Liang Yu
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View article: Efficient n‐Doping of Organic Semiconductors via a Broadly Applicable Nucleophilic‐Attack Mechanism
Efficient n‐Doping of Organic Semiconductors via a Broadly Applicable Nucleophilic‐Attack Mechanism Open
The development of efficient and broadly applicable n‐doping strategies for organic semiconductors (OSCs) is crucial for advancing the performance of various organic electronic devices. Here, a novel nucleophilic‐attack n‐doping mechanism …
View article: Competitive dynamics of ST764 and ST5 MRSA in a new tertiary ICU: enhanced hospital adaptation via agrC mutations post-COVID-19
Competitive dynamics of ST764 and ST5 MRSA in a new tertiary ICU: enhanced hospital adaptation via agrC mutations post-COVID-19 Open
Environmental contamination is the primary source of MRSA transmission in ICUs. The agrC-T43I mutation drives ST5 dominance post-pandemic by enhancing biofilm-dependent persistence, underscoring the need for genomic surveillance to guide i…
View article: Unraveling the mechanism of tetracycline-induced renal injury: an evaluation of drug safety based on network toxicology and molecular dynamics simulations
Unraveling the mechanism of tetracycline-induced renal injury: an evaluation of drug safety based on network toxicology and molecular dynamics simulations Open
View article: Analysis of Fall Incidence and Influencing Factors Among Home-Dwelling Elderly in China
Analysis of Fall Incidence and Influencing Factors Among Home-Dwelling Elderly in China Open
Objective: To explore the current situation of falls among elderly people at home in Hechi City, Guangxi, China, and its influencing factors, so as to provide a basis for the formulation of targeted fall prevention intervention strategies.…
View article: Independent and joint associations of sleep quality and physical activity with glycaemic control in patients with type 2 diabetes mellitus
Independent and joint associations of sleep quality and physical activity with glycaemic control in patients with type 2 diabetes mellitus Open
Background Although determinants of glycaemic control in type 2 diabetes mellitus (T2DM) have been extensively investigated, the joint influence of sleep quality and physical activity (PA) remains insufficiently studied. We aimed to examin…
View article: 1331 HCB101, a next-generation Fc-engineered anti-CD47 SIRPα fusion protein, demonstrates favorable safety and early antitumor activity in advanced cancers
1331 HCB101, a next-generation Fc-engineered anti-CD47 SIRPα fusion protein, demonstrates favorable safety and early antitumor activity in advanced cancers Open
View article: Innovative strategies for high-throughput discovery and engineering of plant immune receptors
Innovative strategies for high-throughput discovery and engineering of plant immune receptors Open
View article: Engineered nano-bacteria hybrids for precision cancer immunotherapy
Engineered nano-bacteria hybrids for precision cancer immunotherapy Open
Bacterial therapy has emerged as a promising modality in precision cancer immunotherapy, leveraging bacteria's innate tumor-homing ability, immunostimulatory properties, and engineering flexibility to overcome limitations in conventional t…
View article: Paraneoplastic Pemphigus Unveiling Occult Lung Adenocarcinoma: A Rituximab‐Responsive Case With Diagnostic and Therapeutic Implications
Paraneoplastic Pemphigus Unveiling Occult Lung Adenocarcinoma: A Rituximab‐Responsive Case With Diagnostic and Therapeutic Implications Open
Paraneoplastic pemphigus (PNP) is a rare autoimmune disorder typically associated with hematologic or squamous cell malignancies. Its association with lung adenocarcinoma (LUAD) is exceptionally uncommon, with only sporadic cases reported.…
View article: Synergistic Catalysis: Sodium Perborate-Mediated Advanced Oxidation Processes Coupled with MIL-88B(Fe) for Photocatalytic Degradation of Methylene Blue
Synergistic Catalysis: Sodium Perborate-Mediated Advanced Oxidation Processes Coupled with MIL-88B(Fe) for Photocatalytic Degradation of Methylene Blue Open
Addressing the growing concerns of water pollution, requires the development of efficient advanced oxidation processes (AOPs). This study investigates a novel AOPs system that integrates the metal-organic framework MIL-88B(Fe) with sodium …
