Yuichi Yamada
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View article: Effects of recumbent isometric yoga on the daily functioning level of patients with myalgic encephalomyelitis/chronic fatigue syndrome: a randomized, controlled trial
Effects of recumbent isometric yoga on the daily functioning level of patients with myalgic encephalomyelitis/chronic fatigue syndrome: a randomized, controlled trial Open
Background Although seated isometric yoga has been shown to reduce the fatigue and pain of patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), some patients who are for the most part bedridden have difficulty practic…
View article: Channel synapse mediates neurotransmission of airway protective chemoreflexes
Channel synapse mediates neurotransmission of airway protective chemoreflexes Open
Neural reflexes to chemicals in the throat protect the airway from aspiration and infection. Mechanistic understanding of these reflexes remains premature, exemplified by chronic cough-a sensitized cough reflex-being a prevalent unmet clin…
View article: Injury Prevalence and Associated Factors in Japanese Competitive Kendo Collegiate Athletes
Injury Prevalence and Associated Factors in Japanese Competitive Kendo Collegiate Athletes Open
In Japan, many schools include kendo as part of the school physical education program. Farther afield, kendo also serves as a life-long method to improve and retain physical fitness and mental skills for adults of all ages around the world…
View article: Prevalence and Factors Associated with Mental Health Complaints in Japanese Collegiate Athletes
Prevalence and Factors Associated with Mental Health Complaints in Japanese Collegiate Athletes Open
Investigations into mental health epidemiology in various cultural contexts were one of the main recommendations by the recent consensus statement on mental health in athletes, but the evidence in different sporting populations is rising s…
View article: Injury prevalence and associated factors among Japanese lacrosse collegiate athletes
Injury prevalence and associated factors among Japanese lacrosse collegiate athletes Open
Context Sports injuries have a substantial impact on athletes' performance and health. To reduce the risk of an injury occurring, the prevalence, localization, and severity need to be established. Objective To examine the prevalence of spo…
View article: Septic arthritis as breakthrough invasive fusariosis after cord blood transplantation
Septic arthritis as breakthrough invasive fusariosis after cord blood transplantation Open
View article: CJN volume 50 issue 5 Cover and Front matter
CJN volume 50 issue 5 Cover and Front matter Open
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View article: Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy
Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy Open
Small cell lung cancer (SCLC) is one of the deadliest human cancers, with a 5-year survival rate of ∼7%. Here, we performed a targeted proteomics analysis of human SCLC samples and thereby identified hypoxanthine phosphoribosyltransferase …
View article: Clinical effects of wasabi extract containing 6-MSITC on myalgic encephalomyelitis/chronic fatigue syndrome: an open-label trial
Clinical effects of wasabi extract containing 6-MSITC on myalgic encephalomyelitis/chronic fatigue syndrome: an open-label trial Open
View article: Cerebral Glucose Metabolism in Patients with Chronic Disorders of Consciousness
Cerebral Glucose Metabolism in Patients with Chronic Disorders of Consciousness Open
Objective: To measure regional cerebral metabolic rate of glucose (CMRGlu) in patients with chronic disorders of consciousness (DOCs) using 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET). Methods: This retrospective cohort …
View article: A new scoring system for the grading of conventional chondrosarcoma: Its clinicopathological significance
