Yue Wu
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View article: Codon Decoding by Split-tRNA: Revisiting the tRNA Selection Mechanism
Codon Decoding by Split-tRNA: Revisiting the tRNA Selection Mechanism Open
The translation machinery is required to process all codon triplets without exception while maintaining high speed and accuracy, despite orders-of-magnitude differences in cognate pairing stability. For stability-based selection to be effi…
View article: High-resolution lifestyle profiling and metabolic subphenotypes of type 2 diabetes
High-resolution lifestyle profiling and metabolic subphenotypes of type 2 diabetes Open
Distinct metabolic susceptibilities (beta-cell dysfunction, insulin resistance (IR), and impaired incretin response) underlie type 2 diabetes (T2D). However, their relationships with habitual lifestyle behaviors are underexplored. This stu…
View article: Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology
Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology Open
Elevated postprandial glycemic responses (PPGRs) are associated with type 2 diabetes and cardiovascular disease. PPGRs to the same foods have been shown to vary between individuals, but systematic characterization of the underlying physiol…
View article: Electrically controlled spin angular momentum of light through lithium niobate domain engineering
Electrically controlled spin angular momentum of light through lithium niobate domain engineering Open
The investigations of spin angular momentum (SAM) of light have demonstrated many interesting photonic-spin-dependent effects. However, it is still a great challenge to manipulate a photonic SAM state in a designable and dynamic way. Here …
View article: DNA bending mediated by ORC is essential for replication licensing in budding yeast
DNA bending mediated by ORC is essential for replication licensing in budding yeast Open
In eukaryotes, the origin recognition complex (ORC) promotes the assembly of minichromosome maintenance 2 to 7 complexes into a head-to-head double hexamer at origin DNA in a process known as replication licensing. In this study, we presen…
View article: Functional Split-tRNA: A New Perspective on the Codon Decoding Mechanism
Functional Split-tRNA: A New Perspective on the Codon Decoding Mechanism Open
The translation machinery must rapidly and accurately process all codon triplets despite large differences in the stability of codon:anticodon duplexes. The constrained structure and intramolecular cooperativity of tRNA complicate understa…
View article: Codon decoding by split-tRNA: revisiting the tRNA selection mechanism
Codon decoding by split-tRNA: revisiting the tRNA selection mechanism Open
The translation machinery is required to process all codon triplets without exception while maintaining high speed and accuracy, despite orders-of-magnitude differences in cognate pairing stability. For stability-based selection to be effi…
View article: Diversity Analysis and Comprehensive Evaluation of 101 Soybean (Glycine max L.) Germplasms Based on Sprout Quality Characteristics
Diversity Analysis and Comprehensive Evaluation of 101 Soybean (Glycine max L.) Germplasms Based on Sprout Quality Characteristics Open
Soybean sprouts are a common culinary vegetable due to their high nutrition and tasty flavors. To select soybean varieties with excellent sprout quality, 101 soybean materials were collected from different regions of China, and eight sprou…
View article: Two Genotypes of Tomato Cultivated in Gobi Agriculture System Show a Varying Response to Deficit Drip Irrigation under Semi-Arid Conditions
Two Genotypes of Tomato Cultivated in Gobi Agriculture System Show a Varying Response to Deficit Drip Irrigation under Semi-Arid Conditions Open
Water-saving irrigation is of extraordinary importance for tomato production in semi-arid areas of northwest China. For this purpose, we conducted a two-season trial in a solar greenhouse of two tomato genotypes named ‘181’ and ‘Mao Fen 80…
View article: Effects of dose nitrogen on yield and global warming potential in a typical rice-wheat rotation system in China
Effects of dose nitrogen on yield and global warming potential in a typical rice-wheat rotation system in China Open
A three-year field experiment was carried out to investigate the methane (CH4) and nitrous oxide (N2O) emissions and calculate the global warming potential (GWP) according to all energy input in response to the nitrogen (N) rate in the typ…
View article: Hypoxia-induced miR-5100 promotes exosome-mediated activation of cancer-associated fibroblasts and metastasis of head and neck squamous cell carcinoma
Hypoxia-induced miR-5100 promotes exosome-mediated activation of cancer-associated fibroblasts and metastasis of head and neck squamous cell carcinoma Open
The invasion-metastasis cascade in head and neck squamous cell carcinoma (HNSCC) is predominantly caused by the interaction between tumor cells and tumor microenvironment, including hypoxia as well as stromal cells. However, the mechanism …
View article: SAND: Automated Time-Domain Modeling of NMR Spectra Applied to Metabolite Quantification
SAND: Automated Time-Domain Modeling of NMR Spectra Applied to Metabolite Quantification Open
Developments in untargeted nuclear magnetic resonance (NMR) metabolomics enable the profiling of thousands of biological samples. The exploitation of this rich source of information requires a detailed quantification of spectral features. …
View article: Transcriptomic and Phenotypic Analyses Reveal the Molecular Mechanism of Dwarfing in Tetraploid Robinia pseudoacacia L.
