Yuhui Li
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View article: Lipid deposition promotes YTHDF3-mediated m6A modification of PPARα to facilitate liver metastasis of colorectal cancer
Lipid deposition promotes YTHDF3-mediated m6A modification of PPARα to facilitate liver metastasis of colorectal cancer Open
The liver is a common site for cancer metastasis and a key metabolic organ. Lipid metabolism irregularities are linked to liver metastasis risk, but the mechanisms are not fully understood. Herein, in colorectal liver metastases (CRLM) cli…
View article: The <i>PTPN22</i> R620W polymorphism is associated with inclusion body myositis: data from the UKMyoNet study
The <i>PTPN22</i> R620W polymorphism is associated with inclusion body myositis: data from the UKMyoNet study Open
View article: Internal carotid artery bifurcation aneurysms are probably formed to decrease the abnormally-enhanced hemodynamic stresses caused by direct flow impaction
Internal carotid artery bifurcation aneurysms are probably formed to decrease the abnormally-enhanced hemodynamic stresses caused by direct flow impaction Open
ICA bifurcation aneurysm formation is closely associated with significantly decreased hemodynamic stresses, and aneurysm formation occurs to decrease the abnormally-enhanced hemodynamic parameters on the bifurcation apex caused by direct f…
View article: Novel regulation mechanism of histone methyltransferase SMYD5 in rheumatoid arthritis
Novel regulation mechanism of histone methyltransferase SMYD5 in rheumatoid arthritis Open
Background Fibroblast-like synoviocytes (FLS) are crucial for maintaining synovial homeostasis. SMYD5, a member of the histone lysine methyltransferase subfamily SMYDs, is involved in many pathological processes. This study aimed to invest…
View article: Berberine Inhibits Protein Citrullination Of Fibroblast-Like Synoviocytes by Suppressing Autophagy Via Stat3/Pad4 Pathway
Berberine Inhibits Protein Citrullination Of Fibroblast-Like Synoviocytes by Suppressing Autophagy Via Stat3/Pad4 Pathway Open
View article: Endolysin E1 as a Synergistic Therapeutic Agent Against Acinetobacter baumannii: From Genomic Discovery to In Vivo Efficacy
Endolysin E1 as a Synergistic Therapeutic Agent Against Acinetobacter baumannii: From Genomic Discovery to In Vivo Efficacy Open
View article: Root exudates regulate soil antibiotic resistance genes via rhizosphere microbes under long-term fertilization
Root exudates regulate soil antibiotic resistance genes via rhizosphere microbes under long-term fertilization Open
Organic fertilizer application promotes the prevalence of antibiotic resistance genes (ARGs), yet the factors driving temporal differences in ARG abundance under long-term organic fertilizer application remain unclear. This study investiga…
View article: Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases
Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases Open
Curcumin reveals potential in treating an array of cardiovascular diseases (CVDs), including lowering cholesterol and preventing the advancement of atherosclerosis. Heart failure, aortic aneurysm, cardiac ischemia, stroke, myocardial infar…
View article: Research on the Application of Virtual Reality in Ideological and Political Education
Research on the Application of Virtual Reality in Ideological and Political Education Open
Virtual Reality, as a rapidly developing information technology, is gradually being applied to the field of education. This research takes the application of Virtual Reality in ideological and political education as the research object, ai…
View article: Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation
Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation Open
While deep brain stimulation (DBS) is widely employed for managing motor symptoms in Parkinson's disease (PD), its exact circuit mechanisms remain controversial. To identify the neural targets affected by therapeutic DBS in PD, we analyzed…
View article: Impact of coronavirus disease 2019 on psoriatic arthritis: A multiregional observational study
Impact of coronavirus disease 2019 on psoriatic arthritis: A multiregional observational study Open
Background Little is known about the characteristics of patients with psoriatic arthritis (PsA) during the coronavirus disease 2019 (COVID‐19) pandemic. This study aimed to evaluate the impact of COVID‐19 on PsA progression and comprehend …
View article: Erratum to: Regulation of different light conditions for efficient biomass production and protein accumulation of Spirulina platensis
Erratum to: Regulation of different light conditions for efficient biomass production and protein accumulation of Spirulina platensis Open
View article: Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation
Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation Open
Summary While deep brain stimulation (DBS) is widely employed for managing motor symptoms in Parkinson’s disease (PD), its exact circuit mechanisms remain controversial. To identify the neural targets affected by therapeutic DBS in PD, we …
View article: Ribosome biogenesis is required in hemogenic endothelial cells to generate hematopoietic stem cells
Ribosome biogenesis is required in hemogenic endothelial cells to generate hematopoietic stem cells Open
Undergoing endothelial-to-hematopoietic transition, a small fraction of embryonic aortic endothelial cells specializes into hemogenic endothelial cells (HECs) and eventually gives rise to hematopoietic stem cells (HSCs). Previously we have…
View article: Root Exudates Regulate Soil Antibiotic Resistance Genes Via Rhizosphere Microbes Under Long-Term Fertilization
Root Exudates Regulate Soil Antibiotic Resistance Genes Via Rhizosphere Microbes Under Long-Term Fertilization Open
