Yuichi Baba
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View article: Discontinuation of Tafamidis in Wild-Type Transthyretin Amyloid Cardiomyopathy Patients
Discontinuation of Tafamidis in Wild-Type Transthyretin Amyloid Cardiomyopathy Patients Open
The period from tafamidis discontinuation to death was shorter in ATTRwt-CM patients hospitalized for non-cardiovascular diseases. Discussions of the right period for discontinuation are needed.
View article: Association Between Improvement in Left Ventricular Ejection Fraction and Prognosis of Patients with Cardiac Sarcoidosis
Association Between Improvement in Left Ventricular Ejection Fraction and Prognosis of Patients with Cardiac Sarcoidosis Open
Changes in the left ventricular ejection fraction (LVEF) of patients with cardiac sarcoidosis (CS) have been reported; however, the prognostic implications remain unknown. This study aimed to investigate the predictive factors for LVEF imp…
View article: Phenotypic Severity of <i>SCN5A</i> Related Bradycardia is Independent of Dominant-Negative and Coupled Gating Effects
Phenotypic Severity of <i>SCN5A</i> Related Bradycardia is Independent of Dominant-Negative and Coupled Gating Effects Open
Background Pathogenic SCN5A variants are associated with inherited arrhythmias such as long QT syndrome, Brugada syndrome, and sick sinus syndrome (SSS). While Na v 1.5, an α-subunit of the cardiac sodium channel encoded by SCN5A , has bee…
View article: The Influence of Lifestyle Factors on the Occurrence of Wild-Type Transthyretin Cardiac Amyloidosis
The Influence of Lifestyle Factors on the Occurrence of Wild-Type Transthyretin Cardiac Amyloidosis Open
Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) is a life-threatening condition caused by the deposition of amyloid fibrils from misfolded transthyretin in the myocardium. While protein misfolding underlies its pathogenesis, the tr…
View article: Consideration on Estimating Mean Pulmonary Artery Pressure Using Early Diastolic Pulmonary Regurgitation Velocity
Consideration on Estimating Mean Pulmonary Artery Pressure Using Early Diastolic Pulmonary Regurgitation Velocity Open
Estimation of mean pulmonary artery pressure (mPAP) using peak velocity of pulmonary regurgitation (PR) obtained via continuous‐wave Doppler echocardiography has been applied in clinical practice. However, the theoretical basis for this me…
View article: Absence of the Left Circumflex Artery in Congenital Heart Disease With Vasospastic Myocardial Infarction
Absence of the Left Circumflex Artery in Congenital Heart Disease With Vasospastic Myocardial Infarction Open
This case highlights the clinical importance of congenital LCx absence, its link to congenital heart defects and coronary spasm, and the crucial role of detailed imaging in diagnosis and management.
View article: Learning from Double Positive and Unlabeled Data for Potential-Customer Identification
Learning from Double Positive and Unlabeled Data for Potential-Customer Identification Open
In this study, we propose a method for identifying potential customers in targeted marketing by applying learning from positive and unlabeled data (PU learning). We consider a scenario in which a company sells a product and can observe onl…
View article: Factors Associated with Long-Term Hospitalization in Older Patients with Heart Failure in Japan
Factors Associated with Long-Term Hospitalization in Older Patients with Heart Failure in Japan Open
With the aging of the patient population with heart failure (HF), the length of hospital stay is increasing, contributing to higher healthcare costs. However, factors associated with long-term hospitalization (LTH) in older patients with H…
View article: Intravenous Verapamil for the Management of Atrial Fibrillation: The Gap Between the Guidelines and Clinical Practice
Intravenous Verapamil for the Management of Atrial Fibrillation: The Gap Between the Guidelines and Clinical Practice Open
Objective According to the current guidelines, the use of non-dihydropyridine calcium-channel blockers for the rate control of atrial fibrillation (AF) is contraindicated in patients with heart failure (HF), especially in those with a redu…
View article: Unveiling Clinical and Genetic Distinctions in Pure‐Apical Versus Distal‐Dominant Apical Hypertrophic Cardiomyopathy
Unveiling Clinical and Genetic Distinctions in Pure‐Apical Versus Distal‐Dominant Apical Hypertrophic Cardiomyopathy Open
Background Original apical hypertrophic cardiomyopathy was characterized by left ventricular hypertrophy confined to the apex below the papillary muscle level. In contrast, apical hypertrophic cardiomyopathy in Western countries often incl…
View article: The Assessment of Interatrial Septum Thickness by Echocardiography in Wild-type Transthyretin Amyloidosis
The Assessment of Interatrial Septum Thickness by Echocardiography in Wild-type Transthyretin Amyloidosis Open
Objective Thickening of the interatrial septum (IAS) is one of red flags for cardiac amyloidosis (CA), but the available evidence concerning it is poor. We evaluated the IAS thickness (IAST) using transthoracic echocardiography to determin…
View article: Prognostic role of high‐sensitivity cardiac troponin T in patients with cardiac sarcoidosis: insights from ILLUMINATE‐CS
Prognostic role of high‐sensitivity cardiac troponin T in patients with cardiac sarcoidosis: insights from ILLUMINATE‐CS Open
Aims The prognostic role of high‐sensitivity cardiac troponin T (hs‐cTnT) as a biomarker in patients with cardiac sarcoidosis (CS) has yet to be fully determined, especially when compared with B‐type natriuretic peptide (BNP). Methods and …
