Yufeng Tian
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View article: Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses
Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses Open
View article: Arginine promotes the activation of human lung fibroblasts independent of its metabolism
Arginine promotes the activation of human lung fibroblasts independent of its metabolism Open
Arginine is a conditionally essential amino acid with known roles in protein production, nitric oxide synthesis, biosynthesis of proline and polyamines, and regulation of intracellular signaling pathways. Arginine biosynthesis and cataboli…
View article: Associations between the risk of LUTS/BPH and the number and class of chronic diseases among middle-aged and elder men
Associations between the risk of LUTS/BPH and the number and class of chronic diseases among middle-aged and elder men Open
View article: HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages
HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages Open
View article: Prognostic role of claudin-18.2 in intrahepatic cholangiocarcinoma
Prognostic role of claudin-18.2 in intrahepatic cholangiocarcinoma Open
View article: Correction: Ong et al. Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker. Diagnostics 2023, 13, 2296
Correction: Ong et al. Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker. Diagnostics 2023, 13, 2296 Open
In the original publication [...]
View article: mTOR signaling regulates multiple metabolic pathways in human lung fibroblasts after TGF-β and in pulmonary fibrosis
mTOR signaling regulates multiple metabolic pathways in human lung fibroblasts after TGF-β and in pulmonary fibrosis Open
Here, we used transcriptomic and metabolomic approaches to develop a more complete understanding of the role that mTOR, and its downstream effector ATF4, play in promoting metabolic reprogramming in lung fibroblasts. We identify novel meta…
View article: Mitochondrial pyruvate dehydrogenase phosphatase metabolism disorder in malignant tumors
Mitochondrial pyruvate dehydrogenase phosphatase metabolism disorder in malignant tumors Open
This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase (PDP) in malignant tumors and its potential mechanisms. Recent research on tumor metabolic mechanisms has shown that PDP dysregulation …
View article: High Intelectin‐1 Expression Associated with Aggressive Tumor Behavior and Worse Survival in Rectal Cancer
High Intelectin‐1 Expression Associated with Aggressive Tumor Behavior and Worse Survival in Rectal Cancer Open
Elevated ITLN1 expression is significantly associated with aggressive tumor behavior and unfavorable survival outcomes in rectal cancer. These findings highlight ITLN1 as a potential prognostic biomarker and provide a foundation for future…
View article: Low CXCL11 expression is indicative of poor prognosis in rectal cancer patients undergoing preoperative chemoradiotherapy: a retrospective cohort study
Low CXCL11 expression is indicative of poor prognosis in rectal cancer patients undergoing preoperative chemoradiotherapy: a retrospective cohort study Open
View article: Role of Arginine and its Metabolism in TGF-β-Induced Activation of Lung Fibroblasts
Role of Arginine and its Metabolism in TGF-β-Induced Activation of Lung Fibroblasts Open
Arginine is a conditionally essential amino acid with known roles in protein production, nitric oxide synthesis, biosynthesis of proline and polyamines, and regulation of intracellular signaling pathways. Arginine biosynthesis and cataboli…
View article: High sodium intake increases interstitial lung disease and pulmonary sarcoidosis based on the Global Burden of Disease study 1999–2019
High sodium intake increases interstitial lung disease and pulmonary sarcoidosis based on the Global Burden of Disease study 1999–2019 Open
View article: Sustained hypoxia but not intermittent hypoxia induces HIF-1α transcriptional response in human aortic endothelial cells
Sustained hypoxia but not intermittent hypoxia induces HIF-1α transcriptional response in human aortic endothelial cells Open
This study investigates how endothelial cells respond to sustained (SH) and intermittent (IH) hypoxia, a hallmark of obstructive sleep apnea. HIF-1α was induced by SH but not by IH. SH and IH activate distinct transcriptional responses.
View article: HIF-1α regulates mitochondrial function in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages
HIF-1α regulates mitochondrial function in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages Open
Summary HIF-1α plays a critical role in shaping macrophage phenotype and effector function. We have previously shown that tissue-resident alveolar macrophages (TR-AMs) have extremely low glycolytic capacity at steady-state, but can shift t…
View article: The clinicopathological significance and prognostic impact of 14-3-3σ/stratifin expression on patients with surgically resectable intrahepatic cholangiocarcinoma
The clinicopathological significance and prognostic impact of 14-3-3σ/stratifin expression on patients with surgically resectable intrahepatic cholangiocarcinoma Open
These findings suggest that stratifin may play a crucial role in iCCA oncogenesis and tumor progression, serving as a potential novel prognostic biomarker.
View article: Surgical Outcomes of Open and Laparoscopic Hartmann Reversal: A Single-Center Comparative Study
Surgical Outcomes of Open and Laparoscopic Hartmann Reversal: A Single-Center Comparative Study Open
Whether using a laparoscopic or an open method, HR is challenging. In our study, patients who underwent LHR were associated with reduced hospital stays and faster bowel movements.
