Yin Ren
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View article: Endoscopic microvascular decompression for primary trigeminal neuralgia: surgical experience and early outcomes
Endoscopic microvascular decompression for primary trigeminal neuralgia: surgical experience and early outcomes Open
View article: Endoscopic Microvascular Decompression for Primary Trigeminal Neuralgia: Surgical Experience and Early Outcomes
Endoscopic Microvascular Decompression for Primary Trigeminal Neuralgia: Surgical Experience and Early Outcomes Open
Objective This study aimed to investigate the clinical efficacy and early outcomes of endoscopic microvascular decompression (MVD) for primary trigeminal neuralgia (TN) and provide clinical experience for the application of full endoscopic…
View article: Malignant otitis externa: What is the role of surgery?
Malignant otitis externa: What is the role of surgery? Open
Objective Malignant otitis externa (MOE) is typically managed with long‐term broad‐spectrum antibiotics. The impact of surgical intervention on clinical outcomes is not well described. This study aims to compare clinical outcomes of MOE pa…
View article: Gene therapy advancements for the treatment of acquired and hereditary hearing loss
Gene therapy advancements for the treatment of acquired and hereditary hearing loss Open
Greater understanding of the molecular intricacies of acquired and hereditary hearing loss has spurred considerable advances in inner ear gene therapy. While approaches like cochlear amplification and cochlear implantation offer varying de…
View article: Creative Design of Cloud Shoulder in Qing Dynasty Based on Fractal Art Theory
Creative Design of Cloud Shoulder in Qing Dynasty Based on Fractal Art Theory Open
Through the in-depth study of fractal art theory and cloud shoulder in Qing Dynasty, this paper discusses the innovation and value of applying fractal art theory to cloud shoulder pattern design in Qing Dynasty. It aims to make traditional…
View article: Tumor biomechanical stiffness by magnetic resonance elastography predicts surgical outcomes and identifies biomarkers in vestibular schwannoma and meningioma
Tumor biomechanical stiffness by magnetic resonance elastography predicts surgical outcomes and identifies biomarkers in vestibular schwannoma and meningioma Open
View article: Cochlear Implantation and Vestibular Schwannoma Management
Cochlear Implantation and Vestibular Schwannoma Management Open
Purpose of Review This review examines recent literature on cochlear implantation (CI) in patients with vestibular schwannomas (VS), both in sporadic and Neurofibromatosis Type 2 (NF2)-associated schwannomatosis. Indications, post-operativ…
View article: Clinical Outcomes of Salvage Microsurgical Resection after Radiation Therapy for Sporadic Vestibular Schwannomas
Clinical Outcomes of Salvage Microsurgical Resection after Radiation Therapy for Sporadic Vestibular Schwannomas Open
Background The purpose of this study was to evaluate clinical outcomes after salvage microsurgery for vestibular schwannoma (VS) treated initially with modern radiotherapy techniques as compared to those treated with primary microsurgical …
View article: Identifying Tumor Microenvironment Biomarkers in Adherent and Cystic Vestibular Schwannomas
Identifying Tumor Microenvironment Biomarkers in Adherent and Cystic Vestibular Schwannomas Open
Objective A subset of vestibular schwannomas (VSs), including cystic tumors, have higher postoperative morbidity because of the presence of adhesions between the tumor, facial nerve (FN), and brainstem. We identify tumor microenvironment (…
View article: Outcomes of Extended Middle Fossa Approach for Petroclival Tumors in the Elderly
Outcomes of Extended Middle Fossa Approach for Petroclival Tumors in the Elderly Open
Objective The aims of the study are (1) to evaluate the extended middle fossa approach (eMCF) for resection of tumors in the petroclivus and anterior cerebellopontine angle (CPA) and (2) to compare surgical outcomes between elderly (≥65 ye…
View article: Comparison of Postoperative Outcomes in Cystic Versus Solid Vestibular Schwannoma in a Multi-institutional Cohort
Comparison of Postoperative Outcomes in Cystic Versus Solid Vestibular Schwannoma in a Multi-institutional Cohort Open
Objective Cystic vestibular schwannomas (cVSs) have more variable and less favorable clinical outcomes after microsurgical resection compared with solid VS (sVS). This study compares the preoperative presentation and postoperative outcomes…
View article: Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma
Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma Open
Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells and typically presenting with hearing loss. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the au…
View article: Identification of Immune-Related Candidate Biomarkers in Plasma of Patients with Sporadic Vestibular Schwannoma
Identification of Immune-Related Candidate Biomarkers in Plasma of Patients with Sporadic Vestibular Schwannoma Open
Vestibular schwannoma (VS) is intracranial tumor arising from neoplastic Schwann cells, causing hearing loss in about 95% of patients. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the a…
View article: Local Tumor Behavior Associated With Survival Among Patients With Paraganglioma of the Head and Neck
Local Tumor Behavior Associated With Survival Among Patients With Paraganglioma of the Head and Neck Open
Objective The purpose of this study was to evaluate the utility of ICD‐O‐3 –classified local tumor behavior as a prognosticator of head and neck paraganglioma (HNP) outcomes. Study Design Retrospective cohort study. Setting National Cancer…
View article: Dispersed Bone Spicules as a Cause of Postoperative Headache after Retrosigmoid Vestibular Schwannoma Surgery: A Myth?
