Fengju Song
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View article: Regular glucosamine supplementation and risk of age-related chronic diseases: evidence from a propensity score-matched cohort study
Regular glucosamine supplementation and risk of age-related chronic diseases: evidence from a propensity score-matched cohort study Open
Regular use of glucosamine was associated with a reduced risk of several age-related chronic diseases. Further studies are needed to confirm these findings and to clarify its potential role in supporting healthy aging.
View article: Circulating proteins associated with histological subtypes of lung cancer from genetic and population-based perspectives
Circulating proteins associated with histological subtypes of lung cancer from genetic and population-based perspectives Open
Lung cancer (LC) is the leading cause of cancer-related mortality worldwide, accounting for millions of deaths annually. Its major subtypes—lung squamous carcinoma (LUSC), lung adenocarcinoma, and small-cell LC—exhibit distinct risk factor…
View article: Joint impacts of genetic and non-genetic risk scores on risks of different subtypes of breast cancer among Chinese females
Joint impacts of genetic and non-genetic risk scores on risks of different subtypes of breast cancer among Chinese females Open
Purpose To investigate the joint impacts of genetic and non-genetic factors on breast cancer (BC) subtypes among Chinese females, and to investigate the performance of optimized subtype-specific polygenic risk scores (PRS) with less single…
View article: Study on the allergenicity and gel properties of transglutaminase cross-linked shrimp myofibrillar protein
Study on the allergenicity and gel properties of transglutaminase cross-linked shrimp myofibrillar protein Open
This study aims to investigate the allergenicity and gel properties of shrimp myofibrillar protein (MP) cross-linked by different concentrations of transglutaminase (TG) for shrimp gel products. The structural changes of the samples were a…
View article: Decreased risk of cardiovascular disease mortality associated with occasional positive screens following cancer screenings
Decreased risk of cardiovascular disease mortality associated with occasional positive screens following cancer screenings Open
View article: Severe obesity, high inflammation, insulin resistance with risks of all-cause mortality and all-site cancers, and potential modification by healthy lifestyles
Severe obesity, high inflammation, insulin resistance with risks of all-cause mortality and all-site cancers, and potential modification by healthy lifestyles Open
Severe obesity is often associated with inflammation and insulin resistance (IR), which expected to increase the risks of mortality and cancers. However, this relationship remains controversial, and it's unclear whether healthy lifestyles …
View article: Association between the oxidative balance score with metabolic syndrome traits in US adults
Association between the oxidative balance score with metabolic syndrome traits in US adults Open
View article: Risk-stratified CA125 screening integrating CA125 trajectories, trajectory-specific progression and transvaginal ultrasound for ovarian cancer
Risk-stratified CA125 screening integrating CA125 trajectories, trajectory-specific progression and transvaginal ultrasound for ovarian cancer Open
Backgrounds Cancer antigen 125 (CA125) is widely used for screening ovarian cancer (OC), yet its effectiveness remains debated. Potential factors may include ineffective cut-off value for CA125 in screening, as well as a lack of considerat…
View article: Preliminary effects of risk-adapted PSA screening for prostate cancer after integrating PRS-specific and age-specific variation
Preliminary effects of risk-adapted PSA screening for prostate cancer after integrating PRS-specific and age-specific variation Open
Background Although the risk of prostate cancer (PCa) varies across different ages and genetic risks, it’s unclear about the effects of genetic-specific and age-specific prostate-specific antigen (PSA) screening for PCa. Methods Weighed an…
View article: Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data
Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data Open
Objective: Few studies have evaluated the benefits of colorectal cancer (CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model (QCancer-10) and a 139-variant po…
View article: Effects of joint screening for prostate, lung, colorectal, and ovarian cancer – results from a controlled trial
Effects of joint screening for prostate, lung, colorectal, and ovarian cancer – results from a controlled trial Open
Background Although screening is widely used to reduce cancer burden, untargeted cancers are frequently missed after single cancer screening. Joint cancer screening is presumed as a more effective strategy to reduce overall cancer burden. …
View article: Reclassified the phenotypes of cancer types and construct a nomogram for predicting bone metastasis risk: A pan‐cancer analysis
Reclassified the phenotypes of cancer types and construct a nomogram for predicting bone metastasis risk: A pan‐cancer analysis Open
Background Numerous of models have been developed to predict the bone metastasis (BM) risk; however, due to the variety of cancer types, it is difficult for clinicians to use these models efficiently. We aimed to perform the pan‐cancer ana…
View article: Pre-Diagnostic Systemic Inflammatory Markers and Triglyceride-Glucose Index with Risk of Colorectal Cancer, and Potential Modification of Healthy Lifestyle and Screening
Pre-Diagnostic Systemic Inflammatory Markers and Triglyceride-Glucose Index with Risk of Colorectal Cancer, and Potential Modification of Healthy Lifestyle and Screening Open
View article: Associations between BMI, polygenic risk score for BMI, lifestyle and the risk of upper gastrointestinal cancer
Associations between BMI, polygenic risk score for BMI, lifestyle and the risk of upper gastrointestinal cancer Open
Objective To investigate the risk of upper gastrointestinal (UG) cancer associated with BMI across different polygenic risk score for BMI (PRSBMI), and to investigate whether healthy lifestyles could attenuate this risk. Methods…
