Yue Chen
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View article: Relationship between serum mineral levels in the second and third trimester of pregnancy and the risk of gestational diabetes mellitus: a retrospective cohort study
Relationship between serum mineral levels in the second and third trimester of pregnancy and the risk of gestational diabetes mellitus: a retrospective cohort study Open
Introduction Gestational diabetes mellitus (GDM) poses significant health risks for both the mother and fetus, and it also increases the mother’s risk of developing type 2 diabetes later in life. Mineral elements may play a crucial role in…
View article: Sex-specific dynamic changes of serum short-chain fatty acids in rhesus monkeys during aging
Sex-specific dynamic changes of serum short-chain fatty acids in rhesus monkeys during aging Open
Serum SCFA profiles varied significantly with both age and sex. The secretion of reproductive and stress-related hormones was highly correlated with these differences. These findings provide new insights into how aging influences sex-depen…
View article: Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation
Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation Open
Macrophages and bone marrow mesenchymal stem cells (BMSCs) share a close relationship within the osteoimmune microenvironment. During mechanically induced bone formation, macrophages respond to stimuli and regulate this microenvironment, i…
View article: Mechanosensitive Piezo channels in mineralized tissues: emerging roles in osteodental adaptation and disease
Mechanosensitive Piezo channels in mineralized tissues: emerging roles in osteodental adaptation and disease Open
Bone and dental tissues are highly mineralized and mechanically sensitive hard tissues. They detect and respond to mechanical forces via mechanosensitive Piezo channels, modulating physiological and pathological processes. While Piezo mech…
View article: L-shaped Design of the Thenar Eminence Perforator Free Flap for Total Reconstruction of the Nasal Ala
L-shaped Design of the Thenar Eminence Perforator Free Flap for Total Reconstruction of the Nasal Ala Open
Summary: We introduce and evaluate a novel L-shaped perforator free flap from the thenar eminence for total nasal ala reconstruction, addressing both the inner and outer linings in complex nasal reconstruction cases. A 74-year-old man with…
View article: Development and validation of machine learning models based on molecular features for estimating the probability of multiple primary lung carcinoma versus intrapulmonary metastasis in patients presenting multiple non-small cell lung cancers
Development and validation of machine learning models based on molecular features for estimating the probability of multiple primary lung carcinoma versus intrapulmonary metastasis in patients presenting multiple non-small cell lung cancers Open
ML models based on the molecular features effectively distcriminate primary tumors from metastases in multiple NSCLCs, which improve the accuracy of multiple NSCLCs diagnosis and assist in clinical decision-making, particularly in challeng…
View article: Gene Therapy for Inherited Liver Disease: To Add or to Edit
Gene Therapy for Inherited Liver Disease: To Add or to Edit Open
Patients suffering from an inherited severe liver disorder require lifelong treatment to prevent premature death. Until recently, the only curative treatment option was liver transplantation, which requires lifelong immune suppression. Now…
View article: Metabolic Assessment in Non-Dialysis Patients with Chronic Kidney Disease
Metabolic Assessment in Non-Dialysis Patients with Chronic Kidney Disease Open
By analyzing the metabolic pathways of different metabolites, we have identified the significant impact of CKD progression. The main metabolic pathways involved are Arginine and Ornithine metabolism, Tryptophan metabolism, and Pentose phos…
View article: Prediction Model for Early-Stage CKD Using the Naples Prognostic Score and Plasma Indoleamine 2,3-dioxygenase Activity
Prediction Model for Early-Stage CKD Using the Naples Prognostic Score and Plasma Indoleamine 2,3-dioxygenase Activity Open
A prediction model based on the NPS and IDO provided good to excellent predictions of early-stage CKD.
View article: Indole Lactic Acid in Plasma and Urine: A Potential Biomarker for Chronic Kidney Disease and Inflammatory
Indole Lactic Acid in Plasma and Urine: A Potential Biomarker for Chronic Kidney Disease and Inflammatory Open
Plasma and urine ILA can potentially be used as biomarkers of CKD and inflammatory status.