Dispersed Bone Spicules as a Cause of Postoperative Headache after Retrosigmoid Vestibular Schwannoma Surgery: A Myth? Open
Objectives Dispersion of bone dust in the posterior fossa during retrosigmoid craniectomy for vestibular schwannoma (VS) resection could be a source of meningeal irritation and lead to development of persistent postoperative headaches (POH…
View article: Auditory Brain Stem Response Predictors of Hearing Outcomes after Middle Fossa Resection of Vestibular Schwannomas
Auditory Brain Stem Response Predictors of Hearing Outcomes after Middle Fossa Resection of Vestibular Schwannomas Open
Objectives To analyze the relationship between preoperative and intraoperative auditory brain stem response (ABR) characteristics and hearing outcomes in patients with vestibular schwannomas (VS) undergoing hearing preservation (HP) surger…
View article: New developments in neurofibromatosis type 2 and vestibular schwannoma
New developments in neurofibromatosis type 2 and vestibular schwannoma Open
Neurofibromatosis type 2 (NF2) is a rare autosomal dominant disorder characterized by the development of multiple nervous system tumors due to mutation in the NF2 tumor suppressor gene. The hallmark feature of the NF2 syndrome is the devel…
View article: MMP-14 (MT1-MMP) Is a Biomarker of Surgical Outcome and a Potential Mediator of Hearing Loss in Patients With Vestibular Schwannomas
MMP-14 (MT1-MMP) Is a Biomarker of Surgical Outcome and a Potential Mediator of Hearing Loss in Patients With Vestibular Schwannomas Open
Improved biomarkers are needed for vestibular schwannoma (VS), the most common tumor of the cerebellopontine angle, as existing clinical biomarkers have poor predictive value. Factors such as tumor size or growth rate do not shed light on …
View article: The Presence of Hürthle Cells Does Not Increase the Risk of Malignancy in Most Bethesda Categories in Thyroid Fine-Needle Aspirates
The Presence of Hürthle Cells Does Not Increase the Risk of Malignancy in Most Bethesda Categories in Thyroid Fine-Needle Aspirates Open
Background: Hürthle cell/oncocytic change is commonly reported on thyroid fine-needle aspiration (FNA) and may be considered an "atypical cell" by clinicians. This study aims to delineate the association between Hürthle cells…
View article: Gene Therapy for Human Sensorineural Hearing Loss
Gene Therapy for Human Sensorineural Hearing Loss Open
Hearing loss is the most common sensory impairment in humans and currently disables 466 million people across the world. Congenital deafness affects at least 1 in 500 newborns, and over 50% are hereditary in nature. To date, existing pharm…
View article: Proteome of normal human perilymph and perilymph from people with disabling vertigo
Proteome of normal human perilymph and perilymph from people with disabling vertigo Open
The vast majority of hearing loss, the most common sensory impairment, and vertigo, which commonly causes falls, both reflect underlying dysfunction of inner ear cells. Perilymph sampling can thus provide molecular cues to hearing and bala…
View article: Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas
Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas Open
Vestibular schwannoma (VS) is the most common tumor of the cerebellopontine angle, and it typically presents with sensorineural hearing loss. The genomic landscape of schwannoma is complex and many of the molecules implicated in VS pathoge…
View article: Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas
Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas Open
To our knowledge this study is the first to combine data from hundreds of patients, treated at multiple institutions, to document a relation between intra-tumor heterogeneity and overall survival in any type of cancer. We suggest applying …