View article: Study on Motion Performance and Mooring Tension Response of 16 MW Tension Leg Platform Floating Wind Turbine Under Extreme Environmental Conditions
Study on Motion Performance and Mooring Tension Response of 16 MW Tension Leg Platform Floating Wind Turbine Under Extreme Environmental Conditions Open
This paper presents a 16 MW typhoon-resistant Tension Leg Platform floating offshore wind turbine (TLP FOWT) designed for the South China Sea. The survivability of the TLP FOWT under extreme environmental conditions is investigated through…
View article: Fluoride‐Engineered Electrolyte for Highly Stable and Efficient Alkaline Seawater Electrolysis at 2 A cm <sup>−2</sup>
Fluoride‐Engineered Electrolyte for Highly Stable and Efficient Alkaline Seawater Electrolysis at 2 A cm <sup>−2</sup> Open
Seawater electrolysis offers an energy‐efficient route for hydrogen production while alleviating freshwater scarcity. However, the presence of Cl − in seawater compromises anode activity and induces severe corrosion, requiring constructing…
View article: The prognostic value of POD24 for multiple myeloma: a comprehensive analysis based on traditional statistics and machine learning
The prognostic value of POD24 for multiple myeloma: a comprehensive analysis based on traditional statistics and machine learning Open
View article: Enveloped Generalized Voronoi Graph and Multi-Topology Path Planning for Navigation in Unknown Environments
Enveloped Generalized Voronoi Graph and Multi-Topology Path Planning for Navigation in Unknown Environments Open
View article: Web engine for tumor pathology image retrievals on massive scales
Web engine for tumor pathology image retrievals on massive scales Open
Hematoxylin and Eosin staining (H&E) is widely used in clinical practice, but efficient and versatile image retrieval tools are lacking. We developed the H&E Retrieval Engine (HERE, https://hereapp.ccr.cancer.gov ) to analyze patient cases…
View article: NPM1 mediated up – regulation of CXCR4 might drive bortezomib resistance in multiple Myeloma
NPM1 mediated up – regulation of CXCR4 might drive bortezomib resistance in multiple Myeloma Open
In conclusion, NPM1 might causes BTZ resistance via up-regulating CXCR4 expression in MM and could be served as both a new prognostic biomarker and a promising therapeutic target.
View article: Cuts or carcasses? Diet form affects fecal microbial and animal fiber fractions in a large carnivore, the Asiatic lion
Cuts or carcasses? Diet form affects fecal microbial and animal fiber fractions in a large carnivore, the Asiatic lion Open
The care of exotic felids in zoos involves numerous factors, and the dietary management is currently considered particularly critical. This study investigated the effects of four different dietary regimens on the fecal microbiota and fecal…
View article: Elevated Nitrogen Fertilization Compromises Lodging Resistance in High-Quality, Late-Season Indica Rice Grown in Southern China
Elevated Nitrogen Fertilization Compromises Lodging Resistance in High-Quality, Late-Season Indica Rice Grown in Southern China Open
While nitrogen is essential for rice production, excessive application promotes lodging, threatening yield stability. In this study, we evaluated the impact of three nitrogen application rates (105, 165, and 225 kg ha−1) on yield formation…
View article: Research note: duck Tembusu virus non-structural protein 3 induced autophagy through endoplasmic reticulum stress
Research note: duck Tembusu virus non-structural protein 3 induced autophagy through endoplasmic reticulum stress Open
View article: Efficient Turn-On Fluorescent Sensor Based on Fluorescent Resonance Energy Transfer between 1,3,6,8-Tetra(4-pyridyl)pyrene and Gold Nanoparticles for Glutathione Detection
Efficient Turn-On Fluorescent Sensor Based on Fluorescent Resonance Energy Transfer between 1,3,6,8-Tetra(4-pyridyl)pyrene and Gold Nanoparticles for Glutathione Detection Open
A fluorescent probe based on fluorescent resonance energy transfer (FRET) between the organic fluorophore 1,3,6,8-tetra-(4-pyridyl) pyrene (TTPY) and gold nanoparticles (AuNPs) was designed for detecting glutathione (GSH) in foods. TTPY, s…
View article: Advances in the combination of CAR-T therapy with small-molecule reagents for hematologic malignancies