View article: The correlation between periodontitis and uncontrolled hypertension is mediated by inflammatory markers: results from a cross-sectional study of urban elderly population in southeast China
The correlation between periodontitis and uncontrolled hypertension is mediated by inflammatory markers: results from a cross-sectional study of urban elderly population in southeast China Open
View article: Self-driven bioactive hybrids co-deliver doxorubicin and indocyanine green nanoparticles for chemo/photothermal therapy of breast cancer
Self-driven bioactive hybrids co-deliver doxorubicin and indocyanine green nanoparticles for chemo/photothermal therapy of breast cancer Open
Breast cancer is characterized by insidious onset, rapid progression, easy recurrence, and metastasis. Conventional monotherapies are usually ineffective due to insufficient drug delivery. Therefore, the combination of multimodal therapy w…
View article: Periodontitis is associated with uncontrolled hypertension: results from a cross-sectional study of urban elderly population in southeast China
Periodontitis is associated with uncontrolled hypertension: results from a cross-sectional study of urban elderly population in southeast China Open
Background Periodontitis is a common local inflammatory disease associated with hypertension, this study aims to explore the relationship between periodontitis and uncontrolled hypertension and whether inflammation indication is a mediator…
View article: Anti-Allergic Effect of Dietary Polyphenols Curcumin and Epigallocatechin Gallate via Anti-Degranulation in IgE/Antigen-Stimulated Mast Cell Model: A Lipidomics Perspective
Anti-Allergic Effect of Dietary Polyphenols Curcumin and Epigallocatechin Gallate via Anti-Degranulation in IgE/Antigen-Stimulated Mast Cell Model: A Lipidomics Perspective Open
Polyphenol-rich foods exhibit anti-allergic/-inflammatory properties. As major effector cells of allergies, mast cells undergo degranulation after activation and then initiate inflammatory responses. Key immune phenomena could be regulated…
View article: Serum Omentin-1 Level is Associated with the Aggregation of Cardiovascular Risk Factors in Adolescents
Serum Omentin-1 Level is Associated with the Aggregation of Cardiovascular Risk Factors in Adolescents Open
The serum omentin-1 level in adolescents is inversely associated with the aggregation of cardiovascular risk factors. Waist circumference and Body Mass Index are factors most closely associated with a decrease in the serum omentin-1 level.
View article: Study on the Effect of Atezolizumab Combined with Bevacizumab after Radical Resection in the Treatment of Hepatocellular Carcinoma
Study on the Effect of Atezolizumab Combined with Bevacizumab after Radical Resection in the Treatment of Hepatocellular Carcinoma Open
To investigate the efficacy of the addition of atezolizumab combined with bevacizumab after radical resection in the treatment of hepatocellular carcinoma. This was a randomized controlled trial in which 84 patients with hepatocellular car…
View article: A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis
A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis Open
View article: Lenvatinib Plus Pembrolizumab vs. Chemotherapy in Pretreated Patients With Advanced Endometrial Cancer: A Cost-Effectiveness Analysis
Lenvatinib Plus Pembrolizumab vs. Chemotherapy in Pretreated Patients With Advanced Endometrial Cancer: A Cost-Effectiveness Analysis Open
Background In the international, randomized, open-label, phase 3 study 309-KEYNOTE-775 trial, lenvatinib plus pembrolizumab (LP) showed improved progression-free survival (PFS) and overall survival (OS) compared with chemotherapy in pretre…
View article: Homologous tumor cell membrane vesicles active preferential self-recognition of tumor cells in vitro
Homologous tumor cell membrane vesicles active preferential self-recognition of tumor cells in vitro Open
Cell membrane vesicles, as delivery carriers of drugs or biological agents in vivo, are an important therapeutic mode in the study of disease treatment. Tumor membrane-derived vesicles have been widely used in tumor therapy because of thei…
View article: Identification of the Myodural Bridge in a Venomous Snake, the Gloydius shedaoensis: What is the Functional Significance?