A new scoring system for the grading of conventional chondrosarcoma: Its clinicopathological significance Open
View article: Chronic kidney disease and clinical outcomes in patients with COVID-19 in Japan
Chronic kidney disease and clinical outcomes in patients with COVID-19 in Japan Open
View article: Clinical, Radiological, and Histopathological Characteristics of Periosteal Chondrosarcoma with a Focus on the Frequency of Medullary Invasion
Clinical, Radiological, and Histopathological Characteristics of Periosteal Chondrosarcoma with a Focus on the Frequency of Medullary Invasion Open
Periosteal chondrosarcoma is an extremely rare malignant cartilage-forming tumour that originates from the periosteum and occurs on the surface of bone. Often, it is difficult to distinguish periosteal chondrosarcoma from other tumours, an…
View article: Autonomous Vehicle Overtaking: Modeling and an Optimal Trajectory Generation Scheme
Autonomous Vehicle Overtaking: Modeling and an Optimal Trajectory Generation Scheme Open
Traffic congestion or accidents may occur as a consequence of the difficulty of performing a safe, comfortable, and efficient overtaking in a timely manner when there is a slow or stopped vehicle, cyclist, or partial lane blockage on the r…
View article: Rectal Phenotype of Perianal Paget Disease: Rare Concomitant Phenomena
Rectal Phenotype of Perianal Paget Disease: Rare Concomitant Phenomena Open
Aim: Classically, ‘Paget disease’ refers to a distinct histological pattern in breast carcinoma. Here, we review the clinicopathological features of anorectal adenocarcinoma with ‘pagetoid’ spread. Materials and Methods: Histological and i…
View article: Concurrent cardiac transthyretin and brain β amyloid accumulation among the older adults: The Hisayama study
Concurrent cardiac transthyretin and brain β amyloid accumulation among the older adults: The Hisayama study Open
Previous studies have revealed risk for cognitive impairment in cardiovascular diseases. We investigated the relationship between degenerative changes of the brain and heart, with reference to Alzheimer's disease (AD) pathologies, cardiac …
View article: Tumor microenvironment in giant cell tumor of bone: evaluation of PD-L1 expression and SIRPα infiltration after denosumab treatment
Tumor microenvironment in giant cell tumor of bone: evaluation of PD-L1 expression and SIRPα infiltration after denosumab treatment Open
View article: Myxoinflammatory Fibroblastic Sarcoma on the Dorsum of the Hand
Myxoinflammatory Fibroblastic Sarcoma on the Dorsum of the Hand Open
63 歳,女性。初診 1 年 8 カ月前に前医で左手背の皮下腫瘤を切除され,皮膚線維腫と診断された。初診 6 カ月前に同部位に皮下腫瘤が出現し増大した。同医を受診し,生検で superficial acral fibromyxoma が疑われ,精査加療目的に当科紹介となった。初診時,左手背に約 4×3 cm のドーム状に隆起した皮下腫瘤を認めた。1 cm のマージンをとり,手背腱膜上で切除し,PAT(perifascial areolar tissue)移植および全層植皮術…
View article: A deep learning model to detect pancreatic ductal adenocarcinoma on endoscopic ultrasound-guided fine-needle biopsy
A deep learning model to detect pancreatic ductal adenocarcinoma on endoscopic ultrasound-guided fine-needle biopsy Open
Histopathological diagnosis of pancreatic ductal adenocarcinoma (PDAC) on endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) specimens has become the mainstay of preoperative pathological diagnosis. However, on EUS-FNB specimen…
View article: Gene expression profiling of α-gustducin-expressing taste cells in mouse fungiform and circumvallate papillae
Gene expression profiling of α-gustducin-expressing taste cells in mouse fungiform and circumvallate papillae Open
Taste buds are complex sensory organs embedded in the epithelium of fungiform papillae (FP) and circumvallate papillae (CV). The sweet, bitter, and umami tastes are sensed by type II taste cells that express taste receptors (Tas1rs and Tas…
View article: The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma
