Yuhai Bi
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View article: Complex Reassortment Dynamics of H9N2 Avian Influenza Viruses in Xinjiang, China: Implications for Zoonotic Spillover
Complex Reassortment Dynamics of H9N2 Avian Influenza Viruses in Xinjiang, China: Implications for Zoonotic Spillover Open
Background H9N2 avian influenza viruses (AIVs) donate their genes to other subtype AIVs, posing significant threats to poultry industries and public health due to their endemicity and zoonotic potential. This study investigates the molecul…
View article: ApoD mediates age-associated increase in vulnerability to influenza virus infection
ApoD mediates age-associated increase in vulnerability to influenza virus infection Open
Influenza A virus (IAV) infection causes significantly greater morbidity and mortality in the elderly population, but the molecular mechanisms in the aging process responsible for severe infection remain unclear. In this study, we found th…
View article: GhSTZ-Mediated Suppression of Metabolic–Immune Coordination Compromises Cotton Defense Against Verticillium Wilt
GhSTZ-Mediated Suppression of Metabolic–Immune Coordination Compromises Cotton Defense Against Verticillium Wilt Open
Verticillium wilt (VW), caused by Verticillium dahliae, poses a significant threat to global cotton production. Through analysis of public transcriptome databases, this study identified GhSTZ, a C2H2 zinc finger protein transcription facto…
View article: Recombinase polymerase amplification combined with CRISPR/Cas12a technology for rapid on-site detection of duck adenovirus 3
Recombinase polymerase amplification combined with CRISPR/Cas12a technology for rapid on-site detection of duck adenovirus 3 Open
Duck adenovirus 3 (DAdV-3) causes liver damage and bleeding, with morbidity rates ranging from 40 to 55% and mortality rates between 35 and 43%. Co-infection with other pathogens complicates disease control, significantly impacting the duc…
View article: The Winners Take It All? Evolutionary Success of H5Nx Reassortants in the 2020–2024 Panzootic
The Winners Take It All? Evolutionary Success of H5Nx Reassortants in the 2020–2024 Panzootic Open
Avian influenza viruses undergo frequent genetic reassortment, which can coincide with phenotypic changes in transmission, pathogenicity, and host species niche. Since 2020, clade 2.3.4.4b H5 high pathogenicity avian influenza viruses (HPA…
View article: Dynamic adaptation mutations and pathogenic characterization of a mouse-adapted seasonal human H3N2 influenza virus
Dynamic adaptation mutations and pathogenic characterization of a mouse-adapted seasonal human H3N2 influenza virus Open
One A(H3N2)-MA strain has been developed that can infect and kill mice. The MA strain showed stronger replication ability and pathogenicity than the A(H3N2)-WT strain. This A(H3N2)-MA model provides a valuable basis for evaluating the effe…
View article: Advancing Forward-looking Research to Tackle the Major Challenges of Emerging and Re-emerging Infectious Diseases
Advancing Forward-looking Research to Tackle the Major Challenges of Emerging and Re-emerging Infectious Diseases Open
View article: A Cotton Laccase Confers Disease Resistance Against <i>Verticillium dahliae</i> by Promoting Cell Wall Lignification
A Cotton Laccase Confers Disease Resistance Against <i>Verticillium dahliae</i> by Promoting Cell Wall Lignification Open
Verticillium wilt (VW), caused primarily by Verticillium dahliae , is a significant threat to cotton production. Lignification of the plant cell wall, a defence response triggered by pathogen invasion, is critical for plant resistance to n…
View article: YIPF5 is an essential host factor for porcine epidemic diarrhea virus double-membrane vesicle formation
YIPF5 is an essential host factor for porcine epidemic diarrhea virus double-membrane vesicle formation Open
Porcine epidemic diarrhea virus (PEDV) is a major coronavirus in swine, causing substantial economic losses in the industry. To deepen our understanding of the PEDV–host cell interactions, we performed whole-genome CRISPR/Cas9 screens on p…
View article: A human-infecting H10N5 avian influenza virus: Clinical features, virus reassortment, receptor-binding affinity, and possible transmission routes
A human-infecting H10N5 avian influenza virus: Clinical features, virus reassortment, receptor-binding affinity, and possible transmission routes Open
Unlike the human-infecting H10N3 and H10N8 AIVs acquiring six internal protein-coding genes from H9N2 AIVs in domestic poultry, the human-infecting H10N5 AIV was generated through multiple reassortments among viruses mainly carried by wild…
View article: H3N2 influenza virus characteristics in China (2019–2022): Genetic, antigenic, and infection dynamics during the COVID-19 pandemic
H3N2 influenza virus characteristics in China (2019–2022): Genetic, antigenic, and infection dynamics during the COVID-19 pandemic Open
Seasonal influenza activity significantly decreased in China during the coronavirus disease 2019 (COVID-19) pandemic, yet the H3N2 virus led to three epidemic waves. Understanding the characteristics of H3N2 epidemic viruses is essential f…
View article: Fatty Acid ABCG Transporter GhSTR1 Mediates Resistance to Verticillium dahliae and Fusarium oxysporum in Cotton
Fatty Acid ABCG Transporter GhSTR1 Mediates Resistance to Verticillium dahliae and Fusarium oxysporum in Cotton Open
Verticillium wilt and Fusarium wilt cause significant losses in cotton (Gossypium hirsutum) production and have a significant economic impact. This study determined the functional role of GhSTR1, a member of the ABCG subfamily of ATP-bindi…
View article: IL-6–Caspase 3 Axis Plays an Important Role in Enteritis Caused by Legionella pneumophila Pulmonary Infection
IL-6–Caspase 3 Axis Plays an Important Role in Enteritis Caused by Legionella pneumophila Pulmonary Infection Open
Background: Since Legionella pneumophila (Lp) is widely present in natural and artificial water environments, it has a high potential risk of outbreak. Diarrhea caused by Lp pulmonary infection is an important symptom of Legionnaires’ dise…