View article: Long non-coding RNA C20orf56 as predictor for response to neoadjuvant CCRT and survival rates of rectal cancers
Long non-coding RNA C20orf56 as predictor for response to neoadjuvant CCRT and survival rates of rectal cancers Open
Introduction: Colorectal cancers are the third most prevalent malignant neoplasms and the second leading cause of cancer mortality globally. The introduction of neoadjuvant concurrent chemoradiotherapy (CCRT) for patients with resectable r…
View article: ATF4 and mTOR regulate metabolic reprogramming in TGF-β-treated lung fibroblasts
ATF4 and mTOR regulate metabolic reprogramming in TGF-β-treated lung fibroblasts Open
Idiopathic pulmonary fibrosis is a fatal disease characterized by the TGF-β-dependent activation of lung fibroblasts, leading to excessive deposition of collagen proteins and progressive replacement of healthy lung with scar tissue. We and…
View article: Comprehensive genomic profiling and therapeutic implications for Taiwanese patients with treatment‐naïve breast cancer
Comprehensive genomic profiling and therapeutic implications for Taiwanese patients with treatment‐naïve breast cancer Open
Background Breast cancer is a heterogeneous disease categorized based on molecular characteristics, including hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) expression levels. The emergence of profiling technolog…
View article: Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma
Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma Open
Cholangiocarcinoma is the most common malignant bile duct tumor in Southeast Asia. The special location of cholangiocarcinoma leads to it being difficult to diagnose. Currently, the progress in clinical prognosis outcomes remains abysmal o…
View article: Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production
Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production Open
A hallmark of Idiopathic Pulmonary Fibrosis is the TGF-β-dependent activation of lung fibroblasts, leading to excessive deposition of collagen proteins and progressive scarring. We have previously shown that synthesis of collagen by lung f…
View article: The effect of modified observation-teaching-discussion pedagogy combined with microteaching on the critical thinking ability of nursing interns in China: a quasi-experimental study
The effect of modified observation-teaching-discussion pedagogy combined with microteaching on the critical thinking ability of nursing interns in China: a quasi-experimental study Open
Aim The aim of this study is to investigate the effect of modified observation-teaching-discussion pedagogy combined with microteaching on improving the critical thinking ability of nursing interns in China. Methods Two hundred baccalaurea…
View article: LAMC2 is a potential prognostic biomarker for cholangiocarcinoma
LAMC2 is a potential prognostic biomarker for cholangiocarcinoma Open
Cholangiocarcinoma is a common malignancy with increasing incidence worldwide. Most patients are diagnosed at the advanced stage with poor survival rate. Laminin subunit γ2 (LAMC2) is a heparin binding-associated gene involved in tumorigen…
View article: Cartilage oligomeric matrix protein overexpression is an independent poor prognostic indicator in patients with intrahepatic cholangiocarcinoma
Cartilage oligomeric matrix protein overexpression is an independent poor prognostic indicator in patients with intrahepatic cholangiocarcinoma Open
Cartilage oligomeric matrix protein (COMP) interacts with various extracellular matrix proteins in tissues. Elevated COMP levels recently linked to worse overall survival in multiple cancer types. COMP's significance in intrahepatic cholan…
View article: Gene Characterization and Protein Expression Analysis of LsARF2 in Lettuce (Lactuca sativa L.) Under High Temperature
Gene Characterization and Protein Expression Analysis of LsARF2 in Lettuce (Lactuca sativa L.) Under High Temperature Open
In this study, our objective is to investigate the gene characteristics of LsARF2, an auxin response factor in leaf lettuce, and analyze how its protein expression responds to high temperature. To achieve this, we cloned the LsARF2 gene an…
View article: Associations between indoor air pollution for cooking and heating with muscle and sarcopenia in Chinese older population
Associations between indoor air pollution for cooking and heating with muscle and sarcopenia in Chinese older population Open
Background Exposure to air pollution brings the advent effect for various diseases, but study about the relationship between air pollution and ageing is scant. We aimed to determine the associations between household air pollution for cook…
View article: Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker
Underexpression of Carbamoyl Phosphate Synthetase I as Independent Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma: A Potential Theranostic Biomarker Open
Intrahepatic cholangiocarcinoma (IHCC) is the second most common malignant neoplasm of the liver. In spite of the increasing incidence worldwide, it is relatively rare in Western countries. IHCC is relatively common in Eastern and Southeas…
View article: Phytochemical composition, antioxidant, anti-tyrosinase, anti-cholinesterase, and anti-inflammatory activities of Rhynchanthus beesianus rhizome extracts
Phytochemical composition, antioxidant, anti-tyrosinase, anti-cholinesterase, and anti-inflammatory activities of Rhynchanthus beesianus rhizome extracts Open
Rhynchanthus beesianus is a medicine food homology plant, and its rhizome is a food spice and traditional Chinese medicine used to treat inflammation-related disorders. Still, little research has been done on its phytochemicals and biologi…
View article: Prognostic Significance of DNA Topoisomerase II Alpha (TOP2A) in Cholangiocarcinoma
Prognostic Significance of DNA Topoisomerase II Alpha (TOP2A) in Cholangiocarcinoma Open
Background: Cholangiocarcinoma (CCA) is a malignant tumor with an increasing incidence worldwide. Although radiation therapy has improved the therapeutic efficiency of CCA treatment, differential expression of genes among cholangiocarcinom…
View article: Punicalagin is cytotoxic to human colon cancer cells by modulating cell proliferation, apoptosis, and invasion
Punicalagin is cytotoxic to human colon cancer cells by modulating cell proliferation, apoptosis, and invasion Open
Purpose: The purpose of this study was to explore the anticancer effect of punicalagin, an abundant bioactive tannin compound isolated from Punica granatum L., on three colon cancer cell lines, namely, HCT 116, HT-29, and LoVo. Research De…