View article: Corticosteroid therapy and long-term outcomes in patients with cardiac sarcoidosis stratified by left ventricular ejection fraction
Corticosteroid therapy and long-term outcomes in patients with cardiac sarcoidosis stratified by left ventricular ejection fraction Open
Aims This study aimed to investigate the relationship between corticosteroid therapy and long-term outcomes in patients with cardiac sarcoidosis, stratified by left ventricular ejection fraction (LVEF) at diagnosis. Methods and results Thi…
View article: Trial in Progress: Phase 1/2 Study of Cereblon-Modulating Agent Golcadomide (BMS-986369/CC-99282) in Relapsed or Refractory (R/R) T-Cell Lymphomas (TCLs) (GOLSEEK-3)
Trial in Progress: Phase 1/2 Study of Cereblon-Modulating Agent Golcadomide (BMS-986369/CC-99282) in Relapsed or Refractory (R/R) T-Cell Lymphomas (TCLs) (GOLSEEK-3) Open
Background and significance: TCLs are a rare form of non-Hodgkin lymphoma originating from mature T cells. There is a wide diversity of subtypes, based on histological, immunophenotypic, and genetic characteristics, most of which are aggre…
View article: 'Color Doppler stripes’ make it difficult to diagnose the severity of valvular heart diseases: a report of two cases
'Color Doppler stripes’ make it difficult to diagnose the severity of valvular heart diseases: a report of two cases Open
These cases highlight the diagnostic challenges posed by color Doppler stripes. Recognizing and understanding this artifact are crucial for the accurate diagnosis and management of VHD, ensuring appropriate treatment and patient outcomes.
View article: Prospective Multicenter Screening With High-Sensitivity Cardiac Troponin T for Wild-Type Transthyretin Cardiac Amyloidosis in Outpatient and Community-Based Settings
Prospective Multicenter Screening With High-Sensitivity Cardiac Troponin T for Wild-Type Transthyretin Cardiac Amyloidosis in Outpatient and Community-Based Settings Open
Measurement of hs-cTnT will help to screen for patients with undiagnosed ATTRwt-CA in primary care practice.
View article: Association of left ventricular ejection fraction improvement with prognosis in patients with cardiac sarcoidosis: insights from the ILLUMINATE-CS study
Association of left ventricular ejection fraction improvement with prognosis in patients with cardiac sarcoidosis: insights from the ILLUMINATE-CS study Open
Introduction While the beneficial impact of enhancing left ventricular ejection fraction (LVEF) is well-documented in patients with heart failure with reduced LVEF, its relevance in cardiac sarcoidosis (CS) remains unclear. Purpose This st…
View article: Importance of fourth heart sound and preserved left atrial function in wild‐type transthyretin amyloidosis
Importance of fourth heart sound and preserved left atrial function in wild‐type transthyretin amyloidosis Open
Aims A fourth heart sound (S4) was reported to be almost never present in patients with amyloid light‐chain cardiomyopathy. There have been no reports on S4 in patients with wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM). This …
View article: Cardiac sarcoidosis treated with nonsteroidal immunosuppressive therapy
Cardiac sarcoidosis treated with nonsteroidal immunosuppressive therapy Open
Nonsteroidal immunosuppressive therapy may be a possible treatment option for patients who are not stabilized with corticosteroids alone or develop corticosteroid side effects.
View article: Effects of renin-angiotensin system inhibitor and beta-blocker use on mortality in older patients with heart failure with reduced ejection fraction in Japan
Effects of renin-angiotensin system inhibitor and beta-blocker use on mortality in older patients with heart failure with reduced ejection fraction in Japan Open
Introduction Guideline-directed medical therapy with renin-angiotensin system (RAS) inhibitors and beta-blockers has improved the survival of patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF). However,…
View article: Clinical features of quadricuspid aortic valve in middle‐aged and elderly patients: Insights from a regional study
Clinical features of quadricuspid aortic valve in middle‐aged and elderly patients: Insights from a regional study Open
Background Quadricuspid aortic valve (QAV) is a rare congenital disease. The clinical characteristics of this disease remain unclear except for those in relatively young patients reported from tertiary referral hospitals. The aim of this s…
View article: Relationship of Mild to Moderate Impairment of Left Ventricular Ejection Fraction With Fatal Ventricular Arrhythmic Events in Cardiac Sarcoidosis
Relationship of Mild to Moderate Impairment of Left Ventricular Ejection Fraction With Fatal Ventricular Arrhythmic Events in Cardiac Sarcoidosis Open
Background Current guidelines recommend placing an implantable cardiac defibrillator for patients with cardiac sarcoidosis and a severely impaired left ventricular ejection fraction (LVEF) of ≤35%. In this study, we determined the associat…
View article: The prognostic value of atrial fibrillation in patients with cardiac sarcoidosis
The prognostic value of atrial fibrillation in patients with cardiac sarcoidosis Open
Background/Introduction The prognostic value of the presence of atrial fibrillation (AF) at the time of diagnosis in patients with cardiac sarcoidosis (CS) is unknown. Purpose The aim of this study is to investigate the association between…