Advances in the combination of CAR-T therapy with small-molecule reagents for hematologic malignancies Open
Chimeric antigen receptor T-cell (CAR-T) therapy has become a cornerstone of the treatment for hematologic malignancies. However, as a monotherapy, it still faces major challenges such as therapy resistance, disease relapse, and minimal re…
View article: A Multiparameter Diagnostic Model Based on MRI Volumetric ADC Histogram and Clinical Variables Accurately Differentiate Thymic Epithelial Tumors From Mediastinal Lymphomas
A Multiparameter Diagnostic Model Based on MRI Volumetric ADC Histogram and Clinical Variables Accurately Differentiate Thymic Epithelial Tumors From Mediastinal Lymphomas Open
Background The management and prognosis of each type of anterior mediastinal mass differ substantially. Radical thymectomy is regarded as the preferred surgical approach for resectable TETs, whereas chemotherapy is the recommended treatmen…
View article: A Bayesian Grid-Free Framework with Global Optimization for Three-Dimensional Acoustic Source Imaging
A Bayesian Grid-Free Framework with Global Optimization for Three-Dimensional Acoustic Source Imaging Open
A common challenge in traditional three-dimensional grid-free localization is the struggle to balance computational efficiency with localization accuracy. To address this trade-off, a Bayesian grid-free framework with global optimization (…
View article: Comprehensive exercise recommendations for pediatric asthma: an evidence synthesis
Comprehensive exercise recommendations for pediatric asthma: an evidence synthesis Open
Background Bronchial asthma is a common chronic respiratory disease in children. For many years, concerns about exercise-induced bronchoconstriction have limited physical activity in this population, with negative consequences for both phy…
View article: Chlorogenic acid modulates mitochondrial damage and mitophagy to repair injured myocardial tissue and cells
Chlorogenic acid modulates mitochondrial damage and mitophagy to repair injured myocardial tissue and cells Open
Background Chlorogenic acid (CGA) is a polyphenolic compound widely present in plants. It is primarily extracted from the leaves of Eucommia ulmoides, a native medicinal herb. Purpose This study aimed to investigate the cardioprotective ef…
View article: Drought Adaptation Strategies of Platycladus orientalis in the Western Loess Plateau: Differential Water Uptake on Sunny and Shady Slopes
Drought Adaptation Strategies of Platycladus orientalis in the Western Loess Plateau: Differential Water Uptake on Sunny and Shady Slopes Open
View article: Fingerprinting Organic Molecules for the Inverse Design of Two-Dimensional Hybrid Perovskites with Target Energetics
Fingerprinting Organic Molecules for the Inverse Design of Two-Dimensional Hybrid Perovskites with Target Energetics Open
Artificial intelligence (AI)-assisted workflows have transformed materials discovery, enabling rapid exploration of chemical spaces of functional materials. Endowed with extraordinary optoelectronic properties, two-dimensional (2D) hybrid …
View article: Interactions of multiple abiotic stresses exacerbate mollusk diversity loss in a high-discharge coastal mangrove wetland
Interactions of multiple abiotic stresses exacerbate mollusk diversity loss in a high-discharge coastal mangrove wetland Open
Coastal regions, as a hotspot region of biodiversity and the most densely populated areas in the world, are increasingly threatened by anthropogenic disturbances, including warming, acidification, eutrophication, salinity fluctuation, and …
View article: Evaluating the use of body mass index change as a proxy for anorexia nervosa recovery: a machine learning perspective
Evaluating the use of body mass index change as a proxy for anorexia nervosa recovery: a machine learning perspective Open
View article: Extensions of a Line-Graph-Based Method for Token Routing in Decentralized Exchanges
Extensions of a Line-Graph-Based Method for Token Routing in Decentralized Exchanges Open
Decentralized exchanges (DEXs) form a cornerstone of the decentralized finance (DeFi) ecosystem, processing token trades worth billions of dollars daily. Yet, a significant fraction of these trades are suboptimal: alternative routing paths…