Yuanqing Fu
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View article: Cross-ethnic Molecular Signatures Underpin the Adverse Impact of Statin Use on Type 2 Diabetes
Cross-ethnic Molecular Signatures Underpin the Adverse Impact of Statin Use on Type 2 Diabetes Open
The use of statins as the primary therapy for reducing low-density lipoprotein cholesterol has raised concerns regarding their potential side effects in increasing the risk of type 2 diabetes (T2D). However, the underlying mechanism remain…
View article: Quantification of personalized glycemic sensitivity to food and its potential for precision nutrition in a series of n-of-1 trials
Quantification of personalized glycemic sensitivity to food and its potential for precision nutrition in a series of n-of-1 trials Open
Our novel PGS provides a framework for quantity differences in glycemic sensitivity among healthy individuals and facilitates further research on tailored dietary advice that improves glucose homeostasis. This trial was registered at clini…
View article: Integrated Gut Microbiota and Lipidome Profiles in Early Pregnancy for Predicting Gestational Diabetes Mellitus Risk
Integrated Gut Microbiota and Lipidome Profiles in Early Pregnancy for Predicting Gestational Diabetes Mellitus Risk Open
View article: Circulating Polyunsaturated Fatty Acids and Glycemic Dynamics Assessed by Continuous Glucose Monitoring: A 13‐Year Prospective Cohort Study
Circulating Polyunsaturated Fatty Acids and Glycemic Dynamics Assessed by Continuous Glucose Monitoring: A 13‐Year Prospective Cohort Study Open
Polyunsaturated fatty acids (PUFA) have been proposed to be involved in the diabetes etiology, but the associations between PUFA biomarkers and glycemic dynamics are unclear. We aimed to investigate the prospective associations of PUFA wit…
View article: Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control
Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control Open
View article: Trajectories of Sleep Duration, Sleep Onset Timing, and Continuous Glucose Monitoring in Adults
Trajectories of Sleep Duration, Sleep Onset Timing, and Continuous Glucose Monitoring in Adults Open
Importance Understanding the interplay between trajectories of sleep duration, sleep onset timing, and glycemic dynamics is crucial for improving preventive strategies against diabetes and related metabolic diseases. Objective To examine t…
View article: Genetic mapping of serum metabolome to chronic diseases among Han Chinese
Genetic mapping of serum metabolome to chronic diseases among Han Chinese Open
Serum metabolites are potential regulators for chronic diseases. To explore the genetic regulation of metabolites and their roles in chronic diseases, we quantified 2,759 serum metabolites and performed genome-wide association studies (GWA…
View article: Longitudinal serum proteome mapping reveals biomarkers for healthy ageing and related cardiometabolic diseases
Longitudinal serum proteome mapping reveals biomarkers for healthy ageing and related cardiometabolic diseases Open
View article: Association of the EAT-Lancet diet, serial measures of serum proteome and gut microbiome, and cardiometabolic health: a prospective study of Chinese middle-aged and elderly adults
Association of the EAT-Lancet diet, serial measures of serum proteome and gut microbiome, and cardiometabolic health: a prospective study of Chinese middle-aged and elderly adults Open
Our study presents key molecular evidence to support the role of EAT-Lancet diet adherence in promoting cardiometabolic health.
View article: Physical Activity During Pregnancy and Preterm Birth Among Women With Gestational Diabetes
Physical Activity During Pregnancy and Preterm Birth Among Women With Gestational Diabetes Open
Importance Physical activity, as a modifiable factor, emerges as a primary intervention strategy for the prevention and management of gestational diabetes (GD). Among women with GD, the association of physical activity during pregnancy wit…
View article: Diet-gut microbiome interaction and its impact on host blood glucose homeostasis: a series of nutritional n-of-1 trials
Diet-gut microbiome interaction and its impact on host blood glucose homeostasis: a series of nutritional n-of-1 trials Open
This work was supported by the National Key R&D Program of China, National Natural Science Foundation of China and Zhejiang Provincial Natural Science Foundation of China.
