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View article: Stereoselective self-assembly of cis- and trans- [Pt2L2] metallacycles via geometrically-asymmetric 90o Pt(II) acceptors
Stereoselective self-assembly of cis- and trans- [Pt2L2] metallacycles via geometrically-asymmetric 90o Pt(II) acceptors Open
Stereoselective synthesis of cis- and trans- configurations remain challenging in molecular systems. Here, asymmetric 90o Pt(II) acceptors enable stereoselective coordination-driven self-assembly of configuration-specific [Pt2L2] metallacy…
View article: Ultralong Room‐Temperature Phosphorescence Achieved by Microcapsule Rupture‐Triggered In‐Situ Polymerization for High‐Contrast Damage Visualization and Advanced Anti‐counterfeiting
Ultralong Room‐Temperature Phosphorescence Achieved by Microcapsule Rupture‐Triggered In‐Situ Polymerization for High‐Contrast Damage Visualization and Advanced Anti‐counterfeiting Open
Polymer materials with mechano‐responsive ultralong room‐temperature phosphorescence (RTP) are highly desired but challenging to achieve. Herein, a microcapsule (MC) rupture‐triggered in‐situ polymerization strategy is proposed to achieve …
View article: Long-term follow-up of patients with relapsed b-ALL after allo-HSCT treated with CD19 CAR-T cell from recipients and donors
Long-term follow-up of patients with relapsed b-ALL after allo-HSCT treated with CD19 CAR-T cell from recipients and donors Open
Background: Acute lymphoblastic leukemia (B-ALL) patients who relapse after allogeneic hematopoietic stem cell transplant (allo-HSCT) had a very poor prognosis. Donor-derived anti-CD19 CAR-T cell therapy had shown surprising effects in the…
View article: Pharmacological advances of the chlorogenic acids family: current insights and future research directions
Pharmacological advances of the chlorogenic acids family: current insights and future research directions Open
Phenolic acids are considered an important source for developing natural drugs due to their extensive biological activities. The chlorogenic acids (CGAs) family is the most widely distributed botanical drug in the phenolic acid group and i…
View article: Hemorrhagic cystitis induced by intravenous esketamine in the treatment of new-onset refractory status epilepticus in children: a case report
Hemorrhagic cystitis induced by intravenous esketamine in the treatment of new-onset refractory status epilepticus in children: a case report Open
Introduction Esketamine, the S-enantiomer of ketamine, has been considered for terminating new-onset refractory status epilepticus (NORSE). However, there is limited large-scale data on its safety and comparative effectiveness. Ketamine-as…
View article: Correlation between the expression of soluble BCMA and short-term/long-term curative effect and survival outcomes of anti-BCMA CAR-T cell therapy in relapsed/refractory multiple myeloma
Correlation between the expression of soluble BCMA and short-term/long-term curative effect and survival outcomes of anti-BCMA CAR-T cell therapy in relapsed/refractory multiple myeloma Open
This study aimed to investigate whether soluble B-cell maturation antigen (sBCMA) levels could be predictive biomarker for short-term and long-term therapeutic efficacy and survival outcomes following anti-BCMA CAR-T cell therapy in relaps…
View article: MMAU-Pro: A Challenging and Comprehensive Benchmark for Holistic Evaluation of Audio General Intelligence
MMAU-Pro: A Challenging and Comprehensive Benchmark for Holistic Evaluation of Audio General Intelligence Open
Audio comprehension-including speech, non-speech sounds, and music-is essential for achieving human-level intelligence. Consequently, AI agents must demonstrate holistic audio understanding to qualify as generally intelligent. However, eva…
View article: Investigating the impact of an efficacy-based nursing program integrated with nutritional intervention strategies on the outcomes of multiple myeloma patients with renal failure
Investigating the impact of an efficacy-based nursing program integrated with nutritional intervention strategies on the outcomes of multiple myeloma patients with renal failure Open
Objective To explore the effect of nursing scheme based on efficacy theory combined with nutritional intervention on patients with multiple myeloma (MM) complicated with renal failure. Methods Ninety-two patients with MM complicated with r…
View article: An adaptive Kalman filter with inaccurate noise covariance matrix and abnormal dynamic model
An adaptive Kalman filter with inaccurate noise covariance matrix and abnormal dynamic model Open
This paper proposes an adaptive Kalman filter (AKF) that can track state changes and estimate noise covariance matrix (NCM) to address the poor performance issue of existing AKFs in handling abnormal dynamic models when the initial NCM is …
View article: Correlates of physical activity and sedentary behavior in children and adolescents during school recess: a systematic review and meta-analysis
Correlates of physical activity and sedentary behavior in children and adolescents during school recess: a systematic review and meta-analysis Open
This review identified several individual, social, physical environment, and organizational and policy level factors that correlate with PA among children and adolescents during school recess. However, it found a correlation only between g…
View article: Identifying ferroptosis-related genes in lung adenocarcinoma using random walk with restart in the PPI network
Identifying ferroptosis-related genes in lung adenocarcinoma using random walk with restart in the PPI network Open
