Yihong Li
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View article: Combined effect of nutritional inflammation as well as depression on mortality in middle-aged and elderly people with osteoporosis and osteopenia
Combined effect of nutritional inflammation as well as depression on mortality in middle-aged and elderly people with osteoporosis and osteopenia Open
Background Inflammation, nutritional status, and depression interact complexly, impacting health outcomes. This study investigates their associations with all-cause and cardiovascular mortality in middle-aged and elderly individuals with o…
View article: 5′ UTR variant in the NDP gene leads to incorrect splicing and familial exudative vitreoretinopathy
5′ UTR variant in the NDP gene leads to incorrect splicing and familial exudative vitreoretinopathy Open
Background Familial exudative vitreoretinopathy (FEVR) represents a clinically and genetically diverse ophthalmic disorder marked by incomplete development of retinal blood vessels. The NDP gene predominantly underlies X-linked FEVR. Metho…
View article: Case Report: Severe gastrointestinal complications in adult IgA vasculitis: a fatal case of acute esophageal necrosis
Case Report: Severe gastrointestinal complications in adult IgA vasculitis: a fatal case of acute esophageal necrosis Open
Henoch–Schönlein purpura (HSP), also known as immunoglobulin A vasculitis (IgAV), is a type of systemic small-vessel inflammatory pathology. Clinical symptoms can range from simple skin purpura to multiorgan damage. IgAV can be divided int…
View article: Epidemiological characteristics and transmission dynamics of the early stage Chikungunya fever outbreak in Foshan City, Guangdong Province, China in 2025
Epidemiological characteristics and transmission dynamics of the early stage Chikungunya fever outbreak in Foshan City, Guangdong Province, China in 2025 Open
Background As of July 22, 2025, the chikungunya virus transmission has been documented across 119 countries and territories of the world. In 2025, an outbreak of chikungunya fever (CF) occurred in Foshan, Guangdong Province, China. We aime…
View article: Allicin Aplealleviates Gouty Arthritis by Regulating the Gut-Joint Axis, Reducing XOD Activity, Inhibiting Oxidative Stress, and Suppressing NLRP3 Inflammasome Activation
Allicin Aplealleviates Gouty Arthritis by Regulating the Gut-Joint Axis, Reducing XOD Activity, Inhibiting Oxidative Stress, and Suppressing NLRP3 Inflammasome Activation Open
This study highlights allicin as a promising therapeutic candidate for GA, emphasizing its potential to inhibit oxidative stress and inflammatory responses by regulating the gut-joint axis.
View article: Genome sequence of <i>Lacticaseibacillus paracasei</i> G277-1.1, a clinical strain that forms enhanced biofilms with <i>Streptococcus mutans</i>
Genome sequence of <i>Lacticaseibacillus paracasei</i> G277-1.1, a clinical strain that forms enhanced biofilms with <i>Streptococcus mutans</i> Open
Lacticaseibacillus paracasei G277-1.1 was isolated from dental plaque of a patient with severe early childhood caries. It forms synergistic biofilms with Streptococcus mutans in vitro . Here, we report its high-quality genome sequence, rev…
View article: DeepHalo: Deep Learning-Powered Exploration of Halogenated Metabolites Uncovering Antibacterial Depsipeptides
DeepHalo: Deep Learning-Powered Exploration of Halogenated Metabolites Uncovering Antibacterial Depsipeptides Open
In the omics era, confident high-throughput analytical tools are crucial for the efficient identification of metabolites. Here, we present DeepHalo, a deep learning-integrated and hierarchically optimized workflow designed for high-through…
View article: A Feature Engineering Framework for Smart Meter Group Failure Rate Prediction
A Feature Engineering Framework for Smart Meter Group Failure Rate Prediction Open
Smart meters play a significant role in power systems, but their condition assessment faces challenges such as inconsistent evaluation criteria and inaccurate assessment results. This paper proposes feature engineering including feature co…
View article: Epidemiological characteristics of acute respiratory infectious diseases in the first year after COVID-19 pandemic in Guangdong Province, China
