Yueqiang Wang
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View article: Target enrichment long-range sequencing (TLES) reveals structural variations missed by PEM-seq
Target enrichment long-range sequencing (TLES) reveals structural variations missed by PEM-seq Open
Introduction: Genome editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), are widely used to engineer universal allogeneic chimeric antigen receptor T (UCAR-T)…
View article: Genetic Background of Blood β-Hydroxybutyrate Acid Concentrations in Early-Lactating Holstein Dairy Cows Based on Genome-Wide Association Analyses
Genetic Background of Blood β-Hydroxybutyrate Acid Concentrations in Early-Lactating Holstein Dairy Cows Based on Genome-Wide Association Analyses Open
Ketosis is a common metabolic disorder in the early lactation of dairy cows. It is typically diagnosed by measuring the concentration of β-hydroxybutyrate (BHB) in the blood. This study aimed to estimate the genetic parameters of blood BHB…
View article: PH13 improves soybean shade traits and enhances yield for high-density planting at high latitudes
PH13 improves soybean shade traits and enhances yield for high-density planting at high latitudes Open
Shading in combination with extended photoperiods can cause exaggerated stem elongation (ESE) in soybean, leading to lodging and reduced yields when planted at high-density in high-latitude regions. However, the genetic basis of plant heig…
View article: Deciphering the myth of cold tolerance in soybean: An overview of molecular breeding applications
Deciphering the myth of cold tolerance in soybean: An overview of molecular breeding applications Open
The soybean is a source of several dietary components, including milk, protein, and oil. Cold stress has significantly curtailed soybean growth and yield in large areas and caused a high risk to global food security. The main objective of …
View article: Molecular Mechanisms and Clinical Phenotypes of GJB2 Missense Variants
Molecular Mechanisms and Clinical Phenotypes of GJB2 Missense Variants Open
The GJB2 gene is the most common gene responsible for hearing loss (HL) worldwide, and missense variants are the most abundant type. GJB2 pathogenic missense variants cause nonsyndromic HL (autosomal recessive and dominant) and syndromic H…
View article: Path Planning of Inspection Robot Based on Improved Intelligent Water Drop Algorithm
Path Planning of Inspection Robot Based on Improved Intelligent Water Drop Algorithm Open
In response to the limitations observed in the Intelligent Water Droplet (IWD) algorithm for path planning, including its weak problem-solving capability and susceptibility to local optimization, this paper presents an enhanced Intelligent…
View article: A Decomposition Method of Carbon Emission Reduction Targets for Office Parks of Power Grid Companies Considering Equity and Efficiency
A Decomposition Method of Carbon Emission Reduction Targets for Office Parks of Power Grid Companies Considering Equity and Efficiency Open
In order to realize the goal of "carbon peak and carbon neutral", power grid companies need to decompose carbon emission reduction targets at the park level. In this paper, the park-level indicators are selected based on the principles of …
View article: Dynamic Planning for Obstacle Avoidance of Crawler Based on Gaussian Model
Dynamic Planning for Obstacle Avoidance of Crawler Based on Gaussian Model Open
In order to solve the problems of obstacle avoidance planning and trajectory optimization of unmanned platform in hilly orchards, this paper proposes a dynamic planning algorithm based on Gaussian probability model to predict dynamic obsta…
View article: The intervention of classical and molecular breeding approaches to enhance flooding stress tolerance in soybean – An review
The intervention of classical and molecular breeding approaches to enhance flooding stress tolerance in soybean – An review Open
Abiotic stresses and climate changes cause severe loss of yield and quality of crops and reduce the production area worldwide. Flooding stress curtails soybean growth, yield, and quality and ultimately threatens the global food supply chai…
View article: Defining the Sensitivity Landscape of 74,389 EGFR Variants to Tyrosine Kinase Inhibitors
Defining the Sensitivity Landscape of 74,389 EGFR Variants to Tyrosine Kinase Inhibitors Open
Background: Tyrosine kinase inhibitors (TKIs) therapy is a standard treatment for patients with advanced non-small-cell lung carcinoma (NSCLC) when activating epidermal growth factor receptor ( EGFR ) mutations are detected. However, excep…
View article: Defining the Sensitivity Landscape of 74,389 EGFR Variants to Tyrosine Kinase Inhibitors
Defining the Sensitivity Landscape of 74,389 EGFR Variants to Tyrosine Kinase Inhibitors Open
Background Tyrosine kinase inhibitors (TKIs) therapy is a standard treatment for patients with advanced non-small-cell lung carcinoma (NSCLC) when activating epidermal growth factor receptor ( EGFR ) mutations are detected. However, except…
View article: Research on the Rational Proportion of Housing Window in Shanghai Based on Ventilation Comfort
Research on the Rational Proportion of Housing Window in Shanghai Based on Ventilation Comfort Open
Taking the natural ventilation process of residential buildings in Shanghai in summer as research samples, this paper aims to obtain a reasonable range of window ratio by comparing the different scenario simulations by using Thsware VENT s…
View article: Additional file 2 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium
Additional file 2 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium Open
Additional file 2: Table S1. The enriched biological processes terms and KEGG pathways for DEGs.
