Yufei Xia
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View article: Drilling dendritic cell activation: Engineering interfacial mechano-biochemical cues for enhanced immunotherapy
Drilling dendritic cell activation: Engineering interfacial mechano-biochemical cues for enhanced immunotherapy Open
View article: Deciphering the molecular mechanisms of FET fusion oncoprotein–DNA hollow co-condensates
Deciphering the molecular mechanisms of FET fusion oncoprotein–DNA hollow co-condensates Open
Biomolecules such as nucleic acids and proteins can undergo phase separation to form biomolecular condensates with diverse architectures. Here, we report that the FUS/EWS/TAF15 family fusion oncoprotein FUS-ERG forms hollow co-condensates …
View article: Combined metabolomics and proteomics analysis of vascular cognitive impairment in hypertensive rats induced by endothelial injury
Combined metabolomics and proteomics analysis of vascular cognitive impairment in hypertensive rats induced by endothelial injury Open
Aim Based on metabolomics and proteomics research, we investigate the molecular biological mechanisms underlying vascular cognitive impairment (VCI) in rats induced by hypertension combined with endothelial damage, aiming to identify prote…
View article: Genetically predicted immune cell mediate the association between plasma lipidomics and osteomyelitis
Genetically predicted immune cell mediate the association between plasma lipidomics and osteomyelitis Open
This study reveals that increased Ceramide (d40:2) levels increase the risk of developing osteomyelitis, with CD27 on IgD-CD38dim mediating part of the effect. At the same time, Diacylglycerol (16:1_18:1) levels were increased and would re…
View article: Engineering a Lipid Nanoparticle with Atypical Calcium Crystal Structure for Enhanced IFNβ‐Mediated Immunotherapy (Adv. Mater. 42/2025)
Engineering a Lipid Nanoparticle with Atypical Calcium Crystal Structure for Enhanced IFNβ‐Mediated Immunotherapy (Adv. Mater. 42/2025) Open
View article: Dual-Targeting Mn@CeO<sub>2</sub> Nanozyme-Modified Probiotic Hydrogel Microspheres Reshape Gut Homeostasis in Inflammatory Bowel Disease
Dual-Targeting Mn@CeO<sub>2</sub> Nanozyme-Modified Probiotic Hydrogel Microspheres Reshape Gut Homeostasis in Inflammatory Bowel Disease Open
Oral microecological agents show potential in reshaping intestinal microbiota and treating inflammatory bowel disease (IBD), but their clinical application is hindered by gastrointestinal challenges, antioxidant instability, and ineffectiv…
View article: [Characteristics of bronchoalveolar lavage fluid microbial distribution at different disease stages and its relationship with immune function in children with refractory <i>Mycoplasma pneumoniae</i> pneumonia].
[Characteristics of bronchoalveolar lavage fluid microbial distribution at different disease stages and its relationship with immune function in children with refractory <i>Mycoplasma pneumoniae</i> pneumonia]. Open
In children with RMPP, the relative abundance of Propionibacterium and the richness and diversity of BALF microbiota in the acute phase are lower than those in the recovery phase, while the relative abundances of Streptococcus
View article: Cationic alkyl chain length and nanoaggregate form of ionic liquids dominate biocompatibility and toxicity
Cationic alkyl chain length and nanoaggregate form of ionic liquids dominate biocompatibility and toxicity Open
View article: Resolve and Regulate: Alum Nanoplatform Coordinating Sting Availability and Agonist Delivery for Enhanced Anti-Tumor Immunotherapy
Resolve and Regulate: Alum Nanoplatform Coordinating Sting Availability and Agonist Delivery for Enhanced Anti-Tumor Immunotherapy Open
View article: Prevalence and risk factors of osteopenia in adults with short bowel syndrome: a retrospective longitudinal cohort study