Epidemiological characteristics of acute respiratory infectious diseases in the first year after COVID-19 pandemic in Guangdong Province, China Open
Background Acute respiratory infections are caused by a diverse range of pathogens. The study aims to elucidate the epidemic characteristics of acute respiratory pathogens in Guangdong Province during the first year after the COVID-19 pand…
View article: Anemoside B4 alleviates ulcerative colitis by attenuating intestinal oxidative stress and NLRP3 inflammasome via activating aryl hydrocarbon receptor through remodeling the gut microbiome and metabolites
Anemoside B4 alleviates ulcerative colitis by attenuating intestinal oxidative stress and NLRP3 inflammasome via activating aryl hydrocarbon receptor through remodeling the gut microbiome and metabolites Open
Ulcerative colitis (UC) is a chronic, non-specific inflammatory disease of the intestines with a significant increase in global incidence in recent years. Oxidative stress and inflammation are two hallmarks of UC pathogenesis. Anemoside B4…
View article: Development and validation of a machine learning-based risk prediction model for stroke-associated pneumonia in older adult hemorrhagic stroke
Development and validation of a machine learning-based risk prediction model for stroke-associated pneumonia in older adult hemorrhagic stroke Open
Objective To develop and validate a machine learning (ML)-based model for predicting stroke-associated pneumonia (SAP) risk in older adult hemorrhagic stroke patients. Methods A retrospective collection of older adult hemorrhagic stroke pa…
View article: Advances and applications of the fungal bioluminescence pathway
Advances and applications of the fungal bioluminescence pathway Open
Bioluminescence has emerged as a valuable resource for developing novel biological tools and engineered luminescent organisms. The fungal bioluminescence pathway (FBP) represents a particularly promising system, employing endogenous, non-t…
View article: Distinct BMP-Smad signaling outputs confer diverse functions in dental mesenchyme
Distinct BMP-Smad signaling outputs confer diverse functions in dental mesenchyme Open
The canonical bone morphogenetic protein (BMP) signaling pathway plays a crucial regulatory role in tooth development by activating Smad proteins to regulate gene expression. We previously identified an atypical canonical BMP signaling in …
View article: Analysis and Solutions for Drug Shortages in Multi-level Medical Institutions in China: References for Developing Countries
Analysis and Solutions for Drug Shortages in Multi-level Medical Institutions in China: References for Developing Countries Open
Background In China, the growth of medical demand has put multi-level medical institutions in a dilemma of drug shortages, which affects medical services and patients' access to medical treatment. This study focuses on China, aiming to ana…
View article: Evaluation of PD-L1 expression status in nasopharyngeal carcinoma by 18F-FDG PET/CT radiomics analysis
Evaluation of PD-L1 expression status in nasopharyngeal carcinoma by 18F-FDG PET/CT radiomics analysis Open
View article: N- and O- Doped Porous Carbon Nanosheets Prepared from Templating Methodology for Supercapacitors
N- and O- Doped Porous Carbon Nanosheets Prepared from Templating Methodology for Supercapacitors Open
Heteroatom-doped biomass-derived porous carbon materials show promising applications as electrode components in energy storage technologies. In this investigation, we present a template-assisted pyrolysis procedure to fabricate nitrogen–ox…
View article: Nonlinear associations between METS-IR and all-cause as well as cardiovascular mortality in adults with osteoporosis and osteopenia: evidence from NHANES 2007–2023
Nonlinear associations between METS-IR and all-cause as well as cardiovascular mortality in adults with osteoporosis and osteopenia: evidence from NHANES 2007–2023 Open
View article: Global status and trends of exosomes in neurodegenerative diseases from 2014 to 2023: a bibliometric and visual analysis
