Yuichiro Kikuchi
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View article: Transcription regulator TrtA modulates oxygen stress response in <i>Treponema denticola</i>
Transcription regulator TrtA modulates oxygen stress response in <i>Treponema denticola</i> Open
Periodontitis is caused by dysbiosis of the subgingival microbiome. Treponema denticola is an obligate anaerobe frequently detected in advanced periodontal lesions. However, the mechanism by which T. denticola evades oxygen stress remains …
View article: Characterization of clustered bacteriocin-type signal domain protein genes in Treponema denticola
Characterization of clustered bacteriocin-type signal domain protein genes in Treponema denticola Open
Background Periodontitis is caused by the dysbiosis of subgingival plaque, and Treponema denticola is the pathogen associated with this disease. Bacteriocins are involved in interbacterial competition during dysbiosis. In our previous stud…
View article: SigH of <i>Porphyromonas gingivalis</i> Regulates Oxidative Stress Resistance and Invasion of Oral Epithelial Cells
SigH of <i>Porphyromonas gingivalis</i> Regulates Oxidative Stress Resistance and Invasion of Oral Epithelial Cells Open
Porphyromonas gingivalis, a key periodontal pathogen, employs extra-cytoplasmic function (ECF) sigma factors to adapt to the dynamic oral environment and establish chronic infection. Among these, PGN_1740 (SigH) has been implicated in oxid…
View article: <i>Treponema Denticola</i> Activates NF-κB Pathway <i>via</i> Toll-like Receptor 2
<i>Treponema Denticola</i> Activates NF-κB Pathway <i>via</i> Toll-like Receptor 2 Open
Treponema denticola is frequently isolated together with Porphyromonas gingivalis from the lesions seen in cases of chronic periodontitis and is considered a major pathogen of this disease. It has several virulence factors, including a maj…
View article: <i>Fusobacterium nucleatum</i> Increases Growth of Motile Bacterium <i>Treponema denticola</i> without Contact <i>In Vitro</i>
<i>Fusobacterium nucleatum</i> Increases Growth of Motile Bacterium <i>Treponema denticola</i> without Contact <i>In Vitro</i> Open
More than 700 types of bacteria coexist in the human oral cavity, including motile and non-motile taxa. Fusobacterium nucleatum plays an important role in this environment as a bridge between early- and late-colonizing bacteria. We hypothe…
View article: Effect of <i>Porphyromonas Gingivalis</i> Infection on Epithelial Rests of Malassez
Effect of <i>Porphyromonas Gingivalis</i> Infection on Epithelial Rests of Malassez Open
The epithelial cell rests of Malassez (ERM) are located within the periodontal ligament. They are reportedly involved in maintaining homeostasis, particularly with regards to the thickness of the periodontal ligament. Their role in apical …
View article: Complete genome sequence of <i>Fusobacterium vincentii</i> strain TDC100 isolated from an apical periodontitis lesion
Complete genome sequence of <i>Fusobacterium vincentii</i> strain TDC100 isolated from an apical periodontitis lesion Open
This study reports the complete genome sequence of Fusobacterium vincentii strain TDC100. The complete circular chromosome of strain TDC100 was obtained and assembled using a combination of short- and long-read sequencing.
View article: Impact of Polymicrobial Infection on Fitness of Streptococcus gordonii <i>In Vivo</i>
Impact of Polymicrobial Infection on Fitness of Streptococcus gordonii <i>In Vivo</i> Open
Bacteria responsible for diseases originating at oral mucosal membranes assemble into polymicrobial communities. However, we know little regarding the fitness determinants of the organisms that initiate community formation.
