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View article: Supplementary Table S1 from Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma
Supplementary Table S1 from Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma Open
gene signature correlated with exons of CD44v
View article: Supplementary Table 2 from Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma
Supplementary Table 2 from Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma Open
amino acid sequences of mAbs in this study
View article: Supplementary Table S3 from Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma
Supplementary Table S3 from Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma Open
serum biochemical parameters
View article: The Crucial Roles of Platelets as Immune Mediators in Sepsis
The Crucial Roles of Platelets as Immune Mediators in Sepsis Open
Sepsis is a life-threatening disease characterized by organ dysfunction resulting from a dysregulated host response to infection, potentially progressing to septic shock. Decreased platelet count and platelet dysfunction serve as crucial c…
View article: Risk factors of linezolid-associated hyponatremia from a retrospective case–control study: decreased serum albumin as a selective predictor in elder patients
Risk factors of linezolid-associated hyponatremia from a retrospective case–control study: decreased serum albumin as a selective predictor in elder patients Open
A decrease in ALB during linezolid therapy is a more selective predictor of hyponatremia than baseline ALB. Linezolid-induced hyponatremia is associated with adverse outcomes, highlighting the importance of monitoring serum sodium and ALB …
View article: Identification and validation of the VEGF/p38MAPK/HSP27 pro-tumor inflammatory pathway: screening of active components from Patrinia villosa and evaluation of their drug-likeness
Identification and validation of the VEGF/p38MAPK/HSP27 pro-tumor inflammatory pathway: screening of active components from Patrinia villosa and evaluation of their drug-likeness Open
Background Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with pro-tumor inflammation playing a critical role in its initiation and progression. Chronic inflammation acts as a major driving force and…
View article: Acute kidney injury of intravenous colistin sulfate compared with colistimethate sodium: a real-world, retrospective cohort study
Acute kidney injury of intravenous colistin sulfate compared with colistimethate sodium: a real-world, retrospective cohort study Open
This was the first study to investigate the nephrotoxicity difference between CS and CMS to our best knowledge. In this study, the incidence rate of AKI was significantly lower in the CS cohort compared with the CMS cohort, however, 30-day…
View article: The improved prediction value of neutrophil to lymphocyte ratio to pneumonia severity scores for mortality in the older people with community-acquired pneumonia
The improved prediction value of neutrophil to lymphocyte ratio to pneumonia severity scores for mortality in the older people with community-acquired pneumonia Open
View article: Epigenetically‐Upregulated <scp>CD98</scp> Shed Light on the Precancerous Diagnosis and Prognosis Prediction of Esophageal Cancer
Epigenetically‐Upregulated <span>CD98</span> Shed Light on the Precancerous Diagnosis and Prognosis Prediction of Esophageal Cancer Open
Esophageal squamous cell carcinoma (ESCC) has a significantly low survival rate, primarily due to the lack of diagnostic markers for early diagnosis and effective therapies. Recently, CD98 has been proposed as a specific marker of mature e…
View article: Correlation between ultrasound-based hepatic steatosis grade and thyroid hormone levels
Correlation between ultrasound-based hepatic steatosis grade and thyroid hormone levels Open
Quantitative USAT evaluation suggested that hepatic steatosis is strongly correlated with thyroid hormones. These data emphasize the relevance of thyroid hormones for regulating hepatic lipid accumulation and metabolism.
