Explanipedia

Association of non-alcoholic fatty liver polygenic risk scores with the incident and progressive non-alcoholic fatty liver disease in Chinese population Open

Yang Zhou, Di Zhou, Shuohua Chen, Chenlu Yang, Shutong Wu , et al. · 2025

This study developed a PRS model specific to East Asian populations, highlighting the potential utility of PRS-EA in assessing and managing NAFLD risk, particularly in individuals with lipid metabolic dysfunction and hypertension.

Phospholipid scramblase 1: a frontline defense against viral infections Open

Alina X. Yang, Carmelissa Norbrun, Parand Sorkhdini, Yang Zhou · 2025

Phospholipid scramblase 1 (PLSCR1) is the most studied member of the phospholipid scramblase protein family. Its main function is to catalyze calcium (Ca 2+ )-dependent, ATP-independent, bidirectional and non-specific translocation of phos…

Phenotypic and functional dysregulations of CD8 + T Cells in myasthenia gravis Open

Chang Liu, Hao Zhang, Yu-Yao Zhai, Jing Dong, Yang Zhou , et al. · 2025

Phospholipid Scramblase 1 (PLSCR1) Regulates Interferon-Lambda Receptor 1 (IFN-λR1) and IFN-λ Signaling in Influenza A Virus (IAV) Infection Open

Alina X. Yang, Lisa Ramos-Rodriguez, Parand Sorkhdini, Dongqin Yang, Carmelissa Norbrun , et al. · 2025

Phospholipid scramblase 1 (PLSCR1) is an antiviral interferon-stimulated gene (ISG) that has several known anti-influenza functions such as interfering with viral nuclear import, regulating toll-like receptor (TLR) 9 and potentiating the e…

Phospholipid Scramblase 1 (PLSCR1) Regulates Interferon-Lambda Receptor 1 (IFN-λR1) and IFN-λ Signaling in Influenza A Virus (IAV) Infection Open

Alina X. Yang, Lisa Ramos-Rodriguez, Parand Sorkhdini, Dongqin Yang, Carmelissa Norbrun , et al. · 2025

Phospholipid scramblase 1 (PLSCR1) is an antiviral interferon-stimulated gene (ISG) that has several known anti-influenza functions. However, the mechanisms in relation to its expression compartment and enzymatic activity have not been com…

When Autophagy Fails: <i>ATG7</i> Variants and Their Impact on Radiation Lung Injury Open

Alina X. Yang, Yang Zhou · 2025

Citrus pectin-coated inhalable PLGA nanoparticles for treatment of pulmonary fibrosis Open

Kalindu Perera, Moez Ghumman, Parand Sorkhdini, Carmelissa Norbrun, Seraphina Negash , et al. · 2025

Citrus pectin coated PLGA nanoparticles can significantly ameliorate pulmonary fibrosis over 24–72 h in vivo .

Phospholipid Scramblase 1 (PLSCR1) Regulates Interferon-Lambda Receptor 1 (IFN-lambdaR1) and IFN-lambda Signaling in Influenza A Virus (IAV) Infection Open

Alina X. Yang, Lisa Ramos-Rodriguez, Parand Sorkhdini, Dongqin Yang, Carmelissa Norbrun , et al. · 2024

Phospholipid scramblase 1 (PLSCR1) is an antiviral interferon-stimulated gene (ISG) that has several known anti-influenza functions. However, the mechanisms in relation to its expression compartment and enzymatic activity have not been com…

[Retracted] SIRT6 promotes ferroptosis and attenuates glycolysis in pancreatic cancer through regulation of the NF‑κB pathway Open

Shuangxi Gong, Lixin Xiong, Zhen Luo, Qinghua Yin, Ming Huang , et al. · 2024

[This retracts the article DOI: 10.3892/etm.2022.11430.].