Identification of the Myodural Bridge in a Venomous Snake, the Gloydius shedaoensis: What is the Functional Significance? Open
Myodural bridges (MDB) are anatomical connections between the suboccipital muscles and the cervical dura mater which pass through both the atlanto-occipital and the atlanto-axial interspaces in mammals. In our previous studies, we found th…
View article: Morphological Index of Fetal Cerebral Ventricular Development: A Diagnostic Ultrasound Study
Morphological Index of Fetal Cerebral Ventricular Development: A Diagnostic Ultrasound Study Open
To establish an unprovable diagnostic indicative index reference for ultrasound examination of the fetal cerebral ventricles, based on the morphological characteristics throughout fetal nervous system development. Key ultrasonic morphologi…
View article: Perturbation of TM6SF2 Expression Alters Lipid Metabolism in a Human Liver Cell Line
Perturbation of TM6SF2 Expression Alters Lipid Metabolism in a Human Liver Cell Line Open
Non-alcoholic fatty liver disease (NAFLD) is caused by excess lipid accumulation in hepatocytes. Genome-wide association studies have identified a strong association of NAFLD with non-synonymous E167K amino acid mutation in the transmembra…
View article: NLRP3 regulates alveolar bone loss in ligature‐induced periodontitis by promoting osteoclastic differentiation
NLRP3 regulates alveolar bone loss in ligature‐induced periodontitis by promoting osteoclastic differentiation Open
Objectives NLRP3 inflammasome is a critical part of the innate immune system and plays an important role in a variety of inflammatory diseases. However, the effects of NLRP3 inflammasome on periodontitis have not been fully studied. Materi…
View article: Development, Reliability, and Validity of the Home Blood Pressure Monitoring Adherence Scale for Patients with Chronic Kidney Disease
Development, Reliability, and Validity of the Home Blood Pressure Monitoring Adherence Scale for Patients with Chronic Kidney Disease Open
Yamin Wang,1,* Kun Li,1,* Huiqun Li,2 Wenbo Zhao,2 Yanru Chen,2 Hongli Shang,2 Min Zhang,3 Jing Zheng4 1School of Nursing, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Department of Nephrology, The Third Affili…
View article: [Increased TRIM5 is associated with a poor prognosis and immune infiltration in glioma patients].
[Increased TRIM5 is associated with a poor prognosis and immune infiltration in glioma patients]. Open
Tripartite motif 5 (TRIM5) plays a significant function in autophagy and involves in immune and tumor processes. While the function of TRIM5 remains poorly understood in glioma. We purpose to evaluate the possible prognostic role of TRIM5 …
View article: B7-H3 Regulates Glioma Growth and Cell Invasion Through a JAK2/STAT3/Slug-Dependent Signaling Pathway
B7-H3 Regulates Glioma Growth and Cell Invasion Through a JAK2/STAT3/Slug-Dependent Signaling Pathway Open
Chuanhong Zhong,1,2 Bei Tao,3 Yitian Chen,4 Zhangchao Guo,1 Xiaobo Yang,1,2 Lilei Peng,1,2 Xiangguo Xia,1,2 Ligang Chen1,2 1Neurosurgery Department, Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of Ch…
View article: Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models
Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models Open
The tumoricidal efficiency of human CAR-T cells is generally evaluated using immune-deficient mouse models; however, due to their immune-incompetency and the species-specific reactivity of a target antigen, these models are problematic to …
View article: Photothermal Therapy: Biodegradable Bi<sub>2</sub>O<sub>2</sub>Se Quantum Dots for Photoacoustic Imaging‐Guided Cancer Photothermal Therapy (Small 1/2020)
Photothermal Therapy: Biodegradable Bi<sub>2</sub>O<sub>2</sub>Se Quantum Dots for Photoacoustic Imaging‐Guided Cancer Photothermal Therapy (Small 1/2020) Open
Two-dimensional Bi2O2Se quantum dots (QDs) are synthesized by a facile top-down approach in article number 1905208 by Yue Chen, Zhenyou Jiang, Jundong Shao, an co-workers. Boasting large photothermal conversion efficiency and excellent pho…
View article: Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image‐Guided Surgery via NIR‐II Fluorescence and PET Bimodal Imaging
Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image‐Guided Surgery via NIR‐II Fluorescence and PET Bimodal Imaging Open
Bimodal imaging with fluorescence in the second near infrared window (NIR‐II) and positron emission tomography (PET) has important significance for tumor diagnosis and management because of complementary advantages. It remains challenging …
View article: [Effect of sclerostin on the functions and related mechanisms of cementoblasts under mechanical stress].
[Effect of sclerostin on the functions and related mechanisms of cementoblasts under mechanical stress]. Open
Under mechanical comprehensive stress, SOST can adjust the bone morphogenetic protein (BMP) /smad signal pathway. Osteosclerosis inhibits the mineralization of cementoblasts under mechanical compressive stress, which may be achieved by inh…