Yuji Hidaka
YOU?
Author Swipe
View article: Synthesis and Cancer Cell Targeting of a Boron-Modified Heat-Stable Enterotoxin Analog for Boron Neutron Capture Therapy (BNCT)
Synthesis and Cancer Cell Targeting of a Boron-Modified Heat-Stable Enterotoxin Analog for Boron Neutron Capture Therapy (BNCT) Open
Heat-stable enterotoxin (STa) is a peptide toxin that induces acute diarrhea by binding to guanylyl cyclase C (GC-C) in intestinal epithelial cells. Interestingly, GC-C is highly expressed not only in intestinal cells but also in certain c…
View article: Mutational Analysis of Substrate Recognition in Trypsin-like Protease Cocoonase: Protein Memory Induced by Alterations in Substrate-Binding Site
Mutational Analysis of Substrate Recognition in Trypsin-like Protease Cocoonase: Protein Memory Induced by Alterations in Substrate-Binding Site Open
To investigate the substrate recognition mechanism of trypsin-like protease cocoonase (CCN), mutational analyses were conducted at key substrate recognition sites, Asp187 and Ser188, and their effects on substrate specificity and enzymatic…
View article: The Cell Adhesion Activity of the Joining Peptide of Proopiomelanocortin
The Cell Adhesion Activity of the Joining Peptide of Proopiomelanocortin Open
Proopiomelanocortin (POMC) is a precursor protein of several peptide hormones, such as ACTH and β-endorphin. Almost all of the peptide hormones in POMC have been drastically investigated in terms of their biological activities. However, th…
View article: A Novel Peptide Reagent for Investigating Disulfide-Coupled Folding Intermediates of Mid-Size Proteins
A Novel Peptide Reagent for Investigating Disulfide-Coupled Folding Intermediates of Mid-Size Proteins Open
Investigations of protein folding have largely involved the use of disulfide-containing proteins, since the disulfide-coupled folding of proteins allows folding intermediates to be trapped and their conformations determined. However, studi…
View article: The Molecular Basis of Heat-Stable Enterotoxin for Vaccine Development and Cancer Cell Detection
The Molecular Basis of Heat-Stable Enterotoxin for Vaccine Development and Cancer Cell Detection Open
Heat-stable enterotoxin (STa) produced by Enterotoxigenic E. coli is responsible for causing acute diarrhea in infants in developing countries. However, the chemical synthesis of STa peptides with the native conformation and the correct in…
View article: Degradation-Suppressed Cocoonase for Investigating the Propeptide-Mediated Activation Mechanism
Degradation-Suppressed Cocoonase for Investigating the Propeptide-Mediated Activation Mechanism Open
Cocoonase is folded in the form of a zymogen precursor protein (prococoonase) with the assistance of the propeptide region. To investigate the role of the propeptide sequence on the disulfide-coupled folding of cocoonase and prococoonase, …
View article: Topological Regulation of the Bioactive Conformation of a Disulfide-Rich Peptide, Heat-Stable Enterotoxin
Topological Regulation of the Bioactive Conformation of a Disulfide-Rich Peptide, Heat-Stable Enterotoxin Open
Heat-stable enterotoxin (STa) produced by enterotoxigenic E. coli causes acute diarrhea and also can be used as a specific probe for colorectal cancer cells. STa contains three intra-molecular disulfide bonds (C1–C4, C2–C5, and C3–C6 conne…
View article: Enzyme Activation Mechanism of Cocoonase
Enzyme Activation Mechanism of Cocoonase Open
View article: Mechanism of the Disulfide-Coupled Folding of a de novo Designed Prouroguanylin Protein
Mechanism of the Disulfide-Coupled Folding of a de novo Designed Prouroguanylin Protein Open
View article: Exploring Serum Proteins to Stabilize the Conformation of the Precursor Protein of ANP
Exploring Serum Proteins to Stabilize the Conformation of the Precursor Protein of ANP Open
View article: Intra-Molecular Chaperone Mediated Folding of a Peptide Hormone in Molecular Evolution
Intra-Molecular Chaperone Mediated Folding of a Peptide Hormone in Molecular Evolution Open
View article: Disulfide-Coupled Folding of Prouroguanylin on Molecular Evolution
Disulfide-Coupled Folding of Prouroguanylin on Molecular Evolution Open
View article: Activation Mechanism of Cocoonase
Activation Mechanism of Cocoonase Open
View article: Folding Analyses of a de novo Designed Prouroguanylin
Folding Analyses of a de novo Designed Prouroguanylin Open
View article: Structural Analyses of a Linker Region of the Amyloid Precursor Protein
Structural Analyses of a Linker Region of the Amyloid Precursor Protein Open
View article: Structural Analysis of the Precursor Protein of Atrial Natriuretic Peptide
Structural Analysis of the Precursor Protein of Atrial Natriuretic Peptide Open
View article: Lipocalin-Type Prostaglandin D Synthase Possesses Two Binding Sites for its Product
Lipocalin-Type Prostaglandin D Synthase Possesses Two Binding Sites for its Product Open
View article: Preparation of a Orexin Precursor Protein by Chemical Digestion
Preparation of a Orexin Precursor Protein by Chemical Digestion Open
View article: Regulation of Protein Folding using Organic Solvents and Ionic Liquids
Regulation of Protein Folding using Organic Solvents and Ionic Liquids Open
View article: Regulation of Folding of de novo Designed Peptides by α-Helix Formation
Regulation of Folding of de novo Designed Peptides by α-Helix Formation Open
View article: Molecular Recognition Mechanism of Hematopoietic Prostaglandin D Synthase with its Cofactor and Substrate
Molecular Recognition Mechanism of Hematopoietic Prostaglandin D Synthase with its Cofactor and Substrate Open
View article: Isothermal Analysis of Interaction between Lipocalin-Type Prostaglandin D Synthase and Prostanoids
Isothermal Analysis of Interaction between Lipocalin-Type Prostaglandin D Synthase and Prostanoids Open
View article: Chemical Acceleration of Disulfide-Coupled Protein Folding
Chemical Acceleration of Disulfide-Coupled Protein Folding Open
View article: Folding Analyses of the Major Folding Intermediate of Prouroguanylin using Deletion Mutants
Folding Analyses of the Major Folding Intermediate of Prouroguanylin using Deletion Mutants Open
View article: Structural Analysis of Lipocalin-Type Prostaglandin D Synthase Complexed with Prostaglandin J2
Structural Analysis of Lipocalin-Type Prostaglandin D Synthase Complexed with Prostaglandin J2 Open
View article: Structural Analysis of Lipocalin-Type Prostaglandin D Synthase Complexed with Prostaglandin J2
Structural Analysis of Lipocalin-Type Prostaglandin D Synthase Complexed with Prostaglandin J2 Open
View article: The Interaction between L-PGDS and its Substrates or Products, as Determined by Isothermal Titration Calorimetry and NMR
The Interaction between L-PGDS and its Substrates or Products, as Determined by Isothermal Titration Calorimetry and NMR Open