View article: Comparison of ultrasound-guided and traditional localisation in intraspinal anesthesia: a systematic review and network meta-analysis
Comparison of ultrasound-guided and traditional localisation in intraspinal anesthesia: a systematic review and network meta-analysis Open
Objectives The optimal puncture technique for neuraxial anaesthesia in different populations is unclear. We sought to obtain data from randomised controlled trials comparing the impact of ultrasound-guided technology and traditional positi…
View article: ASH2L upregulation contributes to diabetic endothelial dysfunction in mice through STEAP4-mediated copper uptake
ASH2L upregulation contributes to diabetic endothelial dysfunction in mice through STEAP4-mediated copper uptake Open
View article: Value of Baseline Metabolic Tumor Volume for Survival Prognosis and Optimization of Risk-Adapted Treatment Therapy in Patients with Extranodal Nasal-Type Natural Killer/T-Cell Lymphoma
Value of Baseline Metabolic Tumor Volume for Survival Prognosis and Optimization of Risk-Adapted Treatment Therapy in Patients with Extranodal Nasal-Type Natural Killer/T-Cell Lymphoma Open
View article: Attenuating midline thalamus bursting to mitigate absence epilepsy
Attenuating midline thalamus bursting to mitigate absence epilepsy Open
Advancing the mechanistic understanding of absence epilepsy is crucial for developing new therapeutics, especially for patients unresponsive to current treatments. Utilizing a recently developed mouse model of absence epilepsy carrying the…
View article: Polymerization force–regulated actin filament–Arp2/3 complex interaction dominates self-adaptive cell migrations
Polymerization force–regulated actin filament–Arp2/3 complex interaction dominates self-adaptive cell migrations Open
Cells migrate by adapting their leading-edge behaviors to heterogeneous extracellular microenvironments (ECMs) during cancer invasions and immune responses. Yet it remains poorly understood how such complicated dynamic behaviors emerge fro…
View article: Retrospective analysis of low-dose interleukin-2 therapy on chronic autoimmune thyroid disease with concurrent systemic lupus erythematosus
Retrospective analysis of low-dose interleukin-2 therapy on chronic autoimmune thyroid disease with concurrent systemic lupus erythematosus Open
Low-dose IL-2 may downregulate the levels of TG-Ab and TPO-Ab by modulating the immune balance of Treg/Tfh and B-cells, providing new avenue for clinical treatment of AITD.
View article: Plasma metagenomics reveals regional variations of emerging and re-emerging pathogens in Chinese blood donors with an emphasis on human parvovirus B19
Plasma metagenomics reveals regional variations of emerging and re-emerging pathogens in Chinese blood donors with an emphasis on human parvovirus B19 Open
At present, many infectious pathogens, especially emerging/re-emerging pathogens, exist in the blood of voluntary blood donors and may be transmitted through blood transfusions. However, most of Chinese blood centers only routinely screen …
View article: Compressive forces stabilize microtubules in living cells
Compressive forces stabilize microtubules in living cells Open
View article: Analysis of coexisting pathogens in nasopharyngeal swabs from COVID-19
Analysis of coexisting pathogens in nasopharyngeal swabs from COVID-19 Open
Background The impact of COVID-19 on the world is still ongoing, and it is currently under regular management. Although most infected people have flu-like symptoms and can cure themselves, coexisting pathogens in COVID-19 patients should n…
View article: Editorial: Mechanobiology at multiple scales
Editorial: Mechanobiology at multiple scales Open
EDITORIAL article Front. Bioeng. Biotechnol., 14 June 2023Sec. Biomechanics Volume 11 - 2023 | https://doi.org/10.3389/fbioe.2023.1226198
View article: Polymerization force-regulated actin filament-Arp2/3 complex interaction dominates self-adaptive cell migrations
Polymerization force-regulated actin filament-Arp2/3 complex interaction dominates self-adaptive cell migrations Open
Cells migrate by adapting their leading-edge behaviours to heterogeneous extracellular microenvironments (ECMs) during cancer invasions and immune responses. Yet it remains poorly understood how such complicated dynamic behaviours emerge f…
View article: Prediction of Peptide and TCR CDR3 Loops in Formation of Class I MHC-Peptide-TCR Complexes Using Molecular Models with Solvation
Prediction of Peptide and TCR CDR3 Loops in Formation of Class I MHC-Peptide-TCR Complexes Using Molecular Models with Solvation Open
View article: ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High Glucose-Induced Glomerular Mesangial Cells
ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High Glucose-Induced Glomerular Mesangial Cells Open
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease and continues to be a threat to patients with diabetes. Dysfunction of glomerular mesangial cells (GMCs) is the main contributing factor to glomerulosclerosis, which i…
View article: Case Report: Differential lung ventilation with jet ventilation via a bronchial blocker for a patient with a large thoracogastric airway fistula after esophagectomy
Case Report: Differential lung ventilation with jet ventilation via a bronchial blocker for a patient with a large thoracogastric airway fistula after esophagectomy Open
Background A thoracogastric airway fistula (TGAF) is a rare and potentially fatal complication of esophagectomy for esophageal and cardia carcinomas. Isolation of the fistula and pulmonary separation is necessary during the surgical repair…
View article: Perioperative transcutaneous electrical acupoint stimulation (pTEAS) in pain management in major spinal surgery patients
Perioperative transcutaneous electrical acupoint stimulation (pTEAS) in pain management in major spinal surgery patients Open