Yanqing Sun
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View article: Digital Design of Peking Opera Facial Makeup Based on Facial Emotion Recognition
Digital Design of Peking Opera Facial Makeup Based on Facial Emotion Recognition Open
This study examines digital technology and cultural innovation in the context of non-genetic inheritance. Traditional digital survival approaches limit public participation and innovation dynamics. To this end, we propose an interdisciplin…
View article: Estimation and Hypothesis Testing of Strain‐Specific Vaccine Efficacy With Missing Strain Types With Application to a COVID‐19 Vaccine Trial
Estimation and Hypothesis Testing of Strain‐Specific Vaccine Efficacy With Missing Strain Types With Application to a COVID‐19 Vaccine Trial Open
Based on data from a randomized, controlled vaccine efficacy trial, this article develops statistical methods for assessing vaccine efficacy (VE) to prevent COVID‐19 infections by a discrete set of genetic strains of SARS‐CoV‐2. Strain‐spe…
View article: Regression analysis of semiparametric Cox-Aalen transformation models with partly interval-censored data
Regression analysis of semiparametric Cox-Aalen transformation models with partly interval-censored data Open
Partly interval-censored data, comprising exact and intervalcensored observations, are prevalent in biomedical, clinical, and epidemiological studies. This paper studies a flexible class of the semiparametric Cox-Aalen transformation model…
View article: Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features
Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features Open
In the ENSEMBLE randomized, placebo-controlled phase 3 trial (NCT04505722), estimated single-dose Ad26.COV2.S vaccine efficacy (VE) was 56% against moderate to severe–critical COVID-19. SARS-CoV-2 Spike sequences were determined from 484 v…
View article: Literacy for Knowledge Building in Two Partnering Science Classrooms
Literacy for Knowledge Building in Two Partnering Science Classrooms Open
Using an interactional ethnography approach, this study analyzes student literacy practices in two Grade 5/6 classrooms that engaged in a science inquiry organized based on the Knowledge Building pedagogy.Students studied human body system…
View article: A Semiparametric Cox–Aalen Transformation Model with Censored Data
A Semiparametric Cox–Aalen Transformation Model with Censored Data Open
We propose a broad class of so-called Cox–Aalen transformation models that incorporate both multiplicative and additive covariate effects on the baseline hazard function within a transformation. The proposed models provide a highly flexibl…
View article: A mark-specific quantile regression model
A mark-specific quantile regression model Open
Summary Quantile regression has become a widely used tool for analysing competing risk data. However, quantile regression for competing risk data with a continuous mark is still scarce. The mark variable is an extension of cause of failure…
View article: Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features
Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features Open
It is of interest to pinpoint SARS-CoV-2 sequence features defining vaccine resistance. In the ENSEMBLE randomized, placebo-controlled phase 3 trial, estimated single-dose Ad26.COV2.S vaccine efficacy (VE) was 56% against moderate to sever…
View article: Amantadine Toxicity in Apostichopus japonicus Revealed by Proteomics
Amantadine Toxicity in Apostichopus japonicus Revealed by Proteomics Open
Amantadine exposure can alter biological processes in sea cucumbers, which are an economically important seafood in China. In this study, amantadine toxicity in Apostichopus japonicus was analyzed by oxidative stress and histopathological …
View article: Existence of solutions to elliptic equations involving regional fractional Laplacian with order $(0,\frac12]$
Existence of solutions to elliptic equations involving regional fractional Laplacian with order $(0,\frac12]$ Open
Our purpose of this paper is to investigate positive solutions of the elliptic equation with regional fractional Laplacian $$ ( - Δ)_{B_1}^s u +u= h(x,u) \quad {\rm in} \ \, B_1,\qquad u\in C_0(B_1), $$ where $( - Δ)_{B_1}^s$ with $s\in(0,…
View article: Estimation of conditional cumulative incidence functions under generalized semiparametric regression models with missing covariates, with application to analysis of biomarker correlates in vaccine trials
Estimation of conditional cumulative incidence functions under generalized semiparametric regression models with missing covariates, with application to analysis of biomarker correlates in vaccine trials Open
This article presents generalized semiparametric regression models for conditional cumulative incidence functions with competing risks data when covariates are missing by sampling design or happenstance. A doubly robust augmented inverse p…
View article: Estimation and Hypothesis Testing of Strain-Specific Vaccine Efficacy with Missing Strain Types, with Applications to a COVID-19 Vaccine Trial
