Yuichi Kondo
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View article: Metformin prevents diabetes development in type 1 diabetes models via suppression of mTOR and STAT3 signaling in immune cells
Metformin prevents diabetes development in type 1 diabetes models via suppression of mTOR and STAT3 signaling in immune cells Open
Type 1 diabetes (T1D) is an organ-specific autoimmune disease caused by T cell-mediated pancreatic β cell destruction. To evaluate the effects of metformin on immune cells in autoimmune diabetes, we administered metformin intraperitoneally…
View article: Compensatory mechanisms underlying arginine vasopressin regulation in transient polyuria during pregnancy
Compensatory mechanisms underlying arginine vasopressin regulation in transient polyuria during pregnancy Open
Transient polyuria during pregnancy is reportedly caused by increased arginine vasopressin (AVP) degradation due to vasopressinase produced by the placenta. The mechanism underlying transient polyuria during pregnancy has not been establis…
View article: Fast backward steps and detachment of single kinesin molecules measured under a wide range of loads
Fast backward steps and detachment of single kinesin molecules measured under a wide range of loads Open
To understand force generation under a wide range of loads, the stepping of single kinesin molecules was measured at loads from −20 to 42 pN by optical tweezers with high temporal resolution. The optical trap has been improved to halve pos…
View article: Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami
Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami Open
Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end. These dyneins are then pulled back when the axoneme bends in the other direction, …
View article: Modeling Perceived Quality on 8K VVC Video Under Various Screen Sizes and Viewing Distances
Modeling Perceived Quality on 8K VVC Video Under Various Screen Sizes and Viewing Distances Open
Perceptual video quality considerably affects the quality of experience (QoE) of watching television (TV) broadcasts. Viewing conditions, such as the screen size and viewing distance, impact the perceived quality. We performed subjective e…
View article: Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami
Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami Open
During repetitive bending of cilia and flagella, axonemal dynein molecules move in an oscillatory manner along a microtubule (MT), but how the minus-end-directed motor dynein can oscillate back and forth is unknown. There are various facto…
View article: Parathyroid carcinoma detected within the thyroid.
Parathyroid carcinoma detected within the thyroid. Open
Parathyroid carcinoma (PC) is a rare disease accounting for approximately 1% of primary hyperparathyroidism cases. The preoperative differentiation of PC is critical because PC can occasionally metastasise and invade the local tissue. Howe…
View article: Quantitative Detection of Cell Activity by Measuring the Fluctuation of Intracellular Motility
Quantitative Detection of Cell Activity by Measuring the Fluctuation of Intracellular Motility Open
The measurement of cell activity changes during damage is important to understand the process of cell death and evaluate the effect of medicines. To evaluate cell activity generally, we extended the method of intensity fluctuation in which…
View article: Flexural Strength Evaluation of Concrete Signal Pole
Flexural Strength Evaluation of Concrete Signal Pole Open
Concrete signal poles have been used on the railways on a wide scale for over 50 years. For determination whether a pole needs to be replaced or not, it is critical to detect a pole without enough strength. Today, this is done only through…
View article: <b>Replacement Criteria for Concrete Catenary Poles</b>
<b>Replacement Criteria for Concrete Catenary Poles</b> Open
Concrete catenary poles for electric railways are load-supporting members which support overhead contact lines and their fittings, etc., and their required mechanical strength is determined in consideration of the load which in turn depend…
View article: A Case of Bloch-Sulzberger Syndrome
A Case of Bloch-Sulzberger Syndrome Open
5 カ月，女児。正期産，自然分娩にて出生した。出生時より四肢を中心に皮疹を認めたため，日齢 8 日に当科を紹介され受診した。初診時，全身に落屑，四肢には紅斑と痂皮の付着を認めた。足部には水疱形成も確認した。紅斑の病理組織学的所見としては，角質増生を伴い表皮は肥厚し，浮腫状であった。表皮内への好酸球浸潤が認められ，真皮上層では血管拡張および血管周囲性のリンパ球浸潤が目立った。プロぺト®外用を行ったところ，紅斑は次第に消退し，生後 1 カ月で四肢に列序性の疣贅状丘疹を認めるよう…
View article: 3E23 Exposition of Revision of Seismic Design Guideline for Overhead Contact Systems(Electrical-Vehicle)
3E23 Exposition of Revision of Seismic Design Guideline for Overhead Contact Systems(Electrical-Vehicle) Open
In Japan, in order to prevent supports in overhead contact systems from collapsing at the time of an earthquake, we design them according to the Seismic Design Guideline for Overhead Contact Systems and Commentary (hereafter referred to as…
View article: A Case of Solitary Lymph Node Metastasis Strongly Positive for PET Following Radiofrequency Ablation for Hepatocellular Carcinoma
A Case of Solitary Lymph Node Metastasis Strongly Positive for PET Following Radiofrequency Ablation for Hepatocellular Carcinoma Open
症例は60歳代，女性．C型肝炎で経過観察中，2010年にS8肝細胞癌に対して肝動脈塞栓術，2011年に同部位局所再発に対してラジオ波焼灼術が施行された．2012年，MRI検査で腹腔リンパ節腫脹が認められ，当科紹介となった．AFP17.1ng/mlと上昇しており，FDG-PET検査で同部位にFDGの強い集積（SUV＝20.15）を認めたが，それ以外に造影CT像上も肝細胞癌の肝内再発や遠隔転移を疑う所見は認められなかった．以上より，孤立性腹腔リンパ節転移再発を疑い，外科的切除を…
View article: A Case of Lymphoepithelial Cyst of the Pancreas
A Case of Lymphoepithelial Cyst of the Pancreas Open
症例は58歳の男性で,健診にて膵尾部に囊胞性腫瘤を指摘されたため,精査加療目的に当科紹介入院となった.血液検査ではCA19-9が79.6U/mlと上昇を認めた.腹部超音波検査では膵尾部に内部不均一で境界明瞭な囊胞性腫瘤を,腹部CTでは膵尾部に8.9cm大の隔壁に造影効果のある多房性囊胞性腫瘤を認めた.MRIでは膵尾部の腫瘤はT1強調画像で低信号,T2強調画像で内部に一部低信号を伴う高信号領域として描出された.CA19-9が高値であり,悪性の可能性も否定できないため腹腔鏡下に…