Yui Harada
YOU?
Author Swipe
View article: Outbreak of leaf spot disease of Cavendish banana caused by <i>Nigrospora</i> spp. in Mindanao Island, Philippines
Outbreak of leaf spot disease of Cavendish banana caused by <i>Nigrospora</i> spp. in Mindanao Island, Philippines Open
Banana leaf diseases are a significant threat to Cavendish banana production. In the Philippines, the main disease has been diagnosed as Black sigatoka disease caused by Pseudocercospora fijiensis based on symptoms. However, our study show…
View article: Protocol for generation of transmitochondrial cybrids under pyruvate/uridine-supplemented conditions using a microfluidic device
Protocol for generation of transmitochondrial cybrids under pyruvate/uridine-supplemented conditions using a microfluidic device Open
View article: Development of Cellular Therapeutics for Cancer Treatment: Functional Enhancements Without Genetic Modification
Development of Cellular Therapeutics for Cancer Treatment: Functional Enhancements Without Genetic Modification Open
View article: 782-F Pseudoprogression and subsequent shrinkage of refractory/relapsed pediatric solid tumors induced by GAIA-102: an interim report of the single-agent cohort in Phase I clinical trial
782-F Pseudoprogression and subsequent shrinkage of refractory/relapsed pediatric solid tumors induced by GAIA-102: an interim report of the single-agent cohort in Phase I clinical trial Open
Background Pseudoprogression and subsequent shrinkage of solid tumor foci are typical clinical processes and are seen in approximately 2–8% of cases during immune checkpoint inhibitor (ICI) treatment. Refractory/relapsed pediatric solid tu…
View article: Supplementary Figures from Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation
Supplementary Figures from Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation Open
Supplementary Figure S1-7
View article: Data from Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation
Data from Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation Open
Peritonitis carcinomatosa is an advanced and intractable state of gastrointestinal and ovarian cancer, where mechanistic elucidation might enable the development of more effective therapies. Peritoneal dissemination of this type of maligna…
View article: Supplementary Figures from Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation
Supplementary Figures from Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation Open
Supplementary Figure S1-7
View article: Data from Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation
Data from Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation Open
Peritonitis carcinomatosa is an advanced and intractable state of gastrointestinal and ovarian cancer, where mechanistic elucidation might enable the development of more effective therapies. Peritoneal dissemination of this type of maligna…
View article: Generation of transmitochondrial cybrids using a microfluidic device
Generation of transmitochondrial cybrids using a microfluidic device Open
Mitochondrial cloning is a promising approach to achieve homoplasmic mitochondrial DNA (mtDNA) mutations. We previously developed a microfluidic device that performs single mitochondrion transfer from a mtDNA-intact cell to a mtDNA-less (ρ…
View article: 150 GAIA-102: a new class off-the-shelf allogeneic NK-like cells that can eliminate solid tumors
150 GAIA-102: a new class off-the-shelf allogeneic NK-like cells that can eliminate solid tumors Open
Background Cancer immunotherapy has been established as a new therapeutic category since the recent success of immune checkpoint inhibitors and a type of adoptive immunotherapy, namely chimeric antigen receptor-modified T cells (CAR-T). Al…
View article: Highly Activated <i>Ex Vivo</i>-expanded Natural Killer Cells in Patients With Solid Tumors in a Phase I/IIa Clinical Study
Highly Activated <i>Ex Vivo</i>-expanded Natural Killer Cells in Patients With Solid Tumors in a Phase I/IIa Clinical Study Open
These results demonstrate that autologous ZNK cells are safe and well-tolerated in patients with different types of advanced solid tumors. Clinical studies using similarly active ZNK cells from human leukocyte antigen/killer cell immunoglo…
View article: Fc-Binding Antibody-Recruiting Molecules Targeting Prostate-Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement
Fc-Binding Antibody-Recruiting Molecules Targeting Prostate-Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement Open
Synthetic small molecules that redirect endogenous antibodies to target cells are promising drug candidates because they overcome the potential shortcomings of therapeutic antibodies, such as immunogenicity. Previously, we reported a no…
View article: Fc-Binding Antibody-Recruiting Molecules Targeting Prostate-Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement
Fc-Binding Antibody-Recruiting Molecules Targeting Prostate-Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement Open
Synthetic small molecules that redirect endogenous antibodies to target cells are promising drug candidates because they overcome the potential shortcomings of therapeutic antibodies, such as immunogenicity. Previously, we reported a novel…
View article: miR-3148 Is a Novel Onco-microRNA that Potentiates Tumor Growth <i>In Vivo</i>
miR-3148 Is a Novel Onco-microRNA that Potentiates Tumor Growth <i>In Vivo</i> Open
MiR-3148 may be a novel onco-microRNA that protects cancer cells from serious stress conditions through the MAPK/ERK pathway, especially in vivo.
