Yuanyuan Fu
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View article: Neural skip metastasis in glioblastoma: A rare case with diagnostic and therapeutic implications
Neural skip metastasis in glioblastoma: A rare case with diagnostic and therapeutic implications Open
View article: Risk factors for abdominal aortic aneurysm in general populations: A systematic review and meta-analysis
Risk factors for abdominal aortic aneurysm in general populations: A systematic review and meta-analysis Open
Background Abdominal aortic aneurysm (AAA) has a high mortality rate after rupture. This study systematically explored the risk factors associated with AAA in the general population using a meta-analytic approach. Materials and methods We …
View article: Liquid biopsy diagnostics for non-small cell lung cancer via elucidation of tRNA signatures
Liquid biopsy diagnostics for non-small cell lung cancer via elucidation of tRNA signatures Open
Background Lung cancer, particularly non-small cell lung cancer (NSCLC), accounts for about 85% of all lung cancer cases and remains a major global health challenge. Traditional diagnostic methods, such as chest X-rays and low-dose CT scan…
View article: Heterogeneous hematoma density predicts poor outcome in patients with supratentorial intracerebral hemorrhage after craniotomy
Heterogeneous hematoma density predicts poor outcome in patients with supratentorial intracerebral hemorrhage after craniotomy Open
View article: A robust machine learning model based on ribosomal‐subunit‐derived piRNAs for diagnostic potential of nonsmall cell lung cancer across multicentre, large‐scale of sequencing data
A robust machine learning model based on ribosomal‐subunit‐derived piRNAs for diagnostic potential of nonsmall cell lung cancer across multicentre, large‐scale of sequencing data Open
Nonsmall cell lung cancer (NSCLC) is a lethal cancer and lacks robust biomarkers for noninvasive clinical diagnosis. Detecting NSCLC at the early stage can decrease the mortality rate and minimise harm caused by various treatments. We cura…
View article: Colistin sulfate versus polymyxin B for the treatment of infections caused by carbapenem-resistant Acinetobacter baumannii: a multicenter retrospective cohort study
Colistin sulfate versus polymyxin B for the treatment of infections caused by carbapenem-resistant Acinetobacter baumannii: a multicenter retrospective cohort study Open
Background Polymyxins are the last line of defense against carbapenem-resistant Gram-negative bacilli infections. However, the efficacy of polymyxins against the independent risk factor of bacterial species is unknown. We aimed to compare …
View article: Development of semi-dwarf Echinacea purpurea by inducing silencing of the endogenous brassinosteroid- biosynthetic gene DWF4
Development of semi-dwarf Echinacea purpurea by inducing silencing of the endogenous brassinosteroid- biosynthetic gene DWF4 Open
Brassinosteroids (BRs) are plant steroidal hormones that are crucial for plant growth and development, with dwarfism being a hallmark of BR deficiency. DWARF4 (DWF4) is a key enzyme that catalyzes the rate-limiting C22 oxidation step in th…
View article: Myocardial Viability by Cardiac Magnetic Resonance Imaging Before Coronary Artery Bypass Grafting
Myocardial Viability by Cardiac Magnetic Resonance Imaging Before Coronary Artery Bypass Grafting Open
Myocardial viability assessment by CMR for patients with ischemic cardiomyopathy who are undergoing surgical revascularization does not predict left ventricular functional improvement or 3-year survival. Our data suggest that nonviable lef…
View article: Zinc-limited <i>Mycobacterium tuberculosis</i> stimulate distinct responses in macrophages compared with standard zinc-replete bacteria
Zinc-limited <i>Mycobacterium tuberculosis</i> stimulate distinct responses in macrophages compared with standard zinc-replete bacteria Open
Tuberculosis (TB) is notoriously difficult to treat, likely due to the complex host-pathogen interactions driven by pathogen heterogeneity. An understudied area of TB pathogenesis is host responses to Mycobacterium tuberculosis bacteria (M…
View article: Mechanisms of Copper-Induced Autophagy and Links with Human Diseases
Mechanisms of Copper-Induced Autophagy and Links with Human Diseases Open
As a structural and catalytic cofactor, copper is involved in many biological pathways and is required for the biochemistry of all living organisms. However, excess intracellular copper can induce cell death due to its potential to catalyz…
View article: A prospective multi-cohort study identifies and validates a 5-gene peripheral blood signature predictive of immunotherapy response in non-small cell lung cancer
A prospective multi-cohort study identifies and validates a 5-gene peripheral blood signature predictive of immunotherapy response in non-small cell lung cancer Open
View article: Bispectral Index-Monitored Anesthesia Induction in Older Adults Undergoing Elective Surgery: Comparing Ciprofol and Propofol in a Prospective, Single-Center, Double-Blind, Randomized Controlled Study
Bispectral Index-Monitored Anesthesia Induction in Older Adults Undergoing Elective Surgery: Comparing Ciprofol and Propofol in a Prospective, Single-Center, Double-Blind, Randomized Controlled Study Open
ChiCTR2200066053.