View article: Localization and pathogenic role of the cysteine protease dentipain in <i>Treponema denticola</i>
Localization and pathogenic role of the cysteine protease dentipain in <i>Treponema denticola</i> Open
The Msp protein complex and the serine protease dentilisin are the best‐characterized virulence factors in Treponema denticola , the major etiological agent of chronic periodontitis. In addition to these outer sheath factors, the cysteine …
View article: Effect of <i>Treponema Denticola</i> Infection on Epithelial Cells
Effect of <i>Treponema Denticola</i> Infection on Epithelial Cells Open
Chronic periodontitis is an infectious disease caused by periodontopathic bacteria in subgingival plaque. One major pathogen of this disease, Treponema denticola, has several virulence factors, including a major surface protein (Msp) and t…
View article: Role of Hyalin-like Protein in Gliding and Biofilm Formation by <i>Capnocytophaga Ochracea</i>
Role of Hyalin-like Protein in Gliding and Biofilm Formation by <i>Capnocytophaga Ochracea</i> Open
Capnocytophaga ochracea possesses a type-IX secretion system that exports proteins which have a gliding motility-associated C-terminal (CTD) domain. This system is found in several species of the Bacteroidetes phylum. Hyalin, a large prote…
View article: Investigation of the potential regulator proteins associated with the expression of major surface protein and dentilisin in <i>Treponema denticola</i>
Investigation of the potential regulator proteins associated with the expression of major surface protein and dentilisin in <i>Treponema denticola</i> Open
Objective Treponema denticola is involved in 'chronic' periodontitis pathogenesis. The mechanism underlying the regulation of the expression of its virulence factors, such as major surface protein (Msp) and prolyl-phenylalanine specific pr…
View article: Treponema denticola transcriptional profiles in serum-restricted conditions
Treponema denticola transcriptional profiles in serum-restricted conditions Open
Treponema denticola is a major pathogen in periodontal disease and is frequently isolated from the lesions of patients with chronic periodontitis. Treponema denticola utilizes serum components as nutrient sources so as to colonize and prol…
View article: Identification of a specific domain of Porphyromonas gingivalis Hgp44 responsible for adhesion to Treponema denticola
Identification of a specific domain of Porphyromonas gingivalis Hgp44 responsible for adhesion to Treponema denticola Open
Interaction between two periodontal pathogens, Porphyromonas gingivalis and Treponema denticola, contributes to plaque biofilm formation. Porphyromonas gingivalis forms aggregates with T. denticola through its adhesion/hemagglutinin domain…
View article: <i>Treponema denticola</i> Induces Epithelial Barrier Dysfunction in Polarized Epithelial Cells
<i>Treponema denticola</i> Induces Epithelial Barrier Dysfunction in Polarized Epithelial Cells Open
Treponema denticola, an anaerobic spirochete found mainly in the oral cavity, is associated with periodontal disease and has a variety of virulence factors. Although in vitro studies have shown that T. denticola is able to penetrate epithe…
View article: Effect of extracytoplasmic function sigma factors on autoaggregation, hemagglutination, and cell surface properties of Porphyromonas gingivalis
Effect of extracytoplasmic function sigma factors on autoaggregation, hemagglutination, and cell surface properties of Porphyromonas gingivalis Open
Porphyromonas gingivalis is a bacterium frequently isolated from chronic periodontal lesions and is involved in the development of chronic periodontitis. To colonize the gingival crevice, P. gingivalis has to adapt to environmental stresse…
View article: Possible Involvement of Surface Antigen Protein 2 in the Morphological Transition and Biofilm Formation of <I>Candida albicans</I>
Possible Involvement of Surface Antigen Protein 2 in the Morphological Transition and Biofilm Formation of <i>Candida albicans</i> Open
Surface antigen protein 2 (Csa2) is a member of the Candida albicans Common in Fungal Extracellular Membranes (CFEM) protein superfamily. We previously established its role in iron acquisition in C. albicans. However, the other roles of Cs…
View article: Involvement of the Type IX Secretion System in Capnocytophaga ochracea Gliding Motility and Biofilm Formation
Involvement of the Type IX Secretion System in Capnocytophaga ochracea Gliding Motility and Biofilm Formation Open
Capnocytophaga ochracea is a Gram-negative, rod-shaped bacterium that demonstrates gliding motility when cultured on solid agar surfaces. C. ochracea possesses the ability to form biofilms; however, factors involved in biofilm formation by…