Lung adenocarcinoma (LUAD), the most common non-small cell lung cancer subtype, often presents with subtle early symptoms leading to delayed diagnosis. Ferroptosis, a cell death process associated with iron metabolism dysregulation, has be…
View article: An attack detection method based on deep learning for internet of things
An attack detection method based on deep learning for internet of things Open
With the rapid development of Internet of Things (IoT) technology, the number of network attack methods it faces is also increasing, and the malicious network traffic generated is growing exponentially. To identify attack traffic for the p…
View article: Targeting MCM10 disrupts cancer stemness and counteracts sorafenib resistance in hepatocellular carcinoma
Targeting MCM10 disrupts cancer stemness and counteracts sorafenib resistance in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the most prevalent primary malignant tumor, with sorafenib as the main treatment for advanced cases. However, the development of resistance to sorafenib, often driven by cancer stemness, significantly limi…
View article: Ultralong Room-Temperature Phosphorescence Achieved by Microcapsule Rupture-Triggered In-Situ Polymerization for High-Contrast Damage Visualization and Advanced Anti-counterfeiting
Ultralong Room-Temperature Phosphorescence Achieved by Microcapsule Rupture-Triggered In-Situ Polymerization for High-Contrast Damage Visualization and Advanced Anti-counterfeiting Open
Polymer materials exhibiting mechano-responsive ultralong room temperature phosphorescence (RTP) are highly desirable, yet it remains challenging to achieve. Herein, a microcapsule (MC) rupture-triggered in-situ polymerization strategy is …
View article: Nutritional and immune-inflammatory scoring system for predicting outcomes in newly diagnosed diffuse large B-cell lymphoma patients
Nutritional and immune-inflammatory scoring system for predicting outcomes in newly diagnosed diffuse large B-cell lymphoma patients Open
Background Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma and often carries a poor prognosis. Current prognostic systems such as the International Prognostic Index (IPI) and National Comprehensive …
View article: Transcriptional Diversity in Response to Aging Across Skeletal Muscles
Transcriptional Diversity in Response to Aging Across Skeletal Muscles Open
Aging leads to a gradual decline in muscle function, yet the mechanisms by which different skeletal muscles respond to aging remain unclear. Here, we constructed transcriptional maps of 11 skeletal muscles with extensive transcriptional di…
View article: Current challenges and emerging opportunities of chimeric antigen receptor-engineered cell immunotherapy
Current challenges and emerging opportunities of chimeric antigen receptor-engineered cell immunotherapy Open
Chimeric antigen receptor (CAR) engineered cellular immunotherapy offers the potential for precise targeting and elimination of tumor cells, providing a tailored approach to cancer treatment. CAR-T cells demonstrate significant anti-tumor …
View article: Grandparental socioeconomic disadvantages and grandchild psychiatric disorders: the mediating role of parental socioeconomic and psychosocial factors
Grandparental socioeconomic disadvantages and grandchild psychiatric disorders: the mediating role of parental socioeconomic and psychosocial factors Open
The aim of this study is to explore the association between grandparental socioeconomic disadvantages and grandchild psychiatric disorders, the role of parental socioeconomic and psychosocial factors in this association, as well as potenti…
View article: Genome-wide identification of potato Trihelix gene family and its response to different abiotic stresses
Genome-wide identification of potato Trihelix gene family and its response to different abiotic stresses Open
The Trihelix transcription factor family, characterized by its unique triple-helix structure (helix-loop-helix-loop-helix), plays a significant role in plant growth, development, and responses to various abiotic stresses. Potato (Solanum t…
View article: Human health risks of chromium in bright-colored leather products: Speciation-based insights into dermal permeation
Human health risks of chromium in bright-colored leather products: Speciation-based insights into dermal permeation Open
Chromium (Cr) is a highly-toxic carcinogenic metal, which exists as chromite (CrIII) and chromate (CrVI) in the enviornment, with CrVI being used in leather production. With the increasing demand for leather products, health risks associat…
View article: Integrating network pharmacology, quantitative transcriptomic analysis, and experimental validation revealed the mechanism of cordycepin in the treatment of obesity
Integrating network pharmacology, quantitative transcriptomic analysis, and experimental validation revealed the mechanism of cordycepin in the treatment of obesity Open
Introduction Evidence of the benefits of cordycepin (Cpn) for treating obesity is accumulating, but detailed knowledge of its therapeutic targets and mechanisms remains limited. This study aimed to systematically identify Cpn’s therapeutic…
View article: Multi-Modal Design, Synthesis, and Biological Evaluation of Novel Fusidic Acid Derivatives
Multi-Modal Design, Synthesis, and Biological Evaluation of Novel Fusidic Acid Derivatives Open
Fusidic acid (FA), a tetracyclic triterpenoid, has been approved to treat methicillin-resistant Staphylococcus aureus (MRSA) infections. However, there are few reports about FA derivatives with high efficacy superior to FA, manifesting the…