Explanipedia

Diet, oxidative stress and MAFLD: a mini review Open

Zhiai Hu, Hui Yue, Na Jiang, Liang Qiao · 2025

Globally, metabolic dysfunction-associated fatty liver disease (MAFLD), also known as non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD), is a common chronic liver disease. The pro…

3D Printing Hierarchical Porous Nanofibrous Scaffold for Bone Regeneration Open

Zhiai Hu, Hengyi Lin, Zhenming Wang, Yating Yi, Shujuan Zou , et al. · 2024

Current limitations in 3D printing pose significant challenges for the fabrication of hierarchical 3D scaffolds with nanofibrous structures that simulate the natural bone extracellular matrix (ECM) for enhanced bone regeneration. This stud…

[Research Progress in the Regulatory Role of circRNA-miRNA Network in Bone Remodeling]. Open

Yuanchen Lan, Liyuan Yu, Zhiai Hu, Shujuan Zou · 2024

The dynamic balance between bone formation and bone resorption is a critical process of bone remodeling. The imbalance of bone formation and bone resorption is closely associated with the occurrence and development of various bone-related …

E7-Conjugated Bio-Inspired Microspheres as a Biological Barrier for Guided Tissue Regeneration Open

Zhiai Hu, Xin Rong, Xiaohua Liu · 2023

Guided tissue regeneration (GTR), which is based on creating a physical barrier to prevent the downgrowth of epithelial and connective tissues into the defect site, has been widely used in clinical practice for periodontal regeneration for…

circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis Open

Liyuan Yu, Kai Xia, Jing Zhou, Zhiai Hu, Xing Yin , et al. · 2022

Mechanosensitive Piezo1 in Periodontal Ligament Cells Promotes Alveolar Bone Remodeling During Orthodontic Tooth Movement Open

Yukun Jiang, Yuzhe Guan, Yuanchen Lan, Shuo Chen, Tian‐Cheng Li , et al. · 2021

Orthodontic tooth movement (OTM) is a process depending on the remodeling of periodontal tissues surrounding the roots. Orthodontic forces trigger the conversion of mechanical stimuli into intercellular chemical signals within periodontal …

[Research Progress in Mechanotransduction Process of Mechanical-Stress-Induced Autophagy]. Open

Yukun Jiang, Zhiai Hu, Yuzhe Guan, Chenchen Zhou, Shujuan Zou · 2021

As a self-protective mechanism for cells to obtain energy by degrading their own structures or substances, autophagy widely occurs in basic physiological process of all kinds of eukaryotic cells. In recent years, studies have shown that au…

Pyrophosphate inhibits periodontal ligament stem cell differentiation and mineralization through MAPK signaling pathways Open

Yongxi Liang, Zhiai Hu, Qian Li, Xiaohua Liu · 2021

Background and Objective Periodontal ligament stem cells (PDLSCs) are the primary cell source for the regeneration and remodeling of periodontal ligament (PDL). It is crucial to prevent PDLSCs from mineralization when using the PDLSCs for …

Multifunctional peptide-conjugated nanocarriers for pulp regeneration in a full-length human tooth root Open

Qian Li, Zhiai Hu, Yongxi Liang, Cancan Xu, Yi Hong , et al. · 2021

Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy Open

Li Huang, Xing Yin, Jun Chen, Ruojing Liu, Xiaoyue Xiao , et al. · 2021

Multifunctional polyplex micelles for efficient microRNA delivery and accelerated osteogenesis Open

Qian Li, Zhiai Hu, Xin Rong, Bei Chang, Xiaohua Liu · 2021

A multifunctional polyplex micelle PPP-RGI efficiently delivers miR-218 (an osteogenic miRNA regulator) to BMSCs for enhanced osteogenesis.

Multifunctional Peptide-Conjugated Nanocarriers for Pulp Regeneration in a Full-Length Human Tooth Root Open

Qian Li, Zhiai Hu, Yongxi Liang, Cancan Xu, Yi Hong , et al. · 2021

Quantitative characterizations of the Sharpey’s fibers of rat molars Open

Yongxi Liang, Zhiai Hu, Bei Chang, Xiaohua Liu · 2019

Background and objective The Sharpey's fibers of periodontal ligament (PDL) anchor the PDL to alveolar bone and cementum and are essential for the function of PDL. While qualitative analyses of the Sharpey's fibers have been widely explore…

Resveratrol represses tumor necrosis factor α/c-Jun N-terminal kinase signaling via autophagy in human dental pulp stem cells Open

Fengming Wang, Zhiai Hu, Xiaohua Liu, Jian Q. Feng, Robert Augsburger , et al. · 2018

Immunomodulatory ECM-like Microspheres for Accelerated Bone Regeneration in Diabetes Mellitus Open

Zhiai Hu, Chi Ma, Xin Rong, Shujuan Zou, Xiaohua Liu · 2017

Bone repair and regeneration process is markedly impaired in diabetes mellitus (DM) that affects hundreds of millions of people worldwide. As a chronic inflammatory disease, DM creates a proinflammatory microenvironment in defective sites.…

Intermittent parathyroid hormone (PTH) promotes cementogenesis and alleviates the catabolic effects of mechanical strain in cementoblasts Open

Yuyu Li, Zhiai Hu, Chenchen Zhou, Yang Xu, Li Huang , et al. · 2017

Severe open bite with mandibular asymmetry treated using micro-implant anchorage Open

Jing Liao, Shushu He, Zhiai Hu, Shujuan Zou · 2017

Background This case report describes the orthodontic treatment of a 20 year-old female who presented with a severe anterior open bite, increased lower facial height and mandibular asymmetry. The patient was diagnosed with a Class I skelet…

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