Explanipedia

Expert consensus of perioperative intensive care and management of critically ill cancer patients (2021) Open

Haijun Wang, Hongzhi Wang, Wei Chen, Heling Zhao, Yuanyu Qian , et al. · 2021

Haijun Wang, Hongzhi Wang, Wei Chen, Heling Zhao, Yuanyu Qian, Limin Shen, Shuangling Li, Jun Duan, Zhiqiang Wang, Keliang Cui, Quan Wang, Xiaoyan Xue, Xiyuan Li, Liwei Hua, Yingping Zhang, Yongshun Feng, Huaiwu He, Lei Li, Nan Zhang, Jun …

Response Efficacy of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-Analysis Open

Shixue Chen, Zhibo Zhang, Xuan Zheng, Haitao Tao, Sujie Zhang , et al. · 2021

Background Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have demonstrated promise in treating a variety of advanced cancers; however, little is known regarding their efficacy under various clinical situations, including di…

The Synergistic Effect of PARP Inhibitors and Immune Checkpoint Inhibitors Open

Zhaozhen Wu, Pengfei Cui, Haitao Tao, Sujie Zhang, Junxun Ma , et al. · 2021

Poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated great promise for treating cancers with homologous recombination (HR) defects, such as germline BRCA1/2 mutation. Further studies suggest that PARP inhibitors (PARPi) can als…

Immune checkpoint inhibitors combined with chemotherapy for the treatment of advanced pancreatic cancer patients Open

Junxun Ma, Danyang Sun, Jinliang Wang, Chun Han, Yuanyu Qian , et al. · 2020

Anti-PD-1 therapy combined with chemotherapy in patients with advanced biliary tract cancer Open

Danyang Sun, Junxun Ma, Jinliang Wang, Chun Han, Yuanyu Qian , et al. · 2019

Akt1-mediated CPR cooling protection targets regulators of metabolism, inflammation and contractile function in mouse cardiac arrest Open

Jing Li, Xiangdong Zhu, Huashan Wang, Chunpei Lee, Sy‐Jou Chen , et al. · 2019

Therapeutic hypothermia initiated during cardiopulmonary resuscitation (CPR) in pre-clinical studies appears to be highly protective against sudden cardiac arrest injury. Given the challenges to implementing CPR cooling clinically, insight…

Akt1-mediated CPR cooling protection targets regulators of metabolism, inflammation and contractile function in mouse cardiac arrest v1 Open

Jing Li, Xiangdong Zhu, Huashan Wang, Chunpei Lee, Sy‐Jou Chen , et al. · 2019

Therapeutic hypothermia initiated during cardiopulmonary resuscitation (CPR) in pre-clinical studies appears to be highly protective against sudden cardiac arrest injury. Given the challenges to implementing CPR cooling clinically, insight…

Risk factors for pneumonitis in patients treated with anti‐programmed death‐1 therapy: A case‐control study Open

Pengfei Cui, Zhefeng Liu, Guoqiang Wang, Junxun Ma, Yuanyu Qian , et al. · 2018

Immune checkpoint blockade‐related pneumonitis is a rare but potentially life‐threatening adverse effect, but its risk factors are not completely understood. This case‐control study was conducted to identify pneumonitis risk factors in pat…

The Expression and Clinical Outcome of pCHK2-Thr68 and pCDC25C-Ser216 in Breast Cancer Open

Huayong Jiang, Bin Wang, Fuli Zhang, Yuanyu Qian, Chia‐Chen Chuang , et al. · 2016

Checkpoint kinase 2 (CHK2) and cell division cycle 25C (CDC25C) are two proteins involved in the DNA damage response pathway, playing essential roles in maintaining genome integrity. As one of the major hallmarks of abnormal cellular divis…

A novel pharmacological strategy by PTEN inhibition for improving metabolic resuscitation and survival after mouse cardiac arrest Open

Jing Li, Huashan Wang, Qiang Zhong, Xiangdong Zhu, Sy‐Jou Chen , et al. · 2015

Sudden cardiac arrest (SCA) is a leading cause of death in the United States. Despite return of spontaneous circulation, patients die due to post-SCA syndrome that includes myocardial dysfunction, brain injury, impaired metabolism, and inf…

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