Yuanling Yu
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View article: High-throughput pseudovirus neutralisation maps the antigenic landscape of influenza A/H1N1 viruses
High-throughput pseudovirus neutralisation maps the antigenic landscape of influenza A/H1N1 viruses Open
View article: Epitope and functional classification of human neutralizing antibodies against SFTSV Gn
Epitope and functional classification of human neutralizing antibodies against SFTSV Gn Open
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a lethal bunyavirus lacking approved countermeasures. From SFTS survivors, we isolated 98 human mAbs against the viral glycoproteins Gn and Gc. Gn-specific mAbs showed superior n…
View article: Antigenic and virological characteristics of SARS-CoV-2 variants BA.3.2, XFG, and NB.1.8.1
Antigenic and virological characteristics of SARS-CoV-2 variants BA.3.2, XFG, and NB.1.8.1 Open
View article: Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1
Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 Open
The emergence of the SARS-CoV-2 saltation variant BA.3.2, which harbors over 50 mutations relative to its ancestral BA.3 lineage, has raised concerns about its potential to drive outbreaks similar to BA.2.86/JN.1. Concurrently, variants su…
View article: The Compensatory Effect of S375F on S371F Is Vital for Maintaining the Infectivity of SARS‐CoV‐2 Omicron Variants
The Compensatory Effect of S375F on S371F Is Vital for Maintaining the Infectivity of SARS‐CoV‐2 Omicron Variants Open
The emergence of Omicron variants dramatically changed the transmission rate and infection characteristics compared to previously prevalent strains, primarily due to spike protein mutations. However, the impact of individual mutations rema…
View article: Virological and antigenic characteristics of SARS-CoV-2 variants LF.7.2.1, NP.1, and LP.8.1
Virological and antigenic characteristics of SARS-CoV-2 variants LF.7.2.1, NP.1, and LP.8.1 Open
XEC and KP.3.1.1 have surpassed KP.3 to become the globally dominant lineages due to their unique NTD mutations. However, several emerging JN.1 sublineages, such as LF.7.2.1, MC.10.1, NP.1, and, especially, LP.8.1, have demonstrated superi…
View article: Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1
Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1 Open
View article: Enhanced immune evasion of SARS-CoV-2 KP.3.1.1 and XEC through NTD glycosylation
Enhanced immune evasion of SARS-CoV-2 KP.3.1.1 and XEC through NTD glycosylation Open
KP.3.1.1 has surpassed KP.3 to become the new globally dominant strain, while XEC, a recombinant variant of KS.1.1/KP.3.3, is rapidly expanding across Europe and North America. Notably, both variants carry mutations, S31del of KP.3.1.1 and…
View article: Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain
Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain Open
A multitude of functional mutations continue to emerge on the N-terminal domain (NTD) of the spike protein in SARS-CoV-2 Omicron subvariants. Understanding the immunogenicity of Omicron NTD and the properties of antibodies elicited by it i…
View article: Prolonged Omicron-specific B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine
Prolonged Omicron-specific B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine Open
SARS-CoV-2 ancestral strain-induced immune imprinting poses great challenges to updating vaccines for new variants. Studies showed that repeated Omicron exposures could override immune imprinting induced by inactivated vaccines but not mRN…
View article: Deletion of V483 in the spike confers evolutionary advantage on SARS-CoV-2 for human adaptation and host-range expansion after a prolonged pandemic
Deletion of V483 in the spike confers evolutionary advantage on SARS-CoV-2 for human adaptation and host-range expansion after a prolonged pandemic Open
Dear Editor,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone continuous evolution since its initial outbreak in 2019.The emergence of Omicron as the dominant variant occurred abruptly after 2022. 1 A highly mutate…
View article: Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain
Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain Open
A multitude of functional mutations continue to emerge on the N-terminal domain (NTD) of the spike protein in SARS-CoV-2 Omicron subvariants. Understanding the immunogenicity of Omicron NTD and the properties of antibodies elicited by it i…
View article: Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity
Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Open
Selective pressures have given rise to a number of SARS-CoV-2 variants during the prolonged course of the COVID-19 pandemic. Recently evolved variants differ from ancestors in additional glycosylation within the spike protein receptor-bind…
View article: Optimization and validation of a virus‐like particle pseudotyped virus neutralization assay for SARS‐CoV‐2
Optimization and validation of a virus‐like particle pseudotyped virus neutralization assay for SARS‐CoV‐2 Open
Spike‐protein‐based pseudotyped viruses were used to evaluate vaccines during the COVID‐19 pandemic. However, they cannot be used to evaluate the envelope (E), membrane (M), and nucleocapsid (N) proteins. The first generation of virus‐like…
View article: Omicron-specific naive B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine
Omicron-specific naive B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine Open