View article: Natural antibody against neuroblastoma of TH-MYCN transgenic mice does not correlate with spontaneous regression
Natural antibody against neuroblastoma of TH-MYCN transgenic mice does not correlate with spontaneous regression Open
View article: Capecitabine reverses tumor escape from anti-VEGF through the eliminating CD11bhigh/Gr1high myeloid cells
Capecitabine reverses tumor escape from anti-VEGF through the eliminating CD11bhigh/Gr1high myeloid cells Open
The anti-VEGF humanized antibody bevacizumab suppresses various malignancies, but tumors can acquire drug resistance. Preclinical studies suggest myeloid-derived suppressor cells (MDSCs) may be associated with tumor refractoriness to anti-…
View article: Clinical Applications of Natural Killer Cells
Clinical Applications of Natural Killer Cells Open
Natural killer (NK) cells are an essential component of the innate immune system, and they play a crucial role in immunity against malignancies. Recent advances in our understanding of NK cell biology have paved the way for new therapeutic…
View article: Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling
Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling Open
View article: BubR1 Insufficiency Results in Decreased Macrophage Proliferation and Attenuated Atherogenesis in Apolipoprotein E‐Deficient Mice
BubR1 Insufficiency Results in Decreased Macrophage Proliferation and Attenuated Atherogenesis in Apolipoprotein E‐Deficient Mice Open
Background Budding uninhibited by benzimidazole‐related 1 (BubR1), a cell cycle–related protein, is an essential component of the spindle checkpoint that regulates cell division. BubR1 insufficiency causes early aging‐associated vascular p…
View article: “The future of revegetation technology in cold regions with snowfall ” Comparison of vegetation and growth properties of <I>Artemisia sacrorum</I> communities in Koshin District and Hokkaido
“The future of revegetation technology in cold regions with snowfall ” Comparison of vegetation and growth properties of <i>Artemisia sacrorum</i> communities in Koshin District and Hokkaido Open
本研究では，イワヨモギ群落の植生と生育特性について甲信地方 (分布域外の積雪地) と北海道 (本来の分布域) とを比較し，積雪地での適応について考察した。各調査地 2つの方形区 (2m × 2m) を設け 2014年に調査を行った。甲信地方 (12調査地) ではすべて施工後 10年以上経過した緑化された切土のり面で，多くは木本層の発達した植生であった。北海道 (7調査地) ではすべて海岸に面した急斜面で，海食崖の自然草原 6地点，緑化されたのり面 1地点であった。草型につい…
View article: Effective recovery of highly purified CD326+ tumor cells from lavage fluid of patients treated with a novel cell-free and concentrated ascites reinfusion therapy (KM-CART)
Effective recovery of highly purified CD326+ tumor cells from lavage fluid of patients treated with a novel cell-free and concentrated ascites reinfusion therapy (KM-CART) Open
View article: Mass-production of human dendritic cells in accordance with gmp for clinical studies
Mass-production of human dendritic cells in accordance with gmp for clinical studies Open
Meeting abstracts Although clinical studies have established that antigen-loaded dendritic cells (DCs) vaccines are safe and promising therapy for various kinds of malignancies, their clinical efficacy remains to be established. Issues tha…