Estimation and Hypothesis Testing of Strain-Specific Vaccine Efficacy with Missing Strain Types, with Applications to a COVID-19 Vaccine Trial Open
Statistical methods are developed for analysis of clinical and virus genetics data from phase 3 randomized, placebo-controlled trials of vaccines against novel coronavirus COVID-19. Vaccine efficacy (VE) of a vaccine to prevent COVID-19 ca…
View article: Semiparametric Additive Time-Varying Coefficients Model for Longitudinal Data with Censored Time Origin
Semiparametric Additive Time-Varying Coefficients Model for Longitudinal Data with Censored Time Origin Open
Statistical analysis of longitudinal data often involves modeling treatment effects on clinically relevant longitudinal biomarkers since an initial event (the time origin). In some studies including preventive HIV vaccine efficacy trials, …
View article: Variable selection for a mark-specific additive hazards model using the adaptive LASSO
Variable selection for a mark-specific additive hazards model using the adaptive LASSO Open
In HIV vaccine efficacy trials, mark-specific hazards models have important applications and can be used to evaluate the strain-specific vaccine efficacy. Additive hazards models have been widely used in practice, especially when continuou…
View article: Semiparametric regression analysis of partly interval‐censored failure time data with application to an AIDS clinical trial
Semiparametric regression analysis of partly interval‐censored failure time data with application to an AIDS clinical trial Open
Failure time data subject to various types of censoring commonly arise in epidemiological and biomedical studies. Motivated by an AIDS clinical trial, we consider regression analysis of failure time data that include exact and left‐, inter…
View article: A Hybrid Approach for The Stratified Mark-Specific Proportional Hazards Model with Missing Covariates and Missing Marks, with Application to Vaccine Efficacy Trials
A Hybrid Approach for The Stratified Mark-Specific Proportional Hazards Model with Missing Covariates and Missing Marks, with Application to Vaccine Efficacy Trials Open
Summary Deployment of the recently licensed tetravalent dengue vaccine based on a chimeric yellow fever virus, CYD-TDV, requires understanding of how the risk of dengue disease in vaccine recipients depends jointly on a host biomarker meas…
View article: Analysis of generalized semiparametric mixed varying‐coefficients models for longitudinal data
Analysis of generalized semiparametric mixed varying‐coefficients models for longitudinal data Open
The generalized semiparametric mixed varying‐coefficient effects model for longitudinal data can accommodate a variety of link functions and flexibly model different types of covariate effects, including time‐constant, time‐varying and cov…
View article: Semiparametric varying‐coefficient regression analysis of recurrent events with applications to treatment switching
Semiparametric varying‐coefficient regression analysis of recurrent events with applications to treatment switching Open
This paper investigates the semiparametric statistical methods for recurrent events. The mean number of the recurrent events are modeled with the generalized semiparametric varying‐coefficient model that can flexibly model three types of c…
View article: Hypothesis tests for stratified mark‐specific proportional hazards models with missing covariates, with application to HIV vaccine efficacy trials
Hypothesis tests for stratified mark‐specific proportional hazards models with missing covariates, with application to HIV vaccine efficacy trials Open
This article develops hypothesis testing procedures for the stratified mark‐specific proportional hazards model with missing covariates where the baseline functions may vary with strata. The mark‐specific proportional hazards model has bee…
View article: Safety‐net versus private hospital setting for brain metastasis patients treated with radiosurgery alone: Disparities in follow‐up care and outcomes
Safety‐net versus private hospital setting for brain metastasis patients treated with radiosurgery alone: Disparities in follow‐up care and outcomes Open
BACKGROUND Stereotactic radiosurgery (SRS) alone is an increasingly accepted treatment for brain metastases, but it requires adherence to frequently scheduled follow‐up neuroimaging because of the risk of distant brain metastasis. The effe…
View article: Generalized Semiparametric Varying-Coefficient Model for Longitudinal Data with Applications to Adaptive Treatment Randomizations
Generalized Semiparametric Varying-Coefficient Model for Longitudinal Data with Applications to Adaptive Treatment Randomizations Open
Summary This article investigates a generalized semiparametric varying-coefficient model for longitudinal data that can flexibly model three types of covariate effects: time-constant effects, time-varying effects, and covariate-varying eff…