Prevalence and risk factors of osteopenia in adults with short bowel syndrome: a retrospective longitudinal cohort study Open
Background Metabolic Bone Disease (MBD) is common in patients with short bowel syndrome (SBS). This study was to investigate the incidence and risk factors of osteopenia in adult SBS patients. Methods Hospital records from January 2010 to …
View article: Enhancement of densification and mechanical property of (Hf <sub>0.2</sub>Zr <sub>0.2</sub>Ti <sub>0.2</sub>Nb <sub>0.2</sub>Ta <sub>0.2</sub>)N high-entropy bulk ceramic via silicon carbide addition
Enhancement of densification and mechanical property of (Hf <sub>0.2</sub>Zr <sub>0.2</sub>Ti <sub>0.2</sub>Nb <sub>0.2</sub>Ta <sub>0.2</sub>)N high-entropy bulk ceramic via silicon carbide addition Open
In this work, high-entropy composite bulk ceramic of (Hf0.2Zr0.2Ti0.2Nb0.2Ta0.2)N/silicon carbide (HEN–SiC) was fabricated via spark plasma sintering (SPS) at 2100 °C with submicron-sized single-phase (Hf0.2Zr0.2Ti0.2Nb0.2Ta0.2)N (HEN) pow…
View article: Targeted Analysis of Mitochondrial Protein Conformations and Interactions by Endogenous ROS‐Triggered Cross‐Linker Release
Targeted Analysis of Mitochondrial Protein Conformations and Interactions by Endogenous ROS‐Triggered Cross‐Linker Release Open
The study of in situ conformations and interactions of mitochondrial proteins plays a crucial role in understanding their biological functions. Current chemical cross‐linking mass spectrometry (CX‐MS) has difficulty in achieving in‐depth a…
View article: Unlocking the Therapeutic Applicability of LNP-mRNA: Chemistry, Formulation, and Clinical Strategies
Unlocking the Therapeutic Applicability of LNP-mRNA: Chemistry, Formulation, and Clinical Strategies Open
Messenger RNA (mRNA) has emerged as an innovative therapeutic modality, offering promising avenues for the prevention and treatment of a variety of diseases. The tremendous success of mRNA vaccines in effectively combatting coronavirus dis…
View article: Assembly and Jamming of Polar Additive-Swollen Microgels at Liquid-Liquid Interfaces: From Inverse Pickering Emulsions to Hierarchical Functional Materials
Assembly and Jamming of Polar Additive-Swollen Microgels at Liquid-Liquid Interfaces: From Inverse Pickering Emulsions to Hierarchical Functional Materials Open
View article: Targeted cross-linker delivery for the in situ mapping of protein conformations and interactions in mitochondria
Targeted cross-linker delivery for the in situ mapping of protein conformations and interactions in mitochondria Open
View article: Development and Optimal Immune Strategy of an Alum-Stabilized Pickering emulsion for Cancer Vaccines
Development and Optimal Immune Strategy of an Alum-Stabilized Pickering emulsion for Cancer Vaccines Open
Therapeutic cancer vaccines are considered as one of the most cost-effective ways to eliminate cancer cells. Although many efforts have been invested into improving their therapeutic effect, transient maturation and activations of dendriti…
View article: Inside-out assembly of viral antigens for the enhanced vaccination
Inside-out assembly of viral antigens for the enhanced vaccination Open
Current attempts in vaccine delivery systems concentrate on replicating the natural dissemination of live pathogens, but neglect that pathogens evolve to evade the immune system rather than to provoke it. In the case of enveloped RNA virus…
View article: Aggregating particles on the O/W interface: Tuning Pickering emulsion for the enhanced drug delivery systems
Aggregating particles on the O/W interface: Tuning Pickering emulsion for the enhanced drug delivery systems Open
The rational design of drug delivery systems has led to enhanced targeting, increased efficiency, and a reduction of side effects in chemotherapies and vaccines. As most biological reactions took place at the interface, particle‐stabilized…