The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma Open
View article: Guillain-Barré Syndrome Developed as a Neurological Immune-related Adverse Event After Response to Combination Chemo-immunotherapy
Guillain-Barré Syndrome Developed as a Neurological Immune-related Adverse Event After Response to Combination Chemo-immunotherapy Open
背景．免疫チェックポイント阻害薬（immune checkpoint inhibitors：ICI）は非小細胞肺癌の標準治療で，様々な免疫関連有害事象の報告がある．免疫関連神経障害（neurological immune-related adverse event：nAE）は稀で，報告例は少ない．症例．64歳男性．肺腺癌cT3N3M0，Stage IIICと診断し，初回治療でシスプラチン，ペメトレキセドおよびペムブロリズマブを開始した．最良効果は部分奏効で，ペメトレキセドお…
View article: The Clinical and Histopathological Features of Cutaneous Immune-Related Adverse Events and Their Outcomes
The Clinical and Histopathological Features of Cutaneous Immune-Related Adverse Events and Their Outcomes Open
Immune checkpoint inhibitors (ICIs) cause a variety of inflammatory eruptions. The understanding of ICI-induced inflammatory eruptions with detailed histopathological findings is not adequate, particularly in Asian populations. In this stu…
View article: Copy number gain of CMTM6 increases the expression of PD-L1 in undifferentiated pleomorphic sarcoma
Copy number gain of CMTM6 increases the expression of PD-L1 in undifferentiated pleomorphic sarcoma Open
Background Undifferentiated pleomorphic sarcoma (UPS) is a sarcoma with a poor prognosis. A clinical trial, SARC028, revealed that treatment with anti-PD-1 drugs was effective against UPS. Studies have reported that UPS expresses PD-L1, so…
View article: A case of a malignant peripheral nerve sheath tumor on the cheek following trauma
A case of a malignant peripheral nerve sheath tumor on the cheek following trauma Open
悪性末梢神経鞘腫瘍（MPNST：malignant peripheral nerve sheath tumor）は 末梢神経由来の肉腫で，高率に局所再発，転移を生じる。頭頸部での発生は稀で，今回，頬部MPNSTを経験したので報告する。症例は75歳，男性。自転車走行中に転倒し顔面を受傷，頬部の腫脹に改善なく当科紹介となった。受傷後1ヶ月のMRIにて左側咬筋内に40×35×25mmの充実性病変を認め，生検でmalignant spindle cell tumorの所見であった。…
View article: Drinking Ice-Cold Water Reduces the Severity of Anticancer Drug-Induced Taste Dysfunction in Mice
Drinking Ice-Cold Water Reduces the Severity of Anticancer Drug-Induced Taste Dysfunction in Mice Open
Taste disorders are common adverse effects of cancer chemotherapy that can reduce quality of life and impair nutritional status. However, the molecular mechanisms underlying chemotherapy-induced taste disorders remain largely unknown. Furt…
View article: Correction to: Association of PD-L1 and IDO1 expression with JAK–STAT pathway activation in soft-tissue leiomyosarcoma
Correction to: Association of PD-L1 and IDO1 expression with JAK–STAT pathway activation in soft-tissue leiomyosarcoma Open
View article: The forkhead box M1 (FOXM1) expression and antitumor effect of FOXM1 inhibition in malignant rhabdoid tumor
The forkhead box M1 (FOXM1) expression and antitumor effect of FOXM1 inhibition in malignant rhabdoid tumor Open
View article: PD‑L1 and IDO‑1 expression in undifferentiated pleomorphic sarcoma: The associations with tumor infiltrating lymphocytes, dMMR and HLA class I
PD‑L1 and IDO‑1 expression in undifferentiated pleomorphic sarcoma: The associations with tumor infiltrating lymphocytes, dMMR and HLA class I Open
The prognosis of undifferentiated pleomorphic sarcoma (UPS) is generally unfavorable. Recently, clinical trials such as SARC028 demonstrated the utility of cancer immunotherapy for soft tissue sarcomas. The aim of the present study was to …
View article: Early detection and diagnosis of thrombotic microangiopathy in two patients induced by gemcitabine treatment of pancreatic cancer
Early detection and diagnosis of thrombotic microangiopathy in two patients induced by gemcitabine treatment of pancreatic cancer Open
血栓性微小血管障害(thrombotic microangiopathy:TMA)とは血小板血栓による臓器障害を特徴とする疾患群であり,生命予後・腎機能予後とも不良な病態である.今回,膵癌に対するgemcitabine(GEM)投与中に生じたTMAを早期診断し,腎機能改善が得られた2症例を経験した.