Yuanzhu Xie
YOU?
Author Swipe
View article: Shengjiang San attenuates sepsis-induced acute intestinal injury via Lactobacillus murinus derived IAAld-mediated macrophage polarization through NF-κB and TGF-β signaling
Shengjiang San attenuates sepsis-induced acute intestinal injury via Lactobacillus murinus derived IAAld-mediated macrophage polarization through NF-κB and TGF-β signaling Open
SJS improves SAII by orchestrating L.M. derived IAAld-mediated macrophage polarization through modulation of NF-κB and TGF-β signaling pathways.
View article: Chaihuang Qingfu Pills Protect Against Acute Pancreatitis—Associated Acute Lung Injury Through MMP9-NLRP3-Pyroptosis Pathway
Chaihuang Qingfu Pills Protect Against Acute Pancreatitis—Associated Acute Lung Injury Through MMP9-NLRP3-Pyroptosis Pathway Open
CHQF exerted a protective role in SAP-ALI by inhibiting macrophage pyroptosis through the MMP9-NLRP3 pathway, providing a novel therapeutic strategy for SAP-ALI.
View article: Design, Synthesis, and Biological Activity of Novel Quinone Derivatives as Potent STAT3 Inhibitors for Psoriasis Treatment
Design, Synthesis, and Biological Activity of Novel Quinone Derivatives as Potent STAT3 Inhibitors for Psoriasis Treatment Open
Psoriasis, which severely affects the sufferer's life quality, is a chronic skin disease still lacking satisfactory medication. Recently, signal transducer and activator of transcription 3 (STAT3) was revealed playing an important role in …
View article: ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis
ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis Open
Argininosuccinate synthase (ASS1), a critical enzyme in the urea cycle, acts as a tumor suppressor in many cancers. To date, the anticancer mechanism of ASS1 has not been fully elucidated. Here, we found that phosphoglycerate dehydrogenase…
View article: Naphthoquinone Derivative ZSW-4B Induces Apoptosis in Triple-negative Breast Cancer via AMPK signal Activation
Naphthoquinone Derivative ZSW-4B Induces Apoptosis in Triple-negative Breast Cancer via AMPK signal Activation Open
Triple-negative breast cancer (TNBC) is the most malignant molecular subtype of breast cancer characterized by its strong aggressiveness, high mortality, significant heterogeneity, and poor prognosis. AMPK plays a critical role in maintain…
View article: An Isoxazoloquinone Derivative Inhibits Tumor Growth by Targeting STAT3 and Triggering Its Ubiquitin-Dependent Degradation
An Isoxazoloquinone Derivative Inhibits Tumor Growth by Targeting STAT3 and Triggering Its Ubiquitin-Dependent Degradation Open
Background: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, with shorter five-year survival than other breast cancer subtypes, and lacks targeted and hormonal treatment strategies. The signal transducer a…
View article: Molecular Cloning and Identification of NADPH Cytochrome P450 Reductase from Panax ginseng
Molecular Cloning and Identification of NADPH Cytochrome P450 Reductase from Panax ginseng Open
Ginseng (Panax ginseng C.A. Mey.) is a precious Chinese traditional medicine, for which ginsenosides are the most important medicinal ingredients. Cytochrome P450 enzymes (CYP450) and their primary redox molecular companion NADPH cytochrom…