View article: Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant
Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant Open
View article: COVID‐19 Vaccines: Particulate Alum via Pickering Emulsion for an Enhanced COVID‐19 Vaccine Adjuvant (Adv. Mater. 40/2020)
COVID‐19 Vaccines: Particulate Alum via Pickering Emulsion for an Enhanced COVID‐19 Vaccine Adjuvant (Adv. Mater. 40/2020) Open
For enhanced COVID‐19 vaccines, in article number 2004210, Yufei Xia, Guanghui Ma, and co‐workers pack licensed alum on a squalene/water interphase. Thereby, this century‐old adjuvant “travels through time” in a new form of alum‐stabilized…
View article: Luminescence Properties of Ce<sup>3+</sup> Doped Garnet Ca<sub>2</sub>LaZr<sub>2</sub>Al<sub>3</sub>O<sub>12</sub> Phosphors
Luminescence Properties of Ce<sup>3+</sup> Doped Garnet Ca<sub>2</sub>LaZr<sub>2</sub>Al<sub>3</sub>O<sub>12</sub> Phosphors Open
A series of novel Ca 2 LaZr 2 Al 3 O 12 : x Ce 3+ garnet phosphors were obtained by conventional high temperature solid-state reaction. Crystal structure, phase purity, micromorphology as well as luminescence properties are studied via X-r…
View article: The Emulsion Particulate Strategy: The Horizon of the Emulsion Particulate Strategy: Engineering Hollow Particles for Biomedical Applications (Adv. Mater. 38/2019)
The Emulsion Particulate Strategy: The Horizon of the Emulsion Particulate Strategy: Engineering Hollow Particles for Biomedical Applications (Adv. Mater. 38/2019) Open
View article: Immune Responses: Bridging Systemic Immunity with Gastrointestinal Immune Responses via Oil‐in‐Polymer Capsules (Adv. Mater. 31/2018)
Immune Responses: Bridging Systemic Immunity with Gastrointestinal Immune Responses via Oil‐in‐Polymer Capsules (Adv. Mater. 31/2018) Open
Typically, parenteral vaccinations hardly induce mucosal immune responses. To address this, in article number 1801067, Zhiguo Su, Guanghui Ma, and co-workers develop oil-in-polymer capsules to co-deliver antigens and retinoic acid, which f…
View article: Bridging Systemic Immunity with Gastrointestinal Immune Responses via Oil‐in‐Polymer Capsules
Bridging Systemic Immunity with Gastrointestinal Immune Responses via Oil‐in‐Polymer Capsules Open
As peripheral lymphocytes are typically excluded from the gastrointestinal lymph tissues, current parenteral vaccinations fail to simultaneously induce systemic and mucosal responses. To break the natural barrier, “immunoticket” capsules a…
View article: Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination
Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination Open
View article: Ca<sub>6</sub>La<sub>4</sub>(SiO<sub>4</sub>)<sub>2</sub>(PO<sub>4</sub>)<sub>4</sub>O<sub>2</sub>:Eu<sup>2+</sup>: a novel apatite green-emitting phosphor for near-ultraviolet excited w-LEDs
Ca<sub>6</sub>La<sub>4</sub>(SiO<sub>4</sub>)<sub>2</sub>(PO<sub>4</sub>)<sub>4</sub>O<sub>2</sub>:Eu<sup>2+</sup>: a novel apatite green-emitting phosphor for near-ultraviolet excited w-LEDs Open
A novel green phosphor Ca6La4(SiO4)2(PO4)4O2:Eu2+ that fabricated with commercial blue and red phosphor coating on a n-UV chip.
View article: Crystal structure evolution and luminescence properties of color tunable solid solution phosphors Ca<sub>2+x</sub>La<sub>8−x</sub>(SiO<sub>4</sub>)<sub>6−x</sub>(PO<sub>4</sub>)<sub>x</sub>O<sub>2</sub>:Eu<sup>2+</sup>
Crystal structure evolution and luminescence properties of color tunable solid solution phosphors Ca<sub>2+x</sub>La<sub>8−x</sub>(SiO<sub>4</sub>)<sub>6−x</sub>(PO<sub>4</sub>)<sub>x</sub>O<sub>2</sub>:Eu<sup>2+</sup> Open
The substitution of La3+ by Ca2+ in a series of phosphors led to a crystal structure variation and the emitted color changing from green to blue.
View article: Chitosan-based mucosal adjuvants: Sunrise on the ocean
Chitosan-based mucosal adjuvants: Sunrise on the ocean Open