Type 2 innate immunity promotes the development of pulmonary fibrosis in Hermansky-Pudlak syndrome Open

Parand Sorkhdini, Kiran Klubock-Shukla, Sunil G. Sheth, Dongqin Yang, Alina X. Yang , et al. · 2024

Hermansky-Pudlak syndrome (HPS), particularly types 1 and 4, is characterized by progressive pulmonary fibrosis, a major cause of morbidity and mortality. However, the precise mechanisms driving pulmonary fibrosis in HPS are not fully eluc…

A Monte Carlo Simulation Dataset of Radiation Field Parameters for a Simple Nuclear Facility Scenario Open

Yisheng Hao, Zhenhua Wu, Yanheng Pu, Yang Zhou, Rui Qiu , et al. · 2024

Radioactive safety in nuclear facilities is of utmost importance. Prior to workers entering these areas, a 3D radiation field is needed for accurately estimating their exposure. Due to the complex relationship between radiation measurement…

Current state of signaling pathways associated with the pathogenesis of idiopathic pulmonary fibrosis Open

Yang Zhou, Tingting Ling, Weihong Shi · 2024

Idiopathic Pulmonary Fibrosis (IPF) represents a chronic and progressive pulmonary disorder distinguished by a notable mortality rate. Despite the elusive nature of the pathogenic mechanisms, several signaling pathways have been elucidated…

Prognostic and predictive value of a mRNA signature in high-grade serous ovarian carcinoma with an integrated computation analysis Open

Fanchun Yang, Yang Zhou, Caihe Liao · 2023

Ovarian cancer (OC) is the leading cause of death among women with gynecologic malignancies. High-grade serous ovarian carcinoma (HGSOC) is the deadliest subtype of OC, accounting for about 90 percent of all ovarian cancer subtypes. Recent…

Methylglyoxal suppresses microglia inflammatory response through NRF2-IκBζ pathway Open

Shu-Li Wei, Ying Yang, Wei-Yue Si, Yang Zhou, Tao Li , et al. · 2023

Identification of novel and potent dual-targeting HDAC1/SPOP inhibitors using structure-based virtual screening, molecular dynamics simulation and evaluation of in vitro and in vivo antitumor activity Open

Yingxue Yang, Shutong Chen, Qinghua Wang, Miaomiao Niu, Yuanqian Qu , et al. · 2023

Cancer is one of the important factors threatening human health. Hence, it is essential to create novel potent drugs to treat it. Due to the strong correlation among histone deacetylase1 (HDAC1), speckle-type POZ protein (SPOP) and cancers…

Phospholipid scramblase-1 regulates innate type 2 inflammation in mouse lungs via CRTH2-dependent mechanisms Open

Ashley Hernandez-Gutierrez, Sonoor Majid, Adam T. Eberle, Ashley Y. Choi, Parand Sorkhdini , et al. · 2023

Exaggerated Type 2 immune responses play critical roles in the pathogenesis of a variety of diseases including asthma, allergy, and pulmonary fibrosis. Recent studies have highlighted the importance of innate type 2 immune responses and in…

Development and characterization of lung surfactant-coated polymer nanoparticles for pulmonary drug delivery Open

Andrea Gonsalves, Parand Sorkhdini, Jasmine Bazinet, Moez Ghumman, Dinesh Dhamecha , et al. · 2023

Discovery of potent and noncovalent KRASG12D inhibitors: Structure-based virtual screening and biological evaluation Open

Yuting Wang, Hai Zhang, Jindong Li, Miaomiao Niu, Yang Zhou , et al. · 2022

KRAS G12D , the most common oncogenic KRAS mutation, is a promising target for the treatment of pancreatic cancer. Herein, we identified four potent and noncovalent KRAS G12D inhibitors (hits 1–4) by using structure-based virtual screening…

Real-world effectiveness of Yindan Jiedu granules-based treatment on patients infected with the SARS-CoV-2 Omicron variants BA.2 combined with high-risk factors: A cohort study Open

Ying Feng, Yao Liu, Long Liu, Yao Liu, Yuyong Jiang , et al. · 2022

Background: Our previous studies have shown that Yindan Jiedu granules (YDJDG) can effectively treat coronavirus disease 2019 (COVID-19); however, the high infectivity and the immune escape potential of the Omicron variant BA.2 make it mor…

Chitinase 3 like 1 contributes to the development of pulmonary vascular remodeling in pulmonary hypertension Open

Xiuna Sun, Erika Nakajima, Carmelissa Norbrun, Parand Sorkhdini, Alina X. Yang , et al. · 2022

Chitinase 3 like 1 (CHI3L1) is the prototypic chitinase-like protein mediating inflammation, cell proliferation, and tissue remodeling. Limited data suggest CHI3L1 is elevated in human pulmonary arterial hypertension (PAH) and is associate…