SARS-CoV-2 ancestral strain-induced immune imprinting poses great challenges to vaccine updates. Studies showed that repeated Omicron exposures could override immune imprinting induced by inactivated vaccines but not mRNA vaccines, a dispa…
View article: COVID-19 Serum Drives Spike-Mediated SARS-CoV-2 Variation
COVID-19 Serum Drives Spike-Mediated SARS-CoV-2 Variation Open
Neutralizing antibodies targeting the spike (S) protein of SARS-CoV-2, elicited either by natural infection or vaccination, are crucial for protection against the virus. Nonetheless, the emergence of viral escape mutants presents ongoing c…
View article: Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1
Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1 Open
The continuous evolution of SARS-CoV-2, particularly the emergence of the BA.2.86/JN.1 lineage replacing XBB lineages, necessitates re-evaluation of current vaccine compositions. Here, we provide a comprehensive analysis of the humoral imm…
View article: Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants
Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants Open
Monoclonal antibodies (mAbs) targeting the SARS-CoV-2 receptor-binding domain (RBD) are used to treat and prevent COVID-19. However, the rapid evolution of SARS-CoV-2 drives continuous escape from therapeutic mAbs. Therefore, the ability t…
View article: Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1
Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1 Open
The recent emergence of a SARS-CoV-2 saltation variant, BA.2.87.1, which features 65 spike mutations relative to BA.2, has attracted worldwide attention. In this study, we elucidate the antigenic characteristics and immune evasion capabili…
View article: Development of a SARS‐CoV‐2 neutralization assay based on a pseudotyped virus using a HIV system
Development of a SARS‐CoV‐2 neutralization assay based on a pseudotyped virus using a HIV system Open
Regarding the extensive global attention to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) that constitutes an international public health emergency, pseudovirus neutralization assays have been widely applied due to their adv…
View article: Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1
Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1 Open
The recent emergence of a SARS-CoV-2 saltation variant, BA.2.87.1, which features 65 spike mutations relative to BA.2, has attracted worldwide attention. In this study, we elucidate the antigenic characteristics and immune evasion capabili…
View article: Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through multiple mechanisms
Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through multiple mechanisms Open
SUMMARY Selective pressures have given rise to a number of SARS-CoV-2 variants during the prolonged course of the COVID-19 pandemic. Recently evolved variants differ from ancestors in additional glycosylation within the spike protein recep…
View article: Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455–456 synergistically enhances antibody evasion and ACE2 binding
Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455–456 synergistically enhances antibody evasion and ACE2 binding Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBB lineages have achieved dominance worldwide and keep on evolving. Convergent evolution of XBB lineages on the receptor-binding domain (RBD) L455F and F456L is observed, result…
View article: Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure
Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure Open
View article: Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting Open
The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19 vaccine compositions. However, immune imprinting induced by vaccination based on the ancestral (hereafter referred to as WT) strain would compromise the…
View article: Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure
Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure Open
While the BA.2.86 variant demonstrated significant antigenic drift and enhanced ACE2 binding affinity, its ability to evade humoral immunity was relatively moderate compared to dominant strains like EG.5 and HK.3. However, the emergence of…
View article: Development of an automated, high-throughput SARS-CoV-2 neutralization assay based on a pseudotyped virus using a vesicular stomatitis virus (VSV) vector
Development of an automated, high-throughput SARS-CoV-2 neutralization assay based on a pseudotyped virus using a vesicular stomatitis virus (VSV) vector Open
ABSTRACTThe global outbreak of COVID-19 has caused a severe threat to human health; therefore, simple, high-throughput neutralization assays are desirable for developing vaccines and drugs against COVID-19. In this study, a high-tit…
View article: Antigenicity and infectivity characterisation of SARS-CoV-2 BA.2.86
Antigenicity and infectivity characterisation of SARS-CoV-2 BA.2.86 Open
View article: Antigenicity and infectivity characterization of SARS-CoV-2 BA.2.86
Antigenicity and infectivity characterization of SARS-CoV-2 BA.2.86 Open
The recently identified SARS-CoV-2 variant, BA.2.86, which carries a substantial number of Spike mutations, has raised a global alarm. An immediate assessment of its antigenic properties and infectivity is necessary. Here, we reveal the di…
View article: Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding
Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding Open
Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBB lineages have achieved dominance worldwide and keep on evolving. Convergent evolution of XBB lineages on the receptor-binding domain (RBD) L455F and F456L is observed…