Yueyi Chen
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Disrupted theta synchronization and synaptic connectivity in the visual cortex of Fmr1 KO mice Open
Fragile X syndrome (FX) is a leading inherited cause of autism spectrum disorder, characterized by sensory hypersensitivity and impaired visual learning. Visual experience induces synchronized theta oscillations in the primary visual corte…
View article: A Global Bibliometric Study of Current Bladder Cancer Cell Death Research
A Global Bibliometric Study of Current Bladder Cancer Cell Death Research Open
Cell death mechanisms offer therapeutic strategies for bladder cancer, yet lack comprehensive bibliometric analysis. Map global research trends and hotspots in bladder cancer cell death mechanisms via bibliometrics. We analyzed 5,392 publi…
Visual Analysis of Cell Death in Bladder Cancer — A Bibliometrics-Based Comprehensive Study Open
Cell death mechanisms offer therapeutic strategies for bladder cancer, yet lack comprehensive bibliometric analysis. Map global research trends and hotspots in bladder cancer cell death mechanisms via bibliometrics. We analyzed 5,392 publi…
Potent, Selective, and Drug‐Like G Protein‐Coupled Receptor Kinase 5 and 6 Inhibitors: Design, Synthesis, and X‐Ray Structural Studies Open
Herein, the design, synthesis, and evaluation of small molecules, drug‐like G protein‐coupled receptor kinase 5 (GRK5) inhibitors are reported. GRK5 has become an important drug development target against heart failure and cancer. GRK6, a …
Sex differences in neural networks recruited by frontloaded binge alcohol drinking Open
Frontloading is an alcohol drinking pattern where intake is skewed towards the onset of access. This study aimed to identify brain regions involved in frontloading. Whole brain imaging was performed in 63 C57Bl/6J (32 female, 31 male) mice…
Impaired Experience-Dependent Theta Oscillation Synchronization and Inter-Areal Synaptic Connectivity in the Visual Cortex of Fmr1 KO Mice Open
Fragile X syndrome (FX) is the most prevalent inheritable form of autism spectrum disorder (ASD), characterized by hypersensitivity, difficulty in habituating to new sensory stimuli, and intellectual disability. Individuals with FX often e…
Sex Differences in Neural Networks Recruited by Frontloaded Binge Alcohol Drinking Open
Frontloading is an alcohol drinking pattern where intake is skewed toward the onset of access. The goal of the current study was to identify brain regions involved in frontloading. Whole brain imaging was performed in 63 C57Bl/6J (32 femal…
The autoactivation of human single-chain urokinase-type plasminogen activator (uPA) Open
Most serine proteases are synthesized as inactive zymogens that are activated by cleavage by another protease in a tightly regulated mechanism. The urokinase-type plasminogen activator (uPA) and plasmin cleave and activate each other, cons…
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder Open
Alcohol use disorder (AUD) is a chronic alcohol-related disorder that typically presents as uncontrolled drinking and preoccupation with alcohol. A key component of AUD research is using translationally relevant preclinical models. Over th…
Predictive value of post-cervical cerclage transabdominal ultrasound measurements of cervical length and anterior cervical angle Open
Cervical cerclage is a surgical procedure commonly used to treat cervical insufficiency, a condition that can lead to preterm birth. Identifying reliable predictors of preterm delivery in women who have undergone cervical cerclage is cruci…
Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms Open
Autism spectrum disorder (ASD) affects ~2% of the population in the US, and monogenic forms of ASD often result in the most severe manifestation of the disorder. Recently, SCN2A has emerged as a leading gene associated with ASD, of which a…
The Hidden Brain: Uncovering Previously Overlooked Brain Regions by Employing Novel Preclinical Unbiased Network Approaches Open
A large focus of modern neuroscience has revolved around preselected brain regions of interest based on prior studies. While there are reasons to focus on brain regions implicated in prior work, the result has been a biased assessment of b…
View article: Genome-Wide Identification and Characterization of Heat-Shock Transcription Factors in Rubber Tree
Genome-Wide Identification and Characterization of Heat-Shock Transcription Factors in Rubber Tree Open
Heat-shock transcription factors (Hsfs) play a pivotal role in the response of plants to various stresses. The present study aimed to characterize the Hsf genes in the rubber tree, a primary global source of natural rubber. In this study, …
View article: Genome-Wide Identification and Characterization of the JAZ Gene Family in Rubber Tree (Hevea brasiliensis)
Genome-Wide Identification and Characterization of the JAZ Gene Family in Rubber Tree (Hevea brasiliensis) Open
Jasmonate signaling plays a vital role in the regulation of secondary laticifer differentiation and natural rubber biosynthesis in Hevea brasiliensis. Jasmonate ZIM-domain (JAZ) proteins are the master regulators of jasmonate signaling. Al…
Comparative transcriptome analysis reveals phytohormone signalings, heat shock module and ROS scavenger mediate the cold-tolerance of rubber tree Open
Two contrasting cold response rubber tree clones, the cold-resistant ‘93-114’ and cold-sensitive ‘Reken501’, were subject to a global transcriptome response assessing via high-throughput RNA-seq technique and comprehensive bioinformatics a…
View article: Transcript Profiling of Hevea brasiliensis during Latex Flow
Transcript Profiling of Hevea brasiliensis during Latex Flow Open
Latex exploitation enhances latex regeneration in rubber trees. The latex exploitation-caused latex flow lasts from 10 min to a few hours, which is convenient for exploring the transcript profiling of latex metabolism-related genes at the …
View article: Evaluation of Reference Genes for Quantitative Real-Time PCR Analysis of the Gene Expression in Laticifers on the Basis of Latex Flow in Rubber Tree (Hevea brasiliensis Muell. Arg.)
Evaluation of Reference Genes for Quantitative Real-Time PCR Analysis of the Gene Expression in Laticifers on the Basis of Latex Flow in Rubber Tree (Hevea brasiliensis Muell. Arg.) Open
Latex exploitation-caused latex flow is effective in enhancing latex regeneration in laticifer cells of rubber tree. It should be suitable for screening appropriate reference gene for analysis of the expression of latex regeneration-relate…
Relationship between the number of tapping-induced secondary laticifer lines and rubber yield among Hevea germplasm Open
The lack of suitable early selection parameters means that traditional rubber breeding for yield is time-consuming and inefficient. Laticifer is a tissue specific for natural rubber biosynthesis and storage in rubber tree. The number of th…