Global status and trends of exosomes in neurodegenerative diseases from 2014 to 2023: a bibliometric and visual analysis Open
Background Neurodegenerative diseases (NDs) are chronic and progressive conditions that significantly impact global public health. Recent years have highlighted exosomes as key mechanisms involved in these diseases. This study aims to visu…
View article: Equilibrate RLHF: Towards Balancing Helpfulness-Safety Trade-off in Large Language Models
Equilibrate RLHF: Towards Balancing Helpfulness-Safety Trade-off in Large Language Models Open
Fine-tuning large language models (LLMs) based on human preferences, commonly achieved through reinforcement learning from human feedback (RLHF), has been effective in improving their performance. However, maintaining LLM safety throughout…
View article: Fukushima Contaminated Water Risk Factor: Global Implications
Fukushima Contaminated Water Risk Factor: Global Implications Open
The discharge of Fukushima radioactively contaminated water into the Pacific Ocean started in August 2023, posing comprehensive threats to marine ecosystems and human health globally. This study introduces the Fukushima Contaminated Water …
View article: Identifying Patterns in Dental Visit Attendance Among Pregnant Women: A Retrospective Cohort Study
Identifying Patterns in Dental Visit Attendance Among Pregnant Women: A Retrospective Cohort Study Open
View article: Association between lipid accumulation products and mortality outcomes in patients with osteoporosis and osteopenia
Association between lipid accumulation products and mortality outcomes in patients with osteoporosis and osteopenia Open
Our study revealed a significant linear negative correlation between the lipid accumulation product (LAP) and both all-cause and cardiovascular mortality in patients diagnosed with osteoporosis (OP) and osteopenia.
View article: A p-n heterojunction sonosensitizer for improved sono-immunotherapy via induction of multimodal cell death mechanisms
A p-n heterojunction sonosensitizer for improved sono-immunotherapy via induction of multimodal cell death mechanisms Open
Rationale: Activating a robust immune system is a crucial strategy for combating solid tumors and preventing recurrences. Studies have shown that cuproptosis and the resulting increased reactive oxygen species (ROS) can trigger immu…
View article: LlamaV-o1: Rethinking Step-by-step Visual Reasoning in LLMs
LlamaV-o1: Rethinking Step-by-step Visual Reasoning in LLMs Open
Reasoning is a fundamental capability for solving complex multi-step problems, particularly in visual contexts where sequential step-wise understanding is essential. Existing approaches lack a comprehensive framework for evaluating visual …
View article: An Outbreak of Chikungunya Fever in China — Foshan City, Guangdong Province, China, July 2025
An Outbreak of Chikungunya Fever in China — Foshan City, Guangdong Province, China, July 2025 Open
View article: An In-Situ Gold Growth Self-Catalytic Signal Amplification System Enhanced Hollow Gold Immunochromatography for Ultrasensitive Detection of P24 Antigen in HIV Infection
An In-Situ Gold Growth Self-Catalytic Signal Amplification System Enhanced Hollow Gold Immunochromatography for Ultrasensitive Detection of P24 Antigen in HIV Infection Open
View article: LlamaV-o1: Rethinking Step-by-step Visual Reasoning in LLMs
LlamaV-o1: Rethinking Step-by-step Visual Reasoning in LLMs Open
View article: Efficacy of a Probiotic Fermented Herb in the Prevention and Treatment of Fish Nocardiosis
Efficacy of a Probiotic Fermented Herb in the Prevention and Treatment of Fish Nocardiosis Open
View article: Effect of Zinc on improving silver diamine fluoride-derived tooth discoloration in vitro
Effect of Zinc on improving silver diamine fluoride-derived tooth discoloration in vitro Open
View article: Effect of Zinc on Improving Silver Diamine Fluoride-derived Tooth Discoloration in Vitro
Effect of Zinc on Improving Silver Diamine Fluoride-derived Tooth Discoloration in Vitro Open
Background Silver Diamine Fluoride (SDF) is effective for arresting dental caries, presenting a valuable non-invasive treatment option in dentistry. Despite its therapeutic advantages, a significant drawback is the tooth discoloration that…