Yuhai Gao
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View article: Sinusoidal alternating electromagnetic field accelerates fracture healing in rats
Sinusoidal alternating electromagnetic field accelerates fracture healing in rats Open
SEMF can accelerate fracture healing by promoting the expression of osteogenic factors and vascular proliferation without significant adverse effects.
View article: Simulated microgravity‐induced oxidative stress and loss of osteogenic potential of osteoblasts can be prevented by protection of primary cilia
Simulated microgravity‐induced oxidative stress and loss of osteogenic potential of osteoblasts can be prevented by protection of primary cilia Open
Oxidative stress has been considered to be closely related to spaceflight‐induced bone loss; however, mechanism is elusive and there are no effective countermeasures. Using cultured rat calvarial osteoblasts exposed to microgravity simulat…
View article: Identifying risk factors for in-stent restenosis in symptomatic intracranial atherosclerotic stenosis: a systematic review and meta-analysis
Identifying risk factors for in-stent restenosis in symptomatic intracranial atherosclerotic stenosis: a systematic review and meta-analysis Open
Background In-stent restenosis (ISR) is an adverse and notable event in the treatment of intracranial atherosclerotic stenosis (ICAS) with percutaneous transluminal angioplasty and stenting (PTAS). The incidence and contributing factors ha…
View article: Computational Surgical Planning Simulation of Intracranial Aneurysms with AneuPlan TM - An exploratory study
Computational Surgical Planning Simulation of Intracranial Aneurysms with AneuPlan TM - An exploratory study Open
Background It is still a challenge to choose the most appropriate endovascular treatment strategy for intracranial aneurysms. In this study, we aimed to investigate the application of AneuPlan™, based on computational fluid dynamics analys…
View article: Functional evaluation of intracranial atherosclerotic stenosis by pressure ratio measurements
Functional evaluation of intracranial atherosclerotic stenosis by pressure ratio measurements Open
View article: Analysis of bacterial diversity and community structure in gastric juice of patients with advanced gastric cancer
Analysis of bacterial diversity and community structure in gastric juice of patients with advanced gastric cancer Open
Background The occurrence and development of gastric cancer are related to microorganisms, which can be used as potential biomarkers of gastric cancer. Objective To screen the microbiological markers of gastric cancer from the microorganis…
View article: Protection of primary cilia is an effective countermeasure against the impairment of osteoblast function induced by simulated microgravity
Protection of primary cilia is an effective countermeasure against the impairment of osteoblast function induced by simulated microgravity Open
The molecular mechanism for the microgravity‐induced decrease in bone formation remains unclear and there is a lack of effective specific preventative therapies. We recently reported that primary cilia of osteoblasts became shorter and eve…
View article: [Low-frequency pulsed electromagnetic fields promote osteoblast mineralization and maturation of rats through the PC2/sAC/PKA/CREB signaling pathway].
[Low-frequency pulsed electromagnetic fields promote osteoblast mineralization and maturation of rats through the PC2/sAC/PKA/CREB signaling pathway]. Open
PC2, located on the surface of the primary cilia of osteoblasts, can perceive and transmit the physical signals from PEMFs and promote the mineralization and maturation of osteoblasts by activating the PC2/ sAC/PKA/CREB signaling pathway.
View article: The Enterprise2 Stent for Endovascular Treatment of Intracranial Aneurysms: Short-Term Results From a Single Center Experience
The Enterprise2 Stent for Endovascular Treatment of Intracranial Aneurysms: Short-Term Results From a Single Center Experience Open
Background: Self-expanding devices, such as the Enterprise VRD (EP-VRD) have widely used for stent-assisted coiling treatment in wided-necked aneuryms while some thromboembolic complications were reported due to its incomplete stent apposi…
View article: Significance of hemodynamic assessment by pressure wire for endovascular therapy of subclavian steal syndrome
Significance of hemodynamic assessment by pressure wire for endovascular therapy of subclavian steal syndrome Open
Objective Subclavian steal syndrome results from hemodynamic impairment due to stenosis or occlusion of subclavian artery. Therefore, it is important for subclavian steal syndrome patients to assess hemodynamic status during endovascular t…
View article: Intestinal microorganisms involved in colorectal cancer complicated with dyslipidosis
Intestinal microorganisms involved in colorectal cancer complicated with dyslipidosis Open
Many CRC patients have abnormal lipid metabolism, and the intestinal microbiota is altered in these CRC patients.
View article: Migration and Differentiation of Osteoclast Precursors under Gradient Fluid Shear Stress
Migration and Differentiation of Osteoclast Precursors under Gradient Fluid Shear Stress Open
The skeleton is able to adapt to mechanical loading through bone remodeling, i.e. bone resorption followed by bone formation. The osteoclasts close to microdamages are believed to initiate bone resorption, but whether local mechanical load…
View article: The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts
The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts Open
Icariin, a prenylated flavonol glycoside isolated from the herb Epimedium, has been considered as a potential alternative therapy for osteoporosis. Previous research has shown that, unlike other flavonoids, icariin is unlikely to ac…
View article: [Effect of low frequency low intensity electromagnetic fields on maturation and mineralization of rat skull osteoblasts <i>in vitro</i>].
[Effect of low frequency low intensity electromagnetic fields on maturation and mineralization of rat skull osteoblasts <i>in vitro</i>]. Open
Objective: To compare the effects of 50 Hz 1.8 mT sinusoidal magnetic field (SEMF) and 50 Hz 0.6 mT pulsed electromagnetic field(PEMF) on the maturation and mineralization of rat calvaria osteoblasts. Methods: Primary culture…
View article: [Primary cilium acts as an oxygen sensor in PC12 cells].
[Primary cilium acts as an oxygen sensor in PC12 cells]. Open
Objective: To investigate the function of primary cilium as an oxygen sensor in PC12 cells. Methods: The PC12 cells were transfected with IFT88 siRNA. The nuclear translocation of hypoxia inducible factor-1α (HIF-1α), nuclear…
View article: Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia
Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia Open
View article: Relevance of parathyroid hormone (PTH), vitamin 25(OH)D3, calcitonin (CT), bone metabolic markers, and bone mass density (BMD) in 860 female cases
Relevance of parathyroid hormone (PTH), vitamin 25(OH)D3, calcitonin (CT), bone metabolic markers, and bone mass density (BMD) in 860 female cases Open
PTH, 25(OH)D3, CT, CTX-1, TRACP, BGP, and BALP were the important technical means for monitoring the level of bone metabolism and the diagnosis and differential diagnosis of osteoporosis.