Xinkang Wang
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View article: In vitro and in vivo characterization of wild type BMP9 and a non-osteogenic variant in models of pulmonary arterial hypertension
In vitro and in vivo characterization of wild type BMP9 and a non-osteogenic variant in models of pulmonary arterial hypertension Open
Endothelial dysfunction and the resulting vascular remodeling are hallmarks of pulmonary hypertension, a debilitating disease of high arterial pressure in the lungs and the right side of the heart. Mutations in the BMPR2 signaling pathway …
View article: Calix[8]Arene‐Tethered Dendritic Octamer Acceptor with Ultrahigh Molecular Weight Enables 20.7% Efficiency Organic Solar Cells with Exceptional Stability
Calix[8]Arene‐Tethered Dendritic Octamer Acceptor with Ultrahigh Molecular Weight Enables 20.7% Efficiency Organic Solar Cells with Exceptional Stability Open
Increasing the molecular weight of the acceptor is an effective strategy to suppress excessive crystallization and molecular diffusion, thereby addressing morphological challenges in organic solar cells (OSCs). Therefore, designing high‐mo…
View article: Changes in dynamic electrocardiogram after COVID-19 infection: a self-controlled study
Changes in dynamic electrocardiogram after COVID-19 infection: a self-controlled study Open
Background: Coronavirus disease 2019 (COVID-19) not only causes respiratory system damage, but also cardiovascular system. Previous studies had shown that COVID-19 can cause abnormal changes in ECG, however few studies reported changes in …
View article: Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis
Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis Open
Background Factor XIa (FXIa) is an emerging therapeutic target, and FXIa inhibition is a promising mechanism to improve therapeutic index over current anticoagulants. Milvexian (BMS-986177/JNJ-70033093) is an oral small-molecule FXIa inhib…
View article: An assessment of the hydrochemical characteristics and nitrate human health risks of groundwater in a semi-arid plain: A case study of western Jilin Province
An assessment of the hydrochemical characteristics and nitrate human health risks of groundwater in a semi-arid plain: A case study of western Jilin Province Open
Groundwater is important for human survival and development, particularly in arid and semi-arid regions, such as western Jilin Province. This study aimed to evaluate the hydrochemical characteristics and nitrate human health risks of groun…
View article: Groundwater Quality Assessment in the Northern Part of Changchun City, Northeast China, Using PIG and Two Improved PIG Methods
Groundwater Quality Assessment in the Northern Part of Changchun City, Northeast China, Using PIG and Two Improved PIG Methods Open
As a numerical indicator, the pollution index of groundwater (PIG) has gained a great deal of popularity in quantifying groundwater quality for drinking purposes. However, its weight-determination procedure is rather subjective due to the …
View article: Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions Open
Activated factor XI (FXIa) inhibitors are promising novel anticoagulants with low bleeding risk compared with current anticoagulants. The discovery of potent FXIa inhibitors with good oral bioavailability has been challenging. Herein, we d…
View article: The Relationship Between P-Wave Dispersion, QTc Dispersion, and Gestational Hypertension
The Relationship Between P-Wave Dispersion, QTc Dispersion, and Gestational Hypertension Open
Background To analyze the relationship between gestational hypertension and P-wave dispersion and QTc interval dispersion. Methods From January 2017 to December 2019, 213 pregnant women who met the diagnosis of hypertension were selected a…
View article: Three-Heartbeat Multilead ECG Recognition Method for Arrhythmia Classification
Three-Heartbeat Multilead ECG Recognition Method for Arrhythmia Classification Open
Electrocardiogram (ECG) is the primary basis for the diagnosis of cardiovascular diseases. However, the amount of ECG data of patients makes manual interpretation time-consuming and onerous. Therefore, the intelligent ECG recognition techn…
View article: Factors associated with psychological resilience in patients with chronic heart failure and efficacy of psycho-cardiology intervention.
Factors associated with psychological resilience in patients with chronic heart failure and efficacy of psycho-cardiology intervention. Open
Age, gender, SAS, and SDS scores are factors associated with psychological resilience in patients with CHF. Psychological resilience was inversely associated with both anxiety and depression. Psycho-cardiology intervention can improve pati…
View article: A community effort to assess and improve computerized interpretation of 12-lead resting electrocardiogram
A community effort to assess and improve computerized interpretation of 12-lead resting electrocardiogram Open
Computerized interpretation of electrocardiogram plays an important role in daily cardiovascular healthcare. However, inaccurate interpretations lead to misdiagnoses and delay proper treatments. In this work, we built a high-quality Chines…
View article: Automated Classification Model With OTSU and CNN Method for Premature Ventricular Contraction Detection
Automated Classification Model With OTSU and CNN Method for Premature Ventricular Contraction Detection Open
Premature ventricular contraction (PVC) is one of the most common arrhythmias which can cause palpitation, cardiac arrest, and other symptoms affecting the work and rest activities of a patient. However, patients hardly decipher their own …
View article: A Distributed PV System Capacity Estimation Approach Based on Support Vector Machine with Customer Net Load Curve Features
A Distributed PV System Capacity Estimation Approach Based on Support Vector Machine with Customer Net Load Curve Features Open
Most distributed photovoltaic systems (DPVSs) are normally located behind the meter and are thus invisible to utilities and retailers. The accurate information of the DPVS capacity is very helpful in many aspects. Unfortunately, the capaci…
View article: Residential Electricity Consumption Level Impact Factor Analysis Based on Wrapper Feature Selection and Multinomial Logistic Regression
Residential Electricity Consumption Level Impact Factor Analysis Based on Wrapper Feature Selection and Multinomial Logistic Regression Open
This paper aims to identity the significant impact factors (IFs) of the residential electricity consumption level (RECL) and to better understand the influence mechanism of IFs on RECL. The analysis of influence mechanism is commonly throu…