan-Cancer Open
Pyrroline-5-carboxylate reductase (PYCR) is pivotal in converting pyrroline-5-carboxylate (P5C) to proline, the final step in proline synthesis. Three isoforms, PYCR1, PYCR2, and PYCR3, existed and played significant regulatory roles in tu…
View article: Magnesium Ion: A New Switch in Tumor Treatment
Magnesium Ion: A New Switch in Tumor Treatment Open
The magnesium ion is an essential cation in the human body and participates in numerous physiological activities. A deficiency in magnesium ions is closely associated with tumor development, and supplementation with magnesium ions has been…
View article: Deciphering the effects of PYCR family on cell function, prognostic value, immune infiltration in ccRCC and pan-cancer
Deciphering the effects of PYCR family on cell function, prognostic value, immune infiltration in ccRCC and pan-cancer Open
Background Pyrroline-5-carboxylate reductase (PYCR) is pivotal in converting pyrroline-5-carboxylate (P5C) to proline, the final step in proline synthesis. Three isoforms, PYCR1, PYCR2, and PYCR3, existed and played significant regulatory …
View article: 237P Genomic profiling of aggressive pathologic features in lung adenocarcinoma
237P Genomic profiling of aggressive pathologic features in lung adenocarcinoma Open
The presence of lympho-vascular invasion (LVI), spread through air spaces (STAS) and Grade 3 pattern (from the International Association for the Study of Lung Cancer grading system) have been related to aggressive phenotype and worse progn…
View article: miR-136 Targets MIEN1 and Involves the Metastasis of Colon Cancer by Suppressing Epithelial-to-Mesenchymal Transition [Retraction]
miR-136 Targets MIEN1 and Involves the Metastasis of Colon Cancer by Suppressing Epithelial-to-Mesenchymal Transition [Retraction] Open
[This retracts the article DOI: 10.2147/OTT.S113359.].
View article: Magnesium sulfate protects retinal dopaminergic neurons in rats with 6-OHDA-induced Parkinson’s disease
Magnesium sulfate protects retinal dopaminergic neurons in rats with 6-OHDA-induced Parkinson’s disease Open
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. The main pathological features of PD are the degeneration and death of dopamine neurons in the substantia nigra-striatal pathway and the accumulation of Lewy bo…
View article: Detection of colorectal cancer in mice with terahertz technology-determination of an optimal frequency
Detection of colorectal cancer in mice with terahertz technology-determination of an optimal frequency Open
Colorectal cancer is one of the most prevalent malignancies worldwide, and long-term chronic colitis is considered to be an important factor in the etiological study of colorectal cancer. As an emerging detection technology, the non-invasi…
View article: Targeting UNC-51-like kinase 1 can inhibit esophageal cancer cell proliferation and regulate autophagy
Targeting UNC-51-like kinase 1 can inhibit esophageal cancer cell proliferation and regulate autophagy Open
The purpose of this study was to investigate the expression of UNC-51-like kinase 1 (ULK1) in esophageal cancer(ESCA) and its prognostic value, its effect on esophageal cancer cell growth and proliferation, and the synergistic effect of it…
View article: PRKCDBP Methylation is a Potential and Promising Candidate Biomarker for Non-small Cell Lung Cancer.
PRKCDBP Methylation is a Potential and Promising Candidate Biomarker for Non-small Cell Lung Cancer. Open
PRKCDBP methylation is a potential and promising candidate biomarker for non-small cell lung cancer.
View article: An Immune Gene Signature for Prediction of Overall Survival and Response to Immune Checkpoint Inhibitors Therapy in Patients with Lung Adenocarcinoma
An Immune Gene Signature for Prediction of Overall Survival and Response to Immune Checkpoint Inhibitors Therapy in Patients with Lung Adenocarcinoma Open
Lung adenocarcinoma is one of the most common malignant tumors worldwide. The purpose of this study was to construct a stable immune gene signature for prediction of prognosis (IGSPP) and response to immune checkpoint inhibitors (ICIs) the…
View article: [Clinicopathological features of intravascular peripheral T-cell lymphoma].
[Clinicopathological features of intravascular peripheral T-cell lymphoma]. Open
Objective: To summarize the clinical and pathological features of intravascular NK and T cell lymphoma for better understanding of such disease to reduce misdiagnosis and miss-diagnosis. Methods: Clinical and pathological features were ana…
View article: [Research of prognostic immunophenotypes in 163 patients of diffuse large B-cell lymphoma].
[Research of prognostic immunophenotypes in 163 patients of diffuse large B-cell lymphoma]. Open
Objective: To screen and analyze the prognostic protein biomarkers of DLBCL, and to explore their value in the prognostic evaluation. Methods: 163 cases of confirmed DLBCLs from January 2011 to December 2016 were collected with their clini…
View article: Hypermethylation of tumor necrosis factor decoy receptor gene in non‑small lung cancer
Hypermethylation of tumor necrosis factor decoy receptor gene in non‑small lung cancer Open
Abnormal methylation of the TNFRSF10C and TNFRSF10D genes has been observed in numerous types of cancer; however, no studies have investigated the methylation of these genes in non-small cell lung cancer (NSCLC). The aim of the present stu…
View article: The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein
The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein Open
The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein. Thus, OTUD1 could be considered as a therapeutic target for curing these cancers.
View article: miR-136 targets MIEN1 and involves the metastasis of colon cancer by suppressing epithelial-to-mesenchymal transition
miR-136 targets MIEN1 and involves the metastasis of colon cancer by suppressing epithelial-to-mesenchymal transition Open
MIEN1 is a novel oncogene, and it involves tumor progression in various cancer types, including colon cancer. However, the definite molecular mechanisms of MIEN1 in colon cancer progression remain to be completely elucidated. In the presen…
View article: Effect of glutamine-enriched nutritional support on intestinal mucosal barrier function, MMP-2, MMP-9 and immune function in patients with advanced gastric cancer during perioperative chemotherapy
Effect of glutamine-enriched nutritional support on intestinal mucosal barrier function, MMP-2, MMP-9 and immune function in patients with advanced gastric cancer during perioperative chemotherapy Open
We studied the effects of glutamine-enriched nutritional support on intestinal mucosal barrier, matrix metalloproteinase (MMP)-2, MMP-9 and immune function during perioperative chemotherapy in patients with advanced gastric cancer. The stu…
View article: AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 β and IL-18
AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 β and IL-18 Open
Chronic sterile inflammation has been implicated in the pathogenesis of many cancers, including skin cancer. Chronic arsenic exposure is closely associated with the development of skin cancer. However, there is a lack of understanding how …
View article: Role of MCP-1 in alcohol-induced aggressiveness of colorectal cancer cells
Role of MCP-1 in alcohol-induced aggressiveness of colorectal cancer cells Open
Epidemiological studies demonstrate that alcohol consumption is associated with an increased risk of colorectal cancer (CRC). In addition to promoting carcinogenesis, alcohol may also accelerate the progression of existing CRC. We hypothes…
View article: Association of THBS1 rs1478605 T>C in 5′-untranslated regions with the development and progression of gastric cancer
Association of THBS1 rs1478605 T>C in 5′-untranslated regions with the development and progression of gastric cancer Open
Thrombospondin 1 (THBS1) plays an important role in angiogenesis and tumor progression. The aim of the present study was to investigate the effects of single-nucleotide polymorphisms (rs1478605 and rs3743125) in the untranslated regions of…