Explanipedia

Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial Open

Yue Cheng, Honghu Tang, Yufeng Qing, Yuan Liu, Wantai Dang , et al. · 2025

Registered in the Chinese Clinical Trial Register (ChiCTR2100042141).

Advancing precision medicine in axial spondyloarthritis: insights from multi-omics approaches Open

Y NI, Quan‐Bo Zhang, Xin Wu, Huji Xu, Yufeng Qing · 2025

Axial Spondyloarthritis (axSpA) is a chronic inflammatory disease influenced by genetic, immune, metabolic, and environmental factors, significantly impacting patients’ quality of life. Recent advancements in multi-omics technologies—such …

Superselective transarterial chemoembolization (SSTACE) as second-line conversion therapy for locally advanced unresectable gastric or gastroesophageal junction adenocarcinoma: a preliminary retrospective cohort study Open

Jingjing Chen, Wei Zhang, Tianyi Wang, Yu Fu, Yufeng Qing , et al. · 2025

SSTACE could potentially offer a novel therapeutic approach for patients with locally advanced unresectable GC or GEJ cancer who have shown limited response to systemic chemotherapy/immunotherapy, characterized by SD or PD. This treatment …

Chymase Deficiency Drives Non-Syndromic Hereditary Gingival Fibromatosis Open

Xin Chen, W Wang, Yufeng Qing, Yang Cao, Chen Zhou , et al. · 2025

Aim or purpose: Hereditary gingival fibromatosis (HGF) is an inherited disease characterized by pathological gingival overgrowth, but the mechanisms underlying HGF remain largely elusive. Materials and methods: Whole-genome sequencing was …

DDX3X could regulate gouty inflammation via NLRP3 Inflammasome activation and macrophage Pyroptosis crosstalk Open

Linrui Zhong, Tianyi Lei, Jianwei Guo, Jianxiong Zheng, Shunbing Wang , et al. · 2025

DDX3X could regulate gouty inflammation by activating the NLRP3 inflammasome and mediating macrophage pyroptosis.

Superselective Transarterial Chemoembolization (SSTACE) for Conversion Therapy in Locally Advanced Unresectable Gastric or Gastroesophageal Junction Adenocarcinoma: A Retrospective Cohort Study Open

Jingjing Chen, Wei Zhang, Tianyi Wang, Yu Fu, Yufeng Qing , et al. · 2025

Background Among patients diagnosed with locally advanced unresectable gastric or gastroesophageal junction adenocarcinoma treated with systemic chemotherapy/immunotherapy, suboptimal efficacy of conversion therapy has been observed, chara…

The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout Open

Zeng Zhang, Peng Wang, Tianyi Lei, Jianwei Guo, Yiguo Jiang , et al. · 2025

Background Interleukin-6 (IL-6) is a pleiotropic cytokine, with specific effects depending on the immune microenvironment. Extensive research has confirmed the pathological roles of the IL-6/JAK2/STAT1/3 signaling pathway in inflammation, …

Circ_0058051 Targeted miR‐129‐5P Regulates Autophagy‐Related Gene ATG7 to Promote the Inflammation of Gout Open

Jianwei Guo, Tianyi Lei, Yi Jiang, Peng Wang, Zeng Zhang , et al. · 2025

Gout is a common autoinflammatory disease that clinically manifests as recurrent joint redness, swelling, and pain, but the molecular mechanism of recurrent gouty inflammation remains unclear. Circular RNAs (circRNAs) might exert their fun…

Exploration of molecular biomarkers in ankylosing spondylitis transcriptomics Open

Y NI, Linrui Zhong, Yanhui Li, Zeng Zhang, Bin Ming , et al. · 2024

Background Inflammation of the spine and sacroiliac joints is a hallmark of the chronic, progressive inflammatory illness known as ankylosing spondylitis (AS). The insidious onset and non-specific early symptoms of AS often lead to delays …