View article: Clinical Characteristics, Prognostic Factors and Therapeutic Strategies in Gastric Cancer Patients With Bone Metastasis: A Retrospective Analysis
Clinical Characteristics, Prognostic Factors and Therapeutic Strategies in Gastric Cancer Patients With Bone Metastasis: A Retrospective Analysis Open
Background Bone metastases are highly refractory and are associated with extremely poor survival. Despite the increasing incidence of bone metastasis in gastric cancer (GC), comprehensive analyses regarding the clinicopathological features…
View article: Efficacy and safety of isavuconazole versus voriconazole for the treatment of invasive fungal infections: a meta-analysis with trial sequential analysis
Efficacy and safety of isavuconazole versus voriconazole for the treatment of invasive fungal infections: a meta-analysis with trial sequential analysis Open
View article: The effect of immunosuppression on outcomes in elderly patients with community-acquired pneumonia
The effect of immunosuppression on outcomes in elderly patients with community-acquired pneumonia Open
View article: The gut-liver axis mediates short-chain chlorinated paraffins-induced hepatic lipid accumulation
The gut-liver axis mediates short-chain chlorinated paraffins-induced hepatic lipid accumulation Open
View article: Study on the physiological mechanism and transcriptional regulatory network of early fruit development in Gleditsia sinensis Lam. (Fabaceae)
Study on the physiological mechanism and transcriptional regulatory network of early fruit development in Gleditsia sinensis Lam. (Fabaceae) Open
View article: Gastrointestinal health and serum proteins are associated with BMD in postmenopausal women: a cross-sectional study
Gastrointestinal health and serum proteins are associated with BMD in postmenopausal women: a cross-sectional study Open
Gastrointestinal symptoms and serum 25(OH)D elevel are associated with increased risk of osteoporosis in postmenopausal women and may be useful in predicting osteoporosis in postmenopausal women.
View article: Respiratory medical quality control system construction in China
Respiratory medical quality control system construction in China Open
The construction of a quality control system for respiratory medicine is of great significance for improving the quality and homogenization of the diagnosis and treatment of respiratory diseases. The national respiratory quality control wo…
View article: Application prospects of deep in-situ condition-preserved coring and testing systems
Application prospects of deep in-situ condition-preserved coring and testing systems Open
Shallow resources are becoming increasingly depleted, deep resource exploration has become a global strategy. The design and testing of deep in-situ core samples are prerequisites for exploring deep resources; however, no in-situ condition…
View article: Natural active products in fruit postharvest preservation: A review
Natural active products in fruit postharvest preservation: A review Open
Abundantly available plants, animals, and microbes are excellent source of active substance to be used as fruit preservatives to delay postharvest fruit from decay, maintain good quality, and increase the shelf life. Although they are effe…
View article: Giredestrant for Estrogen Receptor–Positive, HER2-Negative, Previously Treated Advanced Breast Cancer: Results From the Randomized, Phase II acelERA Breast Cancer Study
Giredestrant for Estrogen Receptor–Positive, HER2-Negative, Previously Treated Advanced Breast Cancer: Results From the Randomized, Phase II acelERA Breast Cancer Study Open
PURPOSE To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor–positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455 …
View article: Association between trough serum vancomycin concentration and vancomycin-associated acute kidney injury and 30-day mortality in critically ill elderly adults
Association between trough serum vancomycin concentration and vancomycin-associated acute kidney injury and 30-day mortality in critically ill elderly adults Open
Background Vancomycin-associated acute kidney injury (VA-AKI) is the most clinically relevant side effect of vancomycin. The objective of this study was to investigate the association between VTC and VA-AKI as well as 30-day mortality in c…
View article: Data from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer
Data from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer Open
Phospholipase C epsilon 1 (PLCE1) is a well-established susceptibility gene for esophageal squamous cell carcinoma (ESCC). Identification of the underlying mechanism(s) regulated by PLCE1 could lead to a better understanding of ESCC…
View article: Figure S5 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer
Figure S5 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer Open
Figure S5
View article: Supplementary Data from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer
Supplementary Data from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer Open
Supplementary Methods and Materials, supplementary tables, supplementary figure legends
View article: Figure S3 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer
Figure S3 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer Open
Figure S3
View article: Figure S5 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer
Figure S5 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer Open
Figure S5
View article: Figure S6 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer
Figure S6 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer Open
Figure S6
View article: Figure S7 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer
Figure S7 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer Open
Figure S7
View article: Figure S8 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer
Figure S8 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer Open
Figure S8
View article: Figure S4 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer
Figure S4 from Phospholipase PLCE1 Promotes Transcription and Phosphorylation of MCM7 to Drive Tumor Progression in Esophageal Cancer Open
Figure S4