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View article: Effects of Multicomponent Otago Exercise Program with Added Resistance Training on Sarcopenia in Pre-Frailty Older Adults in Nursing Homes: A Randomized Controlled Trial
Effects of Multicomponent Otago Exercise Program with Added Resistance Training on Sarcopenia in Pre-Frailty Older Adults in Nursing Homes: A Randomized Controlled Trial Open
OEP combined with RT can improve the sarcopenia-related parameters of the elderly in nursing homes. Short-term unreversed frailty may be related to insufficient intervention intensity or single dimension. Improved muscle and physical funct…
View article: Hypochlorous Acid-Gated Hydrolysis of a Phosphinate Ester Dye in Living Cells
Hypochlorous Acid-Gated Hydrolysis of a Phosphinate Ester Dye in Living Cells Open
Theranostic fluorescent platforms are capable of the selective delivery of small molecules to target cells with simultaneous optical monitoring. Such technologies promise to significantly reduce off-target effects compared with cytotoxic c…
View article: Arthroscopic Fixation of Minimally Displaced Avulsion Fracture of Ischial Tuberosity Using a "Double-Pulley" Suture Anchor Technique
Arthroscopic Fixation of Minimally Displaced Avulsion Fracture of Ischial Tuberosity Using a "Double-Pulley" Suture Anchor Technique Open
View article: Arthroscopic Suspensory Construct for Acute Acromioclavicular Joint Separation
Arthroscopic Suspensory Construct for Acute Acromioclavicular Joint Separation Open
View article: UserTrace: User-Level Requirements Generation and Traceability Recovery from Software Project Repositories
UserTrace: User-Level Requirements Generation and Traceability Recovery from Software Project Repositories Open
Software maintainability critically depends on high-quality requirements descriptions and explicit traceability between requirements and code. Although automated code summarization (ACS) and requirements traceability (RT) techniques have b…
View article: A Modular Platform for the Optogenetic Control of Small GTPase Activity in Living Cells Reveals Long-Range RhoA Signaling
A Modular Platform for the Optogenetic Control of Small GTPase Activity in Living Cells Reveals Long-Range RhoA Signaling Open
Small GTPases are critical regulators of cellular processes, such as cell migration, and comprise a family of over 167 proteins in the human genome. Importantly, the location-dependent regulation of small GTPase activity is integral to coo…
View article: Split-Small GTPase Reassembly as a Method to Control Cellular Signaling with User-Defined Inputs
Split-Small GTPase Reassembly as a Method to Control Cellular Signaling with User-Defined Inputs Open
Small GTPases are critical signaling enzymes that control diverse cellular functions, such as cell migration and proliferation. However, dissecting the roles of these enzymes in cellular signaling is hindered by the lack of a plug-and-play…
View article: Anchor-Free Minimally Invasive Double-Bundle Medial Patellofemoral Ligament Reconstruction With Medial Retinacular Tightening for the Treatment of Recurrent Patella Dislocation
Anchor-Free Minimally Invasive Double-Bundle Medial Patellofemoral Ligament Reconstruction With Medial Retinacular Tightening for the Treatment of Recurrent Patella Dislocation Open
View article: Combined repair technique for patellar tendon rupture using two suture anchors and three transosseous sutures: a retrospective cohort study
Combined repair technique for patellar tendon rupture using two suture anchors and three transosseous sutures: a retrospective cohort study Open
The combined repair technique demonstrated reliable mid-term outcomes with satisfactory functional recovery, radiological healing, and a low complication rate. This technique may serve as a practical and effective option for proximal patel…
View article: Forkhead box O proteins in chondrocyte aging and diseases
Forkhead box O proteins in chondrocyte aging and diseases Open
FoxO transcription factors, especially FoxO1 and FoxO3, are promising therapeutic targets for promoting longevity, stimulating cartilage regeneration, and treating aging-related diseases like OA.
View article: [Early effectiveness of transosseous suture fixation in treatment of recurrent acute patellar dislocation with patellar osteochondral fractures].
[Early effectiveness of transosseous suture fixation in treatment of recurrent acute patellar dislocation with patellar osteochondral fractures]. Open
For recurrent acute patellar dislocation with patellar OCFs, transosseous suture fixation proves to be both safe and effective, achieving satisfactory early effectiveness.
View article: Arthroscopic Bilateral Autologous Iliac Crest Bone Grafting for Restoring Large Bipolar Bone Loss in Anterior Shoulder Dislocation
Arthroscopic Bilateral Autologous Iliac Crest Bone Grafting for Restoring Large Bipolar Bone Loss in Anterior Shoulder Dislocation Open
View article: Methods for Controlling Small GTPase Activity
Methods for Controlling Small GTPase Activity Open
Small GTPases comprise a diverse class of signaling proteins in mammalian cells and regulate a variety of cellular processes such as cell growth, cell movement, vesicle formation, and nuclear transport. Due to their involvement in critical…
View article: [Retrospective clinical analysis of eculizumab treatment for hematopoietic stem cell transplantation-associated thrombotic microangiopathy: a report of 11 cases].
