Yanying Miao
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View article: A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma
A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma Open
Glaucoma is a neurodegenerative disease characterized by the progressive degeneration of retinal ganglion cells (RGCs) and their axons, ultimately leading to irreversible vision loss. Elevated intraocular pressure (IOP) is one of the signi…
View article: Overexpression of the inwardly rectifying potassium channel Kir4.1 or Kir4.1 Tyr9Asp in Müller cells exerts neuroprotective effects in an experimental glaucoma model
Overexpression of the inwardly rectifying potassium channel Kir4.1 or Kir4.1 Tyr9Asp in Müller cells exerts neuroprotective effects in an experimental glaucoma model Open
JOURNAL/nrgr/04.03/01300535-202604000-00043/figure1/v/2025-06-30T060627Z/r/image-tiff Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other g…
View article: Multiple viewpoints projection hologram from multiple angular orthogonal projection images based on GPU
Multiple viewpoints projection hologram from multiple angular orthogonal projection images based on GPU Open
To solve the problem of slow generation of multiple viewpoint projection hologram, a novel method for synthesizing Fresnel holograms based on graphics processing unit (GPU) is proposed with multiple angular orthogonal projection images. Fi…
View article: L- and T-type Ca<sup>2+</sup> channels dichotomously contribute to retinal ganglion cell injury in experimental glaucoma
L- and T-type Ca<sup>2+</sup> channels dichotomously contribute to retinal ganglion cell injury in experimental glaucoma Open
Retinal ganglion cell apoptotic death is the main pathological characteristic of glaucoma, which is the leading cause of irreversible blindness. Disruption of Ca2+ homeostasis plays an important role in glaucoma. Voltage-gated Ca2+ channel…
View article: Interplay between Müller cells and microglia aggravates retinal inflammatory response in experimental glaucoma
Interplay between Müller cells and microglia aggravates retinal inflammatory response in experimental glaucoma Open
Background Glaucoma, the leading cause of irreversible blindness, is a retinal neurodegenerative disease, which results from progressive apoptotic death of retinal ganglion cells (RGCs). Although the mechanisms underlying RGC apoptosis in …
View article: Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma
Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma Open
Background Neuroinflammation plays an important role in the pathogenesis of glaucoma. Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory cytokine released from activated retinal glial cells in glaucoma. Here, we investigated h…
View article: Modulation of Rac1/PAK1/connexin43-Mediated ATP Release from Astrocytes Contributes to Retinal Ganglion Cell Survival in Experimental Glaucoma
Modulation of Rac1/PAK1/connexin43-Mediated ATP Release from Astrocytes Contributes to Retinal Ganglion Cell Survival in Experimental Glaucoma Open
Background: Connexin43 (Cx43) is one of major gap junction proteins in glial cells. Mutation in the gap junction protein alpha 1 gene of Cx43 has been detected in human glaucomatous retinas, suggestive of involvement of Cx43 in pathogenesi…
View article: MiR-31 aggravates inflammation and apoptosis in COPD rats via activating the NF-κB signaling pathway
MiR-31 aggravates inflammation and apoptosis in COPD rats via activating the NF-κB signaling pathway Open
OBJECTIVE: To study the effect of micro ribonucleic acid (miR)-31 on rats with chronic obstructive pulmonary disease (COPD) by activating the nuclear factor-κB (NF-κB) signaling pathway.\n\nMATERIALS AND METHODS: A total of 36 Sprague-Dawl…
View article: Ghrelin Attenuates Retinal Neuronal Autophagy and Apoptosis in an Experimental Rat Glaucoma Model
Ghrelin Attenuates Retinal Neuronal Autophagy and Apoptosis in an Experimental Rat Glaucoma Model Open
All these results suggest that ghrelin may provide neuroprotective effect in COH retinas through activating ghrelin/GHSR-1a system, which was mediated by inhibiting retinal autophagy, ganglion cell apoptosis, and Müller cell gliosis.