View article: Glutamine metabolism-related genes predict the prognostic risk of acute myeloid leukemia and stratify patients by subtype analysis
Glutamine metabolism-related genes predict the prognostic risk of acute myeloid leukemia and stratify patients by subtype analysis Open
View article: Prevalence and risk factors for ventilator-associated pneumonia after cardiac surgery: a systematic review and meta-analysis
Prevalence and risk factors for ventilator-associated pneumonia after cardiac surgery: a systematic review and meta-analysis Open
The incidence of VAP after cardiac surgery was found to be 10%, and the comprehensive risk factors for VAP were identified, emphasizing the critical need for targeted interventions, including optimization of preoperative health and refined…
View article: A point prevalence survey and monitoring indicator research on the second batch of national key monitoring and rational use drugs
A point prevalence survey and monitoring indicator research on the second batch of national key monitoring and rational use drugs Open
Background With the remarkable effect of controlling the increase in drug costs by the first batch of National Key Monitoring and Rational Use Drugs (first NKMRUDs), the National Health Commission of the People’s Republic of China releases…
View article: Who benefit from adjuvant chemotherapy in stage I lung adenocarcinoma? A multi-dimensional model for candidate selection
Who benefit from adjuvant chemotherapy in stage I lung adenocarcinoma? A multi-dimensional model for candidate selection Open
IASLC grading is a significant indicator of DFS, however it could not guide adjuvant therapy in our stage I LUAD cohort. Growth patterns and T indicators together with other risk factors could identify high-risk patients that are potential…
View article: Prevalence and risk factors for ventilator-associated pneumonia after cardiac surgery: A systematic review and meta-analysis
Prevalence and risk factors for ventilator-associated pneumonia after cardiac surgery: A systematic review and meta-analysis Open
View article: UBE3C tunes autophagy via ATG4B ubiquitination
UBE3C tunes autophagy via ATG4B ubiquitination Open
ATG4B is a core protein and essential for cleaving precursor MAP1LC3/LC3 or deconjugating lipidated LC3-II to drive the formation of autophagosomes. The protein stability and activity of ATG4B regulated by post-translational modification (…
View article: Risk factors for abdominal aortic aneurysm in general populations: A systematic review and meta-analysis
Risk factors for abdominal aortic aneurysm in general populations: A systematic review and meta-analysis Open
i v e To systematically explore the risk factors associated with AAA in the general population using a meta-analytic approach.Rationale Abdominal aortic aneurysm (AAA) has a high mortality rate upon rupture.Considering that most AAAs are a…
View article: Metabolic reprogramming involves in transition of activated/resting CD4+ memory T cells and prognosis of gastric cancer
Metabolic reprogramming involves in transition of activated/resting CD4+ memory T cells and prognosis of gastric cancer Open
Background Little is known on how metabolic reprogramming potentially prompts transition of activated and resting CD4 + memory T cells infiltration in tumor microenvironment of gastric cancer (GC). The study aimed to evaluate their interac…
View article: 1972P Molecular mechanism study of recurrence/metastasis for Enneking IIb osteosarcoma
1972P Molecular mechanism study of recurrence/metastasis for Enneking IIb osteosarcoma Open
View article: Effectiveness of various COVID-19 vaccine regimens among 10.4 million patients from the National COVID Cohort Collaborative during Pre-Delta to Omicron periods – United States, 11 December 2020 to 30 June 2022