Host chitinase 3-like-1 is a universal therapeutic target for SARS-CoV-2 viral variants in COVID-19 Open

Suchitra Kamle, Bing Ma, Chang Min Lee, Gail Schor, Yang Zhou , et al. · 2022

Coronavirus disease 2019 (COVID-19) is the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2; SC2), which has caused a worldwide pandemic with striking morbidity and mortality. Evaluation of SC2 strains demonstr…

SIRT6 promotes ferroptosis and attenuates glycolysis in pancreatic cancer through regulation of the NF‑κB pathway Open

Shuangxi Gong, Lixin Xiong, Zhen Luo, Qinghua Yin, Ming Huang , et al. · 2022

Pancreatic cancer (PC) is a malignant tumor with high mortality worldwide. SIRT6 plays versatile roles in human cancers. However, SIRT6 has rarely been studied in PC. The purpose of the present study was to explore the function and potenti…

CRTH2 Mediates Profibrotic Macrophage Differentiation and Promotes Lung Fibrosis Open

Yueming Cao, Jahnavi Rudrakshala, River Williams, Shade Rodriguez, Parand Sorkhdini , et al. · 2022

Idiopathic pulmonary fibrosis (IPF) is a particularly deadly form of pulmonary fibrosis of unknown cause. In patients with IPF, high serum and lung concentrations of CHI3L1 (chitinase 3 like 1) can be detected and are associated with poor …

Targeting Chitinase 1 and Chitinase 3-Like 1 as Novel Therapeutic Strategy of Pulmonary Fibrosis Open

Suh‐Young Lee, Chang-Min Lee, Bing Ma, Suchitra Kamle, Jack A. Elias , et al. · 2022

Chitinase 1 (CHIT1) and chitinase 3-like-1 (CHI3L1), two representative members of 18-Glycosyl hydrolases family, are significantly implicated in the pathogenesis of various human diseases characterized by inflammation and remodeling. Nota…

CPR63 promotes pyrethroid resistance by increasing cuticle thickness in Culex pipiens pallens Open

Yang Xu, Jingwei Xu, Yang Zhou, Xixi Li, Yufen Meng , et al. · 2022

The cuticle protein (CP) encoded by CPR63 plays a role in deltamethrin resistance in Culex pipiens pallens . Herein, we investigated the distribution of CPR63 transcripts in this organism and observed high expression levels in legs and win…

Host Chitinase 3-like-1 is a Universal Therapeutic Target for SARS-CoV-2 Viral Variants in COVID 19 Open

Suchitra Kamle, Bing Ma, Chang Min Lee, Gail Schor, Yang Zhou , et al. · 2022

COVID 19 is the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2; SC2) which has caused a world-wide pandemic with striking morbidity and mortality. Evaluation of SC2 strains demonstrated impressive genetic var…

Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19 Open

Suchitra Kamle, Bing Ma, Chuan He, Bedia Akosman, Yang Zhou , et al. · 2021

COVID-19 is caused by SARS-CoV-2 (SC2) and is more prevalent and severe in elderly and patients with comorbid diseases (CM). Because chitinase 3-like-1 (CHI3L1) is induced during aging and CM, the relationships between CHI3L1 and SC2 were …

Neu-P11 — a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats Open

Xiuping Li, Juan He, Xing Li, Yuxian Li, Yang Zhou , et al. · 2021

Melatonin and its receptor Neu-P11 can reduce the blood glucose level, enhance humoral and cellular immunity, inhibit microglia activation and inflammation, and repair isletβ cell function, and this improve the characterization of T2DM-rel…

Emerging drug delivery strategies for idiopathic pulmonary fibrosis treatment Open

Moez Ghumman, Dinesh Dhamecha, Andrea Gonsalves, Lauren Fortier, Parand Sorkhdini , et al. · 2021

Hermansky-Pudlak Syndrome and Lung Disease: Pathogenesis and Therapeutics Open

Pamela Velázquez-Díaz, Erika Nakajima, Parand Sorkhdini, Ashley Hernandez-Gutierrez, Adam T. Eberle , et al. · 2021

Hermansky-Pudlak Syndrome (HPS) is a rare, genetic, multisystem disorder characterized by oculocutaneous albinism (OCA), bleeding diathesis, immunodeficiency, granulomatous colitis, and pulmonary fibrosis. HPS pulmonary fibrosis (HPS-PF) o…

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