Yuesheng Zhang
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View article: Butyrate prevents chemotherapy-induced gastrointestinal toxicity and microbial dysbiosis
Butyrate prevents chemotherapy-induced gastrointestinal toxicity and microbial dysbiosis Open
Chemotherapy-induced gastrointestinal toxicity is a significant dose-limiting complication for cancer treatment. Disruption of the gastrointestinal (GI) epithelial barrier function by several chemotherapeutic agents results in development …
View article: Butyrate Modulates Intestinal Microbiome and Epithelial Function to Attenuate Irinotecan-induced GI Toxicity
Butyrate Modulates Intestinal Microbiome and Epithelial Function to Attenuate Irinotecan-induced GI Toxicity Open
Chemotherapy-induced gastrointestinal toxicity is a significant dose-limiting complication for cancer treatment. Disruption of the gastrointestinal (GI) epithelial barrier function by several chemotherapeutic agents results in development …
View article: The Impact of CO<sub>2</sub> Regeneration Positions on Electrochemical CO<sub>2</sub> Reduction
The Impact of CO<sub>2</sub> Regeneration Positions on Electrochemical CO<sub>2</sub> Reduction Open
Implementing electrochemical CO 2 reduction can decarbonize practical chemical and fuel production. However, in a typical CO 2 electrolyzer, electrochemical CO 2 capture (i.e., CO 2 reacts with electrochemically produced OH − to form (bi)c…
View article: Substituent tuning of Cu coordination polymers enables carbon-efficient CO2 electroreduction to multi-carbon products
Substituent tuning of Cu coordination polymers enables carbon-efficient CO2 electroreduction to multi-carbon products Open
View article: EP.12G.01 PFS as a Surrogate Endpoint for OS in Real-World Patients with ROS1+ advNSCLC in the United States
EP.12G.01 PFS as a Surrogate Endpoint for OS in Real-World Patients with ROS1+ advNSCLC in the United States Open
View article: The Role of Progenitor Cells in the Pathogenesis of Arteriosclerosis
The Role of Progenitor Cells in the Pathogenesis of Arteriosclerosis Open
The increasing incidence of arteriosclerosis has become a significant global health burden. Arteriosclerosis is characterized by the thickening and hardening of arterial walls, which can lead to the narrowing or complete blockage of blood …
View article: Midterm Outcomes of Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Cardiomyopathy: A Single‐Center, Observational Study
Midterm Outcomes of Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Cardiomyopathy: A Single‐Center, Observational Study Open
Background Percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) has been reported to be safe and effective at midterm follow‐up to treat drug‐refractory hypertrophic obstructive cardiomyopathy in a single center. However, d…
View article: 175P Global burden, trends and risk factors of premenopausal breast cancer from 1990 to 2019 with prediction until 2039
175P Global burden, trends and risk factors of premenopausal breast cancer from 1990 to 2019 with prediction until 2039 Open
Despite the known increasing incidence of breast cancer around the world, the burden of disease for premenopausal breast cancer is not well understood, considering the different impact of attributable risk factor by age and socioeconomic s…
View article: TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophage
TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophage Open
View article: Targeted dual degradation of HER2 and EGFR obliterates oncogenic signaling, overcomes therapy resistance, and inhibits metastatic lesions in HER2-positive breast cancer models
Targeted dual degradation of HER2 and EGFR obliterates oncogenic signaling, overcomes therapy resistance, and inhibits metastatic lesions in HER2-positive breast cancer models Open
This study unravels the therapeutic vulnerability of trastuzumab-resistant HER2-positive BC and shows that an agent that targets the degradation of both HER2 and EGFR is highly effective in overcoming drug resistance in this disease. The f…
View article: 68P Phase II results of ivonescimab (ivo) a novel PD-1/VEGF bispecific in combination with chemotherapy for first-line treatment of patients (pts) with advanced/metastatic squamous (Sq) non-small cell lung cancer (NSCLC)
68P Phase II results of ivonescimab (ivo) a novel PD-1/VEGF bispecific in combination with chemotherapy for first-line treatment of patients (pts) with advanced/metastatic squamous (Sq) non-small cell lung cancer (NSCLC) Open
Ivo is a bispecific antibody with cooperative binding to enhance binding affinity to PD-1 by >18 fold and VEGF by >4 fold with the potential to drive synergistic anti-tumor activity. Ivo has a mean T1/2 of 6-7 days. We aimed to assess the …
View article: Cypher/ZASP drives cardiomyocyte maturation via actin-mediated MRTFA-SRF signalling
Cypher/ZASP drives cardiomyocyte maturation via actin-mediated MRTFA-SRF signalling Open
Rationale: Cardiomyocytes (CMs) undergo dramatic structural and functional changes in postnatal maturation; however, the regulatory mechanisms remain greatly unclear. Cypher/Z-band alternatively spliced PDZ-motif protein (ZASP) is a…
View article: Fibroblasts facilitate lymphatic vessel formation in transplanted heart
Fibroblasts facilitate lymphatic vessel formation in transplanted heart Open
Rationale: Lymphangiogenesis plays a critical role in the transplanted heart. The remodeling of lymphatics in the transplanted heart and the source of newly formed lymphatic vessels are still controversial, especially the mechanism …
View article: S262: SAFETY AND EFFICACY OF OBECABTAGENE AUTOLEUCEL (OBE-CEL), A FAST-OFF RATE CD19 CAR IN RELAPSED/REFRACTORY ADULT B-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA:TOP LINE RESULTS OF THE PIVOTAL FELIX STUDY
S262: SAFETY AND EFFICACY OF OBECABTAGENE AUTOLEUCEL (OBE-CEL), A FAST-OFF RATE CD19 CAR IN RELAPSED/REFRACTORY ADULT B-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA:TOP LINE RESULTS OF THE PIVOTAL FELIX STUDY Open
Background: Obe-cel (AUTO1) is an autologous CD19CAR with a fast off-rate CD19 binding domain designed to reduce CAR-T immunotoxicity and improve persistence. Its clinical activity has been tested in r/r paediatric and adult B-ALL trials (…