[Retrospective clinical analysis of eculizumab treatment for hematopoietic stem cell transplantation-associated thrombotic microangiopathy: a report of 11 cases]. Open
Objective: To evaluate the efficacy of eculizumab in treating hematopoietic stem cell transplantation-associated thrombotic microangiopathy (TA-TMA) . Methods: This retrospective study included 11 patients who developed TA-TM…
View article: Split-Small GTPase Reassembly as a Method to Control Cellular Signaling with User-Defined Inputs
Split-Small GTPase Reassembly as a Method to Control Cellular Signaling with User-Defined Inputs Open
Small GTPases are critical signaling enzymes that control diverse cellular functions such as cell migration and proliferation. However, dissecting the roles of these enzymes in cellular signaling is hindered by the lack of a plug-and-play …
View article: UniTrans: A Unified Vertical Federated Knowledge Transfer Framework for Enhancing Cross-Hospital Collaboration
UniTrans: A Unified Vertical Federated Knowledge Transfer Framework for Enhancing Cross-Hospital Collaboration Open
Cross-hospital collaboration has the potential to address disparities in medical resources across different regions. However, strict privacy regulations prohibit the direct sharing of sensitive patient information between hospitals. Vertic…
View article: Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head
Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head Open
Osteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse of the femoral …
View article: Salvage skull base surgery for a recurrent fibrosarcoma: A case report
Salvage skull base surgery for a recurrent fibrosarcoma: A case report Open
View article: Augmented Repair Technique for Patellar Tendon Rupture Using Two Suture Anchors and Three Transosseous Sutures: a retrospective cohort study
Augmented Repair Technique for Patellar Tendon Rupture Using Two Suture Anchors and Three Transosseous Sutures: a retrospective cohort study Open
Background Patellar tendon rupture is an uncommon injury that usually requires surgical repair, but no consensus exists regarding the ideal repair technique. Suture anchor repair and the transosseous suture method have be widely used, but …
View article: Comparative efficacy and safety of different surgical approaches for the treatment of anterior cruciate ligament injury: a Bayesian network meta-analysis protocol
Comparative efficacy and safety of different surgical approaches for the treatment of anterior cruciate ligament injury: a Bayesian network meta-analysis protocol Open
Introduction Anterior cruciate ligament (ACL) rupture can be treated surgically or non-surgically, with several surgical interventions available at present. However, the comparatively effective surgical intervention with relatively fewer s…
View article: Standardized Parts for Activation of Small GTPase Signaling in Living Cells
Standardized Parts for Activation of Small GTPase Signaling in Living Cells Open
Small GTPases comprise a superfamily of over 167 proteins in the human genome and are critical regulators of a variety of pathways including cell migration and proliferation. Despite the importance of these proteins in cell signaling, a st…
View article: A deep unrolled neural network for real-time MRI-guided brain intervention
A deep unrolled neural network for real-time MRI-guided brain intervention Open
Accurate navigation and targeting are critical for neurological interventions including biopsy and deep brain stimulation. Real-time image guidance further improves surgical planning and MRI is ideally suited for both pre- and intra-operat…
View article: Newly diagnosed extranodal natural killer/T cell lymphoma (ENKTL) treated by anti‐PD‐1 antibody plus histone deacetylase inhibitor followed by P‐GemOx regimen
Newly diagnosed extranodal natural killer/T cell lymphoma (ENKTL) treated by anti‐PD‐1 antibody plus histone deacetylase inhibitor followed by P‐GemOx regimen Open
Background: ENKTL is a highly aggressive NHL with a higher incidence in Asia. In 2020 ASH meeting, we reported Sintilimab(anti-PD-1 antibody) plus Chidamide(an oral subtype-selective HDACi) yielded effective antitumor activity, durable res…
View article: Human iPSC‐Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System
Human iPSC‐Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System Open
Chronic white adipose tissue (WAT) inflammation has been recognized as a critical early event in the pathogenesis of obesity‐related disorders. This process is characterized by the increased residency of proinflammatory M1 macrophages in W…
View article: Mitochondrion: A bridge linking aging and degenerative diseases
Mitochondrion: A bridge linking aging and degenerative diseases Open
Aging is a natural process, characterized by progressive loss of physiological integrity, impaired function, and increased vulnerability to death. For centuries, people have been trying hard to understand the process of aging and find effe…
View article: Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity
Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity Open
Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age-related biophysical alterations are poorly understood. H…
View article: Architecture of the outbred brown fat proteome defines regulators of metabolic physiology
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology Open
View article: Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes
Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes Open
Osteoarthritis (OA) is a chronic degenerative joint disease that causes pain, physical disability, and life quality impairment. The pathophysiology of OA remains largely unclear, and currently no FDA-approved disease-modifying OA drugs (DM…
View article: Expression of CD123 related long non-coding RNA in Acute Myeloid Leukemia bone marrow mononuclear cells and its clinical significance
Expression of CD123 related long non-coding RNA in Acute Myeloid Leukemia bone marrow mononuclear cells and its clinical significance Open
Acute myelogenous leukemia (AML) is a very common hematopoietic malignancy. Hematopoietic stem cell transplantation can improve the therapeutic effect of AML, but the 5-year survival rate is very low. CD123 imbalance, abnormal gene express…
View article: Prognostic Signature: Papillary Thyroid Carcinoma With Poor Prognosis Has Enhanced Immune Escape Capacity And High Tumor Heterogeneity
Prognostic Signature: Papillary Thyroid Carcinoma With Poor Prognosis Has Enhanced Immune Escape Capacity And High Tumor Heterogeneity Open
Background Papillary thyroid carcinoma (PTC) is considered an inflammation-driven cancer. However, a systematic investigation of the relationship between the tumor immune microenvironment and the prognosis of PTC has not been conducted. Me…