Yuejun Yao
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View article: Epicardial transplantation of antioxidant polyurethane scaffold based human amniotic epithelial stem cell patch for myocardial infarction treatment
Epicardial transplantation of antioxidant polyurethane scaffold based human amniotic epithelial stem cell patch for myocardial infarction treatment Open
Myocardial infarction (MI) is a leading cause of death globally. Stem cell therapy is considered a potential strategy for MI treatment. Transplantation of classic stem cells including embryonic, induced pluripotent and cardiac stem cells e…
View article: An orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs
An orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs Open
View article: Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells
Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells Open
Lymph nodes are crucial organs of the adaptive immune system, orchestrating T cell priming, activation and tolerance. T cell activity and function are highly regulated by lymph nodes, which have a unique structure harbouring distinct cells…
View article: Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor
Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor Open
The limited infiltration and persistence of chimeric antigen receptor (CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process…
View article: Material design for oral insulin delivery
Material design for oral insulin delivery Open
Frequent insulin injections remain the primary method for controlling the blood glucose level of individuals with diabetes mellitus but are associated with low compliance. Accordingly, oral administration has been identified as a highly de…
View article: T cell-mimicking platelet-drug conjugates
T cell-mimicking platelet-drug conjugates Open
Cancer metastasis is the leading cause of cancer-related deaths. The indispensable role of platelets in tumor metastasis inspires the targeted delivery strategy by using platelet-drug conjugates (PDCs). Here, we armed platelets with granzy…
View article: Dexamethasone-loaded ROS-responsive poly(thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury
Dexamethasone-loaded ROS-responsive poly(thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury Open
Acute lung injury (ALI) is associated with excessive inflammatory response, leading to acute respiratory distress syndrome (ARDS) without timely treatment. A fewer effective drugs are available currently to treat the ALI/ARDS. Herein, a th…
View article: Micropatterns and peptide gradient on the inner surface of a guidance conduit synergistically promotes nerve regeneration in vivo
Micropatterns and peptide gradient on the inner surface of a guidance conduit synergistically promotes nerve regeneration in vivo Open
Both of the surface topographical features and distribution of biochemical cues can influence the cell-substrate interactions and thereby tissue regeneration in vivo. However, they have not been combined simultaneously onto a biodeg…
View article: The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials
The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials Open
Tissue regeneration is an active multiplex process involving the dynamic inflammatory microenvironment. Under a normal physiological framework, inflammation is necessary for the systematic immunity including tissue repair and regeneration …