Transcriptomic and Phenotypic Analyses Reveal the Molecular Mechanism of Dwarfing in Tetraploid Robinia pseudoacacia L. Open
Polyploid breeding techniques aid in the cultivation of new forestry cultivars, thus expanding the suite of strategies for the improvement of arboreal traits and innovation within the field of forestry. Compared to diploid Robinia pseudoac…
View article: Anti-Apoptosis Therapy for Meniscal Avascular Zone Repair: A Proof-of-Concept Study in a Lapine Model
Anti-Apoptosis Therapy for Meniscal Avascular Zone Repair: A Proof-of-Concept Study in a Lapine Model Open
In the present study, 24 rabbits were firstly used to evaluate the apoptosis index and matrix degeneration after untreated adult meniscal tears. Vertical tears (0.25 cm in length) were prepared in the avascular zone of the anterior horn. S…
View article: Spermidine-capped carbon dots as potent antimicrobial nanomaterials against Escherichia coli
Spermidine-capped carbon dots as potent antimicrobial nanomaterials against Escherichia coli Open
The food industry must prevent food contamination caused by pathogenic Escherichia coli, as they pose a severe public health threat globally, hence the need to explore new antimicrobial materials. In this paper, spermidine capped carbon do…
View article: Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma
Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma Open
Ubiquitination is a reversible process that not only controls protein synthesis and degradation, but also is essential for protein transport, localization and biological activity. Deubiquitinating enzyme (DUB) dysfunction leads to various …
View article: <i>In Vitro</i> Reconstitution and Analysis of SARS-CoV-2/Host Protein–Protein Interactions
<i>In Vitro</i> Reconstitution and Analysis of SARS-CoV-2/Host Protein–Protein Interactions Open
The emergence of viral threats such as Ebola, ZIKA, and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requires a rapid and efficient approach for elucidating mechanisms of pathogenesis and development of therapeutics. In thi…
View article: Cavitation Diagnosis Method for Centrifugal Pumps based on Agglomerative Hierarchical Clustering Algorithm
Cavitation Diagnosis Method for Centrifugal Pumps based on Agglomerative Hierarchical Clustering Algorithm Open
Cavitation in the pump induces vibration and noise, which leads to the degradation of pump performance and damage to the impeller. Therefore, it is of great significance to accurately identify the cavitation state of the centrifugal pump. …
View article: Clinical characteristics and outcomes of cervical lymph node metastasis from unknown primary sites: a single institution’s 14-year experience
Clinical characteristics and outcomes of cervical lymph node metastasis from unknown primary sites: a single institution’s 14-year experience Open
Background Cervical lymph node metastasis from unknown primary sites is a challenging clinical issue with a changing therapy model and unpredictable outcomes, which leads to the difficulty in selecting optimal treatments. Thus, it is valua…
View article: Uncovering in vivo biochemical patterns from time-series metabolic dynamics
Uncovering in vivo biochemical patterns from time-series metabolic dynamics Open
System biology relies on holistic biomolecule measurements, and untangling biochemical networks requires time-series metabolomics profiling. With current metabolomic approaches, time-series measurements can be taken for hundreds of metabol…
View article: The 1q21.3 region driver gene EFNA3 promotes disease progression via inhibition of lung adenocarcinoma cell apoptosis
The 1q21.3 region driver gene EFNA3 promotes disease progression via inhibition of lung adenocarcinoma cell apoptosis Open
As a driver gene in the progression of LUAD, EFNA3 mainly affects the progression of LUAD by regulating LUAD cell apoptosis.
View article: Mechanical, microstructural, and rheological characterization of gelatin-dialdehyde starch hydrogels constructed by dual dynamic crosslinking
Mechanical, microstructural, and rheological characterization of gelatin-dialdehyde starch hydrogels constructed by dual dynamic crosslinking Open
Novel gelatin/dialdehyde starch (GDS) hydrogels based on gelatin were prepared using dialdehyde starch as a macromolecular crosslinking agent. Fourier transform infrared spectroscopy, Raman spectroscopy, and X-ray diffraction showed that t…
View article: Characterizing the gene–environment interaction underlying natural morphological variation in <i>Neurospora crassa</i> conidiophores using high-throughput phenomics and transcriptomics
Characterizing the gene–environment interaction underlying natural morphological variation in <i>Neurospora crassa</i> conidiophores using high-throughput phenomics and transcriptomics Open
Neurospora crassa propagates through dissemination of conidia, which develop through specialized structures called conidiophores. Recent work has identified striking variation in conidiophore morphology, using a wild population collection …
View article: Transcriptome Profiling Reveals Role of MicroRNAs and Their Targeted Genes during Adventitious Root Formation in Dark-Pretreated Micro-Shoot Cuttings of Tetraploid Robinia pseudoacacia L.
Transcriptome Profiling Reveals Role of MicroRNAs and Their Targeted Genes during Adventitious Root Formation in Dark-Pretreated Micro-Shoot Cuttings of Tetraploid Robinia pseudoacacia L. Open
Tetraploid Robinia pseudoacacia L. is a difficult-to-root species, and is vegetatively propagated through stem cuttings. Limited information is available regarding the adventitious root (AR) formation of dark-pretreated micro-shoot cutting…
View article: Identifcation of The Ferroptosis-Related Gene Signature In Placenta of Patients With Early-Onset Preeclampsia
Identifcation of The Ferroptosis-Related Gene Signature In Placenta of Patients With Early-Onset Preeclampsia Open
Background: The accumulation of ROS resulting from upregulated levels of oxidative stress is commonly implicated in preeclampsia (PE). Ferroptosis is a novel form of iron-dependent cell death instigated by lipid peroxidation likely plays i…
View article: Circular RNA EPB41 Expression Predicts Unfavorable Prognoses in NSCLC by Regulating miR-486-3p/eIF5A Axis-Mediated Stemness
Circular RNA EPB41 Expression Predicts Unfavorable Prognoses in NSCLC by Regulating miR-486-3p/eIF5A Axis-Mediated Stemness Open
Dysregulation of circular RNAs (circRNAs) has recently been found to play an important role in the progression and development of cancers such as non-small cell lung cancer (NSCLC). Yet the functions of many circRNAs in NSCLC remain unclea…
View article: JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4
JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4 Open
Background Deubiquitinating enzymes (DUBs) play critical roles in various cancers by modulating functional proteins post-translationally. Previous studies have demonstrated that DUB Josephin Domain Containing 1 (JOSD1) is implicated in tum…