Effectiveness of various COVID-19 vaccine regimens among 10.4 million patients from the National COVID Cohort Collaborative during Pre-Delta to Omicron periods – United States, 11 December 2020 to 30 June 2022 Open
View article: Use of polymyxin B with different administration methods in the critically ill patients with ventilation associated pneumonia: a single-center experience
Use of polymyxin B with different administration methods in the critically ill patients with ventilation associated pneumonia: a single-center experience Open
Background: Whether nebulized polymyxin B should be used as an adjunctive therapy or substitution strategy to intravenous polymyxin B for the treatment of ventilator-associated pneumonia (VAP) remains controversial. This study’s aim is to …
View article: Descending dopaminergic pathway facilitates itch signal processing via activating spinal <scp>GRPR</scp><sup>+</sup> neurons
Descending dopaminergic pathway facilitates itch signal processing via activating spinal <span>GRPR</span><sup>+</sup> neurons Open
A11 dopaminergic neurons regulate somatosensory transduction by projecting from the diencephalon to the spinal cord, but the function of this descending projection in itch remained elusive. Here, we report that dopaminergic projection neur…
View article: The RagA GTPase protects young egg chambers in Drosophila
The RagA GTPase protects young egg chambers in Drosophila Open
The preservation of female fertility under unfavorable conditions is essential for animal reproduction. Inhibition of the target of rapamycin complex 1 (TORC1) is indispensable for Drosophila young egg chamber maintenance under nutrient st…
View article: Downregulation of HHLA2 inhibits ovarian cancer progression via the NF-κB signaling pathway and suppresses the expression of CA9
Downregulation of HHLA2 inhibits ovarian cancer progression via the NF-κB signaling pathway and suppresses the expression of CA9 Open
HHLA2 has been recently demonstrated to play multifaceted roles in several types of cancers. However, its underlying mechanism in the progression of human ovarian cancer (OC) remains largely unexplored. In the present study, we aimed to de…
View article: Downregulation of HHLA2 inhibits ovarian cancer progression via the NF-κB signaling pathway and suppresses the expression of CA9
Downregulation of HHLA2 inhibits ovarian cancer progression via the NF-κB signaling pathway and suppresses the expression of CA9 Open
Background: HHLA2 has been recently demonstrated to play multifaceted roles in several types of cancers. However, its underlying mechanism in the progression of human ovarian cancer (OC) remains largely unexplored. In the present study, we…
View article: Acknowledgement of Reviewers for Journal of Cross-Cultural Gerontology, 2022
Acknowledgement of Reviewers for Journal of Cross-Cultural Gerontology, 2022 Open
View article: Integrated Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Unravels the Influences of SARS-CoV-2 Infections to Cancer Patients
Integrated Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Unravels the Influences of SARS-CoV-2 Infections to Cancer Patients Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious and pathogenic coronavirus that emerged in late 2019 and caused a pandemic of respiratory illness termed as coronavirus disease 2019 (COVID-19). Cancer pat…
View article: Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction
Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction Open
Toosendanin (TSN) is a triterpenoid from the fruit or bark of Melia toosendan Sieb et Zucc, which has clear antitumor and insecticidal activities, but it possesses limiting hepatotoxicity in clinical application. Autophagy is a degradation…