View article: Avian tuberculosis identified as the potential disease in an outbreak in wild migratory birds in China
Avian tuberculosis identified as the potential disease in an outbreak in wild migratory birds in China Open
Impact statement This study identifies avian tuberculosis as a potential cause of mass mortality in wild migratory birds in Inner Mongolia, China. Combining meta‐transcriptomic sequencing and histopathological analysis, it reveals one of t…
View article: Cross-species recognition of two porcine coronaviruses to their cellular receptor aminopeptidase N of dogs and seven other species
Cross-species recognition of two porcine coronaviruses to their cellular receptor aminopeptidase N of dogs and seven other species Open
Porcine deltacoronavirus (PDCoV) and transmissible gastroenteritis coronavirus (TGEV), the two causative agents of porcine diarrhea, have been reported to be at risk of cross-species transmission, including to humans. However, the potentia…
View article: Respiratory Pathogen Profiles of Patients — Beijing Municipality, China, November 2023–April 2024
Respiratory Pathogen Profiles of Patients — Beijing Municipality, China, November 2023–April 2024 Open
Respiratory pathogens exhibited different prevalence trends during the first influenza season following the COVID-19 pandemic. Influenza viruses showed a higher peak incidence and delayed seasonality. Moreover, the co-circulation of viral …
View article: GhGGB Negatively Regulates Drought Resistance in Gossypium hirsutum via Prenylation-Dependent Suppression of ABA Biosynthesis through GhROP1/8 Modification
GhGGB Negatively Regulates Drought Resistance in Gossypium hirsutum via Prenylation-Dependent Suppression of ABA Biosynthesis through GhROP1/8 Modification Open
View article: Cryo-EM structure of Nipah virus L-P polymerase complex
Cryo-EM structure of Nipah virus L-P polymerase complex Open
View article: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus
Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus Open
The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-spe…
View article: Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections in Seals, Russia, 2023
Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections in Seals, Russia, 2023 Open
Highly pathogenic avian influenza A(H5N1) virus was detected in dead seals on Tyuleniy Island in eastern Russia, in the Sea of Okhotsk. Viruses isolated from dead northern fur seals belong to clade 2.3.4.4b and are closely related to virus…
View article: A chimeric mRNA vaccine of S-RBD with HA conferring broad protection against influenza and COVID-19 variants
A chimeric mRNA vaccine of S-RBD with HA conferring broad protection against influenza and COVID-19 variants Open
Influenza and coronavirus disease 2019 (COVID-19) represent two respiratory diseases that have significantly impacted global health, resulting in substantial disease burden and mortality. An optimal solution would be a combined vaccine cap…
View article: Farmed fur animals harbour viruses with zoonotic spillover potential
Farmed fur animals harbour viruses with zoonotic spillover potential Open
View article: Cryo-EM structure of DNA polymerase of African swine fever virus
Cryo-EM structure of DNA polymerase of African swine fever virus Open
African swine fever virus (ASFV) is one of the most important causative agents of animal diseases and can cause highly fatal diseases in swine. ASFV DNA polymerase (DNAPol) is responsible for genome replication and highly conserved in all …
View article: Five-year longitudinal surveillance reveals the continual circulation of both alpha- and beta-coronaviruses in Plateau and Gansu pikas ( <i>Ochotona</i> spp.) at Qinghai Lake, China <sup>1</sup>
Five-year longitudinal surveillance reveals the continual circulation of both alpha- and beta-coronaviruses in Plateau and Gansu pikas ( <i>Ochotona</i> spp.) at Qinghai Lake, China <sup>1</sup> Open
The discovery of alphacoronaviruses and betacoronaviruses in plateau pikas (Ochotona curzoniae) expanded the host range of mammalian coronavirus (CoV) to a new order - Lagomorpha. However, the diversity and evolutionary relationship…
View article: Genetic characteristics of H1N1 influenza virus outbreak in China in early 2023
Genetic characteristics of H1N1 influenza virus outbreak in China in early 2023 Open
• H1N1 strains were collected from Hunan and Jiangsu provinces in early 2023 following the optimized COVID-19 strategy. • Phylogenic analysis revealed that the epidemic H1N1 viruses fell into different HA clades compared to vaccine strains…
View article: The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumonia
The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumonia Open
View article: The multi-kingdom microbiome catalog of the chicken gastrointestinal tract
The multi-kingdom microbiome catalog of the chicken gastrointestinal tract Open
View article: Three novel avastroviruses identified in dead wild crows
Three novel avastroviruses identified in dead wild crows Open
We described three novel avastroviruses identified in dead wild crows by next-generation and Sanger sequencing. They shared 40-50% nucleotide identities to known avastroviruses, and formed a new cluster in the genus Avastrovirus. This stud…
View article: Therapeutic potential of Lonicerae japonicae flos against emerging respiratory viral infections
Therapeutic potential of Lonicerae japonicae flos against emerging respiratory viral infections Open
Background: Respiratory infections continue to rank among the leading global causes of death, and the emergence of new infectious respiratory diseases remains a persistent concern. Throughout Chinese history, particularly in the context of…
View article: The genomic characteristics and pathogenicity of a mammalian orthoreovirus within a new lineage from wild pika in plateau
The genomic characteristics and pathogenicity of a mammalian orthoreovirus within a new lineage from wild pika in plateau Open
Emerging and re-emerging viruses from wild animals have seriously threatened the health of humans and domesticated animals in recent years. Herein, we isolated a new mammalian orthoreovirus (MRV), Pika/MRV/GCCDC7/2019 (PMRV-GCCDC7), in the…