View article: Cohort profile: design and methods of the Chinese colorectal, breast, lung, liver, and stomach cancer screening trial (C-BLAST)
Cohort profile: design and methods of the Chinese colorectal, breast, lung, liver, and stomach cancer screening trial (C-BLAST) Open
Given the rapid changes in social structure (urbanization), economic structure (industrialization), and demographic structure (population aging) in China, cancer has become a major public health problem[1][1]. Extensive evidence has indica…
View article: A causal relationship between antioxidants, minerals and vitamins and metabolic syndrome traits: a Mendelian randomization study
A causal relationship between antioxidants, minerals and vitamins and metabolic syndrome traits: a Mendelian randomization study Open
Background The available evidence regarding the association of antioxidants, minerals, and vitamins with the risk of metabolic syndrome (MetS) traits is currently limited and inconsistent. Therefore, the purpose of this Mendelian randomiza…
View article: Risk-stratified multi-round PSA screening for prostate cancer integrating the screening reference level and subgroup-specific progression indicators
Risk-stratified multi-round PSA screening for prostate cancer integrating the screening reference level and subgroup-specific progression indicators Open
Background Although prostate-specific antigen (PSA) is widely used in prostate cancer (PCa) screening, nearly half of PCa cases are missed and less than one-third of cases are non-lethal. Adopting diagnostic criteria in population-based sc…
View article: Associations of chest X-ray trajectories, smoking, and the risk of lung cancer in two population-based cohort studies
Associations of chest X-ray trajectories, smoking, and the risk of lung cancer in two population-based cohort studies Open
Objectives Despite the increasing use of computed tomography (CT), chest X-ray (CXR) remains the first-line investigation for suspected lung cancer (LC) in primary care. However, the associations of CXR trajectories, smoking and LC risk re…
View article: Integrative analysis of multi-omics data for discovery of ferroptosis-related gene signature predicting immune activity in neuroblastoma
Integrative analysis of multi-omics data for discovery of ferroptosis-related gene signature predicting immune activity in neuroblastoma Open
Immunotherapy for neuroblastoma remains unsatisfactory due to heterogeneity and weak immunogenicity. Exploring powerful signatures for the evaluation of immunotherapy outcomes remain the primary purpose. We constructed a ferroptosis-relate…
View article: Comparisons of clinical characteristics, prognosis, epidemiological factors, and genetic susceptibility between <scp>HER2</scp>‐low and <scp>HER2</scp>‐zero breast cancer among Chinese females
Comparisons of clinical characteristics, prognosis, epidemiological factors, and genetic susceptibility between <span>HER2</span>‐low and <span>HER2</span>‐zero breast cancer among Chinese females Open
Background Traditional human epidermal growth factor receptor 2 (HER2)‐negative breast cancer (BC) is recommended to be divided into HER2‐low and HER2‐zero subtypes due to different prognosis. However, few studies investigated their differ…
View article: The changes of subtype markers between first and second primary breast cancers
The changes of subtype markers between first and second primary breast cancers Open
Background Previous studies investigated the changes of subtype markers [estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)] in several clinical settings, but not for second primary brea…
View article: Supplementary Acknowledgments from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Supplementary Acknowledgments from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Open
Supplementary Acknowledgments
View article: Supplementary Tables S1 - S10 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Supplementary Tables S1 - S10 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Open
Supplementary Table S1. Known risk loci for each cancer. Supplementary Table S2. Regions where known index SNPs for at least two of the three cancers lie within 1 Mb of each other. Supplementary Table S3. Full results from the meta-analysi…
View article: Supplementary Tables S1 - S10 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Supplementary Tables S1 - S10 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Open
Supplementary Table S1. Known risk loci for each cancer. Supplementary Table S2. Regions where known index SNPs for at least two of the three cancers lie within 1 Mb of each other. Supplementary Table S3. Full results from the meta-analysi…
View article: Supplementary Grant Support from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Supplementary Grant Support from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Open
Supplementary Grant Support
View article: Data from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Data from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Open
Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysi…
View article: Data from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Data from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Open
Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysi…
View article: Supplementary Methods, Figures S1 - S3 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Supplementary Methods, Figures S1 - S3 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Open
Supplementary Figure S1. LocusZoom regional association plots for the seven new cross-cancer loci that were > 1 Mb from known index SNPs. Supplementary Figure S2A-B. Box plots showing eQTL associations between (A) rs9375701 and L3MBTL3 in …
View article: Supplementary Grant Support from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Supplementary Grant Support from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Open
Supplementary Grant Support
View article: Supplementary Acknowledgments from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Supplementary Acknowledgments from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Open
Supplementary Acknowledgments