Yuan Gao
YOU?
Author Swipe
View article: Mitochondrial Metabolomics Reveals the Mechanism of SCCP Induced Energy Metabolism Inhibition
Mitochondrial Metabolomics Reveals the Mechanism of SCCP Induced Energy Metabolism Inhibition Open
Short-chain chlorinated paraffins (SCCPs) disturb cellular energy metabolism in vitro, but their subcellular toxicity mechanisms are incompletely understood. This study employed mitochondrial metabolomics integrated with phenotypic assays …
View article: Simulating precipitation-induced karst-stream interactions using a coupled Darcy–Brinkman–Stokes model
Simulating precipitation-induced karst-stream interactions using a coupled Darcy–Brinkman–Stokes model Open
The interaction mechanism between karst aquifers and streams remains unclear, particularly regarding the impact of dynamic groundwater saturation processes under variable precipitation. This challenge hinders the accurate modeling of karst…
View article: Emerging flame retardants in the marine environment: A comprehensive review of occurrence, fate and analytical challenges
Emerging flame retardants in the marine environment: A comprehensive review of occurrence, fate and analytical challenges Open
Emerging flame retardant (EFR) pollutants are ubiquitous in marine environment due to their extensive applications, and capacity for persistence and long-range atmospheric transport. The accurate analysis of EFRs in marine matrices remains…
View article: Statistical Characteristics of Hourly Extreme Heavy Rainfall over the Loess Plateau, China: A 43 Year Study
Statistical Characteristics of Hourly Extreme Heavy Rainfall over the Loess Plateau, China: A 43 Year Study Open
The Loess Plateau, possessing the world’s most extensive loess deposits, is highly vulnerable to accelerated soil erosion and vegetation loss triggered by extreme hourly rainfall (EHR) events due to the inherently erodible nature of its po…
View article: CKD-EHR:Clinical Knowledge Distillation for Electronic Health Records
CKD-EHR:Clinical Knowledge Distillation for Electronic Health Records Open
Electronic Health Records (EHR)-based disease prediction models have demonstrated significant clinical value in promoting precision medicine and enabling early intervention. However, existing large language models face two major challenges…
View article: Determination of four classes of 34 chlorinated persistent organic pollutants in seawater by solid-phase extraction and gas chromatography-electrostatic field orbitrap high resolution mass spectrometry
Determination of four classes of 34 chlorinated persistent organic pollutants in seawater by solid-phase extraction and gas chromatography-electrostatic field orbitrap high resolution mass spectrometry Open
Ocean acts as a "sink" for pollutants in the natural environment. Consequently, issues focused on marine pollution from terrestrial origin is attracting increasing attention. Persistent organic pollutants (POPs), including organochlorine p…
View article: Disaster-Pregnant Environment Stability Evaluation of Geohazards in the Yellow River–Huangshui River Valley, China
Disaster-Pregnant Environment Stability Evaluation of Geohazards in the Yellow River–Huangshui River Valley, China Open
This study aims to identify the key factors contributing to the destabilization of the geohazard disaster-pregnant environment in the Yellow River–Huangshui River Valley and provide a robust scientific basis for proactive disaster preventi…
View article: Determination of short- and medium-chain chlorinated paraffins in different components of human blood using gas chromatography-electron capture negative ion-low resolution mass spectrometry
Determination of short- and medium-chain chlorinated paraffins in different components of human blood using gas chromatography-electron capture negative ion-low resolution mass spectrometry Open
Short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) have attracted significant attention because of their persistence, biotoxicity, bioaccumulation, and long-range migration. Given their worldwide detection in a variety of envi…
View article: What drives income inequality? Bayesian evidence from the emerging market economies
What drives income inequality? Bayesian evidence from the emerging market economies Open
What drives income inequality in emerging market economies? To end it, we approach this topic utilizing Bayesian model averaging and 27 emerging market economies panel dataset from 1990 to 2019. First, differently, we find a U-shaped Kuzne…
View article: Short- and Medium-Chain Chlorinated Paraffins in the Sediment of the East China Sea and Yellow Sea: Distribution, Composition, and Ecological Risks
Short- and Medium-Chain Chlorinated Paraffins in the Sediment of the East China Sea and Yellow Sea: Distribution, Composition, and Ecological Risks Open
Chlorinated paraffins (CPs), a class of complex mixtures synthesized from polychlorinated n-alkanes, are widely used as flame retardants, plasticizers, lubricant additives, coolants, metalworking cutting fluids, and sealants. This study in…
View article: Toxic effects and toxicological mechanisms of chlorinated paraffins: A review for insight into species sensitivity and toxicity difference
Toxic effects and toxicological mechanisms of chlorinated paraffins: A review for insight into species sensitivity and toxicity difference Open
Chlorinated paraffins (CPs), a group of chlorinated alkane mixtures, are frequently detected in various environmental matrices and human bodies. Recently, CPs have garnered considerable attention owing to their potential to induce health h…
View article: Modeling Monthly Nitrate Concentration in a Karst Spring with and without Discrete Conduit Flow
Modeling Monthly Nitrate Concentration in a Karst Spring with and without Discrete Conduit Flow Open
Understanding the coupled continuum pipe-flow framework for modeling contaminant transport in karst systems is critical for protecting water resources therein. This study simulated point and non-point source nitrate concentration in a kars…
View article: Integration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid I
Integration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid I Open
Aristolochic acid (AA) is a group of structurally related compounds what have been used to treat various diseases in recent decades. Aristolochic acid I (AAI), an important ingredient, has been associated with tumorigenesis. Recently, some…
View article: Study of the Contents of Analogues of Aristolochic Acid in Houttuynia cordata by Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry
Study of the Contents of Analogues of Aristolochic Acid in Houttuynia cordata by Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry Open
In this study, a new and simple method was established for the simultaneous determination of analogues of aristolochic acids (aristolochic acid I, aristolochic acid II, aristolactam I and aristolactam AII) in Houttuynia cordata by ultra-hi…
View article: Numerical Simulation of the Effect of Combustion Process on Flue Gas Thermal Deviation in 660MW Boiler
Numerical Simulation of the Effect of Combustion Process on Flue Gas Thermal Deviation in 660MW Boiler Open
In order to analyze the effect of the air volume on the combustion side and the non-uniformity of pulverized coal on the temperature distribution of the boiler outlet flue gas, and then analyze the thermal deviation characteristics of the …
View article: Integration of metabolomics and transcriptomics reveals short-chain chlorinated paraffin-induced hepatotoxicity in male Sprague-Dawley rat
Integration of metabolomics and transcriptomics reveals short-chain chlorinated paraffin-induced hepatotoxicity in male Sprague-Dawley rat Open
Results of this work strongly support the conclusion that low-dose exposure to SCCPs can result in adverse outcomes in the rat model. Significant SCCP-induced inhibition of energy metabolism occurs at environmentally relevant dosages, whic…
View article: Widespread distribution of PET and PC microplastics in dust in urban China and their estimated human exposure
Widespread distribution of PET and PC microplastics in dust in urban China and their estimated human exposure Open
Dust is a fate of many contaminants and may be an important medium for the human exposure to these contaminants. Microplastics (MPs) have been observed in dust in previous studies. However, the mass concentrations of dominant MPs in dust a…