View article: Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor
Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor Open
View article: Associations of dietary isothiocyanate exposure from cruciferous vegetable consumption with recurrence and progression of non–muscle-invasive bladder cancer: findings from the Be-Well Study
Associations of dietary isothiocyanate exposure from cruciferous vegetable consumption with recurrence and progression of non–muscle-invasive bladder cancer: findings from the Be-Well Study Open
View article: Supplementary Figure 3 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
Supplementary Figure 3 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival Open
Supplementary Figure 3 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
View article: Supplementary Figure 3 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
Supplementary Figure 3 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival Open
Supplementary Figure 3 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
View article: Data from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
Data from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival Open
Background: Intake of cruciferous vegetables, a rich source of dietary isothiocyanates, has been inversely associated with risk of bladder cancer. Due to the potent antiproliferative effects of dietary isothiocyanates on bladder can…
View article: Supplementary Figure 1 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
Supplementary Figure 1 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival Open
Supplementary Figure 1 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
View article: Supplementary Figure 2 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
Supplementary Figure 2 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival Open
Supplementary Figure 2 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
View article: Supplementary Figure 2 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
Supplementary Figure 2 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival Open
Supplementary Figure 2 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
View article: Supplementary Figure 1 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
Supplementary Figure 1 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival Open
Supplementary Figure 1 from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
View article: Data from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
Data from Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival Open
Background: Intake of cruciferous vegetables, a rich source of dietary isothiocyanates, has been inversely associated with risk of bladder cancer. Due to the potent antiproliferative effects of dietary isothiocyanates on bladder can…
View article: Supplementary Material for: Clinical features, treatment modalities and outcomes of elderly thymoma patients: A propensity–matched study based on the SEER database
Supplementary Material for: Clinical features, treatment modalities and outcomes of elderly thymoma patients: A propensity–matched study based on the SEER database Open
Introduction: Thymoma is a common mediastinal tumor, but few studies have been performed in thymoma patients 80 years or older. This study aimed to analyze the clinical features, treatment modalities and survival outcomes of thymoma patien…
View article: Supplementary Material for: Clinical features, treatment modalities and outcomes of elderly thymoma patients: A propensity–matched study based on the SEER database
Supplementary Material for: Clinical features, treatment modalities and outcomes of elderly thymoma patients: A propensity–matched study based on the SEER database Open
Introduction: Thymoma is a common mediastinal tumor, but few studies have been performed in thymoma patients 80 years or older. This study aimed to analyze the clinical features, treatment modalities and survival outcomes of thymoma patien…
View article: Supplementary Material for: Clinical features, treatment modalities and outcomes of elderly thymoma patients: A propensity–matched study based on the SEER database
Supplementary Material for: Clinical features, treatment modalities and outcomes of elderly thymoma patients: A propensity–matched study based on the SEER database Open
Introduction: Thymoma is a common mediastinal tumor, but few studies have been performed in thymoma patients 80 years or older. This study aimed to analyze the clinical features, treatment modalities and survival outcomes of thymoma patien…
View article: Tauroursodeoxycholic Acid&nbsp;Alleviates Atherosclerosis by Inhibiting AIM2 Inflammasome Activation and Enhancing Cholesterol Efflux Capacity in Macrophage
Tauroursodeoxycholic Acid Alleviates Atherosclerosis by Inhibiting AIM2 Inflammasome Activation and Enhancing Cholesterol Efflux Capacity in Macrophage Open
View article: Supplementary Material for: Clinical features, treatment modalities and outcomes of elderly thymoma patients: A propensity–matched study based on the SEER database
Supplementary Material for: Clinical features, treatment modalities and outcomes of elderly thymoma patients: A propensity–matched study based on the SEER database Open
Introduction: Thymoma is a common mediastinal tumor, but few studies have been performed in thymoma patients 80 years or older. This study aimed to analyze the clinical features, treatment modalities and survival outcomes of thymoma patien…
View article: Supplementary Material for: Clinical features, treatment modalities and outcomes of elderly thymoma patients: A propensity–matched study based on the SEER database
Supplementary Material for: Clinical features, treatment modalities and outcomes of elderly thymoma patients: A propensity–matched study based on the SEER database Open
Introduction: Thymoma is a common mediastinal tumor, but few studies have been performed in thymoma patients 80 years or older. This study aimed to analyze the clinical features, treatment modalities and survival outcomes of thymoma patien…