View article: Additional file 6 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium
Additional file 6 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium Open
Additional file 6: Table S5. Validation of the predictive drugs in Pubmed.
View article: Additional file 4 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium
Additional file 4 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium Open
Additional file 4: Table S3. The enriched GO terms and KEGG pathways for genes in significant modules identified from PPI network.
View article: Additional file 5 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium
Additional file 5 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium Open
Additional file 5: Table S4. The obtained drug-gene interactions information from GDIdb database.
View article: Additional file 3 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium
Additional file 3 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium Open
Additional file 3: Table S2. Results of topological properties analysis for nodes in PPI network.
View article: Study on Fire Characteristics of Typical Atrium
Study on Fire Characteristics of Typical Atrium Open
According to the theory of architecture and fire engineering, U-shaped enclosed atrium and full enclosed atrium are selected as the research objects to understand the fire characteristics of typical atrium. The fire characteristics of the …
View article: A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments
A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments Open
The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventio…
View article: Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of <i>Foxn1</i> in Thymic Epithelial Cells
Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of <i>Foxn1</i> in Thymic Epithelial Cells Open
The thymus is critical for the establishment of the adaptive immune system and the development of a diverse T cell repertoire. T cell development depends upon cell–cell interactions with epithelial cells in the thymus. The thymus is compos…
View article: Magnetite accelerates syntrophic acetate oxidation in methanogenic systems with high ammonia concentrations
Magnetite accelerates syntrophic acetate oxidation in methanogenic systems with high ammonia concentrations Open
Summary Ammonia accumulation is a major inhibitory substance causing anaerobic digestion upset and failure in CH 4 production. At high ammonia levels, CH 4 production through syntrophic acetate oxidization ( SAO ) pathways is more tolerant…
View article: Genome Writing: Current Progress and Related Applications
Genome Writing: Current Progress and Related Applications Open
The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are …
View article: Transgenic Clustered Regularly Interspaced Short Palindromic Repeat/Cas9-Mediated Viral Gene Targeting for Antiviral Therapy of Bombyx mori Nucleopolyhedrovirus
Transgenic Clustered Regularly Interspaced Short Palindromic Repeat/Cas9-Mediated Viral Gene Targeting for Antiviral Therapy of Bombyx mori Nucleopolyhedrovirus Open
We developed a novel antiviral strategy by combining transposon-based transgenesis and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system for the direct cleavage of Bombyx mori nucleopo…
View article: Cyclosporin A Protects H9c2 Cells Against Chemical Hypoxia-Induced Injury via Inhibition of MAPK Signaling Pathway
Cyclosporin A Protects H9c2 Cells Against Chemical Hypoxia-Induced Injury via Inhibition of MAPK Signaling Pathway Open
This study aimed to investigate the effects and molecular mechanism of cyclosporin A (CsA) on cobalt chloride (CoCl2)-induced injury in H9c2 embryonic rat cardiac cells. The results showed that CsA could protect H9c2 cells against CoCl2-in…