View article: Mapping the gut microbial structural variations in healthy aging within the Chinese population
Mapping the gut microbial structural variations in healthy aging within the Chinese population Open
Mapping gut microbial structural variants (SVs) during human aging may provide fundamental knowledge and mechanistic understanding of the gut microbiome's relationship with healthy aging. We characterize gut microbial SVs from 3,230 Chines…
View article: Microbiome-based correction for random errors in nutrient profiles derived from self-reported dietary assessments
Microbiome-based correction for random errors in nutrient profiles derived from self-reported dietary assessments Open
View article: The temporal dynamics of the gut mycobiome and its association with cardiometabolic health in a nationwide cohort of 12,641 Chinese adults
The temporal dynamics of the gut mycobiome and its association with cardiometabolic health in a nationwide cohort of 12,641 Chinese adults Open
View article: Cross‐Sectional and Prospective Association of Serum 25‐Hydroxyvitamin D with Gut Mycobiota during Pregnancy among Women with Gestational Diabetes
Cross‐Sectional and Prospective Association of Serum 25‐Hydroxyvitamin D with Gut Mycobiota during Pregnancy among Women with Gestational Diabetes Open
Scope Little is known about the effect of blood vitamin D status on the gut mycobiota (i.e., fungi), a crucial component of the gut microbial ecosystem. The study aims to explore the association between 25‐hydroxyvitamin D [25(OH)D] and gu…
View article: Landscape of the gut mycobiome dynamics during pregnancy and its relationship with host metabolism and pregnancy health
Landscape of the gut mycobiome dynamics during pregnancy and its relationship with host metabolism and pregnancy health Open
Objective The remodelling of gut mycobiome (ie, fungi) during pregnancy and its potential influence on host metabolism and pregnancy health remains largely unexplored. Here, we aim to examine the characteristics of gut fungi in pregnant wo…
View article: Genetic Mapping of Serum Metabolome to Chronic Diseases Among Han Chinese
Genetic Mapping of Serum Metabolome to Chronic Diseases Among Han Chinese Open
View article: Proteome‐wide profiling reveals dysregulated molecular features and accelerated aging in osteoporosis: A 9.8‐year prospective study
Proteome‐wide profiling reveals dysregulated molecular features and accelerated aging in osteoporosis: A 9.8‐year prospective study Open
The role of circulatory proteomics in osteoporosis is unclear. Proteome‐wide profiling holds the potential to offer mechanistic insights into osteoporosis. Serum proteome with 413 proteins was profiled by liquid chromatography–tandem mass …
View article: Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies
Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies Open
View article: Cohort Profile: Guangzhou Nutrition and Health Study (GNHS): A Population-based Multi-omics Study
Cohort Profile: Guangzhou Nutrition and Health Study (GNHS): A Population-based Multi-omics Study Open
The cohort will provide data that will be influential in establishing the role of nutrition in metabolic diseases with multi-omics.
View article: Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome
Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome Open
View article: Furan fatty acid metabolite CMPF is associated with lower risk of type 2 diabetes, but not chronic kidney disease: a longitudinal population-based cohort study
Furan fatty acid metabolite CMPF is associated with lower risk of type 2 diabetes, but not chronic kidney disease: a longitudinal population-based cohort study Open
Our findings suggest that serum CMPF was associated with a lower risk of type 2 diabetes but not chronic kidney disease. This study also suggests that CMPF may be a functional metabolite underlying the protective relationship between marin…
View article: PTFS08-06-23 Diet-Gut Microbiome Interaction at Single-Subject Resolution: A Series of N-of-1 Clinical Trials
PTFS08-06-23 Diet-Gut Microbiome Interaction at Single-Subject Resolution: A Series of N-of-1 Clinical Trials Open
View article: P19-032-23 Associations of Furan Fatty Acid Metabolite CMPF With Incident Type 2 Diabetes and Chronic Kidney Disease: A Longitudinal Population-Based Cohort Study
P19-032-23 Associations of Furan Fatty Acid Metabolite CMPF With Incident Type 2 Diabetes and Chronic Kidney Disease: A Longitudinal Population-Based Cohort Study Open
View article: P20-024-23 Lactobacillus reuteri Alleviates Abnormal Body Fat Accumulation by Activating the Deoxycholic Acid-Angptl8 Axis
P20-024-23 Lactobacillus reuteri Alleviates Abnormal Body Fat Accumulation by Activating the Deoxycholic Acid-Angptl8 Axis Open
View article: PTFS08-01-23 Adherence to the EAT-Lancet Diet Benefits Cardiometabolic Health Through Gut Microbiota-Blood Protein Axis
PTFS08-01-23 Adherence to the EAT-Lancet Diet Benefits Cardiometabolic Health Through Gut Microbiota-Blood Protein Axis Open
View article: Continuous glucose monitoring-derived glycemic metrics and adverse pregnancy outcomes among women with gestational diabetes: a prospective cohort study
Continuous glucose monitoring-derived glycemic metrics and adverse pregnancy outcomes among women with gestational diabetes: a prospective cohort study Open
National Key R&D Program of China, National Natural Science Foundation of China, and Westlake Laboratory of Life Sciences and Biomedicine.
View article: The Short-Term Variation of Human Gut Mycobiome in Response to Dietary Intervention of Different Macronutrient Distributions
The Short-Term Variation of Human Gut Mycobiome in Response to Dietary Intervention of Different Macronutrient Distributions Open
While the human gut is home to a complex and diverse community of microbes, including bacteria and fungi, research on the gut microbiome has largely focused on bacteria, with relatively little attention given to the gut mycobiome. This stu…
View article: Integration of multiomics with precision nutrition for gestational diabetes: Study protocol for the Westlake Precision Birth Cohort
Integration of multiomics with precision nutrition for gestational diabetes: Study protocol for the Westlake Precision Birth Cohort Open
We established a prospective birth cohort, the Westlake Precision Birth Cohort (WeBirth), based on 2000 pregnant women with gestational diabetes mellitus (GDM) in the second trimester and their offspring. The WeBirth provides a new framewo…
View article: Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility
Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility Open