Analysis of the Potential Link Between Dermatomyositis and Cancer Open

Jianwei Guo, Tianyi Lei, Xiang Yu, Peng Wang, Hongyuan Xie , et al. · 2024

The findings demonstrate that MIF, C1QA, and CDKN1A are differentially expressed in DM patients, with MIF showing significant alterations in DM patients with cancer. MIF may serve as a crucial prognostic biomarker and therapeutic target fo…

DcR3 suppresses the NF-κB pathway and the NLRP3 inflammasome activation in gouty inflammation Open

Yi Jiang, Xin Tu, Jianwei Guo, Jianxiong Zheng, Xia Liao , et al. · 2024

The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout Open

Zeng Zhang, Peng Wang, Tianyi Lei, Jianwei Guo, Yiguo Jiang , et al. · 2024

BackgroundInterleukin−6 (IL−6) is a pleiotropic cytokine, the specific effects of which depend on the immune microenvironment. Extensive research has confirmed the pathological roles of the IL-6/JAK2/STAT1/3 signaling pathway in inflammati…

Identification and functional prediction of long non-coding RNA and mRNA related to connective tissue disease-associated interstitial lung diseases Open

Fei Dai, Yixi He, Tianyi Lei, Yi Jiang, Quan‐Bo Zhang , et al. · 2023

Objective Recently, the role of long non-coding RNA (lncRNA) in rheumatic immune diseases has attracted widespread attention. However, knowledge of lncRNA in connective tissue disease-associated interstitial lung disease (CTD-ILD) is limit…

New Inflammatory Marker Associated with Disease Activity in Gouty Arthritis: The Systemic Inflammatory Response Index Open

Yi Jiang, Xin Tu, Xia Liao, Yixi He, Shunbing Wang , et al. · 2023

SIRI may be used as a new inflammatory marker of disease activity with gouty arthritis.

Expression Profile of Pyroptosis-Related Genes and the Associated Regulatory Axis in Primary Gout Patients Open

Shaowei Niu, Tian-Yi Lei, Fei Dai, Hongyuan Xie, Xiang Yu , et al. · 2023

There are several differentially expressed PRGs in PBMCs of gout patients, which are involved in the regulation of gout inflammation through multiple pathways. hsa_circRNA_102911-hsa-miR-129-5p-DDX3X\NLRP3\NLRP9 may be the key regulatory p…

Establishment and Validation of Predictive Model of Tophus in Gout Patients Open

Tianyi Lei, Jianwei Guo, Peng Wang, Zeng Zhang, Shaowei Niu , et al. · 2023

(1) Background: A tophus is a clinical manifestation of advanced gout, and in some patients could lead to joint deformities, fractures, and even serious complications in unusual sites. Therefore, to explore the factors related to the occur…

Musculoskeletal Ultrasound in Monitoring the Efficacy of Gout: A Prospective Study Based on Tophus and Double Contour Sign Open

Hongmei Yuan, Yuhong Fan, Xurong Mou, Yufeng Qing, Yan Xiang , et al. · 2023

After one year of uric acid-lowering therapy in patients with gout, an ultrasound indicated that the size of tophus and the semiquantitative ultrasound scoring system of double contour sign score decreased dramatically in the treat-to-targ…

OP0114 IDENTIFICATION AND FUNCTIONAL PREDICTION OF LONG NONCODING RNA RELATED TO CONNECTIVE TISSUE DISEASE-ASSOCIATED INTERSTITIAL LUNG DISEASES Open

Fei Dai, Q. B. Zhang, Yingkai He, Yiping Tang, Tianyi Lei , et al. · 2022

AB0702 Coexistence of systemic sclerosis and microscopic polyangitis associated with pulmonary renal syndrome: a case report and literature review | Annals of the Rheumatic Diseases Open

Yuting Jiang, Yingkai He, Xuan Liao, S. B. Wang, Yufeng Qing · 2022

Coexistence of Systemic Sclerosis and Microscopic Polyangitis Associated With Pulmonary Renal Syndrome: a Case Report and Literature Review Open

Yi Jiang, Xia Liao, Yixi He, Tianyi Lei, Shunbing Wang , et al. · 2022

Objective : To investigate the clinical characteristics, diagnosis and treatment of coexistence of systemic sclerosis (SSc) and microscopic polyangitis（MPA）associated with pulmonary renal syndrome (PRS). Methods : The clinical data, diagno…

Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout Open

Fei Dai, Quan‐Bo Zhang, Yiping Tang, Yixi He, Ting Yi , et al. · 2021

Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) with a single-stranded covalently closed-loop structure, and their abnormal expression may participate in the pathogenesis of various human diseases. Currently, knowledge of circRNAs in…

Circular RNAs in peripheral blood mononuclear cells from ankylosing spondylitis Open

Yiping Tang, Quan‐Bo Zhang, Fei Dai, Xia Liao, Zeng-Rong Dong , et al. · 2021

Background: Circular RNA (circRNA) is a type of closed circular noncoding RNA (ncRNA), mostly formed by back-splicing or alternative splicing of pre-messenger RNA (mRNA). The aim of this study was to explore the expression profile of circR…

AB0075 HSA_CIRC_0012732, HSA_CIRC_0008961, HSA_CIRC_0405239 AND HSA_CIRC_0068784 MIGHT BE INVOLVED IN THE PATHOGENESIS AND DEVELOPMENT OF ANKYLOSING SPONDYLITIS Open

Yuefeng Tang, Yufeng Qing, Zepeng Dong, Fengxian Dai, Judun Zheng , et al. · 2021

POS0136 ROLES OF AUTOPHAGY IN THE PATHOGENESIS OF PRIMARY GOUTY ARTHRITIS Open

Y. Q. Huang, Q. B. Zhang, Jia Zheng, Gonghui Jian, Tianhui Liu , et al. · 2021

POS1146 NONCODING RNA CONTRIBUTE TO PATHOGENESIS IN PRIMARY GOUTY ARTHRITIS Open

Q. B. Zhang, Y. Q. Huang, Fangjing Xiao, Gonghui Jian, Yiping Tang , et al. · 2021

MicroRNA-223 Suppresses IL-1β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome Open

Quan‐Bo Zhang, Dan Zhu, Fei Dai, Yuqin Huang, Jianxiong Zheng , et al. · 2021

Introduction: MicroRNA-223 (MiR-223) serves as an important regulator of inflammatory and immune responses and is implicated in several auto-inflammatory disorders. Here, we measured miR-223 expression in acute and intercritical gout patie…

LncRNAs Landscape in the patients of primary gout by microarray analysis Open

Yufeng Qing, Jianxiong Zheng, Yiping Tang, Fei Dai, Zeng-Rong Dong , et al. · 2021

To determine the expression profile and clinical significance of long non-coding RNAs (lncRNAs) in peripheral blood mononuclear cells (PBMCs) of patients with primary gout and healthy control subjects. Human lncRNA microarrays were used to…

Autophagy dysfunction may be involved in the pathogenesis of ankylosing spondylitis Open

Min Tan, Quan‐Bo Zhang, Tao‐Hong Liu, Yanyu Yang, Jianxiong Zheng , et al. · 2020

The present study aimed to investigate the expression and significance of the mRNA of genes associated with autophagy and long non-coding RNA (lncRNA) GAS5 in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylit…

LncRNAs Landscape in the patients of primary gout by Microarray Analysis Open

Yufeng Qing, Jianxiong Zheng, Yiping Tang, Fei Dai, Zeng-Rong Dong , et al. · 2020

To determine the differential profiles of long non-coding RNAs (lncRNAs) in Peripheral blood mononuclear cells (PBMCs) among acute gout (AG) patients, intercritical gout (IG) patients and healthy control subjects, and to explore the specif…

Aberrant expression of long non‑coding RNAs in peripheral blood mononuclear cells isolated from patients with gouty arthritis Open

Xiaowu Zhong, Yuanhong Peng, Hebin Liao, Chengjiao Yao, Jiulong Li , et al. · 2019

Gouty arthritis (GA) is the most common inflammatory and immune-associated disease, and its prevalence and incidence exhibit yearly increases. The aim of the present study was to analyse the expression profile variation of long non-coding …

Yufeng Qing YOU? Author Swipe